ECSP15021216A - Extracto purificado aislado de pseudolysimachion rotundum var. subintegrum que contene abundante cantidad de un ingrediente activo, preparación del mismo, y composición que lo comprende como un ingrediente activo para prevenir o tratar la inflamación, alergia y asma - Google Patents

Extracto purificado aislado de pseudolysimachion rotundum var. subintegrum que contene abundante cantidad de un ingrediente activo, preparación del mismo, y composición que lo comprende como un ingrediente activo para prevenir o tratar la inflamación, alergia y asma

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Publication number
ECSP15021216A
ECSP15021216A ECIEPI201521216A ECPI201521216A ECSP15021216A EC SP15021216 A ECSP15021216 A EC SP15021216A EC IEPI201521216 A ECIEPI201521216 A EC IEPI201521216A EC PI201521216 A ECPI201521216 A EC PI201521216A EC SP15021216 A ECSP15021216 A EC SP15021216A
Authority
EC
Ecuador
Prior art keywords
active ingredient
asthma
subintegrum
prevent
inflammatory
Prior art date
Application number
ECIEPI201521216A
Other languages
English (en)
Inventor
Ji-Seok Yoo
Yongnam Lee
Dae-Hee Shin
In Sik Shin
Seung Hyung Kim
Byung-Hwan Ryoo
Lee Suui Name:
Ok-Kyoung Kwon
Hyuk-Hwan Song
Doo-Young Kim
Hyeongkyu Lee
Kyung-Seop Ahn
Original Assignee
Korea Res Inst Bioscience & Biotechnology
Yungjin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51736806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP15021216(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Korea Res Inst Bioscience & Biotechnology, Yungjin Pharmaceutical Co Ltd filed Critical Korea Res Inst Bioscience & Biotechnology
Publication of ECSP15021216A publication Critical patent/ECSP15021216A/es

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Abstract

La presente invención se relaciona con un nuevo método industrializado para preparar un extracto purificado que contiene abundantes ingredientes activos tales como derivados de catalpol a partir del extracto de Pseudolysimachion rotundum var subintegrum que el preparado mediante el método de preparación convencional descrito en la técnica anterior y los terapéuticos o alimentos de salud funcionales que comprenden el extracto purificado para tratar y prevenir enfermedades inflamatorias, alérgicas o asmáticas. El extracto purificado mostró una actividad antiinflamatoria, antialérgica y contra el asma más potente que el preparado mediante el método de preparación convencional descrito en la técnica anterior a través de varias pruebas in vivo tales como la prueba de inhibición de la reproducción de eosinófilos, la liberación de inmunoglobulinas y quimiocinas inflamatorias en el plasma y fluido broncoalveolar así como la supresión de la hiperreactividad de las vías respiratorias y la hiperplasia de células caliciformes en un modelo de ratón retado/sensibilizado con OVA.
ECIEPI201521216A 2012-12-31 2015-05-28 Extracto purificado aislado de pseudolysimachion rotundum var. subintegrum que contene abundante cantidad de un ingrediente activo, preparación del mismo, y composición que lo comprende como un ingrediente activo para prevenir o tratar la inflamación, alergia y asma ECSP15021216A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120158130 2012-12-31
KR1020130084167A KR101476045B1 (ko) 2012-12-31 2013-07-17 활성성분을 다량 함유한 산꼬리풀 정제 분획물 (atc2), 이의 제조방법 및 이를 유효성분으로 포함하는 염증, 알레르기 및 천식의 예방 또는 치료용 조성물

Publications (1)

Publication Number Publication Date
ECSP15021216A true ECSP15021216A (es) 2016-01-29

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ECIEPI201521216A ECSP15021216A (es) 2012-12-31 2015-05-28 Extracto purificado aislado de pseudolysimachion rotundum var. subintegrum que contene abundante cantidad de un ingrediente activo, preparación del mismo, y composición que lo comprende como un ingrediente activo para prevenir o tratar la inflamación, alergia y asma

Country Status (14)

