MX2016005680A - Farmaco terapeutico para enfermedades relacionadas con la muerte celular del reticulo endoplasmico en el endotelio de cornea. - Google Patents
Farmaco terapeutico para enfermedades relacionadas con la muerte celular del reticulo endoplasmico en el endotelio de cornea.Info
- Publication number
- MX2016005680A MX2016005680A MX2016005680A MX2016005680A MX2016005680A MX 2016005680 A MX2016005680 A MX 2016005680A MX 2016005680 A MX2016005680 A MX 2016005680A MX 2016005680 A MX2016005680 A MX 2016005680A MX 2016005680 A MX2016005680 A MX 2016005680A
- Authority
- MX
- Mexico
- Prior art keywords
- endoplasmic reticulum
- drug
- cell death
- therapeutic drug
- diseases related
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
Abstract
La presente invención provee un fármaco de tratamiento o fármaco profiláctico para enfermedades, trastornos, o condiciones relacionados con el estrés en el retículo endoplásmico (RE); específicamente, la presente invención provee un fármaco de tratamiento o fármaco profiláctico para enfermedades, trastornos, o condiciones relacionados con el estrés en el retículo endoplásmico (RE) de epitelio de córnea, el fármaco contiene un inhibidor de la señalización de TGFß; como un inhibidor de la señalización de TGFß preferido, el fármaco contiene 4-[4-(1,3-benzodioxol-5-il)-5-(2-piridinil)-1H-imidazol-2-il]benz amida.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013227048 | 2013-10-31 | ||
JP2014184172 | 2014-09-10 | ||
PCT/JP2014/079513 WO2015064768A1 (ja) | 2013-10-31 | 2014-10-30 | 角膜内皮の小胞体細胞死関連疾患治療薬 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016005680A true MX2016005680A (es) | 2016-10-28 |
Family
ID=53004360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016005680A MX2016005680A (es) | 2013-10-31 | 2014-10-30 | Farmaco terapeutico para enfermedades relacionadas con la muerte celular del reticulo endoplasmico en el endotelio de cornea. |
Country Status (9)
Country | Link |
---|---|
US (2) | US11382904B2 (es) |
EP (2) | EP3064222B1 (es) |
JP (1) | JPWO2015064768A1 (es) |
CA (1) | CA2927898C (es) |
ES (1) | ES2847755T3 (es) |
MX (1) | MX2016005680A (es) |
PL (1) | PL3064222T3 (es) |
RU (1) | RU2712967C2 (es) |
WO (1) | WO2015064768A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2016106641A (ru) | 2013-07-30 | 2017-09-01 | Киото Прифекчурал Паблик Юниверсити Корпорэйшн | Терапевтические средства, направленные на ecm эндотелия роговицы |
CA2928626C (en) | 2013-11-14 | 2023-03-14 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
CA3008113A1 (en) * | 2015-12-24 | 2017-06-29 | The Doshisha | Drug for treating or preventing disorder caused by tgf-.beta. signals, and application thereof |
US11446263B2 (en) | 2015-12-24 | 2022-09-20 | The Doshisha | Caspase inhibitor-containing drug for treating or preventing disorders caused by TGF-β, and applications thereof |
KR101840589B1 (ko) | 2016-06-03 | 2018-03-20 | 연세대학교 산학협력단 | 각막이상증 예방 또는 치료용 약학 조성물 |
EP3593817A4 (en) | 2017-03-06 | 2021-04-07 | Tsubota Laboratory, Inc. | MODEL FOR THE INDUCTION OF MURINE MYOPIA AND ENDOPLASMATIC RETICULUM STRESS INHIBITOR FOR THE PREVENTION OR SUPPRESSION OF MYOPIA |
JPWO2018230712A1 (ja) * | 2017-06-16 | 2020-04-16 | 学校法人同志社 | TGF−β阻害剤の新規スクリーニング法 |
KR102619458B1 (ko) | 2017-06-16 | 2023-12-29 | 학교법인 도시샤 | mTOR 인히비터를 포함하는, 눈의 증상, 장해 또는 질환을 치료 또는 예방하기 위한 의약 및 그 응용 |
