MX2019007444A - Metodos y sistemas para analisis de moleculas de acido nucleico. - Google Patents
Metodos y sistemas para analisis de moleculas de acido nucleico.Info
- Publication number
- MX2019007444A MX2019007444A MX2019007444A MX2019007444A MX2019007444A MX 2019007444 A MX2019007444 A MX 2019007444A MX 2019007444 A MX2019007444 A MX 2019007444A MX 2019007444 A MX2019007444 A MX 2019007444A MX 2019007444 A MX2019007444 A MX 2019007444A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- nucleic acid
- systems
- acid molecules
- analysis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 238000004458 analytical method Methods 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 2
- 238000012986 modification Methods 0.000 abstract 2
- 230000030933 DNA methylation on cytosine Effects 0.000 abstract 1
- 238000012300 Sequence Analysis Methods 0.000 abstract 1
- 230000001973 epigenetic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/101—DNA polymerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/107—RNA dependent DNA polymerase,(i.e. reverse transcriptase)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/50—Other enzymatic activities
- C12Q2521/501—Ligase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/164—Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/131—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a member of a cognate binding pair, i.e. extends to antibodies, haptens, avidin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
- C12Q2565/514—Detection characterised by immobilisation to a surface characterised by the use of the arrayed oligonucleotides as identifier tags, e.g. universal addressable array, anti-tag or tag complement array
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438240P | 2016-12-22 | 2016-12-22 | |
| US201762512936P | 2017-05-31 | 2017-05-31 | |
| US201762550540P | 2017-08-25 | 2017-08-25 | |
| PCT/US2017/068329 WO2018119452A2 (en) | 2016-12-22 | 2017-12-22 | Methods and systems for analyzing nucleic acid molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019007444A true MX2019007444A (es) | 2019-08-16 |
Family
ID=61006366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019007444A MX2019007444A (es) | 2016-12-22 | 2017-12-22 | Metodos y sistemas para analisis de moleculas de acido nucleico. |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US11519019B2 (enExample) |
| EP (1) | EP3559270A2 (enExample) |
| JP (3) | JP7300989B2 (enExample) |
| KR (2) | KR102723226B1 (enExample) |
| CN (1) | CN110325650A (enExample) |
| AU (1) | AU2017382439B2 (enExample) |
| BR (1) | BR112019012958A2 (enExample) |
| CA (1) | CA3046007A1 (enExample) |
| IL (2) | IL302912A (enExample) |
| MX (1) | MX2019007444A (enExample) |
| WO (1) | WO2018119452A2 (enExample) |
Families Citing this family (139)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| DK3246416T3 (da) | 2011-04-15 | 2024-09-02 | Univ Johns Hopkins | Sikkert sekventeringssystem |
| CA2865575C (en) | 2012-02-27 | 2024-01-16 | Cellular Research, Inc. | Compositions and kits for molecular counting |
| ES2886507T5 (es) | 2012-10-29 | 2024-11-15 | Univ Johns Hopkins | Prueba de Papanicolaou para cánceres de ovario y de endometrio |
| CN110964796B (zh) | 2013-08-28 | 2024-04-05 | 贝克顿迪金森公司 | 大规模平行单细胞分析 |
| WO2016160844A2 (en) | 2015-03-30 | 2016-10-06 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
| WO2017027653A1 (en) | 2015-08-11 | 2017-02-16 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| KR102638006B1 (ko) | 2016-09-26 | 2024-02-20 | 셀룰러 리서치, 인크. | 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정 |
| US11414710B2 (en) * | 2016-12-28 | 2022-08-16 | Quest Diagnostics Investments Llc | Compositions and methods for detecting circulating tumor DNA |
