MX2019001780A - Composicion de vacuna multivalente novedosa. - Google Patents
Composicion de vacuna multivalente novedosa.Info
- Publication number
- MX2019001780A MX2019001780A MX2019001780A MX2019001780A MX2019001780A MX 2019001780 A MX2019001780 A MX 2019001780A MX 2019001780 A MX2019001780 A MX 2019001780A MX 2019001780 A MX2019001780 A MX 2019001780A MX 2019001780 A MX2019001780 A MX 2019001780A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen
- alum
- ipv
- antigens
- rotavirus
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a una vacuna o vacunas de combinación inmunogénica estables que comprenden una mezcla de antígenos para la prevención y profilaxis de infecciones causadas por el rotavirus, el virus de la poliomielitis, Haemophilus influenzae, Corynebacterium diphtheriae, Clostridium tetani, Bordetella pertussis y el virus de la Hepatitis B. La invención proporciona en particular una vacuna de combinación multivalente que comprende: i) antígenos de IPV Salk o IPV Sabin (IPV) en dosis significativamente reducida, preparados mediante el uso de métodos mejorados de inactivación de formaldehído y adsorción de hidróxido de aluminio, que dan como resultado la recuperación máxima del antígeno D y ii) Antígeno (s) de rotavirus inactivado por calor e inyectable obtenido de cepas de rotavirus (CDC-9) que proporcionan una amplia inmunidad de protección cruzada entre las cepas de rotavirus humano, iii) conjugado de PRP de Hib-proteína transportadora que tiene estabilidad e inmunogenicidad mejoradas en donde el conjugado de PRP Hib-proteína transportadora es inicialmente preparado usando un nuevo proceso de conjugación y posteriormente se mezcla a baja temperatura en presencia de un estabilizador para minimizar la liberación de PRP libre, iv) antígeno de pertussis de células completas con inmunogenicidad y estabilidad mejoradas obtenidas mediante la adición de antígeno de pertussis de células enteras en una etapa posterior en una mezcla, minimizando así la degradación basada en hidrólisis v) fracciones homogéneas de toxoide de difteria y toxoide tetánico obtenidos mediante la eliminación de agregados no deseados por el uso de cromatografía por permeación en gel. También se describe el proceso para producir estas composiciones de vacunas inmunogénicas estables mediante las etapas de i) adsorber individualmente IPV en dosis reducida, antígenos de IRV en el hidróxido de aluminio, manteniendo el otro antígeno (s) no absorbido o adsorbido en fosfato de aluminio, hidróxido de aluminio, en una combinación de hidróxido de aluminio y fosfato de aluminio y ii) usar un orden particular de adición de antígenos durante la mezcla.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201621029037 | 2016-08-26 | ||
| PCT/IB2017/055100 WO2018037365A1 (en) | 2016-08-26 | 2017-08-24 | Multivalent vaccine composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019001780A true MX2019001780A (es) | 2020-01-13 |
Family
ID=60083359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001780A MX2019001780A (es) | 2016-08-26 | 2017-08-24 | Composicion de vacuna multivalente novedosa. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11235054B2 (es) |
| EP (1) | EP3503917B1 (es) |
| JP (3) | JP7384667B2 (es) |
| KR (1) | KR102607295B1 (es) |
| CN (1) | CN110691611A (es) |
| AU (1) | AU2017316768B2 (es) |
| BR (1) | BR112019003419A2 (es) |
| CA (1) | CA3032901A1 (es) |
| CU (1) | CU24682B1 (es) |
| EA (1) | EA201900117A1 (es) |
| IL (1) | IL264605B2 (es) |
| MX (1) | MX2019001780A (es) |
| MY (1) | MY191163A (es) |
| PE (1) | PE20200004A1 (es) |
| PH (1) | PH12019500404A1 (es) |
| SG (1) | SG11201900365WA (es) |
| WO (1) | WO2018037365A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201900365WA (en) * | 2016-08-26 | 2019-02-27 | Serum Institute Of India Pvt Ltd | Multivalent vaccine composition |
