MX2020005311A - Compuestos de derivados de trifenilfosfonio para erradicar celulas madre cancerosas. - Google Patents
Compuestos de derivados de trifenilfosfonio para erradicar celulas madre cancerosas.Info
- Publication number
- MX2020005311A MX2020005311A MX2020005311A MX2020005311A MX2020005311A MX 2020005311 A MX2020005311 A MX 2020005311A MX 2020005311 A MX2020005311 A MX 2020005311A MX 2020005311 A MX2020005311 A MX 2020005311A MX 2020005311 A MX2020005311 A MX 2020005311A
- Authority
- MX
- Mexico
- Prior art keywords
- tpp
- cells
- cscs
- compounds
- cancer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 4
- 210000000130 stem cell Anatomy 0.000 title abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 230000002407 ATP formation Effects 0.000 abstract 1
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 230000001464 adherent effect Effects 0.000 abstract 1
- 229940124650 anti-cancer therapies Drugs 0.000 abstract 1
- 238000011319 anticancer therapy Methods 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 210000003470 mitochondria Anatomy 0.000 abstract 1
- 230000002438 mitochondrial effect Effects 0.000 abstract 1
- 230000036284 oxygen consumption Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000003440 toxic substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El tri-fenil-fosfonio (TPP) es una porción química no tóxica que se comporta funcionalmente como una señalización de fijación como objetivo mitocondrial en células vivas. Los compuestos relacionados con TPP se pueden utilizar para fijar como objetivo las mitocondrias en células madre cancerosas (CSCs), y se pueden usar para tratar y/o prevenir la recurrencia de tumores, metástasis, resistencia a fármacos y/o resistencia a radioterapia, así como también para terapias anticancerosas. Varios compuestos relacionados con TPP que son validados para la inhibición del consumo de oxígeno (OCR), no fueron tóxicos y tuvieron poco o ningún efecto sobre la producción de ATP en fibroblastos humanos normales. No obstante, estos compuestos fijan como objetivo selectivamente células cancerosas "a granel" adherentes. Estos compuestos también inhiben la propagación de CSCs en suspensión. Los compuestos relacionados con TPP proporcionan una estrategia química novedosa para fijar como objetivo de manera efectiva tanto i) células cancerosas "a granel" como ii) CSC, mientras que minimizan o evitan específicamente efectos secundarios distintos a lo deseado en células normales, entre otras terapias útiles.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762590432P | 2017-11-24 | 2017-11-24 | |
| PCT/US2018/062174 WO2019104115A1 (en) | 2017-11-24 | 2018-11-21 | Triphenylphosphonium-derivative compounds for eradicating cancer stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020005311A true MX2020005311A (es) | 2020-08-17 |
Family
ID=66632164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020005311A MX2020005311A (es) | 2017-11-24 | 2018-11-21 | Compuestos de derivados de trifenilfosfonio para erradicar celulas madre cancerosas. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10980821B2 (es) |
| EP (1) | EP3713559B1 (es) |
| JP (1) | JP7066847B2 (es) |
| KR (1) | KR102227834B1 (es) |
| CN (1) | CN111971040B (es) |
| AU (2) | AU2018373053C1 (es) |
| BR (1) | BR112020010313A2 (es) |
| CA (1) | CA3083023A1 (es) |
| CL (1) | CL2020001355A1 (es) |
| CO (1) | CO2020006472A2 (es) |
| CR (1) | CR20200238A (es) |
| EC (1) | ECSP20032315A (es) |
| IL (1) | IL274794B (es) |
| MX (1) | MX2020005311A (es) |
| NZ (1) | NZ779976A (es) |
| PH (1) | PH12020550685A1 (es) |
| RU (1) | RU2020120686A (es) |
| SG (1) | SG11202004729QA (es) |
| WO (1) | WO2019104115A1 (es) |
| ZA (1) | ZA202102179B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3612187B1 (en) | 2017-04-21 | 2022-04-13 | Lunella Biotech, Inc. | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| US11229657B2 (en) | 2017-04-21 | 2022-01-25 | Lunella Biotech, Inc. | Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy |
| EP3624897A4 (en) | 2017-05-19 | 2021-07-14 | Lunella Biotech, Inc. | COMPANION DIAGNOSIS FOR MITOCHONDRIAL INHIBITORS |
| EP3624840A4 (en) | 2017-05-19 | 2021-03-10 | Lunella Biotech, Inc. | ANTIMITOSCINE: TARGETED INHIBITORS OF MITOCHONDRIAL BIOGENESIS TO DESCRIBE CANCER STEM CELLS |
| WO2019075226A1 (en) | 2017-10-11 | 2019-04-18 | Lunella Biotech, Inc. | ANTI-MITOCHONDRIAL INHIBITORS FOR ONCOGENIC RAS AND MYC |
| CA3083023A1 (en) * | 2017-11-24 | 2019-05-31 | Lunella Biotech, Inc. | Triphenylphosphonium-derivative compounds for eradicating cancer stem cells |
| WO2019108729A1 (en) | 2017-12-01 | 2019-06-06 | Lunella Biotech, Inc. | Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