| EP3610034B1 (en) | 2017-04-12 | 2022-06-08 | Karius, Inc. | Sample preparation methods, systems and compositions |
| EP4345172A3 (en) | 2017-06-05 | 2024-07-03 | Becton, Dickinson and Company | Sample indexing for single cells |
| CN111868260B (zh) | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| WO2019195268A2 (en) | 2018-04-02 | 2019-10-10 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
| AU2019262048B2 (en) | 2018-05-03 | 2025-09-04 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
| CN120193081A (zh) | 2018-07-23 | 2025-06-24 | 夸登特健康公司 | 用于通过肿瘤分数和覆盖率调整肿瘤突变负荷的方法和系统 |
| US12178549B2 (en) | 2018-10-11 | 2024-12-31 | Seno Medical Instruments, Inc. | Optoacoustic image analysis method and system for automatically estimating lesion traits |
| AU2019351130B2 (en) | 2018-09-27 | 2025-10-23 | GRAIL, Inc | Methylation markers and targeted methylation probe panel |
| CN118853827A (zh) | 2018-10-01 | 2024-10-29 | 贝克顿迪金森公司 | 确定5’转录物序列 |
| CN112969789A (zh) | 2018-11-08 | 2021-06-15 | 贝克顿迪金森公司 | 使用随机引发的单细胞全转录组分析 |
| EP3894552A1 (en) | 2018-12-13 | 2021-10-20 | Becton, Dickinson and Company | Selective extension in single cell whole transcriptome analysis |
| CN113454218A (zh) * | 2018-12-20 | 2021-09-28 | 夸登特健康公司 | 用于改进核酸分子的回收的方法、组合物和系统 |
| EP3914728B1 (en) | 2019-01-23 | 2023-04-05 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
| AU2020212057A1 (en) * | 2019-01-25 | 2021-08-26 | GRAIL, Inc | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| EP3918089B1 (en) | 2019-01-31 | 2025-01-15 | Guardant Health, Inc. | Method for isolating and sequencing cell-free dna |
| CN113454234B (zh) | 2019-02-14 | 2025-03-18 | 贝克顿迪金森公司 | 杂合体靶向和全转录物组扩增 |
| WO2020176659A1 (en) | 2019-02-27 | 2020-09-03 | Guardant Health, Inc. | Methods and systems for determining the cellular origin of cell-free dna |
| WO2020229437A1 (en) * | 2019-05-14 | 2020-11-19 | F. Hoffmann-La Roche Ag | Devices and methods for sample analysis |
| EP3976822A1 (en) | 2019-05-31 | 2022-04-06 | Guardant Health, Inc. | Methods and systems for improving patient monitoring after surgery |
| EP4004231B1 (en) | 2019-07-22 | 2025-11-12 | Becton, Dickinson and Company | Single cell chromatin immunoprecipitation sequencing assay |
| JP7323703B2 (ja) * | 2019-08-19 | 2023-08-08 | エフ. ホフマン-ラ ロシュ アーゲー | 配列決定用のdna及びrnaのシングルチューブ調製 |
| WO2021067484A1 (en) | 2019-09-30 | 2021-04-08 | Guardant Health, Inc. | Compositions and methods for analyzing cell-free dna in methylation partitioning assays |
| CN114729350A (zh) | 2019-11-08 | 2022-07-08 | 贝克顿迪金森公司 | 使用随机引发获得用于免疫组库测序的全长v(d)j信息 |
| US11898199B2 (en) | 2019-11-11 | 2024-02-13 | Universal Diagnostics, S.A. | Detection of colorectal cancer and/or advanced adenomas |
| ES3031713T3 (en) * | 2019-11-26 | 2025-07-10 | Guardant Health Inc | Methods, compositions and systems for improving the binding of methylated polynucleotides |
| WO2021127208A1 (en) * | 2019-12-20 | 2021-06-24 | Accuragen Holdings Limited | Methods and systems for disease detection |
| US11649497B2 (en) | 2020-01-13 | 2023-05-16 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and RNA |
| GB202000747D0 (en) * | 2020-01-17 | 2020-03-04 | Institute Of Cancer Res | Monitoring tumour evolution |
| EP4097228B1 (en) | 2020-01-29 | 2024-08-14 | Becton, Dickinson and Company | Barcoded wells for spatial mapping of single cells through sequencing |
| CN115516108A (zh) | 2020-02-14 | 2022-12-23 | 约翰斯霍普金斯大学 | 评估核酸的方法和材料 |
| WO2021173719A1 (en) | 2020-02-25 | 2021-09-02 | Becton, Dickinson And Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
| US20210285042A1 (en) * | 2020-02-28 | 2021-09-16 | Grail, Inc. | Systems and methods for calling variants using methylation sequencing data |
