MX2020011690A - Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado. - Google Patents

Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.

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Publication number
MX2020011690A
MX2020011690A MX2020011690A MX2020011690A MX2020011690A MX 2020011690 A MX2020011690 A MX 2020011690A MX 2020011690 A MX2020011690 A MX 2020011690A MX 2020011690 A MX2020011690 A MX 2020011690A MX 2020011690 A MX2020011690 A MX 2020011690A
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Mexico
Prior art keywords
products
production
added value
metabolically engineered
engineered organisms
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MX2020011690A
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English (en)
Inventor
Jo Maertens
Joeri Beauprez
Mey Marjan De
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Inbiose Nv
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Application filed by Inbiose Nv filed Critical Inbiose Nv
Publication of MX2020011690A publication Critical patent/MX2020011690A/es

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    • C—CHEMISTRY; METALLURGY
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2431—Beta-fructofuranosidase (3.2.1.26), i.e. invertase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/305—Pyrimidine nucleotides
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01007—Sucrose phosphorylase (2.4.1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01008—Maltose phosphorylase (2.4.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01022—Lactose synthase (2.4.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01069—Galactoside 2-alpha-L-fucosyltransferase (2.4.1.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01026—Beta-fructofuranosidase (3.2.1.26), i.e. invertase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02002—Phosphoglucomutase (5.4.2.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a organismos genéticamente diseñados, especialmente microorganismos tales como bacterias y levaduras, para la producción de bioproductos de valor agregado tal como sacárido especializado, sacárido activado, nucleósido, glicósido, glicolípido o glicoproteína. Más específicamente, la presente invención se refiere a células hospederas que se diseñan metabólicamente de modo que puedan producir los productos especializados valiosos en grandes cantidades y en una tasa alta al evitar los problemas técnicos clásicos que se presentan en los procesos de producción biocatalíticos o fermentativos.
MX2020011690A 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado. MX2020011690A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10169304 2010-07-12

Publications (1)

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MX2020011690A true MX2020011690A (es) 2020-12-10

Family

ID=44060925

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Application Number Title Priority Date Filing Date
MX2013000460A MX353506B (es) 2010-07-12 2011-07-12 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011714A MX2020011714A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011713A MX2020011713A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011693A MX2020011693A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011690A MX2020011690A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011715A MX2020011715A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011691A MX2020011691A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.

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MX2013000460A MX353506B (es) 2010-07-12 2011-07-12 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011714A MX2020011714A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011713A MX2020011713A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011693A MX2020011693A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.

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MX2020011715A MX2020011715A (es) 2010-07-12 2013-01-11 Organismo metabolicamente diseñados para la produccion de bio productos de valor agregado.
MX2020011691A MX2020011691A (es) 2010-07-12 2013-01-11 Organismos metabolicamente diseñados para la produccion de bio productos de valor agregado.

