MX2019009752A - Antibioticos macrociclicos de amplio espectro. - Google Patents
Antibioticos macrociclicos de amplio espectro.Info
- Publication number
- MX2019009752A MX2019009752A MX2019009752A MX2019009752A MX2019009752A MX 2019009752 A MX2019009752 A MX 2019009752A MX 2019009752 A MX2019009752 A MX 2019009752A MX 2019009752 A MX2019009752 A MX 2019009752A MX 2019009752 A MX2019009752 A MX 2019009752A
- Authority
- MX
- Mexico
- Prior art keywords
- broad spectrum
- compounds
- spectrum antibiotics
- macrocyclic
- macrocyclic broad
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 241000894006 Bacteria Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108010087967 type I signal peptidase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2017/073575 | 2017-02-15 | ||
| CNPCT/CN2017/085075 | 2017-05-19 | ||
| PCT/CN2018/076957 WO2018149419A1 (en) | 2017-02-15 | 2018-02-22 | Macrocyclic broad spectrum antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019009752A true MX2019009752A (es) | 2019-11-11 |
Family
ID=63169158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019009752A MX2019009752A (es) | 2017-02-15 | 2018-02-22 | Antibioticos macrociclicos de amplio espectro. |
| MX2022014485A MX2022014485A (es) | 2017-02-15 | 2019-08-14 | Antibioticos macrociclicos de amplio espectro. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022014485A MX2022014485A (es) | 2017-02-15 | 2019-08-14 | Antibioticos macrociclicos de amplio espectro. |
Country Status (22)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2761476C2 (ru) | 2015-11-20 | 2021-12-08 | АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. | Макроциклические антибиотики широкого спектра действия |
| MX2019003087A (es) | 2016-09-16 | 2019-08-12 | Cortexyme Inc | Inhibidores cetónicos de gingipain de lisina. |
| HRP20231497T8 (hr) * | 2019-05-28 | 2024-08-02 | F. Hoffmann-La Roche Ag | Makrociklični antibiotici širokog spektra |
| CN112480007B (zh) * | 2020-12-08 | 2022-11-18 | 宿迁市科莱博生物化学有限公司 | 一种1，3-二甲基-1h-吡唑-4-羧酸的合成方法 |
| CN116284026B (zh) * | 2023-03-16 | 2024-05-14 | 天津师范大学 | 一种水溶性阳离子分子笼及其合成方法与应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011112441A1 (en) * | 2010-03-09 | 2011-09-15 | Merck Sharp & Dohme Corp. | Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials |
| WO2012036907A2 (en) * | 2010-09-15 | 2012-03-22 | Romesberg Floyd E | Broad spectrum antibiotic arylomycin analogs |
| TWI642684B (zh) * | 2011-05-27 | 2018-12-01 | Ｒｑｘ製藥股份有限公司 | 廣效性抗生素 |
| CN104284664A (zh) * | 2012-03-14 | 2015-01-14 | 斯克里普斯研究所 | 广谱抗生素Arylomycin类似物 |
| WO2014065080A1 (ja) * | 2012-10-23 | 2014-05-01 | 富士電機株式会社 | 半導体装置およびその製造方法 |
| CN103788176A (zh) * | 2012-10-31 | 2014-05-14 | 上海来益生物药物研究开发中心有限责任公司 | 一种arylomycin类化合物及其制备方法和应用 |
| BR112015011697A2 (pt) | 2012-11-21 | 2017-07-11 | Rqx Pharmaceuticals Inc | antibióticos macrocíclicos de amplo espectro |
| US20190067498A1 (en) * | 2017-08-28 | 2019-02-28 | Meng Tao | Light-induced aluminum plating on silicon for solar cell metallization |
| EP3145944B1 (en) * | 2014-05-20 | 2021-05-05 | RQX Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| TWI725075B (zh) * | 2015-11-20 | 2021-04-21 | 美商Ｒｑｘ製藥公司 | 巨環廣效抗生素 |
| RU2761476C2 (ru) * | 2015-11-20 | 2021-12-08 | АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. | Макроциклические антибиотики широкого спектра действия |
| ES2892173T3 (es) * | 2017-03-27 | 2022-02-02 | Hoffmann La Roche | Procedimiento para fabricar análogos de anillo de arilomicina |
-
2018
- 2018-02-22 KR KR1020197026779A patent/KR102671585B1/ko active Active
- 2018-02-22 JP JP2019542369A patent/JP7134177B2/ja active Active
