MX359554B - Microesferas cristalinas y proceso para fabricacion de las mismas. - Google Patents

Microesferas cristalinas y proceso para fabricacion de las mismas.

Info

Publication number
MX359554B
MX359554B MX2014012805A MX2014012805A MX359554B MX 359554 B MX359554 B MX 359554B MX 2014012805 A MX2014012805 A MX 2014012805A MX 2014012805 A MX2014012805 A MX 2014012805A MX 359554 B MX359554 B MX 359554B
Authority
MX
Mexico
Prior art keywords
microspheres
manufacturing
same
api
manufacture
Prior art date
Application number
MX2014012805A
Other languages
English (en)
Other versions
MX2014012805A (es
Inventor
W Propst Cecil
W Meadows Marc
S Todd Michael
Original Assignee
Spi Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spi Pharma Inc filed Critical Spi Pharma Inc
Publication of MX2014012805A publication Critical patent/MX2014012805A/es
Publication of MX359554B publication Critical patent/MX359554B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona a microesferas y composiciones que comprenden una pluralidad de microesferas, en donde las microesferas son perfectamente esféricas y tienen un contenido de humedad menor a 1% y el método de fabricación de los mismos. La presente invención es útil en la fabricación de microesferas de ingredientes farmacéuticos activos (API por sus siglas en inglés) de liberación sostenida y modificada, como un excipiente de fluido libre para minitabletas y en la fabricación de dispersiones de API.
MX2014012805A 2012-04-25 2013-04-25 Microesferas cristalinas y proceso para fabricacion de las mismas. MX359554B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261638073P 2012-04-25 2012-04-25
US201361783603P 2013-03-14 2013-03-14
PCT/US2013/038257 WO2013163453A1 (en) 2012-04-25 2013-04-25 Crystalline microspheres and the process for manufacturing the same

Publications (2)

Publication Number Publication Date
MX2014012805A MX2014012805A (es) 2015-01-22
MX359554B true MX359554B (es) 2018-10-02

Family

ID=49483900

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014012805A MX359554B (es) 2012-04-25 2013-04-25 Microesferas cristalinas y proceso para fabricacion de las mismas.

Country Status (9)

Country Link
US (5) US9089487B2 (es)
EP (2) EP3583935A1 (es)
JP (2) JP6577865B2 (es)
BR (1) BR112014026351B1 (es)
CA (1) CA2871429C (es)
ES (1) ES2729035T3 (es)
IN (1) IN2014DN09416A (es)
MX (1) MX359554B (es)
WO (1) WO2013163453A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL219362A (en) 2012-04-23 2017-04-30 Verint Systems Ltd A system and method for predicting threatened points of interest
BR112014026351B1 (pt) 2012-04-25 2022-09-27 Spi Pharma Inc Composições compreendendo microesferas e formulação farmacêutica contendo tais composições
US10560842B2 (en) 2015-01-28 2020-02-11 Verint Systems Ltd. System and method for combined network-side and off-air monitoring of wireless networks
IL242354B (en) 2015-10-29 2019-09-26 Verint Systems Ltd System and method for identifying genuine base stations that serve rogue base stations
IL245299B (en) 2016-04-25 2021-05-31 Verint Systems Ltd A system and method for decoding communication transmitted in a wireless local communication network
US10639312B1 (en) * 2019-12-06 2020-05-05 Edenbridge Pharmaceuticals, LLC Finished pharmaceutical dosage form of a methenamine salt such as methenamine mandelate