EP3639855A4 (en) * | 2017-06-16 | 2021-03-17 | The Doshisha | COMPOUNDS HAVING CASPASE INHIBITORING ACTIVITY, PHARMACEUTICAL AGENT CONTAINING THEM FOR THE TREATMENT OR PREVENTION OF SYMPTOMS, DISORDERS OR DISEASES OF CORNEAL ENDOTHELIUM, AND APPLICATION OF SUCH PHARMACEUTICAL AGENT |
US11576914B2 (en) | 2017-07-26 | 2023-02-14 | The Doshisha | Drug for treating or preventing disorder caused by TGF-β signaling, and application thereof |
KR20200112834A (ko) * | 2017-12-13 | 2020-10-05 | 학교법인 도시샤 | (t)ew-7197을 포함하는 각막내피 질환을 치료 또는 예방하기 위한 조성물 또는 방법 |
JP7353631B2 (ja) * | 2018-12-14 | 2023-10-02 | 国立大学法人 宮崎大学 | プローブ、ミトコンドリアの状態判定用キット、ミトコンドリアの状態判定方法及びミトコンドリア機能改善剤のスクリーニング方法 |
AR122711A1 (es) | 2020-06-25 | 2022-09-28 | Alchemedicine Inc | COMPUESTO HETEROCÍCLICO COMO INHIBIDOR DE CASEÍNA QUINASA 1d Y/O QUINASA 5 TIPO RECEPTOR DE ACTIVINA |
WO2022196609A1 (ja) * | 2021-03-16 | 2022-09-22 | 学校法人慶應義塾 | 網膜変性抑制用組成物 |
Family Cites Families (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4678783B1 (en) | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
US5262319A (en) | 1985-04-19 | 1993-11-16 | Oncogene Science, Inc. | Method for obtaining bone marrow free of tumor cells using transforming growth factor β3 |
US5654270A (en) | 1988-06-28 | 1997-08-05 | La Jolla Cancer Research Foundation | Use of fibromodulin to prevent or reduce dermal scarring |
US5705609A (en) | 1988-06-28 | 1998-01-06 | La Jolla Cancer Research Foundation | Decorin fragments inhibiting cell regulatory factors |
US5583103A (en) | 1988-06-28 | 1996-12-10 | La Jolla Cancer Research Foundation | Inhibition of transforming growth factor beta activity |
JP2887325B2 (ja) | 1988-06-28 | 1999-04-26 | ラ ホヤ キャンサー リサーチ ファウンデーション | デコリンによる細胞増殖の抑制 |
US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
EP0494264B1 (en) | 1989-09-29 | 1997-06-18 | La Jolla Cancer Research Foundation | Inhibiting transforming growth factor to prevent accumulation of extracellular matrix |
DE69024369T2 (de) | 1989-11-22 | 1996-06-13 | Genentech Inc | Latenz assoziierte peptide und deren verwendung |
WO1991010727A1 (en) | 1990-01-22 | 1991-07-25 | La Jolla Cancer Research Foundation | Inhibitors of cell regulatory factors |
WO1993009228A1 (en) | 1991-10-31 | 1993-05-13 | Whitehead Institute For Biomedical Research | TGF-β TYPE RECEPTOR cDNAS AND USES THEREFOR |
US6008011A (en) | 1991-10-31 | 1999-12-28 | Whitehead Institute For Biomedical Research | TGF-β type II receptor cDNAs |
CA2123418A1 (en) | 1991-11-14 | 1993-05-27 | Erkki I. Ruoslahti | Inhibitors of cell regulatory factors and methods for preventing or reducing scarring |
EP0616536B1 (en) | 1991-12-04 | 1999-03-17 | La Jolla Cancer Research Foundation | Use of decorin or biglycan for the manufacture of a medicament in the treatment of diabetes-associated pathology |
GB9205800D0 (en) | 1992-03-17 | 1992-04-29 | British Tech Group | Treatment of fibrotic disorders |
WO1993019177A1 (en) | 1992-03-18 | 1993-09-30 | The General Hospital Corporation | FOUR NOVEL RECEPTORS OF THE TGF-β RECEPTOR FAMILY |
WO1993019783A1 (en) | 1992-04-01 | 1993-10-14 | The Whittier Institute For Diabetes And Endocrinology | Methods of inhibiting or enhancing scar formation in the cns |
US5821234A (en) | 1992-09-10 | 1998-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of proliferation of vascular smooth muscle cell |
US5869462A (en) | 1992-09-10 | 1999-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of proliferation of vascular smooth muscle cell |
