MX2015010354A - Derivados de acido betulinico modificados con aquilo c-3 y alquenilo utiles en el tratamiento de virus de inmunodeficiencia humana (vih). - Google Patents
Derivados de acido betulinico modificados con aquilo c-3 y alquenilo utiles en el tratamiento de virus de inmunodeficiencia humana (vih).Info
- Publication number
- MX2015010354A MX2015010354A MX2015010354A MX2015010354A MX2015010354A MX 2015010354 A MX2015010354 A MX 2015010354A MX 2015010354 A MX2015010354 A MX 2015010354A MX 2015010354 A MX2015010354 A MX 2015010354A MX 2015010354 A MX2015010354 A MX 2015010354A
- Authority
- MX
- Mexico
- Prior art keywords
- hiv
- alkyl
- treatment
- acid derivatives
- betulinic acid
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 title abstract 2
- -1 alkenyl modified betulinic acid derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 208000030507 AIDS Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768630P | 2013-02-25 | 2013-02-25 | |
| PCT/US2014/017688 WO2014130810A1 (en) | 2013-02-25 | 2014-02-21 | C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of hiv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015010354A true MX2015010354A (es) | 2015-10-09 |
Family
ID=50288267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015010354A MX2015010354A (es) | 2013-02-25 | 2014-02-21 | Derivados de acido betulinico modificados con aquilo c-3 y alquenilo utiles en el tratamiento de virus de inmunodeficiencia humana (vih). |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9249180B2 (enExample) |
| EP (1) | EP2958930A1 (enExample) |
| JP (1) | JP6186012B2 (enExample) |
| KR (1) | KR20150121712A (enExample) |
| CN (1) | CN105102468A (enExample) |
| AR (1) | AR094876A1 (enExample) |
| AU (1) | AU2014218754B2 (enExample) |
| BR (1) | BR112015019590A2 (enExample) |
| CA (1) | CA2902513A1 (enExample) |
| EA (1) | EA027861B1 (enExample) |
| IL (1) | IL240739A0 (enExample) |
| MX (1) | MX2015010354A (enExample) |
| SG (1) | SG11201506445PA (enExample) |
| TW (1) | TW201444862A (enExample) |
| WO (1) | WO2014130810A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| KR20170135970A (ko) * | 2015-04-14 | 2017-12-08 | 비브 헬스케어 유케이 (넘버4) 리미티드 | Hiv 성숙화 억제제를 생산하는 방법 |
| WO2017079140A1 (en) | 2015-11-02 | 2017-05-11 | Blueprint Medicines Corporation | Inhibitors of ret |
| AR107512A1 (es) * | 2016-02-04 | 2018-05-09 | VIIV HEALTHCARE UK Nº 5 LTD | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 |
| UY37155A (es) | 2016-03-17 | 2017-10-31 | Blueprint Medicines Corp | Inhibidores de ret |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
| WO2018044838A1 (en) * | 2016-08-31 | 2018-03-08 | Viiv Healthcare Company | Combinations and uses and treatments thereof |
| CN106749486A (zh) * | 2016-11-30 | 2017-05-31 | 沈阳化工大学 | 一种以乙二胺为连接臂的齐墩果酸衍生物及其应用 |
| CA3075729A1 (en) | 2017-09-14 | 2019-03-21 | Phoenix Biotechnology, Inc. | Use of oleandrin to treatn viral infection |
| JP7370966B2 (ja) | 2017-09-14 | 2023-10-30 | フェニックス・バイオテクノロジー・インコーポレイテッド | 神経学的状態を治療するための方法および改善された神経保護組成物 |
| CA3096043A1 (en) | 2018-04-03 | 2019-10-10 | Blueprint Medicines Corporation | Ret inhibitor for use in treating cancer having a ret alteration |
| PL3924361T3 (pl) | 2019-02-11 | 2024-03-18 | Hetero Labs Limited | Nowe pochodne triterpenu jako inhibitory wirusa hiv |
| CN111440151A (zh) * | 2020-03-25 | 2020-07-24 | 魏威 | 制备抗肿瘤药普拉赛替尼的方法 |
| CN111362923A (zh) * | 2020-03-25 | 2020-07-03 | 魏威 | 制备ret抑制剂普拉塞替尼的方法、以及普拉塞替尼的中间体及其制备方法 |
| EP4009981B1 (en) | 2020-03-31 | 2023-08-16 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
| JP7153083B2 (ja) | 2020-03-31 | 2022-10-13 | フェニックス・バイオテクノロジー・インコーポレイテッド | コロナウイルス感染を治療するための方法および組成物 |
| TW202210468A (zh) | 2020-05-29 | 2022-03-16 | 美商纜圖藥品公司 | 普拉替尼之固體形式 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| US5679828A (en) | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
| US6369101B1 (en) * | 1999-02-26 | 2002-04-09 | Regents Of The University Of Minnesota | Therapeutic method to treat herpes virus infection |
| US20020137755A1 (en) | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| CA2560266A1 (en) | 2004-03-17 | 2005-09-29 | Panacos Pharmaceuticals, Inc. | Pharmaceutical salts of 3-o-(3',3'-dimethylsuccinyl) betulinic acid |
| TW200628161A (en) | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| WO2008115281A2 (en) | 2006-10-16 | 2008-09-25 | Myriad Genetics, Inc. | Compounds for treating viral infections |
