MX2015006929A - Extracto purificado aislado de pseudolysimachion rotundum var. subintegrum que contiene abundante cantidad de in ingrediente activo, preparacion del mismo, y composicion que lo comprende como un ingrediente activo para prevenir o tratar la inflamacion, alergia y asma. - Google Patents

Extracto purificado aislado de pseudolysimachion rotundum var. subintegrum que contiene abundante cantidad de in ingrediente activo, preparacion del mismo, y composicion que lo comprende como un ingrediente activo para prevenir o tratar la inflamacion, alergia y asma.

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Publication number
MX2015006929A
MX2015006929A MX2015006929A MX2015006929A MX2015006929A MX 2015006929 A MX2015006929 A MX 2015006929A MX 2015006929 A MX2015006929 A MX 2015006929A MX 2015006929 A MX2015006929 A MX 2015006929A MX 2015006929 A MX2015006929 A MX 2015006929A
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MX
Mexico
Prior art keywords
purified extract
inflammatory
prepared
prior
method disclosed
Prior art date
Application number
MX2015006929A
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English (en)
Other versions
MX361137B (es
Inventor
Yongnam Lee
Hyeongkyu Lee
Ji-Seok Yoo
Dae-Hee Shin
Sei-Ryang Oh
Kyung-Seop Ahn
Byung-Hwan Ryoo
Ok-Kyoung Kwon
Doo-Young Kim
Jung-Hee Kim
Hyuk-Hwan Song
Original Assignee
Yungjin Pharmaceutical Co Ltd
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Application filed by Yungjin Pharmaceutical Co Ltd filed Critical Yungjin Pharmaceutical Co Ltd
Publication of MX2015006929A publication Critical patent/MX2015006929A/es
Publication of MX361137B publication Critical patent/MX361137B/es

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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/10—Natural spices, flavouring agents or condiments; Extracts thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract

La presente invención se relaciona con un nuevo método industrializado para preparar un extracto purificado que contiene abundantes ingredientes activos tales como derivados de catalpol a partir del extracto de Pseudolysimachion rotundum var subintegrum que el preparado mediante el método de preparación convencional descrito en la técnica anterior y los terapéuticos o alimentos de salud funcionales que comprenden el extracto purificado para tratar y prevenir enfermedades inflamatorias, alérgicas o asmáticas. El extracto purificado mostró una actividad antiinflamatoria, antialérgica y contra el asma más potente que el preparado mediante el método de preparación convencional descrito en la técnica anterior a través de varias pruebas in vivo tales como la prueba de inhibición de la reproducción de eosinófilos, la liberación de inmunoglobulinas y quimiocinas inflamatorias en el plasma y fluido broncoalveolar así como la supresión de la hiperreactividad de las vías respiratorias y la hiperplasia de células caliciformes en un modelo de ratón retado/sensibilizado con OVA.
MX2015006929A 2012-12-31 2013-12-23 Extracto purificado aislado de pseudolysimachion rotundum var. subintegrum que contiene abundante cantidad de un ingrediente activo, preparacion del mismo, y composicion que lo comprende como un ingrediente activo para prevenir o tratar la inflamacion, alergia y asma. MX361137B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20120158130 2012-12-31
KR1020130084167A KR101476045B1 (ko) 2012-12-31 2013-07-17 활성성분을 다량 함유한 산꼬리풀 정제 분획물 (atc2), 이의 제조방법 및 이를 유효성분으로 포함하는 염증, 알레르기 및 천식의 예방 또는 치료용 조성물
PCT/KR2013/011986 WO2014104672A1 (en) 2012-12-31 2013-12-23 A purified extract isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma

Publications (2)

Publication Number Publication Date
MX2015006929A true MX2015006929A (es) 2016-02-05
MX361137B MX361137B (es) 2018-11-27

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MX2015006929A MX361137B (es) 2012-12-31 2013-12-23 Extracto purificado aislado de pseudolysimachion rotundum var. subintegrum que contiene abundante cantidad de un ingrediente activo, preparacion del mismo, y composicion que lo comprende como un ingrediente activo para prevenir o tratar la inflamacion, alergia y asma.