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US (4) US9701992B2 (es)
EP (3) EP4242320A3 (es)
JP (3) JP5998130B2 (es)
CN (3) CN107603935A (es)
AU (1) AU2011278315B2 (es)
CA (1) CA2804713C (es)
DE (1) DE202011111144U1 (es)
DK (1) DK3235907T5 (es)
ES (1) ES2955617T3 (es)
FI (1) FI3235907T3 (es)
MX (7) MX353506B (es)
MY (1) MY185012A (es)
NZ (1) NZ605093A (es)
SG (2) SG10201504733XA (es)
WO (1) WO2012007481A2 (es)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
WO2012112777A2 (en) * 2011-02-16 2012-08-23 Glycosyn LLC Biosynthesis of human milk oligosaccharides in engineered bacteria
RU2658770C2 (ru) * 2011-07-12 2018-06-22 Сайентист Оф Фортчун С.А. Рекомбинантный микроорганизм для получения полезных метаболитов
US20130203136A1 (en) 2011-07-27 2013-08-08 Alliance For Sustainable Energy, Llc Biological production of organic compounds
US9914947B2 (en) 2011-07-27 2018-03-13 Alliance For Sustainable Energy, Llc Biological production of organic compounds
JP6033632B2 (ja) * 2012-10-15 2016-11-30 国立大学法人 新潟大学 セロビオン酸ホスホリラーゼを用いた酸性βグルコシル二糖の製造方法
US9944965B2 (en) * 2012-12-20 2018-04-17 The Board Of Trustees Of The University Of Illinois Biosynthesis of oligosaccharides
ES2715010T3 (es) * 2014-03-31 2019-05-31 Jennewein Biotechnologie Gmbh Fermentación total de oligosacáridos
ES2968677T3 (es) 2014-06-11 2024-05-13 Glycom As Separación de 2’-O-fucosil-lactosa de caldo de fermentación
US10731193B2 (en) 2014-06-27 2020-08-04 Glycom A/S Oligosaccharide production
US11926858B2 (en) 2014-06-27 2024-03-12 Glycom A/S Oligosaccharide production
CN104611249B (zh) * 2014-11-17 2019-06-11 中国科学院天津工业生物技术研究所 一种利用醛缩酶全细胞合成d-阿洛酮糖的方法
US10676770B2 (en) 2014-12-16 2020-06-09 Glycom A/S Separation of 2′-FL from a fermentation broth
WO2016153300A1 (ko) * 2015-03-24 2016-09-29 서울대학교 산학협력단 2-푸코실락토오스 생산 변이 미생물 및 이를 이용한 2-푸코실락토오스의 제조방법
WO2017059278A1 (en) * 2015-10-02 2017-04-06 Bonumose Biochem Llc Enzymatic synthesis of d-tagatose
US10713428B2 (en) 2015-11-02 2020-07-14 Microsoft Technology Licensing, Llc Images associated with cells in spreadsheets
CN108779481A (zh) * 2015-11-12 2018-11-09 派迪瓦私人有限公司 用于制备非致龋持续性能量释放汁液的方法
PL3315610T3 (pl) 2016-10-29 2021-06-14 Jennewein Biotechnologie Gmbh Sposób wytwarzania fukozylowanych oligosacharydów
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
AU2017385601B2 (en) 2016-12-27 2022-08-25 Inbiose N.V. In vivo synthesis of sialylated compounds
JP6878607B2 (ja) * 2017-02-21 2021-05-26 デューク ユニバーシティ ロバストな動的な代謝コントロールの為の組成物及び方法
US10633682B2 (en) 2017-03-07 2020-04-28 DePuy Synthes Products, Inc. Bioresorbable exopolysaccharides
WO2018165077A1 (en) 2017-03-07 2018-09-13 DePuy Synthes Products, Inc. Bioresorbable exopolysaccharides
RU2766710C2 (ru) 2017-03-13 2022-03-15 Бонамоуз, Инк. Ферментативное получение гексоз
JP2021513862A (ja) * 2018-02-23 2021-06-03 ダニスコ・ユーエス・インク ホスホリラーゼ酵素による、アルファ−１，３グリコシド結合を含むグルカンの合成
US20190323053A1 (en) * 2018-04-23 2019-10-24 Dupont Nutrition Biosciences Aps Increasing activity of 2? fucosyllactose transporters endogenous to microbial cells
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
PL3620510T3 (pl) * 2018-09-06 2024-02-19 Chr. Hansen HMO GmbH Fermentacyjne wytwarzanie oligosacharydów przez całkowitą fermentację z wykorzystaniem mieszanego surowca
WO2020058493A1 (en) 2018-09-21 2020-03-26 Universiteit Gent Method for the production of amino sugar containing products
WO2020079146A1 (en) 2018-10-18 2020-04-23 Basf Se Crystalline form ii of 2'-o-fucosyllactose, process for its preparation, nutritional, cosmetic or pharmaceutical formulation containing the same
KR20210107736A (ko) 2018-12-18 2021-09-01 인바이오스 엔.브이. 3-푸코실락토스 및 락토스 전환 α-1,3-푸코실트란스퍼라제 효소를 제조하는 방법
