UA124353C2 - Нова сполука і її фармакологічно прийнятна сіль - Google Patents

Нова сполука і її фармакологічно прийнятна сіль

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Publication number
UA124353C2
UA124353C2 UAA201908271A UAA201908271A UA124353C2 UA 124353 C2 UA124353 C2 UA 124353C2 UA A201908271 A UAA201908271 A UA A201908271A UA A201908271 A UAA201908271 A UA A201908271A UA 124353 C2 UA124353 C2 UA 124353C2
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UA
Ukraine
Prior art keywords
group
atom
pharmaceutically
acceptable salt
hydrogen atom
Prior art date
Application number
UAA201908271A
Other languages
English (en)
Inventor
Кейдзі Тамура
Кейдзи ТАМУРА
Такеру ЯМАКАВА
Сатосі Іссхікі
Сатоси Иссхики
Йосінарі Вакіяма
Йосинари Вакияма
Сохеі Оуті
Сохеи Оути
Такасі Мацухіра
Такаси Мацухира
Нацукі Ісіда
Нацуки Исида
Юдзі Табата
Юдзи ТАБАТА
Original Assignee
Мейдзі Сейка Фарма Ко., Лтд.
Мейдзи Сейка Фарма Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мейдзі Сейка Фарма Ко., Лтд., Мейдзи Сейка Фарма Ко., Лтд. filed Critical Мейдзі Сейка Фарма Ко., Лтд.
Publication of UA124353C2 publication Critical patent/UA124353C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Сполука, що описується загальною формулою (1), наведеною нижче, або її фармакологічно прийнятна сіль: , (1) у формулі (1): R1 і R2 можуть бути однаковими або різними і кожний означає атом водню, атом галогену, гідроксигрупу, карбоксигрупу, ціаногрупу, необов'язково заміщену C1-6-алкільну групу і ін.; R3 означає атом водню; R4 означає необов'язково заміщену 4-10-членну моноциклічну гетероциклічну групу, що містить від 1 до 4 гетероатомів, вибраних з атома кисню, атома азоту і атома сірки; X означає групу, що описується наступною формулою: -CH2-, -CH2-CH2-, -CH2-CH2-CH2- або -CH2-O-CH2-; і Z означає атом водню або гідроксигрупу.
UAA201908271A 2016-12-26 2017-12-26 Нова сполука і її фармакологічно прийнятна сіль UA124353C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016251577 2016-12-26
JP2017089251 2017-04-28
PCT/JP2017/046610 WO2018124060A1 (ja) 2016-12-26 2017-12-26 新規化合物及びその薬理的に許容される塩

Publications (1)

Publication Number Publication Date
UA124353C2 true UA124353C2 (uk) 2021-09-01

Family

ID=62709343

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201908271A UA124353C2 (uk) 2016-12-26 2017-12-26 Нова сполука і її фармакологічно прийнятна сіль

Country Status (22)

Country Link
US (1) US10669283B2 (uk)
EP (1) EP3560925B1 (uk)
JP (1) JP6815417B2 (uk)
KR (1) KR102414365B1 (uk)
CN (1) CN110114358B (uk)
AU (1) AU2017385199B2 (uk)
BR (1) BR112019010571A2 (uk)
CA (1) CA3048170A1 (uk)
CY (1) CY1124643T1 (uk)
DK (1) DK3560925T3 (uk)
ES (1) ES2875548T3 (uk)
HU (1) HUE055468T2 (uk)
IL (1) IL267594B (uk)
MX (1) MX2019007684A (uk)
PH (1) PH12019501391A1 (uk)
PL (1) PL3560925T3 (uk)
PT (1) PT3560925T (uk)
RU (1) RU2767878C2 (uk)
TW (1) TWI752141B (uk)
UA (1) UA124353C2 (uk)
WO (1) WO2018124060A1 (uk)
ZA (1) ZA201904241B (uk)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021155336A (ja) * 2018-06-27 2021-10-07 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規ｐｄｅ４阻害剤
WO2020004521A1 (ja) * 2018-06-27 2020-01-02 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 炎症性疾患、自己免疫疾患、線維化疾患、及びがん疾患の治療剤
AR114977A1 (es) 2018-06-27 2020-11-11 Meiji Seika Pharma Co Ltd Cristales de derivado de benzoxazol
SG11202111198QA (en) 2019-04-30 2021-11-29 Aicuris Gmbh & Co Kg Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
CN111057075B (zh) * 2019-12-24 2021-04-27 武汉九州钰民医药科技有限公司 Ret抑制剂及其制备方法
EP4365174A1 (en) 2021-06-30 2024-05-08 Meiji Seika Pharma Co., Ltd. Method for producing benzoxazole derivative having bicyclic piperazine ring or salt thereof, and method for producing material thereof

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
JPS61166827A (ja) 1985-01-17 1986-07-28 Toray Ind Inc 変性エポキシ系微粒子
JP3193560B2 (ja) * 1993-04-16 2001-07-30 明治製菓株式会社 新規ベンゾオキサゾール誘導体
JP3520177B2 (ja) * 1996-05-09 2004-04-19 明治製菓株式会社 セロトニン５−ｈｔ３受容体部分活性薬
GB0003256D0 (en) * 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
ES2405594T3 (es) * 2002-09-25 2013-05-31 Memory Pharmaceuticals Corporation Idazoles, benzotiazoles y benzisotiazoles, y preparación y usos de los mismos
WO2006089100A1 (en) * 2005-02-17 2006-08-24 Amr Technology, Inc. Benzoxazole carboxamides for treating cinv and ibs-d
US7863271B2 (en) 2006-08-07 2011-01-04 Albany Molecular Research, Inc. 2-aminobenzoxazole carboxamides as 5HT3 modulators
ATE537175T1 (de) 2007-10-19 2011-12-15 Boehringer Ingelheim Int Neue piperazino-dihydrothienopyrimidin-derivate
JP6345664B2 (ja) * 2013-07-10 2018-06-20 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規ｐｄｅ４阻害剤

Also Published As

Publication number Publication date
US10669283B2 (en) 2020-06-02
CN110114358A (zh) 2019-08-09
RU2767878C2 (ru) 2022-03-22
EP3560925A1 (en) 2019-10-30
ZA201904241B (en) 2020-12-23
HUE055468T2 (hu) 2021-11-29
IL267594B (en) 2022-04-01
BR112019010571A2 (pt) 2019-09-17
PT3560925T (pt) 2021-07-28
MX2019007684A (es) 2019-09-09
TW201835080A (zh) 2018-10-01
RU2019122999A3 (uk) 2021-03-31
JP6815417B2 (ja) 2021-01-20
EP3560925A4 (en) 2020-06-10
CA3048170A1 (en) 2018-07-05
US20190322686A1 (en) 2019-10-24
KR102414365B1 (ko) 2022-07-01
JPWO2018124060A1 (ja) 2019-10-31
RU2019122999A (ru) 2021-01-26
WO2018124060A1 (ja) 2018-07-05
CY1124643T1 (el) 2022-11-25
KR20190097235A (ko) 2019-08-20
PL3560925T3 (pl) 2021-12-20
TWI752141B (zh) 2022-01-11
PH12019501391A1 (en) 2020-02-10
ES2875548T3 (es) 2021-11-10
AU2017385199B2 (en) 2021-09-09
EP3560925B1 (en) 2021-06-02
DK3560925T3 (da) 2021-06-28
CN110114358B (zh) 2021-12-03
AU2017385199A1 (en) 2019-07-04

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