| WO2021202752A1 (en) * | 2020-03-31 | 2021-10-07 | Guardant Health, Inc. | Determining tumor fraction for a sample based on methyl binding domain calibration data |
| WO2021222828A1 (en) | 2020-04-30 | 2021-11-04 | Guardant Health, Inc. | Methods for sequence determination using partitioned nucleic acids |
| EP4150117A4 (en) * | 2020-05-12 | 2024-05-29 | The Board of Trustees of the Leland Stanford Junior University | SYSTEM AND METHOD FOR GENE EXPRESSION AND SOURCE TISSUE INFRINGEMENT FROM CELL-FREE DNA |
| WO2021231455A1 (en) * | 2020-05-13 | 2021-11-18 | Accuragen Holdings Limited | Cell-free dna size detection |
| EP4150118A1 (en) | 2020-05-14 | 2023-03-22 | Becton Dickinson and Company | Primers for immune repertoire profiling |
| US12241126B2 (en) | 2020-05-14 | 2025-03-04 | Guardant Health, Inc. | Homologous recombination repair deficiency detection |
| US12467096B2 (en) | 2020-05-15 | 2025-11-11 | Universal Diagnostics, S.A. | Methods and systems for identifying methylation biomarkers |
| AU2021276524A1 (en) | 2020-05-22 | 2023-01-05 | Aqtual, Inc. | Methods for characterizing cell-free nucleic acid fragments |
| EP4407030B1 (en) | 2020-06-02 | 2025-12-17 | Becton, Dickinson and Company | Oligonucleotides and beads for 5 prime gene expression assay |
| WO2022002424A1 (en) | 2020-06-30 | 2022-01-06 | Universal Diagnostics, S.L. | Systems and methods for detection of multiple cancer types |
| WO2023282916A1 (en) | 2021-07-09 | 2023-01-12 | Guardant Health, Inc. | Methods of detecting genomic rearrangements using cell free nucleic acids |
| EP4179111B1 (en) | 2020-07-10 | 2024-04-03 | Guardant Health, Inc. | Methods of detecting genomic rearrangements using cell free nucleic acids |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| CN111826430A (zh) * | 2020-07-24 | 2020-10-27 | 扬州大学 | 一种研究鸡PGCs中lncRNA和组蛋白甲基化酶共调控靶基因的方法 |
| EP4585697A3 (en) | 2020-07-30 | 2025-08-06 | Guardant Health, Inc. | Methods for isolating cell-free dna |
| CN116194589A (zh) | 2020-07-31 | 2023-05-30 | 贝克顿迪金森公司 | 用于转座酶可及染色质的单细胞测定 |
| WO2022040147A1 (en) * | 2020-08-19 | 2022-02-24 | Accuragen Holdings Limited | Methods for selective cell-free nucleic acid analysis |
| JP2023540221A (ja) | 2020-08-25 | 2023-09-22 | ガーダント ヘルス, インコーポレイテッド | バリアントの起源を予測するための方法およびシステム |
| US20220162670A1 (en) * | 2020-09-30 | 2022-05-26 | Guardant Health, Inc. | Methods and systems to improve the signal to noise ratio of dna methylation partitioning assays |
| CA3195797A1 (en) | 2020-10-23 | 2022-04-28 | Andrew Kennedy | Compositions and methods for analyzing dna using partitioning and base conversion |
| WO2022108946A1 (en) | 2020-11-17 | 2022-05-27 | Becton, Dickinson And Company | Combined analysis of cell-free nucleic acids and single cells for oncology diagnostics |
| WO2022109343A1 (en) | 2020-11-20 | 2022-05-27 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| CA3199829A1 (en) | 2020-11-30 | 2022-06-02 | Guardant Health, Inc. | Compositions and methods for enriching methylated polynucleotides |
| US12392771B2 (en) | 2020-12-15 | 2025-08-19 | Becton, Dickinson And Company | Single cell secretome analysis |
| WO2022140629A1 (en) * | 2020-12-23 | 2022-06-30 | Guardant Health, Inc. | Methods and systems for analyzing methylated polynucleotides |
| EP4291679A1 (en) | 2021-02-12 | 2023-12-20 | Guardant Health, Inc. | Methods and compositions for detecting nucleic acid variants |
| WO2022187867A1 (en) * | 2021-03-05 | 2022-09-09 | The Trustees Of Columbia University In The City Of New York | Methods to analyze methylomes in tumor and plasma cell-free dna |
| EP4302301A1 (en) | 2021-03-05 | 2024-01-10 | Guardant Health, Inc. | Methods and related aspects for analyzing molecular response |