Country Status (14)

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US (2) US9592263B2 (es)
EP (2) EP3498287A1 (es)
JP (2) JP5923222B2 (es)
KR (2) KR101476045B1 (es)
CN (2) CN104822386B (es)
AU (1) AU2013371216B2 (es)
BR (2) BR112015012568B1 (es)
CA (2) CA2893410C (es)
EC (1) ECSP15021216A (es)
ES (1) ES2719265T3 (es)
MX (1) MX361137B (es)
PL (1) PL2941263T3 (es)
RU (3) RU2674757C1 (es)
WO (1) WO2014104672A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101476045B1 (ko) 2012-12-31 2014-12-23 영진약품공업주식회사 활성성분을 다량 함유한 산꼬리풀 정제 분획물 (atc2), 이의 제조방법 및 이를 유효성분으로 포함하는 염증, 알레르기 및 천식의 예방 또는 치료용 조성물
US9675658B2 (en) 2012-12-31 2017-06-13 Yungjin Pharmaceutical Co., Ltd Method of treating inflammation, allergy and asthma with a purified extract (ATC2) isolated from Pseudolysimachion rotundam var. subintegrum containing abundant amount of active ingredient
KR101476095B1 (ko) * 2013-04-10 2014-12-23 영진약품공업주식회사 고함량의 카탈폴 유도체를 다량 함유한 산꼬리풀 유래 꼬리풀 신규 정제물 또는 이로부터 분리된 카탈폴 유도체를 유효성분으로 포함하는 만성 폐쇄성 폐질환의 예방 또는 치료용 조성물
KR101638795B1 (ko) * 2014-07-24 2016-07-12 영진약품공업주식회사 산꼬리풀 추출물로부터 분리된 신규 화합물 및 이를 유효성분으로 포함하는 알러지, 염증, 천식 또는 만성 폐쇄성 폐질환의 예방 또는 치료용 조성물
KR101715676B1 (ko) * 2015-06-17 2017-03-13 영진약품공업주식회사 산꼬리풀 추출물로부터 분리된 신규 화합물 (ks 513) 및 이를 유효성분으로 포함하는 알러지, 염증, 천식 또는 만성 폐쇄성 폐질환의 예방 또는 치료용 조성물
CN106353433B (zh) * 2016-10-13 2018-09-14 昆明赛诺制药股份有限公司 一种治疗乙型肝炎美洲大蠊提取物的检测方法
KR20180060201A (ko) * 2016-11-28 2018-06-07 한국과학기술연구원 땅콩 지상부 추출물 및 분획물을 포함하는 피부염 치료용 조성물 및 그의 용도
GB201705403D0 (en) * 2017-04-04 2017-05-17 Givaudan Sa Improvements in or relating to organic compounds
CN107937340B (zh) * 2017-11-21 2021-06-25 大连医科大学附属第一医院 梓醇在促进神经干细胞向少突胶质细胞分化中的应用
CN113347986A (zh) * 2019-05-08 2021-09-03 韩国烟草人参公社 包含草本威灵仙提取物为有效成分的炎症、过敏反应及哮喘的预防或治疗用组合物及其用途
WO2021071375A1 (ru) * 2019-10-07 2021-04-15 Александр Иванович Леляк Функциональная питьевая вода
KR102309959B1 (ko) 2020-03-16 2021-10-08 아주대학교 산학협력단 진세노사이드 Rg 5를 포함하는 점액 과다 분비 질환의 예방 또는 치료용 조성물
CN112774247A (zh) * 2020-12-09 2021-05-11 黄永利 一种化妆品生产用原料提取设备及化妆品生产方法
CN114432330A (zh) * 2022-03-01 2022-05-06 贵州大学 胡黄连苷ii在制备预防和治疗炎症性肠病药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455541B2 (en) * 2005-05-30 2013-06-04 Korea Research Institute Of Bioscience And Biotechnology Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity
KR100860080B1 (ko) * 2005-05-30 2008-09-24 한국생명공학연구원 항염, 항알레르기 및 항천식 활성을 갖는 꼬리풀속 식물추출물을 함유하는 약학조성물
KR20060125499A (ko) * 2005-05-30 2006-12-06 한국생명공학연구원 항염, 항알레르기 및 항천식 활성을 갖는 긴산꼬리풀추출물로부터 분리된 카탈폴 유도체를 함유하는 약학조성물
AU2006253198B2 (en) * 2005-05-30 2010-05-06 Korea Research Institute Of Bioscience And Biotechnology Pharmaceutical composition comprising an extract of Pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity
KR101313860B1 (ko) 2012-01-16 2013-10-14 (주)이오시스템 광학장치
KR101476045B1 (ko) 2012-12-31 2014-12-23 영진약품공업주식회사 활성성분을 다량 함유한 산꼬리풀 정제 분획물 (atc2), 이의 제조방법 및 이를 유효성분으로 포함하는 염증, 알레르기 및 천식의 예방 또는 치료용 조성물
KR20140136790A (ko) 2013-05-21 2014-12-01 김현우 차량의 주차 완료 후 주차 안전거리를 확보하는 방법 및 장치

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