SA515370134B1 - تركيبة صيدلانية تحتوي على عامل علاجي قائم على الهيموغلوبين المعدل لعلاج السرطان المستهدف والتصوير التشخيصي - Google Patents
تركيبة صيدلانية تحتوي على عامل علاجي قائم على الهيموغلوبين المعدل لعلاج السرطان المستهدف والتصوير التشخيصيInfo
- Publication number
- SA515370134B1 SA515370134B1 SA515370134A SA515370134A SA515370134B1 SA 515370134 B1 SA515370134 B1 SA 515370134B1 SA 515370134 A SA515370134 A SA 515370134A SA 515370134 A SA515370134 A SA 515370134A SA 515370134 B1 SA515370134 B1 SA 515370134B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- cancer
- hemoglobin
- therapeutic agent
- pharmaceutical composition
- diagnostic imaging
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 201000011510 cancer Diseases 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 4
- 229940124597 therapeutic agent Drugs 0.000 title abstract 3
- 238000002059 diagnostic imaging Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000008685 targeting Effects 0.000 title 1
- 102000001554 Hemoglobins Human genes 0.000 abstract 5
- 108010054147 Hemoglobins Proteins 0.000 abstract 5
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 abstract 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 abstract 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 201000004101 esophageal cancer Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 201000010536 head and neck cancer Diseases 0.000 abstract 1
- 208000014829 head and neck neoplasm Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 238000010859 live-cell imaging Methods 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6445—Haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Inorganic Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
Abstract
يوفر هذا الاختراع التركيبة الصيدلانية التي تحتوي على عنصر علاجي قائم على الهيموغلوبين hemoglobin لعلاج السرطان. يمكن أن يستهدف جزء الهيموغلوبين الخلايا السرطانية cancer cells ويمكن أن يقضي النصف العلاجي (أي العنصر النشط / العقاقير الدوائية) على الخلايا السرطانية بكفاءة. يمكن أن يُستخدم العنصر العلاجي القائم على الهيموغلوبين المستخدم في هذا الاختراع في علاج السرطانات المختلفة مثل سرطان البنكرياس pancreatic cancer ، سرطان الدم leukemia ، سرطان الرأس والعنق head and neck cancer ، سرطان قولوني مستقيمي colorectal cancer ، سرطان الرئة lung cancer ، سرطان الثدي breast cancer ، سرطان الكبد liver cancer ، سرطان البلعوم nasopharyngeal cancer ، سرطان المريء esophageal cancer أو سرطان الدماغ brain cancer. يمكن استخدام التركيبة وحدها أو بالاشتراك مع عنصر (عناصر) علاجي آخر مثل عنصر العلاج الكيميائي لإعطاء تأثير التآزر في علاج السرطان، ومنع الورم الخبيث و / أو الحد من تكراره. كما يمكن استخدام اثنين من الصبغ المترافقة 5 إف يوم القائمة على الهيموغلوبين و / أو واحدة من الصبغ المترافقة 5 إف يوم ال
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822463P | 2013-05-13 | 2013-05-13 | |
| PCT/US2014/037749 WO2014186301A1 (en) | 2013-05-13 | 2014-05-13 | Pharmaceutical composition comprising modified hemoglobin- based therapeutic agent for cancer targeting treatment and diagnostic imaging |
| US14/275,885 US9636404B2 (en) | 2013-05-13 | 2014-05-13 | Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA515370134B1 true SA515370134B1 (ar) | 2017-10-18 |
Family
