MX2016013985A - Cepas de vacunas de listeria recombinante y metodos para producir las mismas. - Google Patents
Cepas de vacunas de listeria recombinante y metodos para producir las mismas.Info
- Publication number
- MX2016013985A MX2016013985A MX2016013985A MX2016013985A MX2016013985A MX 2016013985 A MX2016013985 A MX 2016013985A MX 2016013985 A MX2016013985 A MX 2016013985A MX 2016013985 A MX2016013985 A MX 2016013985A MX 2016013985 A MX2016013985 A MX 2016013985A
- Authority
- MX
- Mexico
- Prior art keywords
- recombinant
- recombinant listeria
- producing
- methods
- same
- Prior art date
Links
- 241000186781 Listeria Species 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 108700026244 Open Reading Frames Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000004898 n-terminal fragment Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983732P | 2014-04-24 | 2014-04-24 | |
| PCT/US2015/025690 WO2015164121A1 (en) | 2014-04-24 | 2015-04-14 | Recombinant listeria vaccine strains and methods of producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016013985A true MX2016013985A (es) | 2017-01-11 |
Family
ID=54333010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013985A MX2016013985A (es) | 2014-04-24 | 2015-04-14 | Cepas de vacunas de listeria recombinante y metodos para producir las mismas. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10258679B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3134510B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP7009061B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102491332B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106459887A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015250111A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016024352A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2946716A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL248483A0 (cg-RX-API-DMAC7.html) |
| MA (1) | MA39849A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2016013985A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2016145464A (cg-RX-API-DMAC7.html) |
| SG (2) | SG10202011841WA (cg-RX-API-DMAC7.html) |
| TW (2) | TWI722858B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015164121A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| AU2012229218B2 (en) | 2011-03-11 | 2017-03-02 | Advaxis, Inc. | Listeria-based adjuvants |
| HK1205944A1 (en) | 2012-03-12 | 2015-12-31 | 阿德瓦希斯公司 | Suppressor cell function inhibition following listeria vaccine treatment |
| JP2017511796A (ja) | 2014-02-18 | 2017-04-27 | アドバクシス, インコーポレイテッド | 多標的免疫療法を目的とするバイオマーカー |
| SG10202011841WA (en) | 2014-04-24 | 2021-01-28 | Advaxis Inc | Recombinant listeria vaccine strains and methods of producing the same |
| EP3207142A4 (en) * | 2014-10-14 | 2018-07-04 | The Trustees Of The University Of Pennsylvania | Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| EP3389630B1 (en) | 2015-12-16 | 2023-11-08 | Gritstone bio, Inc. | Neoantigen identification, manufacture, and use |
| US11897927B2 (en) | 2016-11-30 | 2024-02-13 | Advaxis, Inc. | Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof |
| CN106978381A (zh) * | 2017-03-23 | 2017-07-25 | 上海理工大学 | prfA基因缺失单核细胞增生李斯特氏菌及制备方法 |
| AU2018336988B2 (en) | 2017-09-19 | 2023-06-22 | Advaxis, Inc. | Compositions and methods for lyophilization of bacteria or Listeria strains |
| JP7227237B2 (ja) | 2017-10-10 | 2023-02-21 | グリットストーン バイオ インコーポレイテッド | ホットスポットを利用した新生抗原の特定 |
| CN111511392A (zh) | 2017-10-31 | 2020-08-07 | 潘塔希生物科学股份有限公司 | 用于治疗和/或预防肺癌的免疫治疗方法 |
| CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
| CN112074737A (zh) * | 2018-03-09 | 2020-12-11 | 阿德瓦希斯公司 | 用于评估李斯特菌菌株的减毒和感染性的组合物和方法 |
| CN110408634B (zh) * | 2018-04-27 | 2021-08-03 | 苏州若泰医药科技有限公司 | 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| WO2021259963A1 (en) | 2020-06-23 | 2021-12-30 | Pandora Endocrine Innovation B.V. | Immunization against wnt4 for treatment and prophylaxis of breast cancer |
| US20250026818A1 (en) | 2021-10-19 | 2025-01-23 | Sciencemed Spóka z ograniczon odpowiedzialnoci | Male contraception |
