MX2020009272A - Receptores de antígeno quimérico del antígeno de membrana específico de próstata y métodos de uso de los mismos. - Google Patents

Receptores de antígeno quimérico del antígeno de membrana específico de próstata y métodos de uso de los mismos.

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Publication number
MX2020009272A
MX2020009272A MX2020009272A MX2020009272A MX2020009272A MX 2020009272 A MX2020009272 A MX 2020009272A MX 2020009272 A MX2020009272 A MX 2020009272A MX 2020009272 A MX2020009272 A MX 2020009272A MX 2020009272 A MX2020009272 A MX 2020009272A
Authority
MX
Mexico
Prior art keywords
modified
prostate
cells
psma
receptor
Prior art date
Application number
MX2020009272A
Other languages
English (en)
Spanish (es)
Inventor
Yangbing Zhao
Szu Hua Sharon Lin
Xiaojun Liu
Anne Chew
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX2020009272A publication Critical patent/MX2020009272A/es

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/42—Cancer antigens
    • A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K—PEPTIDES
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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MX2020009272A 2018-03-06 2019-03-05 Receptores de antígeno quimérico del antígeno de membrana específico de próstata y métodos de uso de los mismos. MX2020009272A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862639321P 2018-03-06 2018-03-06
PCT/US2019/020729 WO2019173324A1 (en) 2018-03-06 2019-03-05 Prostate-specific membrane antigen cars and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2020009272A true MX2020009272A (es) 2021-01-08

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MX2020009272A MX2020009272A (es) 2018-03-06 2019-03-05 Receptores de antígeno quimérico del antígeno de membrana específico de próstata y métodos de uso de los mismos.

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US (3) US10780120B2 (https=)
EP (2) EP3762410A4 (https=)
JP (4) JP7526097B2 (https=)
KR (1) KR20200130709A (https=)
CN (1) CN112119157B (https=)
AU (2) AU2019231205A1 (https=)
CA (2) CA3093078A1 (https=)
MX (1) MX2020009272A (https=)
TW (2) TW201940520A (https=)
WO (2) WO2019173324A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010099205A1 (en) * 2009-02-24 2010-09-02 The Trustees Of The University Of Pennsylvania Methods for treating progressive multifocal leukoencephalopathy (pml)
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
KR102211837B1 (ko) 2013-01-14 2021-02-03 젠코어 인코포레이티드 신규한 이형이량체 단백질
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