MX2019007684A - Compuesto novedoso y sal de este aceptable desde el punto de vista farmacologico. - Google Patents
Compuesto novedoso y sal de este aceptable desde el punto de vista farmacologico.Info
- Publication number
- MX2019007684A MX2019007684A MX2019007684A MX2019007684A MX2019007684A MX 2019007684 A MX2019007684 A MX 2019007684A MX 2019007684 A MX2019007684 A MX 2019007684A MX 2019007684 A MX2019007684 A MX 2019007684A MX 2019007684 A MX2019007684 A MX 2019007684A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- atom
- pharmaceutically
- acceptable salt
- hydrogen atom
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto representado por la Fórmula general (1) a continuación o una sal de este aceptable desde el punto de vista farmacológico: (Ver Fórmula) en la Fórmula (1), R1 y R2 pueden ser iguales o diferentes, y cada uno representa un átomo de hidrógeno, un átomo de alógeno, un grupo hidroxilo, un grupo carboxi, un grupo ciano, un grupo C1-6 alquilo opcionalmente sustituido et al.; R3 representa un átomo de hidrogeno; R4 representa un grupo heterocíclico monocíclico opcionalmente sustituido de 4 a 10 miembros que contiene 1 a 4 heteroátomos seleccionados de un átomo de oxígeno, un átomo de nitrógeno y un átomo de azufre; X representa a un grupo representado por la fórmula siguiente: -CH2-, -CH2-CH2-, -CH2-CH2-CH2- o -CH2-O-CH2-; y Z representa un átomo de hidrogeno o un grupo hidroxilo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016251577 | 2016-12-26 | ||
JP2017089251 | 2017-04-28 | ||
PCT/JP2017/046610 WO2018124060A1 (ja) | 2016-12-26 | 2017-12-26 | 新規化合物及びその薬理的に許容される塩 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019007684A true MX2019007684A (es) | 2019-09-09 |
Family
ID=62709343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019007684A MX2019007684A (es) | 2016-12-26 | 2017-12-26 | Compuesto novedoso y sal de este aceptable desde el punto de vista farmacologico. |
Country Status (22)
Country | Link |
---|---|
US (1) | US10669283B2 (es) |
EP (1) | EP3560925B1 (es) |
JP (1) | JP6815417B2 (es) |
KR (1) | KR102414365B1 (es) |
CN (1) | CN110114358B (es) |
AU (1) | AU2017385199B2 (es) |
BR (1) | BR112019010571A2 (es) |
CA (1) | CA3048170A1 (es) |
CY (1) | CY1124643T1 (es) |
DK (1) | DK3560925T3 (es) |
ES (1) | ES2875548T3 (es) |
HU (1) | HUE055468T2 (es) |
IL (1) | IL267594B (es) |
MX (1) | MX2019007684A (es) |
PH (1) | PH12019501391A1 (es) |
PL (1) | PL3560925T3 (es) |
PT (1) | PT3560925T (es) |
RU (1) | RU2767878C2 (es) |
TW (1) | TWI752141B (es) |
UA (1) | UA124353C2 (es) |
WO (1) | WO2018124060A1 (es) |
ZA (1) | ZA201904241B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR114977A1 (es) | 2018-06-27 | 2020-11-11 | Meiji Seika Pharma Co Ltd | Cristales de derivado de benzoxazol |
JP6815566B2 (ja) * | 2018-06-27 | 2021-01-20 | Meiji Seikaファルマ株式会社 | 炎症性疾患、自己免疫疾患、線維化疾患、及びがん疾患の治療剤 |
JP2021155336A (ja) * | 2018-06-27 | 2021-10-07 | Meiji Seikaファルマ株式会社 | 新規pde4阻害剤 |
AU2020265392A1 (en) | 2019-04-30 | 2021-12-23 | Aicuris Gmbh & Co. Kg | Novel indolizine-2-carboxamides active against the hepatitis B virus (HBV) |
CN111057075B (zh) * | 2019-12-24 | 2021-04-27 | 武汉九州钰民医药科技有限公司 | Ret抑制剂及其制备方法 |
AR126290A1 (es) | 2021-06-30 | 2023-10-04 | Meiji Seika Pharma Co Ltd | Método para producir derivado de benzoxazol que tiene anillo bicíclico de piperazina o sal de este, y método para producir materia prima de este |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61166827A (ja) | 1985-01-17 | 1986-07-28 | Toray Ind Inc | 変性エポキシ系微粒子 |