Country Link
US (2) US9592263B2 (es)
EP (2) EP3498287A1 (es)
JP (2) JP5923222B2 (es)
KR (2) KR101476045B1 (es)
CN (2) CN105963312B (es)
AU (1) AU2013371216B2 (es)
BR (2) BR112015012568B1 (es)
CA (2) CA2893410C (es)
EC (1) ECSP15021216A (es)
ES (1) ES2719265T3 (es)
MX (1) MX361137B (es)
PL (1) PL2941263T3 (es)
RU (3) RU2674757C1 (es)
WO (1) WO2014104672A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9675658B2 (en) 2012-12-31 2017-06-13 Yungjin Pharmaceutical Co., Ltd Method of treating inflammation, allergy and asthma with a purified extract (ATC2) isolated from Pseudolysimachion rotundam var. subintegrum containing abundant amount of active ingredient
KR101476045B1 (ko) 2012-12-31 2014-12-23 영진약품공업주식회사 활성성분을 다량 함유한 산꼬리풀 정제 분획물 (atc2), 이의 제조방법 및 이를 유효성분으로 포함하는 염증, 알레르기 및 천식의 예방 또는 치료용 조성물
KR101476095B1 (ko) * 2013-04-10 2014-12-23 영진약품공업주식회사 고함량의 카탈폴 유도체를 다량 함유한 산꼬리풀 유래 꼬리풀 신규 정제물 또는 이로부터 분리된 카탈폴 유도체를 유효성분으로 포함하는 만성 폐쇄성 폐질환의 예방 또는 치료용 조성물
KR101638795B1 (ko) * 2014-07-24 2016-07-12 영진약품공업주식회사 산꼬리풀 추출물로부터 분리된 신규 화합물 및 이를 유효성분으로 포함하는 알러지, 염증, 천식 또는 만성 폐쇄성 폐질환의 예방 또는 치료용 조성물
KR101715676B1 (ko) * 2015-06-17 2017-03-13 영진약품공업주식회사 산꼬리풀 추출물로부터 분리된 신규 화합물 (ks 513) 및 이를 유효성분으로 포함하는 알러지, 염증, 천식 또는 만성 폐쇄성 폐질환의 예방 또는 치료용 조성물
CN106353433B (zh) * 2016-10-13 2018-09-14 昆明赛诺制药股份有限公司 一种治疗乙型肝炎美洲大蠊提取物的检测方法
KR20180060201A (ko) * 2016-11-28 2018-06-07 한국과학기술연구원 땅콩 지상부 추출물 및 분획물을 포함하는 피부염 치료용 조성물 및 그의 용도
GB201705403D0 (en) * 2017-04-04 2017-05-17 Givaudan Sa Improvements in or relating to organic compounds
CN107937340B (zh) * 2017-11-21 2021-06-25 大连医科大学附属第一医院 梓醇在促进神经干细胞向少突胶质细胞分化中的应用
WO2020226204A1 (ko) * 2019-05-08 2020-11-12 주식회사 케이티앤지 냉초 추출물을 유효성분으로 포함하는 염증, 알레르기 및 천식의 예방 또는 치료용 조성물 및 이의 용도
WO2021071375A1 (ru) * 2019-10-07 2021-04-15 Александр Иванович Леляк Функциональная питьевая вода
KR102309959B1 (ko) 2020-03-16 2021-10-08 아주대학교 산학협력단 진세노사이드 Rg 5를 포함하는 점액 과다 분비 질환의 예방 또는 치료용 조성물
CN112774247A (zh) * 2020-12-09 2021-05-11 黄永利 一种化妆品生产用原料提取设备及化妆品生产方法
CN114432330A (zh) * 2022-03-01 2022-05-06 贵州大学 胡黄连苷ii在制备预防和治疗炎症性肠病药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100860080B1 (ko) * 2005-05-30 2008-09-24 한국생명공학연구원 항염, 항알레르기 및 항천식 활성을 갖는 꼬리풀속 식물추출물을 함유하는 약학조성물
US8455541B2 (en) * 2005-05-30 2013-06-04 Korea Research Institute Of Bioscience And Biotechnology Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity
KR20060125499A (ko) 2005-05-30 2006-12-06 한국생명공학연구원 항염, 항알레르기 및 항천식 활성을 갖는 긴산꼬리풀추출물로부터 분리된 카탈폴 유도체를 함유하는 약학조성물
WO2006129964A1 (en) * 2005-05-30 2006-12-07 Korea Research Institute Of Bioscience And Biotechnology Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity
KR101313860B1 (ko) 2012-01-16 2013-10-14 (주)이오시스템 광학장치
KR101476045B1 (ko) 2012-12-31 2014-12-23 영진약품공업주식회사 활성성분을 다량 함유한 산꼬리풀 정제 분획물 (atc2), 이의 제조방법 및 이를 유효성분으로 포함하는 염증, 알레르기 및 천식의 예방 또는 치료용 조성물
KR20140136790A (ko) 2013-05-21 2014-12-01 김현우 차량의 주차 완료 후 주차 안전거리를 확보하는 방법 및 장치

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