US5703047A (en) | 1992-09-21 | 1997-12-30 | Board Of Regents, The University Of Texas System | Methods and treatments for corneal healing with growth factors |
WO1994009812A1 (en) | 1992-10-26 | 1994-05-11 | Kirin Brewery Company, Limited | METHOD FOR PRODUCING LARGE LATENT TRANSFORMING GROWTH FACTOR-β COMPLEXES AND LARGE LATENCY ASSOCIATED PEPTIDE |
JPH08504763A (ja) | 1992-10-29 | 1996-05-21 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | 治療薬としてのTGF−βレセプターフラグメントの使用 |
EP0667870A4 (en) | 1992-10-30 | 1998-04-01 | Hsc Res Dev Lp | COMPOSITIONS AND METHODS FOR MODIFYING THE REGULATORY ACTIVITY OF TGF-BETA. |
US5830847A (en) | 1992-10-30 | 1998-11-03 | Hsc Research & Development Limited Partnership | Soluble TGF-β-binding endoglin polypeptides and homodimers |
ATE235549T1 (de) | 1993-04-30 | 2003-04-15 | Biognostik Ges | Antisense oligonukleotide zur behandlung von immunsuppressiven wirkungen von tgf-beta2 |
EP0737071A1 (en) | 1993-06-15 | 1996-10-16 | Il- Yang Pharm. Co., Ltd. | Anti-sense oligodeoxynucleotide to fibrogenic cytokines and use thereof |
AU8016894A (en) | 1993-10-15 | 1995-05-04 | La Jolla Cancer Research Foundation | Betaglycan polypeptides having tgf-beta binding activity |
US5962427A (en) | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
EP1195372A1 (en) | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-heterocyclic substituted benzamide derivatives with antihypertensive activity |
ATE208494T1 (de) | 1994-05-04 | 2001-11-15 | Mount Sinai Hospital Corp | Modulatoren der cytokine der tgf-beta überfamilie und verfahren zu ihrer bestimmung |
US5772995A (en) | 1994-07-18 | 1998-06-30 | Sidney Kimmel Cancer Center | Compositions and methods for enhanced tumor cell immunity in vivo |
CA2156767A1 (en) | 1994-08-25 | 1996-02-26 | Kenichi Matsunaga | Binding agent for growth factor |
JPH08119984A (ja) | 1994-08-31 | 1996-05-14 | Nkk Corp | ストレプトミセス属放線菌及びこの菌由来のTGF−β 阻害剤 |
US5834248A (en) | 1995-02-10 | 1998-11-10 | Millennium Pharmaceuticals Inc. | Compositions and methods using rchd534, a gene uregulated by shear stress |
US5824655A (en) | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
US5824299A (en) | 1995-06-22 | 1998-10-20 | President & Fellows Of Harvard College | Modulation of endothelial cell proliferation with IP-10 |
GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
JP3421217B2 (ja) | 1995-11-20 | 2003-06-30 | 麒麟麦酒株式会社 | Rho標的タンパク質Rhoキナーゼ |
WO1997031020A1 (en) | 1996-02-22 | 1997-08-28 | The General Hospital Corporation | METHODS AND COMPOSITIONS FOR ENHANCING CELLULAR RESPONSE TO TGF-β LIGANDS |
CA2232682A1 (en) | 1996-04-30 | 1997-11-06 | Susan M. Richards | Use of prolactin as a tgf-beta antagonist |
JPH1067674A (ja) | 1996-06-19 | 1998-03-10 | Advanced Sukin Res Kenkyusho:Kk | 細胞外マトリツクスの異常蓄積抑制剤 |
ATE412751T1 (de) | 1996-07-24 | 2008-11-15 | Chugai Pharmaceutical Co Ltd | Menschliche tak1 und für diese kodierende dna |
US5807708A (en) | 1996-07-30 | 1998-09-15 | Millennium Pharmaceuticals, Inc. | Conservin nucleic acid molecules and compositions |
WO1998007735A1 (en) | 1996-08-16 | 1998-02-26 | Human Genome Sciences, Inc. | Pancreas-derived plasminogen activator inhibitor |
US6017755A (en) | 1996-08-22 | 2000-01-25 | Hsc Research & Development Limited | MADR2 tumour suppressor gene |
AU3215597A (en) | 1996-08-30 | 1998-03-19 | Biomeasure Incorporated | Method of inhibiting fibrosis with a somatostatin agonist |
DE69734894T2 (de) | 1996-10-25 | 2006-07-20 | Ethicon, Inc. | Testverfahren für antifibrotischen wirkstoff |
