MX2015013364A - Deteccion especifica de anticuerpos de rata en suero de raton. - Google Patents

Deteccion especifica de anticuerpos de rata en suero de raton.

Info

Publication number
MX2015013364A
MX2015013364A MX2015013364A MX2015013364A MX2015013364A MX 2015013364 A MX2015013364 A MX 2015013364A MX 2015013364 A MX2015013364 A MX 2015013364A MX 2015013364 A MX2015013364 A MX 2015013364A MX 2015013364 A MX2015013364 A MX 2015013364A
Authority
MX
Mexico
Prior art keywords
rat
antibody
antibody binding
avidity
sample
Prior art date
Application number
MX2015013364A
Other languages
English (en)
Inventor
Kay-Gunnar Stubenrauch
Uwe Wessels
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015013364A publication Critical patent/MX2015013364A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Un aspecto, como se reporta en el presente documento, es un método para detectar un anticuerpo de rata en una muestra de suero o plasma (obtenida) de un ratón que comprende los pasos de a) proveer la muestra que ha de ser analizada b) incubar la muestra de suero o plasma con un anticuerpo que se une específicamente a IgG de rata y que no se une específicamente a IgG de ratón, en donde el anticuerpo es i) una mezcla de un anticuerpo que se une a la cadena ligera kappa de rata y un anticuerpo que se une a la cadena ligera lambda de rata, o ii) una mezcla de un anticuerpo que se une a IgG1 de rata con una avidez de 4.1 x 1010 M-1 o más, un anticuerpo que se une a IgG2a de rata con una avidez de 8.6 x 109 M-1 o más, un anticuerpo que se une a IgG2b de rata con una avidez de 6.4 x 1010 M-1 o más y un anticuerpo que se une a IgG2c de rata con una avidez de 9.5 x 1010 M-1 o más, c) opcionalmente incubar la muestra con un reactivo apropiado para la detección selectiva del anticuerpo de rata total, activo o unido a antígeno, y d) correlacionar el complejo formado en (b) o (c) con la concentración del anticuerpo de rata en la muestra.
MX2015013364A 2013-03-20 2014-03-19 Deteccion especifica de anticuerpos de rata en suero de raton. MX2015013364A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13160143 2013-03-20
PCT/EP2014/055462 WO2014147101A1 (en) 2013-03-20 2014-03-19 Specific detection of rat antibodies in mouse serum

Publications (1)

Publication Number Publication Date
MX2015013364A true MX2015013364A (es) 2015-12-15

Family

ID=47891548

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015013364A MX2015013364A (es) 2013-03-20 2014-03-19 Deteccion especifica de anticuerpos de rata en suero de raton.

Country Status (11)

Country Link
US (1) US10502746B2 (es)
EP (1) EP2986990B1 (es)
JP (1) JP6561043B2 (es)
KR (1) KR20150133196A (es)
CN (1) CN105051544B (es)
BR (1) BR112015018834A2 (es)
CA (1) CA2899835A1 (es)
HK (1) HK1217231A1 (es)
MX (1) MX2015013364A (es)
RU (1) RU2015140955A (es)
WO (1) WO2014147101A1 (es)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62257395A (ja) * 1986-04-28 1987-11-09 Sumitomo Electric Ind Ltd ラツト免疫グロブリンに対するモノクロ−ナル抗体
US6306626B1 (en) * 1990-04-27 2001-10-23 Research Development Foundation Anti-IgM monoclonal antibodies and methods of their use
CA2115060C (en) 1991-08-06 2003-05-06 Rene De Waal Malefyt Use of interleukin-10 analogs or antagonists to treat endotoxin- or superantigen induced toxicity
JPH06113830A (ja) * 1991-12-06 1994-04-26 Nippon Bio Tesuto Kenkyusho:Kk ヒトヘモグロビンの特異的検出法
US5332665A (en) * 1991-12-18 1994-07-26 The General Hospital Corporation Species specific, high affinity monoclonal antibodies
DE4418513A1 (de) 1994-05-27 1995-11-30 Bayer Ag Immuntest zum Nachweis hochmolekularer Antigene
JP3914342B2 (ja) 1997-09-25 2007-05-16 武田薬品工業株式会社 ｇｐ３４結合阻害物を有効成分として含有する医薬組成物
JP2004045384A (ja) * 2002-05-22 2004-02-12 Matsushita Electric Ind Co Ltd 免疫学的測定方法、免疫学的測定装置、生体成分測定用トイレ、抗アルブミンモノクローナル抗体、それを産生する細胞株、およびアルブミン検出キット
EP1680666A4 (en) * 2003-10-27 2008-03-26 Monogram Biosciences Inc ANTI-THERAPEUTIC HUMAN ANTIBODY DETECTION
CN101088014B (zh) * 2004-12-23 2012-10-03 弗·哈夫曼-拉罗切有限公司 在实验动物中检测治疗性抗体
CN101506659B (zh) * 2006-09-12 2012-12-12 弗·哈夫曼-拉罗切有限公司 抗药物抗体测定法
ES2428876T3 (es) * 2006-09-12 2013-11-12 F. Hoffmann-La Roche Ag Ensayo de anticuerpo antifármaco
CN110179989B (zh) * 2009-05-13 2022-06-24 基酶有限公司 治疗狼疮的方法和组合物
CN105624118B (zh) * 2009-10-19 2019-08-13 弗·哈夫曼-拉罗切有限公司 非交叉反应性抗IgG抗体

Also Published As

Publication number Publication date
EP2986990A1 (en) 2016-02-24
US20170370941A2 (en) 2017-12-28
US20160077100A1 (en) 2016-03-17
CA2899835A1 (en) 2014-09-25
US10502746B2 (en) 2019-12-10
RU2015140955A (ru) 2017-04-21
US20160266135A2 (en) 2016-09-15
JP2016514831A (ja) 2016-05-23
KR20150133196A (ko) 2015-11-27
CN105051544B (zh) 2018-11-23
HK1217231A1 (zh) 2016-12-30
BR112015018834A2 (pt) 2017-07-18
JP6561043B2 (ja) 2019-08-14
WO2014147101A1 (en) 2014-09-25
EP2986990B1 (en) 2018-08-15
CN105051544A (zh) 2015-11-11
RU2015140955A3 (es) 2018-03-20

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