HK1223037A1 - 用於癌症靶向治療和診斷成像的包含基於修飾的血紅蛋白的治療劑的藥物組合物 - Google Patents
用於癌症靶向治療和診斷成像的包含基於修飾的血紅蛋白的治療劑的藥物組合物Info
- Publication number
- HK1223037A1 HK1223037A1 HK16111399.6A HK16111399A HK1223037A1 HK 1223037 A1 HK1223037 A1 HK 1223037A1 HK 16111399 A HK16111399 A HK 16111399A HK 1223037 A1 HK1223037 A1 HK 1223037A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pharmaceutical composition
- therapeutic agent
- diagnostic imaging
- based therapeutic
- cancer targeting
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000002059 diagnostic imaging Methods 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6445—Haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822463P | 2013-05-13 | 2013-05-13 | |
| PCT/US2014/037749 WO2014186301A1 (en) | 2013-05-13 | 2014-05-13 | Pharmaceutical composition comprising modified hemoglobin- based therapeutic agent for cancer targeting treatment and diagnostic imaging |
| US14/275,885 US9636404B2 (en) | 2013-05-13 | 2014-05-13 | Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1223037A1 true HK1223037A1 (zh) | 2017-07-21 |
Family
ID=51864923
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16110826.1A HK1222574A1 (zh) | 2013-05-13 | 2016-09-13 | 用於癌症靶向治療和診斷成像的包含基於修飾的血紅蛋白的治療劑的藥物組合物 |
| HK16111399.6A HK1223037A1 (zh) | 2013-05-13 | 2016-09-29 | 用於癌症靶向治療和診斷成像的包含基於修飾的血紅蛋白的治療劑的藥物組合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16110826.1A HK1222574A1 (zh) | 2013-05-13 | 2016-09-13 | 用於癌症靶向治療和診斷成像的包含基於修飾的血紅蛋白的治療劑的藥物組合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9636404B2 (zh) |
| EP (1) | EP3001813B1 (zh) |
| JP (1) | JP6392855B2 (zh) |
| KR (1) | KR102013015B1 (zh) |
| CN (1) | CN105407911B (zh) |
| AU (1) | AU2014265659B2 (zh) |
| BR (1) | BR112015028340A2 (zh) |
| CA (1) | CA2911414C (zh) |
| CL (1) | CL2015003343A1 (zh) |
| EA (1) | EA032164B1 (zh) |
| HK (2) | HK1222574A1 (zh) |
| IL (1) | IL242422B (zh) |
| MA (1) | MA38571B1 (zh) |
| MX (1) | MX362001B (zh) |
| MY (1) | MY176175A (zh) |
| PH (1) | PH12015502536A1 (zh) |
| SA (1) | SA515370134B1 (zh) |
| SG (1) | SG11201509042YA (zh) |
| TW (1) | TWI610685B (zh) |
| WO (1) | WO2014186301A1 (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9636404B2 (en) * | 2013-05-13 | 2017-05-02 | Vision Global Holdings Ltd. | Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| US9814759B2 (en) * | 2014-07-02 | 2017-11-14 | Cheer Global Ltd. | Pharmaceutical composition comprising recombinant hemoglobin protein or subunit-based therapeutic agent for cancer targeting treatment |
| TW201609152A (zh) | 2014-09-03 | 2016-03-16 | 免疫原公司 | 包含細胞結合劑及細胞毒性劑之偶聯物 |
| TR201606102A2 (tr) * | 2016-05-10 | 2016-10-21 | Tolgay Tuyan Ilhan | Karin i̇çi̇ uygulanan kanser tedavi̇leri̇nde oksi̇jen konsantrasyonu ölçümü yapabi̇len ve veri̇len oksi̇jen dozaji üzeri̇nde deği̇şi̇kli̇k yapmayi sağlayan ci̇haz |
| CA3028589A1 (en) * | 2016-06-21 | 2017-12-28 | Therapure Biopharma Inc. | Hemoglobin-targeted drug delivery for the treatment of cancer |
| WO2018111989A1 (en) * | 2016-12-14 | 2018-06-21 | Purdue Research Foundation | Fibroblast activation protein (fap)-targeted imaging and therapy |
| US11560384B2 (en) | 2017-05-04 | 2023-01-24 | University Of Utah Research Foundation | Benzonorbornadiene derivatives and reactions thereof |
| CN107153771B (zh) * | 2017-05-17 | 2020-06-30 | 许昌学院 | 一种药物分子的同步控制方法及其应用 |
| US11504417B2 (en) | 2017-07-18 | 2022-11-22 | VirTech Bio, Inc. | Blood substitutes comprising hemoglobin and methods of making |
| WO2021013131A1 (en) * | 2019-07-19 | 2021-01-28 | Cheer Global Limited | Hemoglobin-based therapeutic agents |
| CN114605338B (zh) * | 2022-05-11 | 2022-10-28 | 深圳厚存纳米药业有限公司 | 一种含尿嘧啶衍生物的纳米粒、核酸纳米复合物及其制备方法和用途 |
