MX348655B - Biomarcadores para pronosticar sensibilidad a tratamientos contra el cancer. - Google Patents

Biomarcadores para pronosticar sensibilidad a tratamientos contra el cancer.

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Publication number
MX348655B
MX348655B MX2013011334A MX2013011334A MX348655B MX 348655 B MX348655 B MX 348655B MX 2013011334 A MX2013011334 A MX 2013011334A MX 2013011334 A MX2013011334 A MX 2013011334A MX 348655 B MX348655 B MX 348655B
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MX
Mexico
Prior art keywords
biomarkers
cancer treatments
predicting sensitivity
sensitivity
predicting
Prior art date
Application number
MX2013011334A
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English (en)
Other versions
MX2013011334A (es
Inventor
Somasekar Seshagiri
Kui Lin
Elizabeth Punnoose
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2013011334A publication Critical patent/MX2013011334A/es
Publication of MX348655B publication Critical patent/MX348655B/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Health & Medical Sciences (AREA)
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Abstract

La presente invención se refiere a un método in vitro para pronosticar la sensibilidad de crecimiento de una célula de tumor a partir de una muestra fisiológica obtenida de un paciente a un inhibidor AKT, que comprende determinar la presencia de una mutación a AKT, en donde la presencia de una mutación a AKT se correlaciona con sensibilidad incrementada de la célula al inhibidor AKT, en donde el inhibidor AKT es (S) -2-4(4-clorofenil)-1-(4-((5R,7R)-7 -hidroxi -5-metil -6, 7-dihidro -5H - ciclopenta [d] pirimidin-4-il) piperazin-1-il)-3-(isopropilamin) propan-1-ona, o una sal farmacéutica aceptable del mismo, en donde la mutación corresponde a o se alinea con L52, K189 O d323.
MX2013011334A 2011-04-01 2012-03-30 Biomarcadores para pronosticar sensibilidad a tratamientos contra el cancer. MX348655B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161471036P 2011-04-01 2011-04-01
PCT/US2012/031662 WO2012135749A2 (en) 2011-04-01 2012-03-30 Biomarkers for predicting sensitivity to cancer treatments

Publications (2)

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MX2013011334A MX2013011334A (es) 2014-08-22
MX348655B true MX348655B (es) 2017-06-21

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MX2013011334A MX348655B (es) 2011-04-01 2012-03-30 Biomarcadores para pronosticar sensibilidad a tratamientos contra el cancer.

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US (3) US20140031259A1 (es)
EP (2) EP2694959B8 (es)
JP (4) JP6293655B2 (es)
KR (2) KR102165122B1 (es)
CN (1) CN103858007B (es)
AU (1) AU2012236134A1 (es)
BR (1) BR112013025356B1 (es)
CA (1) CA2850175C (es)
ES (1) ES2768081T3 (es)
IL (1) IL228636A0 (es)
MX (1) MX348655B (es)
PL (1) PL2694959T3 (es)
RU (1) RU2635193C2 (es)
SG (2) SG194050A1 (es)
WO (1) WO2012135749A2 (es)

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KR102129532B1 (ko) * 2018-07-19 2020-07-02 조성은 Pten 억제제에 대한 췌장암 치료 반응성 예측용 바이오마커 및 이의 용도
CN113025713B (zh) * 2021-02-23 2022-11-22 浙江东睿生物科技有限公司 用于预测肿瘤患者对特定抗肿瘤药物的敏感性的生物标志物的应用

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EP2694959B1 (en) 2019-11-13
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KR20190011813A (ko) 2019-02-07
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