MX341565B - 3-amino-piridinas como agonistas de receptor de acido biliar acoplado a proteina g1 (gpbar1). - Google Patents

3-amino-piridinas como agonistas de receptor de acido biliar acoplado a proteina g1 (gpbar1).

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Publication number
MX341565B
MX341565B MX2013009356A MX2013009356A MX341565B MX 341565 B MX341565 B MX 341565B MX 2013009356 A MX2013009356 A MX 2013009356A MX 2013009356 A MX2013009356 A MX 2013009356A MX 341565 B MX341565 B MX 341565B
Authority
MX
Mexico
Prior art keywords
pyridines
amino
gpbar1 agonists
gpbar1
agonists
Prior art date
Application number
MX2013009356A
Other languages
English (en)
Other versions
MX2013009356A (es
Inventor
David Erickson Shawn
Mattei Patrizio
Richter Hans
Lynn Pietranico-Cole Sherrie
Dehmlow Henrietta
Bissantz Caterina
E Martin Rainer
Obst Sander Ulrike
Ullmer Christoph
Saba Karnachi Prabha
Kim Kyungjin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013009356A publication Critical patent/MX2013009356A/es
Publication of MX341565B publication Critical patent/MX341565B/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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  • Organic Chemistry (AREA)
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Abstract

La invención se refiere a las nuevas 3-aminopiridinas de la fórmula (I) en donde B1, B2 y R1 a R6 son como se definen en la descripción y en las reivindicaciones, así como las sales farmacéuticamente aceptables de los mismos. Estos compuestos son agonistas de GPBAR1 y pueden ser utilizados como medicamentos para el tratamiento de trastornos tales como la diabetes tipo II.
MX2013009356A 2011-03-03 2012-02-29 3-amino-piridinas como agonistas de receptor de acido biliar acoplado a proteina g1 (gpbar1). MX341565B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11156711 2011-03-03
PCT/EP2012/053386 WO2012117000A1 (en) 2011-03-03 2012-02-29 3-amino-pyridines as gpbar1 agonists

Publications (2)

Publication Number Publication Date
MX2013009356A MX2013009356A (es) 2013-09-26
MX341565B true MX341565B (es) 2016-08-25

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MX2013009356A MX341565B (es) 2011-03-03 2012-02-29 3-amino-piridinas como agonistas de receptor de acido biliar acoplado a proteina g1 (gpbar1).

Country Status (12)

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US (2) US8987307B2 (es)
EP (1) EP2681194B1 (es)
JP (1) JP5702001B2 (es)
KR (1) KR101573997B1 (es)
CN (1) CN103415507B (es)
BR (1) BR112013022110B1 (es)
CA (1) CA2827718C (es)
ES (1) ES2538655T3 (es)
HK (1) HK1190707A1 (es)
MX (1) MX341565B (es)
RU (1) RU2594886C2 (es)
WO (1) WO2012117000A1 (es)

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WO2013060653A1 (en) * 2011-10-26 2013-05-02 F. Hoffmann-La Roche Ag 1-cycloalkyl- or 1-heterocyclyl-hydroxyimino-3-phenyl-propanes
WO2013102929A1 (en) 2011-12-26 2013-07-11 Cadila Healthcare Limited Novel compounds for treatment of diabetes, obesity or related disorders
EP2834226B1 (en) * 2012-04-04 2016-05-25 F.Hoffmann-La Roche Ag 1,2-pyridazine, 1,6-pyridazine or pyrimidine-benzamide derivatives as gpbar1 modulators
BR112015015584A2 (pt) * 2012-12-27 2017-12-12 Baruch S Blumberg Inst novos agentes antivirais contra infecção por hbv
AP2015008664A0 (en) 2013-02-22 2015-08-31 Pfizer Pyrrolo [2,3-D] pyrimidine derivatives as inhibitors of janus-related kinases (JAK)
CN103333112B (zh) * 2013-06-14 2018-09-28 南开大学 联苯吡菌胺类衍生物的制备及应用
CN103333113B (zh) * 2013-06-14 2018-09-28 南开大学 氟唑菌酰胺类似衍生物的制备及应用研究
WO2015187499A1 (en) * 2014-06-03 2015-12-10 Gilead Sciences, Inc. Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor
WO2016024185A1 (en) 2014-08-12 2016-02-18 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase
KR101698124B1 (ko) * 2015-05-29 2017-01-19 한국외국어대학교 연구산학협력단 3-(메틸아미노)-3-((r)-피롤리딘-3-일)프로판니트릴 또는 이의 염의 제조방법
JP6916175B2 (ja) 2015-10-26 2021-08-11 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 有害生物防除剤としての縮合二環式ヘテロ環誘導体
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