| WO2022192189A1 (en) * | 2021-03-09 | 2022-09-15 | Claret Bioscience, Llc | Methods and compositions for analyzing nucleic acid |
| EP4305200A1 (en) | 2021-03-09 | 2024-01-17 | Guardant Health, Inc. | Detecting the presence of a tumor based on off-target polynucleotide sequencing data |
| WO2022204730A1 (en) | 2021-03-25 | 2022-09-29 | Guardant Health, Inc. | Methods and compositions for quantifying immune cell dna |
| EP4314340A4 (en) * | 2021-03-30 | 2024-11-27 | Resolution Bioscience, Inc. | COMPOSITIONS AND METHODS FOR SIMULTANEOUS GENETIC ANALYSIS OF MULTIPLE LIBRARIES |
| EP4326906A4 (en) * | 2021-04-23 | 2025-03-12 | The Translational Genomics Research Institute | Analysis of fragment ends in dna |
| WO2022251655A1 (en) | 2021-05-28 | 2022-12-01 | Guardant Health, Inc. | Compositions and methods for assaying circulating molecules |
| EP4359562A1 (en) | 2021-06-21 | 2024-05-01 | Guardant Health, Inc. | Methods and compositions for copy-number informed tissue-of-origin analysis |
| US20250283170A1 (en) * | 2021-07-12 | 2025-09-11 | The Trustees Of The University Of Pennsylvania | Modified adapters for enzymatic dna deamination and methods of use thereof for epigenetic sequencing of free and immobilized dna |
| WO2023056065A1 (en) | 2021-09-30 | 2023-04-06 | Guardant Health, Inc. | Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements |
| EP4426858A2 (en) | 2021-11-02 | 2024-09-11 | Guardant Health, Inc. | Quality control method |
| EP4430396A1 (en) | 2021-11-12 | 2024-09-18 | Guardant Health, Inc. | Method of analysis of methylated dna-binding proteins |
| WO2023122623A1 (en) | 2021-12-21 | 2023-06-29 | Guardant Health, Inc. | Methods and systems for combinatorial chromatin-ip sequencing |
| WO2023122740A1 (en) | 2021-12-23 | 2023-06-29 | Guardant Health, Inc. | Compositions and methods for detection of metastasis |
| WO2023147568A2 (en) * | 2022-01-28 | 2023-08-03 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for making and using an immortalized library |
| JP2025513786A (ja) | 2022-04-07 | 2025-04-30 | ガーダント ヘルス, インコーポレイテッド | 無細胞核酸分子のメチル化状態に基づいた腫瘍の存在の検出 |
| EP4547857A1 (en) | 2022-06-30 | 2025-05-07 | Guardant Health, Inc. | Enrichment of aberrantly methylated dna |
| JP2025523964A (ja) | 2022-07-21 | 2025-07-25 | ガーダント ヘルス, インコーポレイテッド | 試料調製により誘発されるメチル化アーチファクトの検出および低減のための方法 |
| WO2024040006A2 (en) * | 2022-08-15 | 2024-02-22 | Bioscreening & Diagnostics Llc | Ai and ml-based system to predict cancer from epigenetic data |
| WO2024059840A1 (en) | 2022-09-16 | 2024-03-21 | Guardant Health, Inc. | Compositions and methods for analyzing soluble proteins |
| WO2024073508A2 (en) | 2022-09-27 | 2024-04-04 | Guardant Health, Inc. | Methods and compositions for quantifying immune cell dna |
| KR20250110272A (ko) | 2022-11-15 | 2025-07-18 | 가던트 헬쓰, 인크. | 순환 종양 dna (ctdna)로부터 기준선 ctdna 수준 및 시간 경과에 따른 ctdna 수준의 종단적 변화 둘 다로부터의 신호를 이용하여 비소세포 폐암 (nsclc) 환자 약물 반응 또는 사망 또는 암 진행까지의 시간을 예측하는 방법 |
| CN120569782A (zh) | 2022-12-21 | 2025-08-29 | 夸登特健康公司 | 基于无细胞核酸分子的甲基化状态检测同源重组缺陷 |
| WO2024137880A2 (en) | 2022-12-22 | 2024-06-27 | Guardant Health, Inc. | Methods involving methylation preserving amplification with error correction |
| EP4638782A2 (en) | 2022-12-22 | 2025-10-29 | Guardant Health, Inc. | Integrated targeted and whole genome somatic and dna methylation sequencing workflows |
| EP4649489A1 (en) | 2023-01-11 | 2025-11-19 | Guardant Health, Inc. | Joint modeling of longitudinal and time-to-event data to predict patient survival |
| EP4655416A1 (en) | 2023-01-25 | 2025-12-03 | Guardant Health, Inc. | Nucleic acid methylation profiling method |
| WO2024186768A1 (en) * | 2023-03-07 | 2024-09-12 | Guardant Health, Inc. | Hybrid ssdna- and dsdna-ngs library preparation methods |
