BR112014026351A2 - microesferas de cristal e processo para a produção das mesmas - Google Patents

microesferas de cristal e processo para a produção das mesmas

Info

Publication number
BR112014026351A2
BR112014026351A2 BR112014026351A BR112014026351A BR112014026351A2 BR 112014026351 A2 BR112014026351 A2 BR 112014026351A2 BR 112014026351 A BR112014026351 A BR 112014026351A BR 112014026351 A BR112014026351 A BR 112014026351A BR 112014026351 A2 BR112014026351 A2 BR 112014026351A2
Authority
BR
Brazil
Prior art keywords
microspheres
producing
production
api
present
Prior art date
Application number
BR112014026351A
Other languages
English (en)
Other versions
BR112014026351B1 (pt
Inventor
W Propst Cecil
W Meadow Marc
S Todd Michael
Original Assignee
Spi Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spi Pharma Inc filed Critical Spi Pharma Inc
Publication of BR112014026351A2 publication Critical patent/BR112014026351A2/pt
Publication of BR112014026351B1 publication Critical patent/BR112014026351B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

resumo patente de invenção: "microesferas de cristal e processo para a produção das mesmas". a presente invenção refere-se a microesferas e composições compreendendo uma pluralidade de microesferas, em que as microesferas são perfeitamente esféricas e têm um teor de umidade inferior a 1%, e ao método de produção das mesmas. a presente invenção é útil na produção de microesferas de princípio farmacêutico ativo (api) de liberação sistemática e modificada, como um excipiente de escoamento livre para minicomprimidos e na produção de dispersões de api.
BR112014026351-5A 2012-04-25 2013-04-25 Composições compreendendo microesferas e formulação farmacêutica contendo tais composições BR112014026351B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261638073P 2012-04-25 2012-04-25
US61/638,073 2012-04-25
US201361783603P 2013-03-14 2013-03-14
US61,783,603 2013-03-14
PCT/US2013/038257 WO2013163453A1 (en) 2012-04-25 2013-04-25 Crystalline microspheres and the process for manufacturing the same

Publications (2)

Publication Number Publication Date
BR112014026351A2 true BR112014026351A2 (pt) 2017-06-27
BR112014026351B1 BR112014026351B1 (pt) 2022-09-27

Family

ID=49483900

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014026351-5A BR112014026351B1 (pt) 2012-04-25 2013-04-25 Composições compreendendo microesferas e formulação farmacêutica contendo tais composições

Country Status (9)

Country Link
US (5) US20150140097A1 (pt)
EP (2) EP3583935A1 (pt)
JP (2) JP6577865B2 (pt)
BR (1) BR112014026351B1 (pt)
CA (1) CA2871429C (pt)
ES (1) ES2729035T3 (pt)
IN (1) IN2014DN09416A (pt)
MX (1) MX359554B (pt)
WO (1) WO2013163453A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL219362A (en) 2012-04-23 2017-04-30 Verint Systems Ltd A system and method for predicting threatened points of interest
CA2871429C (en) 2012-04-25 2018-07-31 Spi Pharma, Inc. Crystalline microspheres and the process for manufacturing the same
US10560842B2 (en) 2015-01-28 2020-02-11 Verint Systems Ltd. System and method for combined network-side and off-air monitoring of wireless networks
IL242354B (en) 2015-10-29 2019-09-26 Verint Systems Ltd System and method for identifying genuine base stations that serve rogue base stations
IL245299B (en) 2016-04-25 2021-05-31 Verint Systems Ltd A system and method for decoding communication transmitted in a wireless local communication network
US10639312B1 (en) * 2019-12-06 2020-05-05 Edenbridge Pharmaceuticals, LLC Finished pharmaceutical dosage form of a methenamine salt such as methenamine mandelate