| EP2257567A1 (en) | 2008-02-14 | 2010-12-08 | Virochem Pharma Inc. | Novel 17 beta lupane derivatives |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| CA2801487C (en) * | 2010-06-04 | 2017-12-05 | Bristol-Myers Squibb Company | Modified c-3 betulinic acid derivatives as hiv maturation inhibitors |
| DK2576586T3 (en) * | 2010-06-04 | 2015-11-23 | Bristol Myers Squibb Co | C-28 AMINES OF MODIFIED C-3-BETULIN ACID DERIVATIVES AS ANTI-HUMIDITY INHIBITORS |
| CN103429607B (zh) | 2011-01-31 | 2016-02-17 | 百时美施贵宝公司 | 具有hiv成熟抑制活性的c-17和c-3经修饰的三萜系化合物 |
| DK2670764T3 (en) | 2011-01-31 | 2015-12-07 | Bristol Myers Squibb Co | C-28 AMINES OF MODIFIED C-3-BETULIN ACID DERIVATIVES AS ANTI-HUMIDITY INHIBITORS |
| US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
-
2014
- 2014-02-21 AU AU2014218754A patent/AU2014218754B2/en not_active Ceased
- 2014-02-21 US US14/186,533 patent/US9249180B2/en not_active Expired - Fee Related
- 2014-02-21 EP EP14710687.6A patent/EP2958930A1/en not_active Withdrawn
- 2014-02-21 JP JP2015558996A patent/JP6186012B2/ja not_active Expired - Fee Related
- 2014-02-21 WO PCT/US2014/017688 patent/WO2014130810A1/en not_active Ceased
- 2014-02-21 MX MX2015010354A patent/MX2015010354A/es unknown
- 2014-02-21 BR BR112015019590A patent/BR112015019590A2/pt not_active Application Discontinuation
- 2014-02-21 CA CA2902513A patent/CA2902513A1/en not_active Abandoned
- 2014-02-21 KR KR1020157026070A patent/KR20150121712A/ko not_active Withdrawn
- 2014-02-21 EA EA201591545A patent/EA027861B1/ru not_active IP Right Cessation
- 2014-02-21 SG SG11201506445PA patent/SG11201506445PA/en unknown
- 2014-02-21 CN CN201480010426.3A patent/CN105102468A/zh active Pending
- 2014-02-24 TW TW103106131A patent/TW201444862A/zh unknown
- 2014-02-24 AR ARP140100580A patent/AR094876A1/es unknown
-
2015
- 2015-08-20 IL IL240739A patent/IL240739A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016509062A (ja) | 2016-03-24 |
| EA201591545A1 (ru) | 2015-12-30 |
| CN105102468A (zh) | 2015-11-25 |
| JP6186012B2 (ja) | 2017-08-23 |
| US9249180B2 (en) | 2016-02-02 |
| AU2014218754A1 (en) | 2015-10-15 |
| EP2958930A1 (en) | 2015-12-30 |
| TW201444862A (zh) | 2014-12-01 |
| AU2014218754B2 (en) | 2017-04-20 |
| AR094876A1 (es) | 2015-09-02 |
| EA027861B1 (ru) | 2017-09-29 |
| SG11201506445PA (en) | 2015-09-29 |
| CA2902513A1 (en) | 2014-08-28 |
| BR112015019590A2 (pt) | 2017-07-18 |
| IL240739A0 (en) | 2015-10-29 |
| WO2014130810A1 (en) | 2014-08-28 |
| KR20150121712A (ko) | 2015-10-29 |
| US20140243298A1 (en) | 2014-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2015010354A (es) | Derivados de acido betulinico modificados con aquilo c-3 y alquenilo utiles en el tratamiento de virus de inmunodeficiencia humana (vih). | |
| TN2013000321A1 (en) | C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity | |
| MX2013008359A (es) | Aminas de c-28 de derivados de acido betulinico modificado de c-3 como inhibidores de la maduracion del virus de inmunodeficiencia humana. | |
| NZ715747A (en) | Syk inhibitors | |
| MD4666B1 (ro) | Inhibitori ai Syk | |
| MX2012013703A (es) | Derivados de acido c-3-betulinico modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). | |
| MX2015010003A (es) | Triterpenoides c-19 modificados, con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana (vih). | |
| MX2012013628A (es) | Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). | |
| MX353412B (es) | Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. | |
| EA201590450A1 (ru) | Сульфамоил-ариламиды и их применение в качестве лекарственных препаратов для лечения гепатита b | |
| PH12015501412A1 (en) | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR | |
| MX2014013089A (es) | Aminas biciclicas c-17 de triterpenoides con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana (vih). | |
| MX2014012695A (es) | Derivados de isoindolona. | |
| MY163202A (en) | Indolizine derivatives, proces for the preparation thereof and therapeutic use thereof | |
| EA201491531A1 (ru) | C-3 циклоалкенил тритерпеноиды, ингибирующие созревание вич | |
| MX2014002936A (es) | Nuevos derivados de acido betulinico con actividad antiviral. | |
| IN2015DN01119A (enExample) | ||
| MY199668A (en) | C-3 and c-17 modified triterpenoids as hiv-1 inhibitors | |
| PH12015502429A1 (en) | Dicarboxylic acid compound | |
| PH12018501640A1 (en) | C-3 and c-17 modified triterpenoids as hiv-1 inhibitors | |
| MX2013008536A (es) | Triterpenoides c-17 y c-3 modificados con actividad inhibidora de la maduracion del virus de inmunodeficiencia humana. |