| CN116068189A (zh) * | 2023-04-07 | 2023-05-05 | 吉林重明生物科技有限公司 | 早期癌检测试剂及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4584130A (en) * | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| EP0206448B1 (en) * | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| MC2260A1 (fr) * | 1990-06-18 | 1993-04-26 | Dow Chemical Co | Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation |
| ATE168014T1 (de) * | 1991-11-08 | 1998-07-15 | Somatogen Inc | Hämoglobine als arzneimittelabgabesystem |
| EP0757694A4 (en) * | 1994-04-29 | 1998-05-06 | Univ Missouri | THIOETHER COMPOUNDS FOR THE PREPARATION OF BIFUNCTIONAL CHELATING AGENTS FOR THERAPEUTIC RADIOPHARMACEUTICALS |
| US5998361A (en) * | 1996-10-18 | 1999-12-07 | University Of Maryland At Baltimore | Polymerized hemoglobin |
| CA2236344A1 (en) * | 1998-04-30 | 1999-10-30 | Hemosol Inc. | Hemoglobin-haptoglobin complexes |
| US20050059576A1 (en) * | 1998-04-30 | 2005-03-17 | Adamson J. Gordon | Targeted delivery of antiviral compounds through hemoglobin bioconjugates |
| EP1469011B1 (en) * | 2003-04-17 | 2007-11-07 | Ezio Panzeri | Hemoglobin conjugates |
| US7235639B2 (en) | 2003-04-23 | 2007-06-26 | Ezio Panzeri | Hemoglobin conjugates |
| WO2010059315A1 (en) * | 2008-11-18 | 2010-05-27 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| US7989593B1 (en) * | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
| US8048856B1 (en) * | 2010-06-23 | 2011-11-01 | Billion King, Ltd. | Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition |
| US8084581B1 (en) * | 2011-04-29 | 2011-12-27 | Bing Lou Wong | Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus |
| US20130052232A1 (en) * | 2011-08-31 | 2013-02-28 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking |
| US20140106004A1 (en) * | 2012-10-12 | 2014-04-17 | Bing Lou Wong | Hemoglobin-based oxygen carrier-containing pharmaceutical composition for cancer targeting treatment and prevention of cancer recurrence |
| US9636404B2 (en) * | 2013-05-13 | 2017-05-02 | Vision Global Holdings Ltd. | Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging |
-
2014
- 2014-05-13 US US14/275,885 patent/US9636404B2/en active Active
- 2014-05-13 TW TW103116929A patent/TWI610685B/zh not_active IP Right Cessation
- 2014-05-13 WO PCT/US2014/037749 patent/WO2014186301A1/en active Application Filing
- 2014-05-13 SG SG11201509042YA patent/SG11201509042YA/en unknown
- 2014-05-13 EA EA201501065A patent/EA032164B1/ru not_active IP Right Cessation
- 2014-05-13 EP EP14798660.8A patent/EP3001813B1/en active Active
- 2014-05-13 MX MX2015015555A patent/MX362001B/es active IP Right Grant
- 2014-05-13 MY MYPI2015703946A patent/MY176175A/en unknown
- 2014-05-13 KR KR1020157032973A patent/KR102013015B1/ko active IP Right Grant
- 2014-05-13 JP JP2016514013A patent/JP6392855B2/ja active Active
- 2014-05-13 BR BR112015028340A patent/BR112015028340A2/pt not_active Application Discontinuation
- 2014-05-13 CN CN201480040021.4A patent/CN105407911B/zh active Active
- 2014-05-13 MA MA38571A patent/MA38571B1/fr unknown
- 2014-05-13 AU AU2014265659A patent/AU2014265659B2/en active Active
- 2014-05-13 CA CA2911414A patent/CA2911414C/en active Active
-
2015
- 2015-11-03 IL IL242422A patent/IL242422B/en not_active IP Right Cessation
- 2015-11-05 PH PH12015502536A patent/PH12015502536A1/en unknown
- 2015-11-12 SA SA515370134A patent/SA515370134B1/ar unknown
- 2015-11-13 CL CL2015003343A patent/CL2015003343A1/es unknown
-
2016
- 2016-09-13 HK HK16110826.1A patent/HK1222574A1/zh unknown
- 2016-09-29 HK HK16111399.6A patent/HK1223037A1/zh unknown
-
2017
- 2017-03-27 US US15/469,978 patent/US10322180B2/en active Active
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