WO1998024466A1 (en) * | 1996-12-05 | 1998-06-11 | Alcon Laboratories, Inc. | THE USE OF INHIBITORS OF TGF-β'S FUNCTIONS TO AMELIORATE OCULAR PATHOLOGY |
US5948639A (en) | 1997-04-10 | 1999-09-07 | Millennium Pharmaceuticals, Inc. | TGF-β pathway genes |
BR9808934A (pt) | 1997-04-18 | 2000-08-01 | Biogen Inc | Proteìnas de fusão de região constante de receptor/imunoglobulina tgf-beta do tipo ii |
JPH10295381A (ja) | 1997-04-23 | 1998-11-10 | Seibutsu Bunshi Kogaku Kenkyusho:Kk | 新規シグナル伝達因子、およびそれをコードする遺伝子 |
EP0983360A1 (en) | 1997-05-20 | 2000-03-08 | Ludwig Institute For Cancer Research | Smad7 and uses thereof |
US6365711B1 (en) | 1997-05-28 | 2002-04-02 | President And Fellows Of Harvard College | Methods and reagents for modulating TGF-β superfamily signalling |
CA2291754C (en) | 1997-06-02 | 2009-11-17 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Smad-interacting polypeptides and their use |
US6270994B1 (en) | 1997-06-13 | 2001-08-07 | Japanese Foundation For Cancer Research | Smad6 and uses thereof |
WO1999020620A1 (fr) | 1997-10-22 | 1999-04-29 | Nippon Shinyaku Co Ltd | Derive d'isoquinoleine et medicament |
CA2324476A1 (en) | 1998-03-27 | 1999-10-07 | Eli Lilly And Company | Treatment and prevention of vascular disease |
ATE324362T1 (de) | 1998-05-25 | 2006-05-15 | Santen Pharmaceutical Co Ltd | Neue vinylbenzolderivate |
ES2146552B1 (es) * | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
US6492497B1 (en) | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
MXPA02009695A (es) | 2000-04-07 | 2003-03-27 | Sang Geon Kim | Uso profilactico y terapeutico de oltipraz como un agente antifibrotico y anticirrotico en el higado y composicion farmaceutica que contiene oltipraz. |
AR035792A1 (es) | 2001-03-23 | 2004-07-14 | Bayer Corp | Compuestos de n-(4-quinazolinil)-n-(1h-indazol-5-il) amina, inhibidor de la rho-quinasa, su uso para la fabricacion de un medicamento y metodo para prepararlo |
US20030125344A1 (en) | 2001-03-23 | 2003-07-03 | Bayer Corporation | Rho-kinase inhibitors |
JP4204326B2 (ja) | 2001-04-11 | 2009-01-07 | 千寿製薬株式会社 | 視覚機能障害改善剤 |
WO2002100833A1 (fr) | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Inhibiteurs de rho kinase |
WO2003059913A1 (en) | 2002-01-10 | 2003-07-24 | Bayer Healthcare Ag | Roh-kinase inhibitors |
ATE381557T1 (de) | 2002-01-23 | 2008-01-15 | Bayer Pharmaceuticals Corp | Rho-kinase inhibitoren |
AU2003229305A1 (en) * | 2002-05-17 | 2003-12-02 | Scios, Inc. | TREATMENT OF FIBROPROLIFERATIVE DISORDERS USING TGF-Beta INHIBITORS |
EP1541559A4 (en) | 2002-07-22 | 2007-08-22 | Asahi Kasei Pharma Corp | 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE |
CA2400996A1 (en) | 2002-09-03 | 2004-03-03 | Lisa Mckerracher | 1,4-substituted cyclohexane derivatives |
US7160894B2 (en) | 2003-06-06 | 2007-01-09 | Asahi Kasei Pharma Corporation | Tricyclic compound |
EP1644365A2 (en) | 2003-07-02 | 2006-04-12 | Biofocus Discovery Ltd | Pyrazine and pyridine derivatives as rho kinase inhibitors |
US8158589B2 (en) | 2003-08-22 | 2012-04-17 | Proyecto Biomedicine Cima, S.L. | Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1) |
US20050182061A1 (en) | 2003-10-02 | 2005-08-18 | Jeremy Green | Phthalimide compounds useful as protein kinase inhibitors |
JP2007507549A (ja) | 2003-10-06 | 2007-03-29 | グラクソ グループ リミテッド | キナーゼ阻害剤としての1,6,7−三置換アザベンゾイミダゾールの調製 |