ID=51864923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA515370134A SA515370134B1 (ar) | 2013-05-13 | 2015-11-12 | تركيبة صيدلانية تحتوي على عامل علاجي قائم على الهيموغلوبين المعدل لعلاج السرطان المستهدف والتصوير التشخيصي |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9636404B2 (ar) |
| EP (1) | EP3001813B1 (ar) |
| JP (1) | JP6392855B2 (ar) |
| KR (1) | KR102013015B1 (ar) |
| CN (1) | CN105407911B (ar) |
| AU (1) | AU2014265659B2 (ar) |
| BR (1) | BR112015028340A2 (ar) |
| CA (1) | CA2911414C (ar) |
| CL (1) | CL2015003343A1 (ar) |
| EA (1) | EA032164B1 (ar) |
| HK (2) | HK1222574A1 (ar) |
| IL (1) | IL242422B (ar) |
| MA (1) | MA38571B1 (ar) |
| MX (1) | MX362001B (ar) |
| MY (1) | MY176175A (ar) |
| PH (1) | PH12015502536B1 (ar) |
| SA (1) | SA515370134B1 (ar) |
| SG (1) | SG11201509042YA (ar) |
| TW (1) | TWI610685B (ar) |
| WO (1) | WO2014186301A1 (ar) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA38571B1 (fr) * | 2013-05-13 | 2018-10-31 | Vision Global Holdings Ltd | Composition pharmaceutique comprenant un agent thérapeutique à base d'hémoglobine modifiée pour un traitement de ciblage du cancer et imagerie diagnostique |
| US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
| US9814759B2 (en) * | 2014-07-02 | 2017-11-14 | Cheer Global Ltd. | Pharmaceutical composition comprising recombinant hemoglobin protein or subunit-based therapeutic agent for cancer targeting treatment |
| CA2957964A1 (en) | 2014-09-03 | 2016-03-10 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| TR201606102A2 (tr) * | 2016-05-10 | 2016-10-21 | Tolgay Tuyan Ilhan | Karin i̇çi̇ uygulanan kanser tedavi̇leri̇nde oksi̇jen konsantrasyonu ölçümü yapabi̇len ve veri̇len oksi̇jen dozaji üzeri̇nde deği̇şi̇kli̇k yapmayi sağlayan ci̇haz |
| EP3471775A4 (en) * | 2016-06-21 | 2020-02-19 | Therapure Biopharma Inc. | HEMOGLOBIN-TARGETED DRUG ADMINISTRATION FOR CANCER TREATMENT |
| ES2972577T3 (es) | 2016-12-14 | 2024-06-13 | Purdue Research Foundation | Formación de imágenes y terapia dirigidas a la proteína de activación de fibroblastos (FAP) |
| US11560384B2 (en) | 2017-05-04 | 2023-01-24 | University Of Utah Research Foundation | Benzonorbornadiene derivatives and reactions thereof |
| CN107153771B (zh) * | 2017-05-17 | 2020-06-30 | 许昌学院 | 一种药物分子的同步控制方法及其应用 |
| US11504417B2 (en) | 2017-07-18 | 2022-11-22 | VirTech Bio, Inc. | Blood substitutes comprising hemoglobin and methods of making |
| US11576978B2 (en) * | 2019-07-19 | 2023-02-14 | Cheer Global Limited | Hemoglobin-based therapeutic agents |
| CN114577557B (zh) * | 2020-11-30 | 2024-06-18 | 中国科学院大连化学物理研究所 | 一种基于催化酶激活的靶向交联剂在蛋白分析中的应用 |
| CN114605338B (zh) * | 2022-05-11 | 2022-10-28 | 深圳厚存纳米药业有限公司 | 一种含尿嘧啶衍生物的纳米粒、核酸纳米复合物及其制备方法和用途 |
| CN116068189A (zh) * | 2023-04-07 | 2023-05-05 | 吉林重明生物科技有限公司 | 早期癌检测试剂及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4584130A (en) * | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| DE3675588D1 (de) * | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| MC2260A1 (fr) * | 1990-06-18 | 1993-04-26 | Dow Chemical Co | Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation |
| WO1993008842A1 (en) * | 1991-11-08 | 1993-05-13 | Somatogen, Inc. | Hemoglobins as drug delivery agents |