| CN116218754B (zh) * | 2023-04-10 | 2025-06-03 | 四川大学 | 一种提高绵羊李斯特菌膜囊泡产量的方法及应用 |
| CN119060155B (zh) * | 2024-11-07 | 2025-03-07 | 山东大学 | 一种蛋白在调节肠道稳态及抵抗致病菌感染中的应用 |
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| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
| US7794729B2 (en) * | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
| US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| US7662396B2 (en) | 2001-03-26 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
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| US6099848A (en) | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| US6855320B2 (en) | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| AU2001255196A1 (en) | 2000-03-29 | 2001-10-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
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| JP2005527240A (ja) | 2002-05-29 | 2005-09-15 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 弱毒リステリア種とこれを使用する方法 |
| WO2004062597A2 (en) | 2003-01-09 | 2004-07-29 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector |
| DK1789559T3 (en) | 2004-08-13 | 2015-08-24 | Univ Pennsylvania | Methods to construct vaccines with no antibiotic resistance |
| US7855064B2 (en) | 2004-08-13 | 2010-12-21 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free vaccines and methods for constructing and using same |
| US7858097B2 (en) * | 2004-08-13 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free Listeria strains and methods for constructing and using same |
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| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| US8241636B2 (en) | 2006-08-15 | 2012-08-14 | The Trustees Of The University Of Pennsylvania | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof |
| US8268326B2 (en) | 2006-08-15 | 2012-09-18 | The Trustees Of The University Of Pennsylvania | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof |
| WO2008130551A2 (en) | 2007-04-16 | 2008-10-30 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free listeria strains and methods for constructing and using same |
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| KR20240038103A (ko) | 2014-02-25 | 2024-03-22 | 어드박시스, 인크. | Her2/neu 과발현 종양의 치료를 위한 조성물 및 방법 |
| MA39717A (fr) | 2014-03-05 | 2017-01-11 | Advaxis Inc | Procédés et compositions pour accroître le rapport des lymphocytes t effecteurs aux lymphocytes t régulateurs |
| SG10202011841WA (en) | 2014-04-24 | 2021-01-28 | Advaxis Inc | Recombinant listeria vaccine strains and methods of producing the same |
| CA2947677A1 (en) | 2014-05-02 | 2015-11-05 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of her-2-positive cancers |
| MX2017000838A (es) | 2014-07-18 | 2017-09-01 | Advaxis Inc | Cepa de listeria recombinante que expresa proteinas de fusion con antigenos heterologos y metodos para el uso de estas. |
| WO2016011320A1 (en) | 2014-07-18 | 2016-01-21 | Advaxis, Inc. | Bivalent listeria-based delivery system of heterologous antigens |
| WO2016011362A1 (en) | 2014-07-18 | 2016-01-21 | Advaxis, Inc. | Listeria-based immunogenic compositions for eliciting anti-tumor responses |
| EP3193921A4 (en) | 2014-07-18 | 2018-04-25 | Advaxis, Inc. | Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer |
| EP3207142A4 (en) | 2014-10-14 | 2018-07-04 | The Trustees Of The University Of Pennsylvania | Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy |
| MA41217A (fr) | 2014-12-19 | 2017-10-24 | Advaxis Inc | Polythérapies ayant des souches de listeria recombinées |
| US20160220652A1 (en) | 2015-02-03 | 2016-08-04 | Advaxis, Inc. | Methods of using recombinant listeria vaccine strains in disease immunotherapy |
| WO2016126876A2 (en) | 2015-02-03 | 2016-08-11 | Advaxis, Inc. | Listeria-based adjuvants |
| WO2016126878A2 (en) | 2015-02-03 | 2016-08-11 | The Trustees Of The University Of Pennsylvania | Listeria-based immunomodulation |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| WO2016154412A2 (en) | 2015-03-26 | 2016-09-29 | The Trustees Of The University Of Pennsylvania | Combination of a pd-1 antagonist and a listeria based vaccine for treating pancreatic cancer |