| CN113164504A (zh) | 2018-10-02 | 2021-07-23 | 卢内拉生物技术有限公司 | 作为反老药物的阿奇霉素和罗红霉素衍生物 |
| CA3136811A1 (en) * | 2019-04-16 | 2020-10-22 | Lunella Biotech, Inc. | Alkyl-tpp compounds for mitochondria targeting and anti-cancer treatments |
| EP3976197A4 (en) | 2019-05-24 | 2023-07-19 | Lunella Biotech, Inc. | THERAPEUTIC AGENTS AND METHODS FOR PREDICTING AND OVERCOMING ENDOCRINE RESISTANCE IN BREAST CANCER |
| CA3144666A1 (en) * | 2019-06-26 | 2020-12-30 | Lunella Biotech, Inc. | Carbocyanine compounds for targeting mitochondria and eradicating cancer stem cells |
| WO2021024208A1 (en) * | 2019-08-06 | 2021-02-11 | Lunella Biotech, Inc. | Tpp-derivatives for mitochondria-targeted cancer therapies |
| WO2021081500A1 (en) * | 2019-10-24 | 2021-04-29 | The Medical College Of Wisconsin, Inc. | Mitochondria-targeted atovaquone: a more potent and more effective antitumor, antimicrobial, and antimalarial drug |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1046046B (de) * | 1956-06-29 | 1958-12-11 | Basf Ag | Verfahren zur Herstellung von quartaeren Phosphoniumhalogeniden |
| US3662065A (en) * | 1970-02-09 | 1972-05-09 | Monsanto Co | Chloro substituted benzyl triphenyl phosphonium halides as anthelmintics |
| US4187300A (en) * | 1978-12-20 | 1980-02-05 | The United States Of America As Represented By The Secretary Of The Army | Use of phosphonium salts in treatment of African trypanosomiasis |
| WO2005019233A1 (en) | 2003-08-22 | 2005-03-03 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| RU2318500C2 (ru) * | 2005-10-18 | 2008-03-10 | Общество С Ограниченной Ответственностью "Митотехнология" | Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели |
| CN101641643B (zh) * | 2007-04-03 | 2013-08-07 | 巴斯夫欧洲公司 | 可光活化的氮碱 |
| DE102007025423A1 (de) | 2007-05-30 | 2008-12-04 | Friedrich-Schiller-Universität Jena | Triphenylphosphonium-Derivate zum gezielten Transport und Freisetzen von Substanzen in Mitochondrien sowie Verfahren zu deren Verwendung |
| WO2013019975A1 (en) | 2011-08-03 | 2013-02-07 | University Of Iowa Research Foundation | Compositions and methods of treating cancer |
| US20150366884A1 (en) * | 2013-02-08 | 2015-12-24 | University Of Iowa Research Foundation | Compositions and methods for cancer therapy |
| PT2989110T (pt) | 2013-04-24 | 2018-11-15 | Jira Neuzil | Derivados de tamoxifeno para o tratamento de doenças neoplásicas, especialmente com nível elevado de proteína her2 |
| WO2016007921A1 (en) * | 2014-07-10 | 2016-01-14 | Rhodel Island Hospital | Treating arrhythmia with mitochondrial-targeted antioxidants |
| CZ307146B6 (cs) * | 2015-03-31 | 2018-02-07 | Kkcg Se | Trifenylfosfoniové analogy biguanidu, způsob jejich přípravy a jejich použití jako léčiva |
| PL229277B1 (pl) * | 2015-07-28 | 2018-06-29 | Centrum Badan Molekularnych I Makromolekularnych Polskiej Akademii Nauk | Zastosowanie medyczne soli trifenylofosfoniowych |
| CN105325454B (zh) * | 2015-11-20 | 2017-06-06 | 华南农业大学 | 新型复合季鏻盐及其制备方法与抗菌应用 |
| CA3083023A1 (en) * | 2017-11-24 | 2019-05-31 | Lunella Biotech, Inc. | Triphenylphosphonium-derivative compounds for eradicating cancer stem cells |
| CN113164504A (zh) * | 2018-10-02 | 2021-07-23 | 卢内拉生物技术有限公司 | 作为反老药物的阿奇霉素和罗红霉素衍生物 |
-
2018
- 2018-11-21 CA CA3083023A patent/CA3083023A1/en active Pending
- 2018-11-21 SG SG11202004729QA patent/SG11202004729QA/en unknown
- 2018-11-21 MX MX2020005311A patent/MX2020005311A/es unknown
- 2018-11-21 CN CN201880084974.9A patent/CN111971040B/zh active Active
- 2018-11-21 NZ NZ779976A patent/NZ779976A/en unknown
- 2018-11-21 EP EP18880479.3A patent/EP3713559B1/en active Active
- 2018-11-21 KR KR1020207017888A patent/KR102227834B1/ko active IP Right Grant
- 2018-11-21 JP JP2020528317A patent/JP7066847B2/ja active Active
- 2018-11-21 WO PCT/US2018/062174 patent/WO2019104115A1/en active Search and Examination
- 2018-11-21 BR BR112020010313-6A patent/BR112020010313A2/pt not_active Application Discontinuation
- 2018-11-21 RU RU2020120686A patent/RU2020120686A/ru unknown
- 2018-11-21 CR CR20200238A patent/CR20200238A/es unknown
- 2018-11-21 AU AU2018373053A patent/AU2018373053C1/en active Active
- 2018-11-21 US US16/766,472 patent/US10980821B2/en active Active
-
2020
- 2020-05-20 IL IL274794A patent/IL274794B/en active IP Right Grant
- 2020-05-22 CL CL2020001355A patent/CL2020001355A1/es unknown
- 2020-05-22 PH PH12020550685A patent/PH12020550685A1/en unknown
- 2020-06-15 EC ECSENADI202032315A patent/ECSP20032315A/es unknown
- 2020-06-23 CO CONC2020/0006472A patent/CO2020006472A2/es unknown
-
2021
- 2021-03-11 US US17/199,087 patent/US11738034B2/en active Active
- 2021-03-31 ZA ZA2021/02179A patent/ZA202102179B/en unknown
- 2021-04-07 AU AU2021202123A patent/AU2021202123B2/en active Active
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