| WO1995029925A1 (en) * | 1994-04-29 | 1995-11-09 | The Curators Of The University Of Missouri | Thioether compounds for use in preparing bifunctional chelating agents for therapeutic radiopharmaceuticals |
| US5998361A (en) * | 1996-10-18 | 1999-12-07 | University Of Maryland At Baltimore | Polymerized hemoglobin |
| US20050059576A1 (en) * | 1998-04-30 | 2005-03-17 | Adamson J. Gordon | Targeted delivery of antiviral compounds through hemoglobin bioconjugates |
| CA2236344A1 (en) * | 1998-04-30 | 1999-10-30 | Hemosol Inc. | Hemoglobin-haptoglobin complexes |
| DE60317303T2 (de) * | 2003-04-17 | 2008-06-19 | Ezio Panzeri | Hämoglobin-Konjugate |
| US7235639B2 (en) | 2003-04-23 | 2007-06-26 | Ezio Panzeri | Hemoglobin conjugates |
| US8927694B2 (en) * | 2008-11-18 | 2015-01-06 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| US7989593B1 (en) * | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
| US8048856B1 (en) * | 2010-06-23 | 2011-11-01 | Billion King, Ltd. | Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition |
| US8084581B1 (en) * | 2011-04-29 | 2011-12-27 | Bing Lou Wong | Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus |
| US20130052232A1 (en) * | 2011-08-31 | 2013-02-28 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking |
| US20140106004A1 (en) * | 2012-10-12 | 2014-04-17 | Bing Lou Wong | Hemoglobin-based oxygen carrier-containing pharmaceutical composition for cancer targeting treatment and prevention of cancer recurrence |
| MA38571B1 (fr) * | 2013-05-13 | 2018-10-31 | Vision Global Holdings Ltd | Composition pharmaceutique comprenant un agent thérapeutique à base d'hémoglobine modifiée pour un traitement de ciblage du cancer et imagerie diagnostique |
-
2014
- 2014-05-13 MA MA38571A patent/MA38571B1/fr unknown
- 2014-05-13 MY MYPI2015703946A patent/MY176175A/en unknown
- 2014-05-13 TW TW103116929A patent/TWI610685B/zh not_active IP Right Cessation
- 2014-05-13 SG SG11201509042YA patent/SG11201509042YA/en unknown
- 2014-05-13 WO PCT/US2014/037749 patent/WO2014186301A1/en active Application Filing
- 2014-05-13 CN CN201480040021.4A patent/CN105407911B/zh active Active
- 2014-05-13 BR BR112015028340A patent/BR112015028340A2/pt not_active Application Discontinuation
- 2014-05-13 JP JP2016514013A patent/JP6392855B2/ja not_active Expired - Fee Related
- 2014-05-13 MX MX2015015555A patent/MX362001B/es active IP Right Grant
- 2014-05-13 CA CA2911414A patent/CA2911414C/en active Active
- 2014-05-13 AU AU2014265659A patent/AU2014265659B2/en active Active
- 2014-05-13 EP EP14798660.8A patent/EP3001813B1/en active Active
- 2014-05-13 US US14/275,885 patent/US9636404B2/en active Active
- 2014-05-13 KR KR1020157032973A patent/KR102013015B1/ko active IP Right Grant
- 2014-05-13 EA EA201501065A patent/EA032164B1/ru not_active IP Right Cessation
-
2015
- 2015-11-03 IL IL242422A patent/IL242422B/en not_active IP Right Cessation
- 2015-11-05 PH PH12015502536A patent/PH12015502536B1/en unknown
- 2015-11-12 SA SA515370134A patent/SA515370134B1/ar unknown
- 2015-11-13 CL CL2015003343A patent/CL2015003343A1/es unknown
-
2016
- 2016-09-13 HK HK16110826.1A patent/HK1222574A1/zh unknown
- 2016-09-29 HK HK16111399.6A patent/HK1223037A1/zh unknown
-
2017
- 2017-03-27 US US15/469,978 patent/US10322180B2/en active Active
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