MX2016000452A - Produccion de diterpeno. - Google Patents

Produccion de diterpeno.

Info

Publication number
MX2016000452A
MX2016000452A MX2016000452A MX2016000452A MX2016000452A MX 2016000452 A MX2016000452 A MX 2016000452A MX 2016000452 A MX2016000452 A MX 2016000452A MX 2016000452 A MX2016000452 A MX 2016000452A MX 2016000452 A MX2016000452 A MX 2016000452A
Authority
MX
Mexico
Prior art keywords
polypeptide
rebaudioside
glucose
catalyzing
addition
Prior art date
Application number
MX2016000452A
Other languages
English (en)
Inventor
Igor Galaev
Viktor Marius Boer
Robertus Antonius Mijndert Van Der Hoeven
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2016000452A publication Critical patent/MX2016000452A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
    • A23G9/32—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/10—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L23/00—Soups; Sauces; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/60—Salad dressings; Mayonnaise; Ketchup
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
    • A23L9/10—Puddings; Dry powder puddings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se relaciona con un microorganismo recombinante que comprende las secuencias de nucleótidos que codifican: un polipéptido que tiene actividad de ent-copalil pirofosfato sintasa; un polipéptido que tiene actividad de ent-Kaureno sintasa; un polipéptido que tiene actividad de ent-Kaureno oxidasa; y un polipéptido que tiene actividad de ácido kaurenoico 13-hidroxilasa, un polipéptido capaz de catalizar la adición de una glucosa en la posición C-13 de esteviol, un polipéptido capaz de catalizar la adición de una glucosa en la posición C-13 de esteviolmonósido o en la posición C-19 de rebaudiósido A, un polipéptido capaz de catalizar la adición de una glucosa en la posición C-19 de esteviolbiósido; y un polipéptido capaz de catalizar la adición de una glucosa en la posición C-13 de esteviósido o en la posición C-19 de rebaudiósido D, mediante el cual la expresión de las secuencia de nucleótidos confieren en el microorganismo la capacidad para producir al menos rebaudiósido M. Tal microorganismo recombinante se puede utilizar en un método de producción de rebaudiósido M.
MX2016000452A 2013-07-15 2014-07-15 Produccion de diterpeno. MX2016000452A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201313942491A 2013-07-15 2013-07-15
PCT/EP2014/065179 WO2015007748A1 (en) 2013-07-15 2014-07-15 Diterpene production

Publications (1)

Publication Number Publication Date
MX2016000452A true MX2016000452A (es) 2016-05-12

Family

ID=51229878

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000452A MX2016000452A (es) 2013-07-15 2014-07-15 Produccion de diterpeno.

Country Status (8)