| US20250101522A1 (en) | 2023-04-12 | 2025-03-27 | Guardant Health, Inc. | Brca1 promoter methylation in sporadic breast cancer patients detected by liquid biopsy |
| WO2024229143A1 (en) | 2023-05-01 | 2024-11-07 | Guardant Health, Inc. | Quality control method for enzymatic conversion procedures |
| WO2024229433A1 (en) | 2023-05-03 | 2024-11-07 | Guardant Health, Inc. | Methods for analysis of dna methylation |
| WO2024233502A1 (en) | 2023-05-05 | 2024-11-14 | Guardant Health, Inc. | Cell-free dna blood-based test for cancer screening |
| US20240420800A1 (en) | 2023-06-15 | 2024-12-19 | Guardant Health, Inc. | METHOD FOR HRD DETECTION IN TARGETED cfDNA SAMPLES USING DE NOVO MUTATIONAL SIGNATURES |
| WO2024264065A1 (en) | 2023-06-23 | 2024-12-26 | Guardant Health, Inc. | Methods and compositions for quantifying immune cell nucleic acids |
| WO2025007034A1 (en) | 2023-06-29 | 2025-01-02 | Guardant Health, Inc. | Methods for determining surveillance and therapy for diseases |
| WO2025007038A1 (en) | 2023-06-30 | 2025-01-02 | Guardant Health, Inc. | Methods for early detection of cancer |
| WO2025019297A1 (en) | 2023-07-14 | 2025-01-23 | Guardant Health, Inc. | Classification of colorectal tumors using dna methylation from liquid biopsy |
| WO2025019370A1 (en) * | 2023-07-14 | 2025-01-23 | Natera, Inc. | Methods for assaying circulating tumor dna |
| WO2025019254A1 (en) | 2023-07-14 | 2025-01-23 | Guardant Health, Inc. | Classification of breast tumors using dna methylation from liquid biopsy |
| WO2025024497A1 (en) | 2023-07-24 | 2025-01-30 | Guardant Health, Inc. | Significance modeling of clonal-level target variants using methylation detection |
| WO2025029645A1 (en) | 2023-07-28 | 2025-02-06 | Guardant Health, Inc. | Methods and systems for identifying an origin of a variant |
| WO2025029475A1 (en) | 2023-07-28 | 2025-02-06 | Guardant Health, Inc. | Methods to enrich nucleotide variants by negative selection |
| US20250218587A1 (en) | 2023-07-31 | 2025-07-03 | Guardant Health, Inc. | Methods and systems for identifying tumor origin |
| WO2025038399A1 (en) | 2023-08-11 | 2025-02-20 | Guardant Health, Inc. | Methylated enrichment methods for single-molecule genetic and epigenetic sequencing |
| US20250084469A1 (en) | 2023-09-12 | 2025-03-13 | Guardant Health, Inc. | Methods for analyzing nucleic acids using sequence read family size distribution |
| WO2025064706A1 (en) | 2023-09-19 | 2025-03-27 | Guardant Health, Inc. | Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules |
| WO2025064489A1 (en) | 2023-09-20 | 2025-03-27 | Guardant Health, Inc. | Systems and methods for real world evidence database data integration |
| WO2025072084A1 (en) * | 2023-09-25 | 2025-04-03 | Foundation Medicine, Inc. | Updating records based on consensus annotations of genetic variants |
| WO2025072467A1 (en) | 2023-09-29 | 2025-04-03 | Guardant Health, Inc. | Genotyping cyp2d6 |
| WO2025076425A1 (en) | 2023-10-06 | 2025-04-10 | Guardant Health, Inc. | Genomic and methylation biomarkers for prediction of copy number loss / gene deletion |
| WO2025085784A1 (en) | 2023-10-18 | 2025-04-24 | Guardant Health, Inc. | Genomic and methylation biomarkers for determining patient risk of heart disease and novel genomic and epigenomic drug targets to decrease risk of heart disease and/or improve patient outcome after myocardial infarction or cardiac injury |
| WO2025090954A1 (en) | 2023-10-26 | 2025-05-01 | Guardant Health, Inc. | Methods for detecting nucleic acid variants |
| WO2025090956A1 (en) | 2023-10-26 | 2025-05-01 | Guardant Health, Inc. | Methods for detecting nucleic acid variants using capture probes |
| WO2025106796A1 (en) | 2023-11-15 | 2025-05-22 | Guardant Health, Inc. | Non-small cell lung cancer (nsclc) histology classification using dna methylation data captured from liquid biopsies |