- 2018-02-22 IL IL268483A patent/IL268483B2/en unknown
- 2018-02-22 MY MYPI2019004670A patent/MY199461A/en unknown
- 2018-02-22 CN CN201880025278.0A patent/CN110520413B/zh active Active
- 2018-02-22 MX MX2019009752A patent/MX2019009752A/es unknown
- 2018-02-22 SG SG11201907448RA patent/SG11201907448RA/en unknown
- 2018-02-22 AU AU2018222093A patent/AU2018222093B2/en active Active
- 2018-02-22 WO PCT/CN2018/076957 patent/WO2018149419A1/en not_active Ceased
- 2018-02-22 EP EP24161427.0A patent/EP4371982A3/en active Pending
- 2018-02-22 CR CR20190428A patent/CR20190428A/es unknown
- 2018-02-22 CR CR20210144A patent/CR20210144A/es unknown
- 2018-02-22 BR BR112019017003A patent/BR112019017003A2/pt not_active Application Discontinuation
- 2018-02-22 PE PE2019001675A patent/PE20191618A1/es unknown
- 2018-02-22 PE PE2024002053A patent/PE20242298A1/es unknown
- 2018-02-22 CA CA3053205A patent/CA3053205A1/en active Pending
- 2018-02-22 SG SG10202108876TA patent/SG10202108876TA/en unknown
- 2018-02-22 MA MA047514A patent/MA47514A/fr unknown
- 2018-02-22 EP EP18754727.8A patent/EP3583096B1/en active Active
- 2018-02-22 UA UAA201909231A patent/UA126027C2/uk unknown
- 2018-02-22 ES ES18754727T patent/ES2979245T3/es active Active
-
2019
- 2019-08-13 US US16/539,947 patent/US20210198316A9/en not_active Abandoned
- 2019-08-14 MX MX2022014485A patent/MX2022014485A/es unknown
- 2019-08-14 ZA ZA2019/05371A patent/ZA201905371B/en unknown
- 2019-08-14 CL CL2019002305A patent/CL2019002305A1/es unknown
- 2019-08-15 PH PH12019501904A patent/PH12019501904A1/en unknown
- 2019-09-13 CO CONC2019/0010001A patent/CO2019010001A2/es unknown
-
2022
- 2022-03-11 AU AU2022201724A patent/AU2022201724B9/en active Active
- 2022-08-30 JP JP2022137159A patent/JP7461425B2/ja active Active
- 2022-10-18 US US18/047,624 patent/US20230133667A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2016015218A (es) | Antibioticos macrociclicos de amplio espectro. | |
| MX2015006340A (es) | Antibioticos macrociclicos de amplio espectro. | |
| ZA202502195B (en) | Macrocyclic broad spectrum antibiotics | |
| PH12019501904A1 (en) | Macrocyclic broad spectrum antibiotics | |
| MX386742B (es) | Antibióticos de amplio espectro macrocíclico. | |
| MX2022006525A (es) | Activo de polipeptidos de lisina contra bacterias gram-negativas. | |
| WO2018208985A3 (en) | Antibacterial compounds | |
| EP4596048A3 (en) | Cd73 inhibitors | |
| MX2021003084A (es) | Compuestos antibacterianos. | |
| TW200734344A (en) | Antibacterial agents | |
| PH12021551058A1 (en) | Antibiotic compounds, methods of manufacturing the same, pharmaceutical compositions containing the same and uses thereof | |
| WO2017218922A8 (en) | Compositions and methods for the treatment of bacterial infections | |
| MX387476B (es) | Antibióticos de amplio espectro macrocíclico. | |
| WO2019067498A3 (en) | Peptide antibiotic complexes and methods of use thereof | |
| WO2021004958A3 (en) | Compositions comprising bacterial strains | |
| WO2020014501A8 (en) | Compositions and methods for the treatment of bacterial infections | |
| WO2020102243A3 (en) | In-flow photooxygenation of aminothienopyridinones generates novel ptp4a3 phosphatase inhibitors | |
| WO2020232471A3 (en) | Methods and compositions comprising staphylococcus protein a (spa) variants | |
| WO2021081110A3 (en) | Peptides and use thereof | |
| PH12021550070A1 (en) | Composition for inactivation of gram-positive bacteria and bacterial spores and mehtods of making and using same | |
| WO2021026455A3 (en) | Antibiotic peptides, compositions and uses thereof |