EP3702468A1 (en) * 2019-03-01 2020-09-02 Jennewein Biotechnologie GmbH Fermentative production of carbohydrates by microbial cells utilizing a mixed feedstock
CN110241062A (zh) * 2019-06-27 2019-09-17 江南大学 新大肠杆菌表达系统
JP2022541287A (ja) 2019-07-19 2022-09-22 インバイオス エン．フェー． 宿主細胞におけるフコシルラクトースの産生
CN110452845B (zh) * 2019-08-15 2021-03-02 江南大学 一种产蔗糖磷酸化酶的大肠杆菌
CN110527704B (zh) * 2019-10-31 2020-03-13 烟台华康荣赞生物科技有限公司 一种合成乳-n-二糖的方法
EP3819382A1 (en) * 2019-11-05 2021-05-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Enzymatic method for preparation of udp-glcnac
JP2023506287A (ja) 2019-12-17 2023-02-15 インバイオス エン．フェー． ラクトースを変換するアルファ－１，２－フコシルトランスフェラーゼ酵素
EP4077678A1 (en) 2019-12-18 2022-10-26 Inbiose N.V. Production of sialylated oligosaccharide in host cells
CA3171157A1 (en) 2020-02-14 2021-08-19 Inbiose N.V. Production of glycosylated product in host cells
EP4103685A1 (en) 2020-02-14 2022-12-21 Inbiose N.V. Glycominimized bacterial host cells
CN111172174B (zh) * 2020-03-06 2022-02-15 沈阳农业大学 OsUGE3基因在改善水稻性状中的应用
EP3954769A1 (en) 2020-08-10 2022-02-16 Inbiose N.V. Production of oligosaccharide mixtures by a cell
CN115803443A (zh) 2020-07-13 2023-03-14 格礼卡姆股份公司 寡糖的制造
EP4192945A1 (en) 2020-08-10 2023-06-14 Inbiose N.V. Cellular production of sialylated di- and/or oligosaccharides
WO2022034079A2 (en) 2020-08-10 2022-02-17 Inbiose N.V. Process for purification of an oligosaccharide solution produced by cell cultivation or microbial fermentation
CN116323927A (zh) 2020-08-10 2023-06-23 因比奥斯公司 双糖及/或寡糖的细胞生产
CN116261597A (zh) 2020-08-10 2023-06-13 因比奥斯公司 α-1,3糖基化形式的Fuc-a1,2-Gal-R的产生
EP4192965A1 (en) 2020-08-10 2023-06-14 Inbiose N.V. Method to produce a purified mixture of different oligosaccharides produced by cell cultivation or microbial fermentation
ES2966260T3 (es) 2020-08-10 2024-04-19 Inbiose Nv Producción de una mezcla de oligosacáridos neutros no fucosilados por una célula
WO2022040411A2 (en) * 2020-08-19 2022-02-24 Conagen Inc. Biosynthetic production of 2-fucosyllactose
WO2022124302A1 (ja) * 2020-12-08 2022-06-16 国立大学法人神戸大学 有用化合物を高生産する代謝改変微生物株の構築方法及び代謝改変大腸菌株
CN116710559A (zh) 2020-12-18 2023-09-05 因比奥斯公司 变体蔗糖渗透酶多肽
US20240084347A1 (en) 2021-01-18 2024-03-14 Inbiose N.V. Cellular production of glycosylated products
EP4281577A1 (en) 2021-01-20 2023-11-29 Inbiose N.V. Production of oligosaccharides comprising ln3 as core structure in host cells
US20240294959A1 (en) 2021-04-16 2024-09-05 Inbiose N.V. Cellular production of bioproducts
EP4323507A2 (en) 2021-04-16 2024-02-21 Inbiose N.V. Fermentative production
AU2022258874A1 (en) 2021-04-16 2023-11-30 Inbiose N.V. Cellular production of sialylated di- and/or oligosaccharides
WO2022243311A1 (en) 2021-05-17 2022-11-24 Dsm Ip Assets B.V. Microbial strain expressing an invertase/sucrose hydrolase
CN117321071A (zh) * 2021-05-17 2023-12-29 帝斯曼知识产权资产管理有限公司 表达转化酶/蔗糖水解酶的微生物菌株
CN113265434B (zh) * 2021-05-19 2023-05-02 吉林大学 一种合成udp-半乳糖及合成半乳糖基化合物的方法
EP4370664A1 (en) 2021-07-16 2024-05-22 Inbiose N.V. Lacto-n-biose converting fucosyltransferases
WO2023000243A1 (zh) * 2021-07-22 2023-01-26 深圳先进技术研究院 重组酵母生物转化生产葡萄糖的方法
EP4396209A1 (en) * 2021-09-02 2024-07-10 Amyris, Inc. Methods of producing human milk oligosaccharides and compositions thereof
EP4448734A1 (en) 2021-12-14 2024-10-23 Inbiose N.V. Production of alpha-1,3-fucosylated compounds
EP4448781A1 (en) 2021-12-14 2024-10-23 Inbiose N.V. Production of alpha-1,4-fucosylated compounds
CN114645070B (zh) * 2022-02-28 2022-12-20 北京焉支山科技有限公司 一种己糖-6-磷酸组合物的制备方法及其在化妆品中的应用
BR102022004731A2 (pt) * 2022-03-15 2023-09-26 Yessinergy Holding S/A Processo para produção e purificação de frutooligossacarídeos, produto obtido por tal processo