| EP3621645A4 (en) * | 2017-05-10 | 2021-01-27 | University of Massachusetts | BIVALENT DENGUE / HEPATITIS B VACCINES |
| JOP20190242A1 (ar) * | 2018-10-12 | 2020-04-12 | Serum Institute Of India Pvt Ltd | تركيبة لقاح توليفي تشمل فيروس شلل الأطفال ذو جرعة مخفّضة خاملة التنشيط وطريقة لتحضيرها |
| JOP20200214A1 (ar) | 2019-09-03 | 2021-03-03 | Serum Institute Of India Pvt Ltd | تركيبات مولدة للمناعة ضد الأمراض المعوية وطرق لتحضيرها |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006113528A2 (en) | 2005-04-18 | 2006-10-26 | Novartis Vaccines And Diagnostics Inc. | Expressing hepatitis b virus surface antigen for vaccine preparation |
| MX2009002560A (es) * | 2006-09-07 | 2009-03-20 | Glaxosmithkline Biolog Sa | Vacuna. |
| PE20100365A1 (es) * | 2008-10-24 | 2010-05-21 | Panacea Biotec Ltd | Novedosas vacunas de combinacion con tos ferina de celulas enteras y metodo para su elaboracion |
| CA3121471A1 (en) | 2009-05-12 | 2010-11-18 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention | New human rotavirus strains and vaccines |
| EP3459562B1 (en) * | 2011-01-05 | 2024-03-20 | Bharat Biotech International Limited | A combination heptavalent vaccine |
| US20140112950A1 (en) * | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| HUE049104T2 (hu) * | 2014-10-07 | 2020-08-28 | Serum Institute Of India Pvt Ltd | Javított eljárások poliovírus inaktiválására, adjuváns adszorpciója |
| SG11201900365WA (en) * | 2016-08-26 | 2019-02-27 | Serum Institute Of India Pvt Ltd | Multivalent vaccine composition |
-
2017
- 2017-08-24 SG SG11201900365WA patent/SG11201900365WA/en unknown
- 2017-08-24 AU AU2017316768A patent/AU2017316768B2/en active Active
- 2017-08-24 CU CU2019000013A patent/CU24682B1/es unknown
- 2017-08-24 BR BR112019003419-6A patent/BR112019003419A2/pt active Search and Examination
- 2017-08-24 US US16/327,513 patent/US11235054B2/en active Active
- 2017-08-24 EA EA201900117A patent/EA201900117A1/ru unknown
- 2017-08-24 KR KR1020197008377A patent/KR102607295B1/ko active IP Right Grant
- 2017-08-24 CN CN201780052380.5A patent/CN110691611A/zh active Pending
- 2017-08-24 MY MYPI2019001011A patent/MY191163A/en unknown
- 2017-08-24 IL IL264605A patent/IL264605B2/en unknown
- 2017-08-24 PE PE2019000409A patent/PE20200004A1/es unknown
- 2017-08-24 CA CA3032901A patent/CA3032901A1/en active Pending
- 2017-08-24 MX MX2019001780A patent/MX2019001780A/es unknown
- 2017-08-24 JP JP2019532214A patent/JP7384667B2/ja active Active
- 2017-08-24 EP EP17783992.5A patent/EP3503917B1/en active Active
- 2017-08-24 WO PCT/IB2017/055100 patent/WO2018037365A1/en active Search and Examination
-
2019
- 2019-02-26 PH PH12019500404A patent/PH12019500404A1/en unknown
-
2021
- 2021-07-16 JP JP2021118038A patent/JP2021181445A/ja active Pending
-
2023
- 2023-10-06 JP JP2023174503A patent/JP2024009899A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR102607295B1 (ko) | 2023-11-29 |
| EP3503917B1 (en) | 2024-07-03 |
| IL264605B2 (en) | 2023-04-01 |
| IL264605B (en) | 2022-12-01 |
| MY191163A (en) | 2022-06-03 |
| SG11201900365WA (en) | 2019-02-27 |
| WO2018037365A8 (en) | 2018-09-20 |
| KR20190142311A (ko) | 2019-12-26 |
| AU2017316768B2 (en) | 2024-04-11 |
| CA3032901A1 (en) | 2018-03-01 |
| US11235054B2 (en) | 2022-02-01 |
| EP3503917A1 (en) | 2019-07-03 |
| EA201900117A1 (ru) | 2019-09-30 |
| PH12019500404A1 (en) | 2020-01-20 |
| JP7384667B2 (ja) | 2023-11-21 |
| WO2018037365A1 (en) | 2018-03-01 |
| JP2024009899A (ja) | 2024-01-23 |
| JP2021181445A (ja) | 2021-11-25 |
| PE20200004A1 (es) | 2020-01-06 |
| CN110691611A (zh) | 2020-01-14 |
| AU2017316768A1 (en) | 2019-04-11 |
| US20190175722A1 (en) | 2019-06-13 |
| CU20190013A7 (es) | 2019-10-04 |
| IL264605A (en) | 2019-02-28 |
| CU24682B1 (es) | 2023-10-06 |
| JP2019526635A (ja) | 2019-09-19 |
| BR112019003419A2 (pt) | 2019-05-21 |
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