MX2010000474A - Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral. - Google Patents
Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral.Info
- Publication number
- MX2010000474A MX2010000474A MX2010000474A MX2010000474A MX2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A
- Authority
- MX
- Mexico
- Prior art keywords
- akt
- compound
- subject invention
- cell
- pkb
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Abstract
La invención se refiere a materiales y métodos para inhibir la vía Akt/PKB; en una modalidad, un compuesto de la invención inhibe la actividad de quinasa y/o los niveles de fosforilación de las proteínas Akt; la invención también se refiere a métodos para inhibir o eliminar una célula cancerosa u otra célula en la que la expresión de una proteína Akt esta elevada o constitutivamente activa, que comprende poner en contacto la célula con una cantidad efectiva de un compuesto de fórmula I; la invención también se refiere a métodos para tratar cáncer o un tumor en una persona o animal que comprende administrar una cantidad efectiva de un compuesto de fórmula I a la persona o animal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94936507P | 2007-07-12 | 2007-07-12 | |
PCT/US2008/069974 WO2009009793A2 (en) | 2007-07-12 | 2008-07-14 | Inhibitors of akt/pkb with anti-tumor activity |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010000474A true MX2010000474A (es) | 2010-06-23 |
Family
ID=40229514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010000474A MX2010000474A (es) | 2007-07-12 | 2008-07-14 | Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral. |
Country Status (10)
Country | Link |
---|---|
US (2) | US8183249B2 (es) |
EP (1) | EP2173352B1 (es) |
JP (1) | JP5568471B2 (es) |
KR (1) | KR101618037B1 (es) |
CN (1) | CN101743007B (es) |
AU (1) | AU2008274956B2 (es) |
BR (1) | BRPI0815563A2 (es) |
CA (1) | CA2695330C (es) |
MX (1) | MX2010000474A (es) |
WO (1) | WO2009009793A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2576765C (en) * | 2004-09-03 | 2013-05-28 | Applied Research Systems Ars Holding N.V. | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors |
US8183249B2 (en) * | 2007-07-12 | 2012-05-22 | University Of South Florida | Inhibitors of AKT/PKB with anti-tumor activity |
JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ,インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
CA2810844C (en) | 2010-09-07 | 2017-03-21 | Dmi Acquisition Corp. | Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions |
WO2012158197A2 (en) * | 2010-11-11 | 2012-11-22 | Lyndor Biosciences L.L.C. | Compounds useful as akt/pkb modulators and uses thereof |
MX348655B (es) * | 2011-04-01 | 2017-06-21 | Genentech Inc | Biomarcadores para pronosticar sensibilidad a tratamientos contra el cancer. |
CA2831935A1 (en) | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use |
CN102225067B (zh) * | 2011-04-29 | 2012-10-03 | 济南环肽医药科技有限公司 | 一种治疗胃癌的药物组合物 |
SG10201608087WA (en) | 2011-10-10 | 2016-11-29 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
ES2795803T3 (es) | 2011-10-10 | 2020-11-24 | Ampio Pharmaceuticals Inc | Tratamiento de artropatía degenerativa |
AU2012328605B9 (en) | 2011-10-28 | 2017-08-03 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
GB201207722D0 (en) * | 2012-05-02 | 2012-06-13 | Bergenbio As | Method |
KR101461626B1 (ko) * | 2012-08-02 | 2014-11-28 | 서울대학교산학협력단 | Akt1 억제제 및 소수성 항암제를 포함하는 항암용 약학적 조성물 |
WO2014074883A1 (en) * | 2012-11-08 | 2014-05-15 | Lyndor Biosciences L.L.C. | Novel synthesis of ld101 |