| WO2025106263A1 (en) | 2023-11-15 | 2025-05-22 | Guardant Health, Inc. | Joint modeling of longitudinal and time-to-event data to predict patient survival |
| WO2025106837A1 (en) | 2023-11-15 | 2025-05-22 | Guardant Health, Inc. | Tumor fraction and outcome association in a real-world non-small cell lung cancer (nsclc) cohort using a methylation-based circulating tumor dna (ctdna) assay |
| US20250243550A1 (en) | 2023-11-15 | 2025-07-31 | Guardant Health, Inc. | Minimum residual disease (mrd) detection in early stage cancer using urine |
| WO2025137620A1 (en) | 2023-12-21 | 2025-06-26 | Guardant Health, Inc. | Methods for high quality and high accuracy methylation sequencing |
| WO2025160433A1 (en) | 2024-01-24 | 2025-07-31 | Guardant Health, Inc. | Methods for analyzing sequencing reads |
| WO2025207817A1 (en) | 2024-03-26 | 2025-10-02 | Guardant Health, Inc. | Method of determining the likelihood of a disease by combining biomarkers and imaging |
| WO2025207788A1 (en) | 2024-03-27 | 2025-10-02 | Guardant Health, Inc. | Inferring cnvs from the distribution of molecules in hyper partition |
| WO2025207921A1 (en) | 2024-03-28 | 2025-10-02 | Guardant Health, Inc. | Methods for methylation enrichment using cpg-specific deamination |
| WO2025208044A1 (en) | 2024-03-28 | 2025-10-02 | Guardant Health, Inc. | Methods for cancer detection using molecular patterns |
| WO2025212664A1 (en) | 2024-04-01 | 2025-10-09 | Guardant Health, Inc. | Small variant calling with error-rate based model |
| WO2025235602A1 (en) | 2024-05-07 | 2025-11-13 | Guardant Health, Inc. | Predictive, prognostic signatures for immuno-oncology using liquid biopsy |
| WO2025235889A1 (en) | 2024-05-10 | 2025-11-13 | Guardant Health, Inc. | Methods involving multiplexed pooled pcr |
| WO2025245433A1 (en) | 2024-05-23 | 2025-11-27 | Guardant Health, Inc. | Generalized probabilistic generative modeling method for analysis of tumor methylated molecules in target capture regions |
| WO2025250544A1 (en) | 2024-05-31 | 2025-12-04 | Guardant Health, Inc. | Methods for analyzing chromatin architecture in tissue to boost detection of cancer associated signals in cell-free dna |
| US12467087B1 (en) | 2024-06-25 | 2025-11-11 | Guardant Health, Inc. | Sequencing methods with partitioning |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US20030017081A1 (en) | 1994-02-10 | 2003-01-23 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| AU2002359522A1 (en) | 2001-11-28 | 2003-06-10 | Applera Corporation | Compositions and methods of selective nucleic acid isolation |
| US8962247B2 (en) * | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| US9115386B2 (en) * | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| US20130157266A1 (en) * | 2009-03-15 | 2013-06-20 | Ribomed Biotechnologies, Inc. | Abscription based molecular detection of dna methylation |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| HUE039766T2 (hu) | 2010-10-22 | 2019-02-28 | Cold Spring Harbor Laboratory | Nukleinsavak változatainak megszámlálása genom kópiaszám információ megszerzésére |
| EP3904533B1 (en) * | 2011-12-13 | 2025-02-26 | Oslo Universitetssykehus HF | Method for detection of hydroxymethylation status |
| EP4234713A3 (en) * | 2012-03-20 | 2024-02-14 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| ES2693349T3 (es) * | 2012-06-06 | 2018-12-11 | The Trustees Of Princeton University | Aplicación de códigos de barras de ADN de bancos de matrices de cromatinas y mononucleosomas diseñadores para la creación de perfiles de lectores, escritores, borradores y moduladores de cromatina de los mismos |