US7547779B2 (en) | 2003-10-06 | 2009-06-16 | Glaxo Group Limited | Preparation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors |
EP1689393A4 (en) | 2003-10-06 | 2008-12-17 | Glaxo Group Ltd | PREPARATION OF 1,7-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS |
CN1863779B (zh) | 2003-10-15 | 2010-05-05 | 宇部兴产株式会社 | 吲唑衍生物 |
JP2007008816A (ja) | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
JP2007015928A (ja) | 2003-10-15 | 2007-01-25 | Ube Ind Ltd | 新規オレフィン誘導体 |
JP2007523202A (ja) | 2004-02-24 | 2007-08-16 | ビオアクソン・テラプティーク・インコーポレーテッド | 4置換ピペリジン誘導体 |
CN101014597A (zh) | 2004-04-02 | 2007-08-08 | 沃泰克斯药物股份有限公司 | 可用作rock和其他蛋白激酶抑制剂的吖吲哚 |
CN101056656A (zh) * | 2004-09-15 | 2007-10-17 | 哈佛大学校长及研究员协会 | 在治疗肥胖症和糖尿病中降低er应力 |
EP1829876A4 (en) | 2004-11-26 | 2009-04-01 | Asahi Kasei Pharma Corp | NITROGENIC TRICYCLIC COMPOUND |
KR20080012258A (ko) * | 2005-02-10 | 2008-02-11 | 리전츠 오브 더 유니버스티 오브 미네소타 | 시각장애를 치료하는 방법 |
WO2006096011A1 (en) | 2005-03-08 | 2006-09-14 | Medigenes Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR TREATING AVELLINO CORNEA DYSTROPHY COMPRISING AN ANTIBODY AGAINST TGF-β |
KR101149954B1 (ko) | 2005-08-30 | 2012-06-01 | 아사히 가세이 파마 가부시키가이샤 | 술폰아미드 화합물 |
ZA200804496B (en) * | 2005-12-16 | 2009-09-30 | Alcon Inc | Control of intraocular pressure using ALK5 modulation agents |
US8946201B2 (en) | 2007-08-27 | 2015-02-03 | Saint Louis University | Methods for inhibiting TGF-β |
US20100087486A1 (en) * | 2008-05-30 | 2010-04-08 | Hiroshi Nakamura | Methods for using tgf-b receptor inhibitors or activin-like kinase (alk) 5 inhibitors a-83-01 and sb-431542 to treat eye disease and wound healing conditions |
JP2012524073A (ja) | 2009-04-17 | 2012-10-11 | スムマ ヘルス システムズ エルエルシー | 眼球瘢痕化を抑制するための形質転換成長因子−β受容体阻害剤の使用 |
US20130288985A1 (en) | 2010-07-15 | 2013-10-31 | The Schepens Eye Research Institute Inc. | Compositions and methods of treatment of corneal endothelium disorders |
EP2408113B1 (en) | 2010-07-16 | 2013-03-06 | ST-Ericsson SA | Delta-sigma analog-to-digital converter and method for operating the same. |
KR101258166B1 (ko) * | 2010-09-01 | 2013-04-25 | 연세대학교 산학협력단 | Tgfbi 유전자 변이 각막 이상증의 예방 또는 치료용 약제학적 조성물 및 그의 스크리닝 방법 |
US9752118B2 (en) | 2011-12-06 | 2017-09-05 | Astellas Institute For Regenerative Medicine | Method of directed differentiation producing corneal endothelial cells from neural crest stem cells by PDGFB and DKK2, compositions thereof, and uses thereof |
US20150044178A1 (en) | 2011-12-28 | 2015-02-12 | Kyoto Prefectural Public University Corporation | Normalization of culture of corneal endothelial cells |
JP5959291B2 (ja) | 2012-04-26 | 2016-08-02 | 積水化成品工業株式会社 | 保冷容器 |
RU2016106641A (ru) | 2013-07-30 | 2017-09-01 | Киото Прифекчурал Паблик Юниверсити Корпорэйшн | Терапевтические средства, направленные на ecm эндотелия роговицы |
JP5847227B2 (ja) | 2014-04-10 | 2016-01-20 | 株式会社大一商会 | 遊技機 |
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CA2927898C (en) | 2021-11-16 |
RU2016121150A (ru) | 2017-12-05 |
EP3064222A1 (en) | 2016-09-07 |
EP3064222A4 (en) | 2017-07-19 |
EP3804760A1 (en) | 2021-04-14 |
WO2015064768A1 (ja) | 2015-05-07 |
US11382904B2 (en) | 2022-07-12 |
CA2927898A1 (en) | 2015-05-07 |
RU2016121150A3 (es) | 2018-08-20 |
US20220296580A1 (en) | 2022-09-22 |
RU2712967C2 (ru) | 2020-02-03 |
US20160296505A1 (en) | 2016-10-13 |
ES2847755T3 (es) | 2021-08-03 |
JPWO2015064768A1 (ja) | 2017-03-09 |
PL3064222T3 (pl) | 2021-04-19 |
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