EA201500943A1 (ru) | 2013-03-15 | 2016-08-31 | Ампио Фармасьютикалс, Инк. | Составы для мобилизации, хоуминга, размножения и дифференцировки стволовых клеток и способы применения составов |
US9974774B2 (en) | 2013-07-26 | 2018-05-22 | Race Oncology Ltd. | Combinatorial methods to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof |
US9986375B2 (en) * | 2014-02-12 | 2018-05-29 | Google Llc | Energy-efficient location determination |
US9956217B2 (en) | 2014-08-18 | 2018-05-01 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
FR3033499A1 (fr) * | 2015-03-11 | 2016-09-16 | Centre Leon-Berard | Composition pour le traitement des tumeurs neuroendocrines pancreatiques |
EP3310375A4 (en) | 2015-06-22 | 2019-02-20 | Ampio Pharmaceuticals, Inc. | USE OF LOW MOLECULAR WEIGHT HUMAN SERUM ALBUMIN FRACTIONS FOR TREATING DISEASES |
CN114099681B (zh) * | 2020-12-04 | 2023-03-10 | 周清华 | Akt/stat3作为免疫检查点抑制剂的靶点的用途 |
WO2023168291A1 (en) * | 2022-03-02 | 2023-09-07 | Terremoto Biosciences, Inc. | Covalent modifiers of akt1 and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
LU84979A1 (fr) * | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
US5167649A (en) * | 1988-08-22 | 1992-12-01 | Zook Gerald P | Drug delivery system for the removal of dermal lesions |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
JP4407008B2 (ja) * | 2000-05-11 | 2010-02-03 | パナソニック株式会社 | カラー画像形成装置 |
UA72612C2 (en) | 2000-07-06 | 2005-03-15 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells | |
BR0309581A (pt) * | 2002-05-06 | 2005-03-29 | Genelabs Tech Inc | Derivados de nucleosìdeo para tratamento de infecção por vìrus de hepatite c |
AU2005228410A1 (en) * | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
US8828451B2 (en) * | 2006-10-04 | 2014-09-09 | University Of South Florida | Akt sensitization of cancer cells |
US8183249B2 (en) * | 2007-07-12 | 2012-05-22 | University Of South Florida | Inhibitors of AKT/PKB with anti-tumor activity |
-
2008
- 2008-07-14 US US12/172,831 patent/US8183249B2/en active Active
- 2008-07-14 EP EP08772544.6A patent/EP2173352B1/en active Active
- 2008-07-14 WO PCT/US2008/069974 patent/WO2009009793A2/en active Application Filing
- 2008-07-14 CN CN200880024470.4A patent/CN101743007B/zh not_active Expired - Fee Related
- 2008-07-14 KR KR1020107002898A patent/KR101618037B1/ko active IP Right Grant
- 2008-07-14 AU AU2008274956A patent/AU2008274956B2/en not_active Ceased
- 2008-07-14 CA CA2695330A patent/CA2695330C/en not_active Expired - Fee Related
- 2008-07-14 BR BRPI0815563-1A2A patent/BRPI0815563A2/pt not_active IP Right Cessation
- 2008-07-14 JP JP2010516297A patent/JP5568471B2/ja not_active Expired - Fee Related
- 2008-07-14 MX MX2010000474A patent/MX2010000474A/es active IP Right Grant
-
2012
- 2012-05-21 US US13/476,098 patent/US9359347B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2010533206A (ja) | 2010-10-21 |
EP2173352A2 (en) | 2010-04-14 |
US20090028855A1 (en) | 2009-01-29 |
CA2695330A1 (en) | 2009-01-15 |
KR20100066438A (ko) | 2010-06-17 |
WO2009009793A2 (en) | 2009-01-15 |
CA2695330C (en) | 2017-06-13 |
WO2009009793A3 (en) | 2009-03-26 |
EP2173352A4 (en) | 2011-07-27 |
CN101743007A (zh) | 2010-06-16 |
BRPI0815563A2 (pt) | 2015-02-18 |
KR101618037B1 (ko) | 2016-05-04 |
JP5568471B2 (ja) | 2014-08-06 |
EP2173352B1 (en) | 2016-09-07 |
AU2008274956A1 (en) | 2009-01-15 |
US20130034598A1 (en) | 2013-02-07 |
AU2008274956B2 (en) | 2014-08-21 |
US8183249B2 (en) | 2012-05-22 |
US9359347B2 (en) | 2016-06-07 |
CN101743007B (zh) | 2015-04-08 |
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Legal Events
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FG | Grant or registration |