MX2017009534A - Conjugados de acidos grasos y apelina sintetica con mayor vida media. - Google Patents
Conjugados de acidos grasos y apelina sintetica con mayor vida media.Info
- Publication number
- MX2017009534A MX2017009534A MX2017009534A MX2017009534A MX2017009534A MX 2017009534 A MX2017009534 A MX 2017009534A MX 2017009534 A MX2017009534 A MX 2017009534A MX 2017009534 A MX2017009534 A MX 2017009534A MX 2017009534 A MX2017009534 A MX 2017009534A
- Authority
- MX
- Mexico
- Prior art keywords
- fatty acid
- conjugates
- heart failure
- life
- diabetes
- Prior art date
Links
- 235000014113 dietary fatty acids Nutrition 0.000 title abstract 3
- 229930195729 fatty acid Natural products 0.000 title abstract 3
- 239000000194 fatty acid Substances 0.000 title abstract 3
- -1 apelin fatty acid Chemical class 0.000 title abstract 2
- 102000018746 Apelin Human genes 0.000 title 1
- 108010052412 Apelin Proteins 0.000 title 1
- 206010007556 Cardiac failure acute Diseases 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108091008803 APLNR Proteins 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010003658 Atrial Fibrillation Diseases 0.000 abstract 1
- 206010059027 Brugada syndrome Diseases 0.000 abstract 1
- 206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010016807 Fluid retention Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 abstract 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010042496 Sunburn Diseases 0.000 abstract 1
- 208000032109 Transient ischaemic attack Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 150000001735 carboxylic acids Chemical group 0.000 abstract 1
- 230000009787 cardiac fibrosis Effects 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000004104 gestational diabetes Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 201000011461 pre-eclampsia Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 150000003573 thiols Chemical group 0.000 abstract 1
- 201000010875 transient cerebral ischemia Diseases 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
- 206010047302 ventricular tachycardia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562107040P | 2015-01-23 | 2015-01-23 | |
| PCT/IB2016/050206 WO2016116842A1 (en) | 2015-01-23 | 2016-01-15 | Synthetic apelin fatty acid conjugates with improved half-life |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017009534A true MX2017009534A (es) | 2018-04-10 |
Family
ID=55229773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017009534A MX2017009534A (es) | 2015-01-23 | 2016-01-15 | Conjugados de acidos grasos y apelina sintetica con mayor vida media. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9931372B2 (https=) |
| EP (1) | EP3247405B1 (https=) |
| JP (1) | JP2018507187A (https=) |
| KR (1) | KR20170103970A (https=) |
| CN (1) | CN107406490A (https=) |
| AR (1) | AR104479A1 (https=) |
| AU (1) | AU2016209968B2 (https=) |
| BR (1) | BR112017014194A2 (https=) |
| CA (1) | CA2972871A1 (https=) |
| CO (1) | CO2017007244A2 (https=) |
| CR (1) | CR20170338A (https=) |
| CU (1) | CU20170093A7 (https=) |
| EA (1) | EA201791668A1 (https=) |
| IL (1) | IL253105A0 (https=) |
| MA (1) | MA41580A (https=) |
| MX (1) | MX2017009534A (https=) |
| PE (1) | PE20171328A1 (https=) |
| PH (1) | PH12017501112A1 (https=) |
| SG (1) | SG11201704758XA (https=) |
| TW (1) | TW201632197A (https=) |
| UY (1) | UY36523A (https=) |
| WO (1) | WO2016116842A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| KR102396217B1 (ko) * | 2017-09-19 | 2022-05-09 | 임문워크 아이엔씨 | 알부민과의 결합 친화성이 증대된 약학 구조물 |
| WO2019229242A1 (en) | 2018-05-31 | 2019-12-05 | Novo Nordisk A/S | Derivatives comprising an apelin analogue and uses thereof |
| TW202304500A (zh) * | 2021-04-21 | 2023-02-01 | 瑞士商諾華公司 | 升糖素樣肽化合物 |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2951135A1 (de) | 1979-12-19 | 1981-06-25 | Hoechst Ag, 6230 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
| US4617307A (en) | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| US4889861A (en) | 1982-12-21 | 1989-12-26 | Ciba-Geigy Corp. | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors |
| DE3347565A1 (de) | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JPS6354321A (ja) | 1985-03-27 | 1988-03-08 | Ajinomoto Co Inc | 血糖降下剤 |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| ATE164852T1 (de) | 1990-01-24 | 1998-04-15 | Douglas I Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