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| KR20180026670A (ko) | 2015-05-26 | 2018-03-13 | 어드박시스, 인크. | 맞춤형 전달 벡터-기반의 면역 요법 및 이의 용도 |
| KR20180027501A (ko) | 2015-06-24 | 2018-03-14 | 어드박시스, 인크. | 맞춤형 전달 벡터-기반 면역 요법을 위한 제조 장치 및 공정 |
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| MX2018004598A (es) | 2015-10-14 | 2018-11-29 | Advaxis Inc | Cepas vacunales recombinantes de listeria y métodos para usar las mismas en la inmunoterapia contra el cáncer. |
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| CN109641945A (zh) | 2016-07-05 | 2019-04-16 | 阿德瓦希斯公司 | 包含维尔姆斯瘤蛋白抗原的基于李斯特菌的免疫原性组合物及其使用方法 |
| MA46721A (fr) | 2016-11-07 | 2019-09-11 | Advaxis Inc | Combinaison d'un vaccin à base de listeria avec des anticorps anti-ctla-4 ou anti-cd137 |
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| US11897927B2 (en) | 2016-11-30 | 2024-02-13 | Advaxis, Inc. | Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof |
| WO2018129306A1 (en) | 2017-01-05 | 2018-07-12 | Advaxis, Inc. | Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy |
-
2015
- 2015-04-14 SG SG10202011841WA patent/SG10202011841WA/en unknown
- 2015-04-14 EP EP15782800.5A patent/EP3134510B1/en active Active
- 2015-04-14 WO PCT/US2015/025690 patent/WO2015164121A1/en not_active Ceased
- 2015-04-14 SG SG11201608820WA patent/SG11201608820WA/en unknown
- 2015-04-14 AU AU2015250111A patent/AU2015250111A1/en not_active Abandoned
- 2015-04-14 RU RU2016145464A patent/RU2016145464A/ru not_active Application Discontinuation
- 2015-04-14 CA CA2946716A patent/CA2946716A1/en not_active Abandoned
- 2015-04-14 MA MA039849A patent/MA39849A/fr unknown
- 2015-04-14 MX MX2016013985A patent/MX2016013985A/es unknown
- 2015-04-14 KR KR1020227003655A patent/KR102491332B1/ko active Active
- 2015-04-14 CN CN201580021074.6A patent/CN106459887A/zh active Pending
- 2015-04-14 US US15/306,289 patent/US10258679B2/en active Active
- 2015-04-14 JP JP2016564032A patent/JP7009061B2/ja not_active Expired - Fee Related
- 2015-04-14 KR KR1020167029990A patent/KR102359691B1/ko not_active Expired - Fee Related
- 2015-04-14 BR BR112016024352-8A patent/BR112016024352A2/pt not_active Application Discontinuation
- 2015-04-21 TW TW109111533A patent/TWI722858B/zh not_active IP Right Cessation
- 2015-04-21 TW TW104112751A patent/TWI692525B/zh not_active IP Right Cessation
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2016
- 2016-10-25 IL IL248483A patent/IL248483A0/en unknown
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2019
- 2019-02-14 US US16/276,520 patent/US20190240303A1/en not_active Abandoned
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2020
- 2020-03-18 JP JP2020047632A patent/JP2020099352A/ja not_active Withdrawn
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2022
- 2022-05-30 JP JP2022087587A patent/JP7300041B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SG10202011841WA (en) | 2021-01-28 |
| KR102491332B1 (ko) | 2023-01-27 |
| US20190240303A1 (en) | 2019-08-08 |
| TW202041671A (zh) | 2020-11-16 |
| JP7300041B2 (ja) | 2023-06-28 |
| KR102359691B1 (ko) | 2022-02-10 |
| KR20160145627A (ko) | 2016-12-20 |
| CN106459887A (zh) | 2017-02-22 |
| WO2015164121A1 (en) | 2015-10-29 |
| US10258679B2 (en) | 2019-04-16 |
| MA39849A (fr) | 2017-03-01 |
| TWI722858B (zh) | 2021-03-21 |
| TW201546276A (zh) | 2015-12-16 |
| KR20220021021A (ko) | 2022-02-21 |
| JP2017513502A (ja) | 2017-06-01 |
| BR112016024352A2 (pt) | 2018-01-23 |
| EP3134510A1 (en) | 2017-03-01 |
| CA2946716A1 (en) | 2015-10-29 |
| EP3134510A4 (en) | 2018-04-25 |
| EP3134510B1 (en) | 2023-11-01 |
| US20170042996A1 (en) | 2017-02-16 |
| JP2022105768A (ja) | 2022-07-14 |
| IL248483A0 (en) | 2016-12-29 |
| AU2015250111A1 (en) | 2016-12-08 |
| TWI692525B (zh) | 2020-05-01 |
| JP7009061B2 (ja) | 2022-01-25 |
| RU2016145464A (ru) | 2018-05-24 |
| SG11201608820WA (en) | 2016-11-29 |
| JP2020099352A (ja) | 2020-07-02 |
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