| EP2872648B1 (en) | 2012-07-13 | 2019-09-04 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| KR102393608B1 (ko) * | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| WO2014152155A1 (en) | 2013-03-14 | 2014-09-25 | The Broad Institute, Inc. | Massively multiplexed rna sequencing |
| US20160047001A1 (en) * | 2013-04-08 | 2016-02-18 | Carmel-Haifa University Economic Corporation Ltd. | Sept4/ARTS AS A TUMOR SUPPRESSOR IN THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF HEPATIC DISORDERS |
| EP2805769A1 (en) * | 2013-05-24 | 2014-11-26 | European Molecular Biology Laboratory | Methods for nano-scale single cell analysis |
| EP4227947A1 (en) | 2013-10-21 | 2023-08-16 | Verinata Health, Inc. | Method for improving the sensitivity of detection in determining copy number variations |
| WO2015159293A2 (en) * | 2014-04-14 | 2015-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
| US20170211143A1 (en) | 2014-07-25 | 2017-07-27 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| EP3191628B1 (en) | 2014-09-12 | 2022-05-25 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acids |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US9984201B2 (en) * | 2015-01-18 | 2018-05-29 | Youhealth Biotech, Limited | Method and system for determining cancer status |
| US10844428B2 (en) * | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
| EP4488686A3 (en) | 2016-04-14 | 2025-04-30 | Guardant Health, Inc. | Methods for early detection of cancer |
| US11702702B2 (en) * | 2016-04-15 | 2023-07-18 | Predicine, Inc. | Systems and methods for detecting genetic alterations |
| JP2019515674A (ja) * | 2016-04-19 | 2019-06-13 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝的解析および他の適用のための固定化ベースのシステムおよび方法 |
| CA3022606A1 (en) | 2016-05-03 | 2017-11-09 | University Health Network | Methods of capturing cell-free methylated dna and uses of same |
| EP4257701A3 (en) * | 2016-06-30 | 2023-12-20 | Grail, LLC | Differential tagging of rna for preparation of a cell-free dna/rna sequencing library |
| JP7448310B2 (ja) | 2016-07-06 | 2024-03-12 | ガーダント ヘルス, インコーポレイテッド | セルフリー核酸のフラグメントームプロファイリングのための方法 |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| EP3652741A4 (en) | 2017-07-12 | 2021-04-21 | University Health Network | DETECTION AND CLASSIFICATION OF CANCER USING METHYLOMA ANALYSIS |
-
2017
- 2017-12-22 IL IL302912A patent/IL302912A/en unknown
- 2017-12-22 CA CA3046007A patent/CA3046007A1/en active Pending
- 2017-12-22 JP JP2019533331A patent/JP7300989B2/ja active Active
- 2017-12-22 KR KR1020197020828A patent/KR102723226B1/ko active Active
- 2017-12-22 AU AU2017382439A patent/AU2017382439B2/en active Active
- 2017-12-22 MX MX2019007444A patent/MX2019007444A/es unknown
- 2017-12-22 EP EP17832453.9A patent/EP3559270A2/en active Pending
- 2017-12-22 CN CN201780087130.5A patent/CN110325650A/zh active Pending
- 2017-12-22 KR KR1020247035472A patent/KR20240158369A/ko active Pending
- 2017-12-22 BR BR112019012958-8A patent/BR112019012958A2/pt active IP Right Grant
- 2017-12-22 WO PCT/US2017/068329 patent/WO2018119452A2/en not_active Ceased
-
2019
- 2019-06-17 IL IL267424A patent/IL267424A/en unknown
- 2019-06-24 US US16/450,918 patent/US11519019B2/en active Active
-
2022
- 2022-12-05 US US18/061,898 patent/US11952616B2/en active Active
-
2023
- 2023-04-04 JP JP2023060942A patent/JP7756676B2/ja active Active
-
2024
- 2024-04-03 US US18/625,882 patent/US12428670B2/en active Active
- 2024-07-11 US US18/770,298 patent/US12359245B2/en active Active
- 2024-07-11 US US18/770,271 patent/US12312634B2/en active Active
- 2024-07-16 JP JP2024113220A patent/JP2024147684A/ja active Pending
-
2025
- 2025-01-16 US US19/025,566 patent/US20250154558A1/en active Pending
- 2025-01-17 US US19/029,558 patent/US20250171826A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019012958A2 (pt) | 2019-11-26 |