Country Link
US (1) US20160153017A1 (es)
EP (2) EP3885443A1 (es)
CN (1) CN108064135A (es)
AU (1) AU2014292150B2 (es)
BR (1) BR112016000745B1 (es)
CA (1) CA2914900A1 (es)
MX (1) MX2016000452A (es)
WO (1) WO2015007748A1 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122021005283B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Hospedeiro recombinante que compreende genes recombinantes para produção deesteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol
EP2954061B1 (en) 2013-02-11 2023-11-22 Evolva SA Efficient production of steviol glycosides in recombinant hosts
WO2015011209A1 (en) 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia
JP2017528134A (ja) 2014-09-09 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの生産
AU2015327862B2 (en) 2014-10-03 2020-05-07 Conagen Inc. Non-caloric sweeteners and methods for synthesizing
WO2016055578A1 (en) * 2014-10-08 2016-04-14 Dsm Ip Assets B.V. Steviol glycoside production
WO2016120486A1 (en) 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
BR112017019625A2 (pt) 2015-03-16 2018-05-08 Dsm Ip Assets Bv udp-glicosiltransferases
WO2016151046A1 (en) 2015-03-23 2016-09-29 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
EP3286303A1 (en) 2015-04-21 2018-02-28 DSM IP Assets B.V. Microbial production of terpenoids
AU2016271125A1 (en) 2015-05-29 2017-12-21 Cargill, Incorporated Heat treatment to produce glycosides
US11225678B2 (en) 2015-05-29 2022-01-18 Cargill, Incorporated Fermentation methods for producing steviol glycosides with multi-phase feeding
CA2987585C (en) 2015-05-29 2023-08-29 Cargill, Incorporated Fermentation methods for producing steviol glycosides using high ph and compositions obtained therefrom
EP4043579A1 (en) 2015-07-10 2022-08-17 DSM IP Assets B.V. Method for preparing a steviol glycoside compostion
CA2994288A1 (en) 2015-08-06 2017-02-09 Cargill, Incorporated Fermentation methods for producing steviol glycosides
WO2017025362A1 (en) 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts
CN107922913B (zh) 2015-08-13 2022-04-05 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷转运
US11297862B2 (en) 2015-08-13 2022-04-12 Dsm Ip Assets B.V. Steviol glycoside transport
EP3359654B1 (en) * 2015-10-05 2022-01-05 DSM IP Assets B.V. Kaurenoic acid hydroxylases
US10760085B2 (en) 2015-10-05 2020-09-01 Dsm Ip Assets B.V. Kaurenoic acid hydroxylases
WO2017068017A1 (en) 2015-10-23 2017-04-27 Dsm Ip Assets B.V. Low sugar flavoured yogurt
US20190010508A1 (en) * 2016-01-08 2019-01-10 Adam G. LAWRENCE Mating type switch in yarrowia lipolytica
SG11201808856TA (en) 2016-04-13 2018-11-29 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
US11878992B2 (en) * 2016-08-09 2024-01-23 Dsm Ip Assets B.V. Crystallization of steviol glycosides
WO2018029274A1 (en) 2016-08-09 2018-02-15 Dsm Ip Assets B.V. Crystallization of steviol glycosides
PT3497222T (pt) 2016-08-12 2022-02-09 Amyris Inc Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos
CN109890961B (zh) 2016-10-27 2024-03-08 帝斯曼知识产权资产管理有限公司 香叶基香叶基焦磷酸酯合酶
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018104238A1 (en) 2016-12-08 2018-06-14 Dsm Ip Assets B.V. Kaurenoic acid hydroxylases
WO2018114995A1 (en) 2016-12-22 2018-06-28 Dsm Ip Assets B.V. Fermentation process for producing steviol glycosides
EP3878967A3 (en) 2017-02-03 2021-12-08 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
WO2019002264A1 (en) 2017-06-27 2019-01-03 Dsm Ip Assets B.V. UDP-glycosyltransferase
WO2018224698A1 (en) 2017-08-23 2018-12-13 Dsm Ip Assets B.V. Yoghurt comprising rebaudioside m
US11608364B2 (en) 2018-04-30 2023-03-21 Dsm Ip Assets B.V. Steviol glycoside transport
US20210244058A1 (en) 2018-07-24 2021-08-12 Dsm Ip Assets B.V. Steviol glycoside aggregates with specific particle size distribution
CN110818750B (zh) * 2019-11-22 2020-11-06 江西师范大学 一种甜菊苷r的合成方法
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
CA3198626A1 (en) 2020-10-22 2022-04-28 Dsm Ip Assets B.V. Microorganisms for diterpene production
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
CN115820759B (zh) * 2022-07-25 2023-08-08 北京大学深圳研究生院 一种制备对映-玫瑰烷和对映-海松烷骨架化合物的方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014423A1 (en) 1989-05-18 1990-11-29 The Infergene Company Microorganism transformation
JP3273609B2 (ja) 1989-07-07 2002-04-08 ユニリーバー・ナームローゼ・ベンノートシヤープ 発現ベクターのマルチコピー組込みにより形質転換した真菌による蛋白質の製法
DE69432543T2 (de) 1993-07-23 2003-12-24 Dsm Nv Selektionmarker-genfreie rekombinante Stämme: Verfahren zur ihrer Herstellung und die Verwendung dieser Stämme
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
US6432672B1 (en) 1997-04-11 2002-08-13 Gerardus Cornelis Maria Selten Gene conversion as a tool for the construction of recombinant industrial filamentous fungi
ID27054A (id) 1998-05-19 2001-02-22 Dsm Nv Perbaikan produksi sepalosporin di dalam organisme yang hidup
JP2002533092A (ja) 1998-12-22 2002-10-08 デーエスエム・ナムローゼ・フェンノートシャップ セファロスポリンの改良されたｉｎｖｉｖｏ産生
US7402383B2 (en) 2001-07-23 2008-07-22 Dsm Ip Assets B.V. Process for preparing variant polynucleotides
WO2003010311A2 (en) 2001-07-23 2003-02-06 Dsm Ip Assets B.V. Process for preparing variant polynucleotides
DE60325457D1 (de) 2002-01-23 2009-02-05 Royal Nedalco B V Fermentation von pentosezuckern
SE0202090D0 (sv) 2002-05-08 2002-07-04 Forskarpatent I Syd Ab A modifierd yeast consuming L-arabinose
PL2301949T3 (pl) 2003-05-02 2015-10-30 Cargill Inc Genetycznie modyfikowane gatunki drożdży i sposoby fermentacji z użyciem genetycznie modyfikowanych drożdży
EP1673380A2 (en) 2003-10-14 2006-06-28 DSM IP Assets B.V. Method for preparing a modified host cell
JP5796925B2 (ja) 2004-07-16 2015-10-21 ディーエスエム アイピー アセッツ ビー．ブイ． キシロース発酵性真核細胞の代謝工学
EP1863901A1 (en) 2005-03-11 2007-12-12 Forskarpatent i Syd AB Arabinose- and xylose-fermenting saccharomyces cerevisiae strains
BR122021005283B1 (pt) * 2010-06-02 2022-02-22 Evolva, Inc Hospedeiro recombinante que compreende genes recombinantes para produção deesteviol ou glicosídeo de esteviol, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol
WO2012075030A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20200057799A (ko) * 2011-08-08 2020-05-26 에볼바 에스아 스테비올 글리코시드의 재조합 생산
DK2793618T3 (en) * 2011-12-19 2018-02-26 Coca Cola Co DRINK THAT INCLUDES STEVIOL Glycosides
CN104203005A (zh) * 2012-01-23 2014-12-10 帝斯曼知识产权资产管理有限公司 二萜的生产
BR112014028819A2 (pt) * 2012-05-22 2017-07-25 Purecircle Sdn Bhd glicosídeos de esteviol de pureza elevada
CA2899276C (en) * 2013-02-06 2022-11-01 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
EP2954061B1 (en) * 2013-02-11 2023-11-22 Evolva SA Efficient production of steviol glycosides in recombinant hosts
EP3502264A3 (en) * 2013-05-31 2019-11-06 DSM IP Assets B.V. Microorganisms for diterpene production
WO2015011209A1 (en) * 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia

Also Published As

Publication number Publication date
CA2914900A1 (en) 2015-01-22
US20160153017A1 (en) 2016-06-02
EP3885443A1 (en) 2021-09-29
EP3021689A1 (en) 2016-05-25
BR112016000745B1 (pt) 2021-01-05
AU2014292150A1 (en) 2016-01-28
CN108064135A (zh) 2018-05-22
EP3021689B1 (en) 2021-03-24
WO2015007748A1 (en) 2015-01-22
AU2014292150B2 (en) 2019-04-04
BR112016000745A2 (pt) 2017-09-05

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