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820627A (en) * 1986-03-24 1989-04-11 Em Diagnostic Systems, Inc. Method of preparing particles suitable for tabletting into diagnostic reagents
JPH0192403A (ja) 1987-09-30 1989-04-11 Aprica Kassai Inc 使い捨ておむつ
FR2670398B1 (fr) * 1990-12-14 1995-02-17 Roquette Freres Composition pulverulente directement compressible et procede d'obtention.
US5573783A (en) 1995-02-13 1996-11-12 Nano Systems L.L.C. Redispersible nanoparticulate film matrices with protective overcoats
US6548095B1 (en) 1996-08-24 2003-04-15 Südzucker Aktiengesellschaft Sugar-free compressed products
US6235947B1 (en) * 1997-04-14 2001-05-22 Takeda Chemical Industries, Ltd. D-mannitol and its preparation
US5780055A (en) 1996-09-06 1998-07-14 University Of Maryland, Baltimore Cushioning beads and tablet comprising the same capable of forming a suspension
JP3447042B2 (ja) * 1997-07-23 2003-09-16 フロイント産業株式会社 単一物質球形粒の製造方法
GB9716432D0 (en) * 1997-08-05 1997-10-08 Cerestar Holding Bv Tableting of erythritol
JP2000128774A (ja) 1998-10-26 2000-05-09 Tanabe Seiyaku Co Ltd 薬物を含有する球形微粒子の製法
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
WO2002035991A2 (en) * 2000-10-30 2002-05-10 The Board Of Regents, The University Of Texas System Spherical particles produced by a hot-melt extrusion/spheronization process
WO2003043603A1 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
US7118765B2 (en) 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
EP2087882A1 (en) * 2002-03-26 2009-08-12 Teva Pharmaceutical Industries Ltd. Drug microparticles
GB0228826D0 (en) * 2002-12-11 2003-01-15 Okpala Joseph Hair technology in creating particles with improved delivery capabilities
EP1589824A4 (en) * 2003-01-29 2006-12-27 Spi Polyols Inc POLYOLGRANULATE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
WO2005009375A2 (en) 2003-07-22 2005-02-03 Baxter International Inc. Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
US20070092562A1 (en) 2003-10-28 2007-04-26 Spi Pharma, Inc. Product and process for increasing compactibility of carbohydrates
EP1677736A4 (en) * 2003-10-28 2007-09-12 Spi Pharma Inc PRODUCT AND PROCESS FOR INCREASING COMPACTION ABILITY FOR CARBOHYDRATES
CA2549225A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
US8333995B2 (en) 2004-05-12 2012-12-18 Baxter International, Inc. Protein microspheres having injectable properties at high concentrations
WO2006058250A2 (en) 2004-11-24 2006-06-01 Spi Pharma, Inc. Orally disintegrating compositions
WO2006109653A1 (ja) 2005-04-06 2006-10-19 Sanyo Chemical Industries, Ltd. 樹脂粒子および樹脂分散体
JP2007217651A (ja) * 2006-02-20 2007-08-30 Daicel Chem Ind Ltd 環状ポリオレフィン系樹脂の球状粒子およびその製造方法
CA2659918C (en) * 2006-08-01 2013-02-05 The Procter & Gamble Company Benefit agent containing delivery particle
EP2091519B1 (en) 2006-11-30 2015-06-24 Bend Research, Inc Multiparticulates of spray-coated drug and polymer on a meltable core
US20080181932A1 (en) 2007-01-30 2008-07-31 Drugtech Corporation Compositions for oral delivery of pharmaceuticals
CA2687794C (en) * 2007-05-28 2015-01-27 Jin Satomi Spherical particle of crystalline mannitol
JP5258268B2 (ja) 2007-11-19 2013-08-07 フロイント産業株式会社 球形粒の製造方法
EP2327424A4 (en) * 2008-08-18 2014-10-01 Mitsubishi Shoji Foodtech Co Ltd NEW AUXILIARY FOR MANNITOL TABLETTING
ES2588429T3 (es) 2009-03-09 2016-11-02 Spi Pharma, Inc. Excipientes y sistemas de excipientes de compresión directa altamente compactables y durables
AU2010244194B2 (en) * 2009-05-08 2014-12-04 Orexo Ab Composition for sustained drug delivery comprising geopolymeric binder
JP2011157348A (ja) * 2010-01-05 2011-08-18 Fuji Chem Ind Co Ltd 崩壊性高強度球状粒子組成物
DE102010045479A1 (de) 2010-09-16 2014-10-30 Brace Capital Gmbh Verfahren zur Mikroverkapselung, Herstellung von festen Formen mehrphasiger mischbarer und nichtmischbarer Materialien und Methode zur Herstellung vorgenannter Systeme
ES2833075T3 (es) 2010-09-20 2021-06-14 Spi Pharma Inc Procedimiento de microencapsulación y producto
CA2871429C (en) 2012-04-25 2018-07-31 Spi Pharma, Inc. Crystalline microspheres and the process for manufacturing the same

Also Published As

Publication number Publication date
BR112014026351B1 (pt) 2022-09-27
US9089487B2 (en) 2015-07-28
CA2871429A1 (en) 2013-10-31
US20160015640A1 (en) 2016-01-21
JP2015514809A (ja) 2015-05-21
CA2871429C (en) 2018-07-31
JP6577865B2 (ja) 2019-09-18
JP2019112438A (ja) 2019-07-11
EP3583935A1 (en) 2019-12-25
US10245232B2 (en) 2019-04-02
EP2841057B1 (en) 2019-03-20
WO2013163453A1 (en) 2013-10-31
US11278496B2 (en) 2022-03-22
US20150140097A1 (en) 2015-05-21
MX359554B (es) 2018-10-02
US20140099372A1 (en) 2014-04-10
ES2729035T3 (es) 2019-10-29
EP2841057A1 (en) 2015-03-04
IN2014DN09416A (pt) 2015-07-17
MX2014012805A (es) 2015-01-22
EP2841057A4 (en) 2015-09-16
US20220151932A1 (en) 2022-05-19
US20190224126A1 (en) 2019-07-25

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/04/2013, OBSERVADAS AS CONDICOES LEGAIS