| AU654331B2 (en) | 1991-03-30 | 1994-11-03 | Kissei Pharmaceutical Co. Ltd. | Succinic acid compounds |
| US5155100A (en) | 1991-05-01 | 1992-10-13 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipeptide derivatives |
| RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| DK0589874T3 (da) | 1991-06-21 | 2000-04-03 | Boehringer Ingelheim Pharma | Anvendelse af (S) (+) -2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl ]aminocarbonylmethyl]-benzoesyre til fremstil |
| ES2100291T3 (es) | 1991-07-30 | 1997-06-16 | Ajinomoto Kk | Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos. |
| WO1993011782A1 (en) | 1991-12-19 | 1993-06-24 | Southwest Foundation For Biomedical Research | Cetp inhibitor polypeptide, antibodies against the synthetic polypeptide and prophylactic and therapeutic anti-atherosclerosis treatments |
| CA2167818A1 (en) * | 1993-08-02 | 1995-02-09 | Robert George Whittaker | Therapeutic compound - fatty acid conjugates |
| IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| TW313568B (https=) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
| DE122010000020I1 (de) | 1996-04-25 | 2010-07-08 | Prosidion Ltd | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| KR20010033601A (ko) | 1997-12-24 | 2001-04-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 폴리펩티드, 그의 제법 및 용도 |
| WO1999043357A1 (en) * | 1998-02-25 | 1999-09-02 | Micrologix Biotech Inc. | Indolicidin and cationic peptides conjugated with polymers |
| US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
| CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| US6683113B2 (en) | 1999-09-23 | 2004-01-27 | Pharmacia Corporation | (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity |
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| HUP0301335A3 (en) | 2000-04-12 | 2006-02-28 | Novartis Ag | Combination of organic compounds |
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-
2016
- 2016-01-15 MA MA041580A patent/MA41580A/fr unknown
- 2016-01-15 CU CUP2017000093A patent/CU20170093A7/xx unknown
- 2016-01-15 AU AU2016209968A patent/AU2016209968B2/en not_active Ceased
- 2016-01-15 EP EP16701560.1A patent/EP3247405B1/en active Active
- 2016-01-15 PE PE2017001257A patent/PE20171328A1/es not_active Application Discontinuation
- 2016-01-15 CR CR20170338A patent/CR20170338A/es unknown
- 2016-01-15 US US14/996,418 patent/US9931372B2/en active Active
- 2016-01-15 BR BR112017014194A patent/BR112017014194A2/pt not_active IP Right Cessation
- 2016-01-15 WO PCT/IB2016/050206 patent/WO2016116842A1/en not_active Ceased
- 2016-01-15 SG SG11201704758XA patent/SG11201704758XA/en unknown
- 2016-01-15 CN CN201680006640.0A patent/CN107406490A/zh active Pending
- 2016-01-15 KR KR1020177022999A patent/KR20170103970A/ko not_active Withdrawn
- 2016-01-15 EA EA201791668A patent/EA201791668A1/ru unknown
- 2016-01-15 JP JP2017538728A patent/JP2018507187A/ja active Pending
- 2016-01-15 MX MX2017009534A patent/MX2017009534A/es unknown
- 2016-01-15 CA CA2972871A patent/CA2972871A1/en not_active Abandoned
- 2016-01-20 UY UY0001036523A patent/UY36523A/es not_active Application Discontinuation
- 2016-01-22 TW TW105102112A patent/TW201632197A/zh unknown
- 2016-01-22 AR ARP160100180A patent/AR104479A1/es unknown
-
2017
- 2017-06-15 PH PH12017501112A patent/PH12017501112A1/en unknown
- 2017-06-22 IL IL253105A patent/IL253105A0/en unknown
- 2017-07-19 CO CONC2017/0007244A patent/CO2017007244A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN107406490A (zh) | 2017-11-28 |
| EP3247405B1 (en) | 2019-07-17 |
| EA201791668A1 (ru) | 2017-11-30 |
| KR20170103970A (ko) | 2017-09-13 |
| WO2016116842A9 (en) | 2016-12-08 |
| MA41580A (fr) | 2017-11-29 |
| CR20170338A (es) | 2017-09-12 |
| CA2972871A1 (en) | 2016-07-28 |
| IL253105A0 (en) | 2017-08-31 |
| EP3247405A1 (en) | 2017-11-29 |
| TW201632197A (zh) | 2016-09-16 |
| BR112017014194A2 (pt) | 2018-01-09 |
| JP2018507187A (ja) | 2018-03-15 |
| SG11201704758XA (en) | 2017-08-30 |
| AU2016209968A1 (en) | 2017-07-20 |
| WO2016116842A1 (en) | 2016-07-28 |
| UY36523A (es) | 2016-08-31 |
| CO2017007244A2 (es) | 2017-10-10 |
| AU2016209968B2 (en) | 2018-11-29 |
| US9931372B2 (en) | 2018-04-03 |
| PH12017501112A1 (en) | 2017-11-27 |
| US20160213743A1 (en) | 2016-07-28 |
| CU20170093A7 (es) | 2017-09-06 |
| PE20171328A1 (es) | 2017-09-12 |
| AR104479A1 (es) | 2017-07-26 |
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