MX2016013035A - Derivados de dihidrotiazina y dihidrooxazina que tienen actividad inhibidora de enzima de escision de proteina precursora amiloide 1 en sitio beta (bace1). - Google Patents

Derivados de dihidrotiazina y dihidrooxazina que tienen actividad inhibidora de enzima de escision de proteina precursora amiloide 1 en sitio beta (bace1).

Info

Publication number
MX2016013035A
MX2016013035A MX2016013035A MX2016013035A MX2016013035A MX 2016013035 A MX2016013035 A MX 2016013035A MX 2016013035 A MX2016013035 A MX 2016013035A MX 2016013035 A MX2016013035 A MX 2016013035A MX 2016013035 A MX2016013035 A MX 2016013035A
Authority
MX
Mexico
Prior art keywords
dihydrothiazine
dihydrooxazine
derivatives
substituted
inhibitory activity
Prior art date
Application number
MX2016013035A
Other languages
English (en)
Inventor
Fuchino Kouki
Ichi Kusakabe Ken-
Tadano Genta
Komano Kazuo
Nakahara Kenji
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MX2016013035A publication Critical patent/MX2016013035A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención proporciona un compuesto que tiene un efecto de inhibir la producción de amiloide ß, especialmente un efecto de inhibir BACE1, y que es útil como un agente terapéutico o profiláctico para enfermedades inducidas por la producción, secreción y/o deposición de proteínas amiloides ß. Un compuesto de la fórmula (I) (ver Fórmula) en la que X es -S- o -O-, R3a es alquilo, haloalquilo, es alquilo, haloalquilo o similares, R2a es H, halógeno, alquiloxi, haloalquiloxi o similares, R2b es H o similares, R3b es H o alquilo, el anillo A y el anillo B es cada uno independientemente un carbociclo aromático sustituido o no sustituido, un heterociclo aromático sustituido o no sustituido o similares, y es alquilo sustituido o no sustituido o similares, o una sal farmacéuticamente sal aceptable del mismo.
MX2016013035A 2014-04-11 2015-04-10 Derivados de dihidrotiazina y dihidrooxazina que tienen actividad inhibidora de enzima de escision de proteina precursora amiloide 1 en sitio beta (bace1). MX2016013035A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014081524 2014-04-11
PCT/JP2015/062314 WO2015156421A1 (en) 2014-04-11 2015-04-10 Dihydrothiazine and dihydrooxazine derivatives having bace1 inhibitory activity

Publications (1)

Publication Number Publication Date
MX2016013035A true MX2016013035A (es) 2017-01-09

Family

ID=53284477

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016013035A MX2016013035A (es) 2014-04-11 2015-04-10 Derivados de dihidrotiazina y dihidrooxazina que tienen actividad inhibidora de enzima de escision de proteina precursora amiloide 1 en sitio beta (bace1).

Country Status (15)

Country Link
US (1) US20170073337A1 (es)
EP (1) EP3129370A1 (es)
JP (1) JP2017510587A (es)
KR (1) KR20160141849A (es)
CN (1) CN106414431A (es)
AR (1) AR100049A1 (es)
AU (1) AU2015244702A1 (es)
CA (1) CA2945272A1 (es)
EA (1) EA201692048A1 (es)
IL (1) IL248228A0 (es)
MX (1) MX2016013035A (es)
PH (1) PH12016501891A1 (es)
SG (1) SG11201607999VA (es)
TW (1) TW201623295A (es)
WO (1) WO2015156421A1 (es)

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Also Published As

Publication number Publication date
KR20160141849A (ko) 2016-12-09
CA2945272A1 (en) 2015-10-15
EP3129370A1 (en) 2017-02-15
CN106414431A (zh) 2017-02-15
JP2017510587A (ja) 2017-04-13
PH12016501891A1 (en) 2016-12-19
IL248228A0 (en) 2016-11-30
EA201692048A1 (ru) 2017-04-28
SG11201607999VA (en) 2016-10-28
WO2015156421A1 (en) 2015-10-15
TW201623295A (zh) 2016-07-01
AR100049A1 (es) 2016-09-07
AU2015244702A1 (en) 2016-10-06
US20170073337A1 (en) 2017-03-16

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