MX2018001605A - Complejos de anillos macrocíclicos de pentaaza que poseen biodisponibilidad oral. - Google Patents
Complejos de anillos macrocíclicos de pentaaza que poseen biodisponibilidad oral.Info
- Publication number
- MX2018001605A MX2018001605A MX2018001605A MX2018001605A MX2018001605A MX 2018001605 A MX2018001605 A MX 2018001605A MX 2018001605 A MX2018001605 A MX 2018001605A MX 2018001605 A MX2018001605 A MX 2018001605A MX 2018001605 A MX2018001605 A MX 2018001605A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- formula
- alkyl
- oral bioavailability
- macrocyclic ring
- Prior art date
Links
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052723 transition metal Inorganic materials 0.000 abstract 2
- 150000003624 transition metals Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/04—Nickel compounds
- C07F15/045—Nickel compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los aspectos de la presente descripción se refieren a compuestos que tienen mejor biodisponibilidad oral. Un complejo de metal de transición incluye un metal de transición coordinado por un macrociclo que comprende el anillo macrocíclico de 15 miembros de pentaaza que corresponde a la Formula A y dos ligandos axiales que tienen la formula -OC (O) X1. (Formula A) cada uno de los dos ligandos axiales tiene la formula -OC (=O) X1, donde cada X1 es fenilo independientemente sustituido o no sustituido o -C (-X2) (-X3) (-X4): cada X2 es fenilo independientemente sustituido o no sustituido o alquilo sustituido o no sustituido; cada X3 es independientemente hidrogeno, hidroxilo, alquilo, amino, -X5C(O)R13 donde X5 es NH u O, y R13 es alquilo C1-C18, arilo sustituido o no sustituido o aralquilo C1-C18, o -OR14, donde R14 es alquilo C1-C18, arilo sustituido o no sustituido o aralquilo C1-C18, o junto con X4 es =O; y cada X4 es independientemente hidrogeno o junto con X3 es =O.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562203761P | 2015-08-11 | 2015-08-11 | |
PCT/US2016/046599 WO2017027728A1 (en) | 2015-08-11 | 2016-08-11 | Pentaaza macrocyclic ring complexes possessing oral bioavailability |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018001605A true MX2018001605A (es) | 2018-09-26 |
Family
ID=57984526
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018001605A MX2018001605A (es) | 2015-08-11 | 2016-08-11 | Complejos de anillos macrocíclicos de pentaaza que poseen biodisponibilidad oral. |
MX2022010230A MX2022010230A (es) | 2015-08-11 | 2018-02-07 | Complejos de anillos macrociclicos de pentaaza que poseen biodisponibilidad oral. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022010230A MX2022010230A (es) | 2015-08-11 | 2018-02-07 | Complejos de anillos macrociclicos de pentaaza que poseen biodisponibilidad oral. |
Country Status (29)
Country | Link |
---|---|
US (5) | US10597415B2 (es) |
EP (2) | EP3738967A1 (es) |
JP (3) | JP7041959B2 (es) |
KR (1) | KR20180064380A (es) |
CN (3) | CN108350009B (es) |
AU (3) | AU2016306568B2 (es) |
CA (1) | CA2994845A1 (es) |
CL (1) | CL2018000371A1 (es) |
CO (1) | CO2018002544A2 (es) |
CY (1) | CY1123960T1 (es) |
DK (1) | DK3334744T3 (es) |
EA (1) | EA201890471A1 (es) |
ES (1) | ES2807528T3 (es) |
HK (1) | HK1257313A1 (es) |
HR (1) | HRP20201092T1 (es) |
HU (1) | HUE049926T2 (es) |
IL (3) | IL297735B1 (es) |
LT (1) | LT3334744T (es) |
MX (2) | MX2018001605A (es) |
MY (1) | MY196401A (es) |
PH (1) | PH12018500296A1 (es) |
PL (1) | PL3334744T3 (es) |
PT (1) | PT3334744T (es) |
RS (1) | RS60558B1 (es) |
SG (1) | SG10202002859QA (es) |
SI (1) | SI3334744T1 (es) |
UA (1) | UA126788C2 (es) |
WO (1) | WO2017027728A1 (es) |
ZA (2) | ZA201801546B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2056675B1 (en) | 2006-10-12 | 2019-01-09 | Galera Labs, LLC | Methods of treating oral mucositis |
EP2760874A4 (en) | 2011-09-26 | 2015-04-08 | Galera Therapeutics Llc | METHOD FOR THE TREATMENT OF ILLNESSES |
CA2994845A1 (en) | 2015-08-11 | 2017-02-16 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes possessing oral bioavailability |
EP3506907B1 (en) | 2016-09-01 | 2023-06-07 | Galera Labs, LLC | Combination cancer therapy with a pentaaza macrocyclic ring complex and an ascorbate compound |
WO2018152353A2 (en) | 2017-02-15 | 2018-08-23 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes for local intestinal delivery |
MX2019012259A (es) * | 2017-04-13 | 2020-02-26 | Galera Labs Llc | Inmunoterapia combinada contra el cancer con complejo de anillo pentaazamacrociclico. |
US11246950B2 (en) | 2017-04-13 | 2022-02-15 | Galera Labs, Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
JP2022551494A (ja) * | 2019-10-10 | 2022-12-09 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー | マンガン含有配位錯体の水性製剤の製造方法、製剤および処置方法 |
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2016
- 2016-08-11 CA CA2994845A patent/CA2994845A1/en active Pending
- 2016-08-11 SI SI201630852T patent/SI3334744T1/sl unknown
- 2016-08-11 EP EP20168046.9A patent/EP3738967A1/en active Pending
- 2016-08-11 MX MX2018001605A patent/MX2018001605A/es unknown
- 2016-08-11 ES ES16835928T patent/ES2807528T3/es active Active
- 2016-08-11 KR KR1020187006846A patent/KR20180064380A/ko not_active Application Discontinuation
- 2016-08-11 DK DK16835928.9T patent/DK3334744T3/da active
- 2016-08-11 MY MYPI2018700525A patent/MY196401A/en unknown
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