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JPH0192403A (ja) 1987-09-30 1989-04-11 Aprica Kassai Inc 使い捨ておむつ
FR2670398B1 (fr) * 1990-12-14 1995-02-17 Roquette Freres Composition pulverulente directement compressible et procede d'obtention.
US5573783A (en) 1995-02-13 1996-11-12 Nano Systems L.L.C. Redispersible nanoparticulate film matrices with protective overcoats
US6548095B1 (en) 1996-08-24 2003-04-15 Südzucker Aktiengesellschaft Sugar-free compressed products
US6235947B1 (en) * 1997-04-14 2001-05-22 Takeda Chemical Industries, Ltd. D-mannitol and its preparation
US5780055A (en) 1996-09-06 1998-07-14 University Of Maryland, Baltimore Cushioning beads and tablet comprising the same capable of forming a suspension
JP3447042B2 (ja) * 1997-07-23 2003-09-16 フロイント産業株式会社 単一物質球形粒の製造方法
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WO2002035991A2 (en) * 2000-10-30 2002-05-10 The Board Of Regents, The University Of Texas System Spherical particles produced by a hot-melt extrusion/spheronization process
US20030129250A1 (en) * 2001-11-20 2003-07-10 Advanced Inhalation Research Inc. Particulate compositions for improving solubility of poorly soluble agents
US7118765B2 (en) 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
ES2334991T3 (es) * 2002-03-26 2010-03-18 Teva Pharmaceutical Industries Ltd. Microparticulas de farmaco.
GB0228826D0 (en) * 2002-12-11 2003-01-15 Okpala Joseph Hair technology in creating particles with improved delivery capabilities
WO2004067595A2 (en) * 2003-01-29 2004-08-12 Spi Polyols, Inc. Compositions of polyol granules and processes of manufacture
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WO2005044193A2 (en) * 2003-10-28 2005-05-19 Spi Pharma, Inc. Product and process for increasing compactibility of carbohydrates
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BRPI0417348A (pt) 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
CN103393601A (zh) * 2004-05-12 2013-11-20 巴克斯特国际公司 含有蛋白并在高浓度蛋白下显示可注射性的微球体
EP1817009A2 (en) 2004-11-24 2007-08-15 Spi Pharma, Inc. Orally disintegrating compositions
CN101155859B (zh) * 2005-04-06 2012-04-25 三洋化成工业株式会社 树脂颗粒和树脂分散体
JP2007217651A (ja) 2006-02-20 2007-08-30 Daicel Chem Ind Ltd 環状ポリオレフィン系樹脂の球状粒子およびその製造方法
ATE491433T1 (de) 2006-08-01 2011-01-15 Procter & Gamble Pflegemittel mit freisetzungspartikel
WO2008065504A1 (en) 2006-11-30 2008-06-05 Pfizer Products Inc. Multiparticulates of spray-coated drug and polymer on a meltable core
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EP2168601B1 (en) * 2007-05-28 2013-08-21 Mitsubishi Shoji Foodtech Co., Ltd Spherical mannitol crystal particle
JP5258268B2 (ja) 2007-11-19 2013-08-07 フロイント産業株式会社 球形粒の製造方法
CA2734847C (en) * 2008-08-18 2016-08-30 Mitsubishi Shoji Foodtech Co., Ltd. Novel excipient for mannitol tableting
US8617588B2 (en) 2009-03-09 2013-12-31 Spi Pharma, Inc. Highly compactable and durable direct compression excipients and excipient systems
EA027618B1 (ru) * 2009-05-08 2017-08-31 Эмпликюре Аб Композиция для непрерывной доставки лекарственного средства, содержащая геополимерное связующее
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BR112014026351B1 (pt) * 2012-04-25 2022-09-27 Spi Pharma Inc Composições compreendendo microesferas e formulação farmacêutica contendo tais composições

Also Published As

Publication number Publication date
ES2729035T3 (es) 2019-10-29
JP2019112438A (ja) 2019-07-11
US20190224126A1 (en) 2019-07-25
EP2841057A1 (en) 2015-03-04
IN2014DN09416A (es) 2015-07-17
MX2014012805A (es) 2015-01-22
US20140099372A1 (en) 2014-04-10
BR112014026351A2 (pt) 2017-06-27
US9089487B2 (en) 2015-07-28
EP3583935A1 (en) 2019-12-25
US10245232B2 (en) 2019-04-02
JP2015514809A (ja) 2015-05-21
CA2871429A1 (en) 2013-10-31
EP2841057B1 (en) 2019-03-20
US20150140097A1 (en) 2015-05-21
WO2013163453A1 (en) 2013-10-31
EP2841057A4 (en) 2015-09-16
US20220151932A1 (en) 2022-05-19
US20160015640A1 (en) 2016-01-21
US11278496B2 (en) 2022-03-22
CA2871429C (en) 2018-07-31
BR112014026351B1 (pt) 2022-09-27
JP6577865B2 (ja) 2019-09-18

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