JP3193560B2 (ja) * | 1993-04-16 | 2001-07-30 | 明治製菓株式会社 | 新規ベンゾオキサゾール誘導体 |
JP3520177B2 (ja) * | 1996-05-09 | 2004-04-19 | 明治製菓株式会社 | セロトニン5−ht3受容体部分活性薬 |
GB0003256D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
PL210065B1 (pl) * | 2002-09-25 | 2011-11-30 | Memory Pharm Corp | Związki indazole, benzotiazole i benzoizotiazole, kompozycje farmaceutyczne je zawierające oraz zastosowanie związków |
NZ560969A (en) * | 2005-02-17 | 2010-08-27 | Albany Molecular Res Inc | Benzoxazole carboxamides for treating chemotherapy-induced vomiting and irritable bowel syndrome |
EP2061460A2 (en) | 2006-08-07 | 2009-05-27 | Albany Molecular Research, Inc. | 2-aminobenzoxazole carboxamides as 5ht3 modulators |
WO2009050236A1 (de) * | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Neue piperazino-dihydrothienopyrimidin-derivate |
WO2015005429A1 (ja) * | 2013-07-10 | 2015-01-15 | Meiji Seikaファルマ株式会社 | 新規pde4阻害剤 |
-
2017
- 2017-12-26 CN CN201780080389.7A patent/CN110114358B/zh active Active
- 2017-12-26 BR BR112019010571A patent/BR112019010571A2/pt active Search and Examination
- 2017-12-26 PT PT178859179T patent/PT3560925T/pt unknown
- 2017-12-26 DK DK17885917.9T patent/DK3560925T3/da active
- 2017-12-26 WO PCT/JP2017/046610 patent/WO2018124060A1/ja unknown
- 2017-12-26 TW TW106145711A patent/TWI752141B/zh active
- 2017-12-26 ES ES17885917T patent/ES2875548T3/es active Active
- 2017-12-26 CA CA3048170A patent/CA3048170A1/en active Pending
- 2017-12-26 PL PL17885917T patent/PL3560925T3/pl unknown
- 2017-12-26 EP EP17885917.9A patent/EP3560925B1/en active Active
- 2017-12-26 AU AU2017385199A patent/AU2017385199B2/en active Active
- 2017-12-26 RU RU2019122999A patent/RU2767878C2/ru active
- 2017-12-26 JP JP2018559513A patent/JP6815417B2/ja active Active
- 2017-12-26 KR KR1020197021334A patent/KR102414365B1/ko active IP Right Grant
- 2017-12-26 MX MX2019007684A patent/MX2019007684A/es unknown
- 2017-12-26 HU HUE17885917A patent/HUE055468T2/hu unknown
- 2017-12-26 UA UAA201908271A patent/UA124353C2/uk unknown
- 2017-12-26 US US16/473,507 patent/US10669283B2/en active Active
-
2019
- 2019-06-18 PH PH12019501391A patent/PH12019501391A1/en unknown
- 2019-06-23 IL IL267594A patent/IL267594B/en unknown
- 2019-06-27 ZA ZA2019/04241A patent/ZA201904241B/en unknown
-
2021
- 2021-09-01 CY CY20211100780T patent/CY1124643T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2017385199B2 (en) | 2021-09-09 |
KR20190097235A (ko) | 2019-08-20 |
ZA201904241B (en) | 2020-12-23 |
RU2019122999A (ru) | 2021-01-26 |
JPWO2018124060A1 (ja) | 2019-10-31 |
RU2767878C2 (ru) | 2022-03-22 |
ES2875548T3 (es) | 2021-11-10 |
KR102414365B1 (ko) | 2022-07-01 |
PL3560925T3 (pl) | 2021-12-20 |
CN110114358B (zh) | 2021-12-03 |
BR112019010571A2 (pt) | 2019-09-17 |
CA3048170A1 (en) | 2018-07-05 |
JP6815417B2 (ja) | 2021-01-20 |
WO2018124060A1 (ja) | 2018-07-05 |
EP3560925B1 (en) | 2021-06-02 |
US10669283B2 (en) | 2020-06-02 |
US20190322686A1 (en) | 2019-10-24 |
IL267594B (en) | 2022-04-01 |
TWI752141B (zh) | 2022-01-11 |
HUE055468T2 (hu) | 2021-11-29 |
CY1124643T1 (el) | 2022-11-25 |
EP3560925A1 (en) | 2019-10-30 |
UA124353C2 (uk) | 2021-09-01 |
DK3560925T3 (da) | 2021-06-28 |
AU2017385199A1 (en) | 2019-07-04 |
TW201835080A (zh) | 2018-10-01 |
RU2019122999A3 (es) | 2021-03-31 |
PH12019501391A1 (en) | 2020-02-10 |
PT3560925T (pt) | 2021-07-28 |
CN110114358A (zh) | 2019-08-09 |
EP3560925A4 (en) | 2020-06-10 |
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