MX2022002832A - Tratamiento del cancer con recombinacion homologa deficiente. - Google Patents

Tratamiento del cancer con recombinacion homologa deficiente.

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Publication number
MX2022002832A
MX2022002832A MX2022002832A MX2022002832A MX2022002832A MX 2022002832 A MX2022002832 A MX 2022002832A MX 2022002832 A MX2022002832 A MX 2022002832A MX 2022002832 A MX2022002832 A MX 2022002832A MX 2022002832 A MX2022002832 A MX 2022002832A
Authority
MX
Mexico
Prior art keywords
dnph1
treatment
inhibition
hmdu
finding
Prior art date
Application number
MX2022002832A
Other languages
English (en)
Inventor
Kasper Fugger
Stephen West
Original Assignee
The Francis Crick Institute Ltd
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Publication date
Application filed by The Francis Crick Institute Ltd filed Critical The Francis Crick Institute Ltd
Publication of MX2022002832A publication Critical patent/MX2022002832A/es

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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

La presente invención se refiere al descubrimiento de que las células deficientes en recombinación homóloga (HR) son sensibles a la inhibición de PARP mediante (i) la inhibición catalítica o la ablación genética de la 2'-desoxinucleósido 5'-fosfato N-hidrolasa 1 (DNPH1) o (ii) la administración de un sustrato de DNPH1, tal como la 5-hidroximetil desoxiuridina (hmdU). La invención también se relaciona con el hallazgo de que la inhibición catalítica o la ablación genética de DNPH1 combinada con la administración de hmdU causa letalidad sintética en células deficientes en HR en ausencia de inhibición de PARP. Se proporcionan métodos y compuestos para usarse en el tratamiento de cáncer deficiente de HR.
MX2022002832A 2019-09-10 2020-09-09 Tratamiento del cancer con recombinacion homologa deficiente. MX2022002832A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1913030.1A GB201913030D0 (en) 2019-09-10 2019-09-10 Treatment of hr deficient cancer
PCT/EP2020/075245 WO2021048235A1 (en) 2019-09-10 2020-09-09 Treatment of hr deficient cancer

Publications (1)

Publication Number Publication Date
MX2022002832A true MX2022002832A (es) 2022-04-06

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MX2022002832A MX2022002832A (es) 2019-09-10 2020-09-09 Tratamiento del cancer con recombinacion homologa deficiente.

Country Status (10)

Country Link
US (1) US20220339179A1 (es)
EP (1) EP4028009A1 (es)
JP (1) JP2022547206A (es)
KR (1) KR20220064380A (es)
AU (1) AU2020344145A1 (es)
CA (1) CA3153692A1 (es)
GB (1) GB201913030D0 (es)
IL (1) IL291170A (es)
MX (1) MX2022002832A (es)
WO (1) WO2021048235A1 (es)

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CN112853502B (zh) * 2021-01-14 2022-07-15 中国医学科学院基础医学研究所 小鼠表观遗传基因敲除筛选文库及其构建方法
US20240238283A1 (en) * 2021-05-18 2024-07-18 Onconic Therapeutics Inc. Parp inhibitor-resistant cancer therapeutic agent

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AU2020344145A1 (en) 2022-03-31
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GB201913030D0 (en) 2019-10-23
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