MX2015007493A - Derivados de indol carboxamida como antagonistas del receptor p2x7. - Google Patents

Derivados de indol carboxamida como antagonistas del receptor p2x7.

Info

Publication number
MX2015007493A
MX2015007493A MX2015007493A MX2015007493A MX2015007493A MX 2015007493 A MX2015007493 A MX 2015007493A MX 2015007493 A MX2015007493 A MX 2015007493A MX 2015007493 A MX2015007493 A MX 2015007493A MX 2015007493 A MX2015007493 A MX 2015007493A
Authority
MX
Mexico
Prior art keywords
carboxamide derivatives
receptor antagonists
indole carboxamide
indole
derivatives
Prior art date
Application number
MX2015007493A
Other languages
English (en)
Other versions
MX368044B (es
Inventor
Kurt Hilpert
Francis Hubler
Thierry Kimmerlin
Dorte Renneberg
Simon Stamm
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2015007493A publication Critical patent/MX2015007493A/es
Publication of MX368044B publication Critical patent/MX368044B/es

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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems

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Abstract

La invención se refiere a derivados de indol carboxamida de fórmula (I), (ver Fórmula) en donde R1, R2, R3, R4, R5 y R6 son como se define en la descripción, a su preparación y su uso como compuestos farmacéuticamente activos.
MX2015007493A 2012-12-12 2013-12-11 Derivados de indol carboxamida como antagonistas del receptor p2x7. MX368044B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12196711 2012-12-12
PCT/IB2013/060794 WO2014091415A1 (en) 2012-12-12 2013-12-11 Indole carboxamide derivatives as p2x7 receptor antagonists

Publications (2)

Publication Number Publication Date
MX2015007493A true MX2015007493A (es) 2015-09-04
MX368044B MX368044B (es) 2019-09-17

Family

ID=47325947

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015007493A MX368044B (es) 2012-12-12 2013-12-11 Derivados de indol carboxamida como antagonistas del receptor p2x7.

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US (1) US9718774B2 (es)
EP (1) EP2931717B1 (es)
JP (1) JP6295269B2 (es)
KR (1) KR102232742B1 (es)
CN (1) CN104812749B (es)
AR (1) AR093921A1 (es)
AU (1) AU2013356850B2 (es)
BR (1) BR112015013463B1 (es)
CA (1) CA2890886C (es)
CL (1) CL2015001529A1 (es)
EA (1) EA029644B1 (es)
ES (1) ES2618056T3 (es)
IL (1) IL239295A0 (es)
MA (1) MA38192B1 (es)
MX (1) MX368044B (es)
PH (1) PH12015501339A1 (es)
PL (1) PL2931717T3 (es)
SG (1) SG11201504369SA (es)
TW (1) TWI612034B (es)
WO (1) WO2014091415A1 (es)
ZA (1) ZA201504974B (es)

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