WO2024017987A1 (en) 2022-07-20 2024-01-25 Inbiose N.V. Production of oligosaccharides in host cells
CN117866789A (zh) * 2023-01-05 2024-04-12 山东恒鲁生物科技有限公司 一种合成二糖的酵母基因工程菌
WO2024165525A1 (en) 2023-02-06 2024-08-15 Inbiose N.V. Production of a saccharide, lactobionic acid and/or glycosylated forms of lactobionic acid
WO2024165524A1 (en) 2023-02-06 2024-08-15 Inbiose N.V. Production of a saccharide by a cell with reduced synthesis of lactobionic acid
WO2024165611A1 (en) 2023-02-07 2024-08-15 Inbiose N.V. Production of a disaccharide and/or milk oligosaccharide by a cell with reduced synthesis of udp-glcnac
CN116948928B (zh) * 2023-06-02 2024-06-18 虹摹生物科技(上海)有限公司 种子培养基及无抗生素、无iptg诱导剂的2’-岩藻糖基乳糖的发酵生产方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716837A (en) 1995-02-10 1998-02-10 Monsanto Company Expression of sucrose phosphorylase in plants
CN1258599C (zh) * 1996-09-17 2006-06-07 协和发酵工业株式会社 糖核苷酸类及复合糖类的制备方法
ID21487A (id) 1996-11-13 1999-06-17 Du Pont Metoda pembuatan 1,3 - propandiol dengan organisme rekombinan
FR2796082B1 (fr) 1999-07-07 2003-06-27 Centre Nat Rech Scient Procede de production d'oligosaccharides
JP2001546898A (en) 1999-12-21 2003-06-10 Kyowa Hakko Kogyo Kk MODIFIED alpha -1,2-FUCOSYLTRANSFERASE GENE AND PROCESS FOR PRODUCING alpha -1,2-FUCOSYLTRANSFERASE AND FUCOSE-CONTAINING SUGAR CHAIN
WO2001077313A1 (fr) 2000-04-11 2001-10-18 Kyowa Hakko Kogyo Co., Ltd. α1,2-FUCOSYLTRANSFERASE ET PROCEDE SERVANT A PREPARER UN GLUCIDE COMPLEXE CONTENANT FUCOSE
ATE421577T1 (de) * 2001-04-04 2009-02-15 Genencor Int Entkoppelte anabole und katabole stoffwechselwege in wirtszellen
WO2003018794A1 (en) 2001-08-24 2003-03-06 Kyowa Hakko Kogyo Co., Ltd. α-1,2-FUCOSYL TRANSFERASE AND DNA ENCODING THE SAME
AU2003902253A0 (en) * 2003-05-12 2003-05-29 The University Of Queensland Method for increasing product yield
DK1661985T3 (en) * 2003-09-04 2018-01-08 Ezaki Glico Co PROCEDURE FOR PREPARING HEAT STABLE SUCROSE PHOSPHORYLASE (SP)
CN1906294B (zh) * 2003-11-19 2013-09-11 陶氏环球技术公司 改良的蛋白表达系统
US7422880B2 (en) 2005-01-19 2008-09-09 Ajinomoto Co., Inc. Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having a pathway of glycogen biosynthesis disrupted
NZ566406A (en) 2005-10-26 2012-04-27 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US20080274526A1 (en) * 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
WO2007101862A1 (en) * 2006-03-09 2007-09-13 Centre National De La Recherche Scientifique (Cnrs) Method of producing sialylated oligosaccharides
AT504347B8 (de) 2006-09-21 2008-09-15 Univ Graz Tech Verfahren zur herstellung von glucosederivaten
JP5570821B2 (ja) 2007-03-23 2014-08-13 メタボリック エクスプローラー 進化と合理的設計の組合せによって得られた、１，２−プロパンジオールの製造のための新規微生物
US8426173B2 (en) 2007-05-02 2013-04-23 Butamax (Tm) Advanced Biofuels Llc Method for the production of 1-butanol
CN101970648A (zh) * 2007-12-18 2011-02-09 韩国科学技术院 具有使用蔗糖作为碳源能力的重组微生物
DK2235193T3 (da) 2007-12-23 2016-02-29 Gevo Inc Gærorganisme, der producerer isobutanol med højt udbytte
BRPI0907542A2 (pt) * 2008-02-25 2015-07-28 Ajinomoto Kk Método para produzir ácido 5'-guanílico, e, microrganismo com uma capacidade de converter ácido inosínico em ácido 5'-guanílico
JP5254353B2 (ja) * 2008-11-05 2013-08-07 三井化学株式会社 ２−デオキシ−シロ−イノソース（ｄｏｉ）生産細菌及びこれを用いた２−デオキシ−シロ−イノソース（ｄｏｉ）生産方法
WO2010051849A1 (en) * 2008-11-07 2010-05-14 Metabolic Explorer Use of sucrose as substrate for fermentative production of 1,2-propanediol
EP2186904B1 (en) * 2008-11-14 2012-07-18 Technische Universität Graz Method for producing glucose derivatives
CA2770842A1 (en) 2009-08-12 2011-02-17 Gevo, Inc. Cytosolic isobutanol pathway localization for the production of isobutanol

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