| IL267424A (en) | 2019-08-29 |
| US20240409979A1 (en) | 2024-12-12 |
| EP3559270A2 (en) | 2019-10-30 |
| US20240279714A1 (en) | 2024-08-22 |
| CN110325650A (zh) | 2019-10-11 |
| US20190390253A1 (en) | 2019-12-26 |
| AU2017382439A1 (en) | 2019-06-20 |
| US20240409980A1 (en) | 2024-12-12 |
| US11952616B2 (en) | 2024-04-09 |
| JP2024147684A (ja) | 2024-10-16 |
| US11519019B2 (en) | 2022-12-06 |
| US20230332206A1 (en) | 2023-10-19 |
| WO2018119452A2 (en) | 2018-06-28 |
| KR20190095410A (ko) | 2019-08-14 |
| US12428670B2 (en) | 2025-09-30 |
| US20250154558A1 (en) | 2025-05-15 |
| JP7300989B2 (ja) | 2023-06-30 |
| JP2020504606A (ja) | 2020-02-13 |
| JP2023089062A (ja) | 2023-06-27 |
| IL302912A (en) | 2023-07-01 |
| JP7756676B2 (ja) | 2025-10-20 |
| US12359245B2 (en) | 2025-07-15 |
| US20250171826A1 (en) | 2025-05-29 |
| KR20240158369A (ko) | 2024-11-04 |
| KR102723226B1 (ko) | 2024-10-30 |
| CA3046007A1 (en) | 2018-06-28 |
| WO2018119452A3 (en) | 2018-08-09 |
| US12312634B2 (en) | 2025-05-27 |
| AU2017382439B2 (en) | 2024-08-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2019007444A (es) | Metodos y sistemas para analisis de moleculas de acido nucleico. | |
| CY1125171T1 (el) | Αυτοματοποιημενες μεθοδοι επεξεργασιας κυτταρου, δομοστοιχεια, οργανα, και συστηματα | |
| MX2021003771A (es) | Analisis de analitos multiples usando un ensayo unico. | |
| MX2022010611A (es) | Identificacion libre de bisulfito de modificaciones de citosina por resolucion de base. | |
| GB2568608A (en) | Personalized genetic testing | |
| CY1124717T1 (el) | Μεθοδοι, kit και συσκευη για επεκταση πληθυσμου κυτταρων | |
| MX2016016904A (es) | Analisis de secuencias de acidos nucleicos. | |
| EP3529357A4 (en) | METHODS AND SYSTEMS FOR BARCODING NUCLEIC ACID MOLECULES FROM INDIVIDUAL CELLS OR CELL POPULATIONS | |
| MX2020006803A (es) | Estrategias de descodificacion para identificacion de proteinas. | |
| MX2016016902A (es) | Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas. | |
| WO2019222523A3 (en) | Methods for processing nucleic acid samples | |
| GB201319347D0 (en) | Compositions and kits for molecular counting | |
| EP4234716A3 (en) | Methods for determining spatial patterns of biological targets in a sample | |
| BR112015017686A2 (pt) | métodos e sistemas para usar um ambiente de computação em nuvem para compartilhar dados biológicos relacionados | |
| BR112017008082A2 (pt) | composições e métodos para detectar um vírus de rna | |
| MY170164A (en) | Aptamer-based multiplexed assays | |
| MX390589B (es) | Analisis digital de analitos moleculares usando deteccion de molecula individual. | |
| EP4006169C0 (en) | PRETREATMENT METHOD, PRETREATMENT SOLUTION, KIT FOR DETECTION OF VIRAL NUCLEIC ACIDS AND THEIR USE | |
| BR112021018125A2 (pt) | Métodos para gerar um molde de ácido nucleico de fita dupla de extremidade fechada assimétrico, para gerar um molde de ácido nucleico de fita dupla assimétrico a partir do dna tagmentado e de sequenciamento de dna tagmentado | |
| MX2015012319A (es) | Sistemas de instrumento analitico. | |
| BR112016004515A8 (pt) | método para uso no diagnóstico de rejeição aguda (ar), de ar, ou do risco de desenvolvimento de ar, método para uso na identificação de um indivíduo para tratamento de ar de um transplante renal, sistema, kit, artigo de manufatura e agente(s) ativo(s) para uso no diagnóstico de ar | |
| BR112016006312A2 (pt) | método e kit para determinar a presença ou ausência de staphylococcus aureus resistente à meticilina em uma amostra biológica | |
| MX2016016062A (es) | Metodo para analisis de metilacion. | |
| WO2020005846A8 (en) | Labeling of dna | |
| MX2017001134A (es) | Composiciones y metodos para la deteccion y analisis de tuberculosis micobacteriana. |