MX2014008157A - Anticuerpos anti-lrp5 y metodos de uso. - Google Patents

Anticuerpos anti-lrp5 y metodos de uso.

Info

Publication number
MX2014008157A
MX2014008157A MX2014008157A MX2014008157A MX2014008157A MX 2014008157 A MX2014008157 A MX 2014008157A MX 2014008157 A MX2014008157 A MX 2014008157A MX 2014008157 A MX2014008157 A MX 2014008157A MX 2014008157 A MX2014008157 A MX 2014008157A
Authority
MX
Mexico
Prior art keywords
antibody
seq
amino acid
norrin
hvr
Prior art date
Application number
MX2014008157A
Other languages
English (en)
Spanish (es)
Inventor
Weilan Ye
Yan Wu
Cecilia Chiu
Jeremy Bryant Burton
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2014008157A publication Critical patent/MX2014008157A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MX2014008157A 2012-01-18 2013-01-18 Anticuerpos anti-lrp5 y metodos de uso. MX2014008157A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261588100P 2012-01-18 2012-01-18
PCT/US2013/022045 WO2013109819A1 (en) 2012-01-18 2013-01-18 Anti-lrp5 antibodies and methods of use

Publications (1)

Publication Number Publication Date
MX2014008157A true MX2014008157A (es) 2014-10-06

Family

ID=47604271

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008157A MX2014008157A (es) 2012-01-18 2013-01-18 Anticuerpos anti-lrp5 y metodos de uso.

Country Status (24)

Country Link
US (4) US9200072B2 (OSRAM)
EP (1) EP2804629A1 (OSRAM)
JP (1) JP6242813B2 (OSRAM)
KR (1) KR20140116490A (OSRAM)
CN (1) CN104066449B (OSRAM)
AR (1) AR089752A1 (OSRAM)
AU (1) AU2013209707A1 (OSRAM)
BR (1) BR112014017518A2 (OSRAM)
CA (1) CA2862422A1 (OSRAM)
CL (1) CL2014001888A1 (OSRAM)
CO (1) CO7000747A2 (OSRAM)
CR (1) CR20140382A (OSRAM)
EA (1) EA028202B1 (OSRAM)
IL (1) IL233317A0 (OSRAM)
IN (1) IN2014DN05885A (OSRAM)
MA (1) MA35898B1 (OSRAM)
MX (1) MX2014008157A (OSRAM)
NZ (1) NZ626520A (OSRAM)
PE (1) PE20141561A1 (OSRAM)
PH (1) PH12014501605A1 (OSRAM)
SG (2) SG11201404198TA (OSRAM)
TW (1) TW201335187A (OSRAM)
WO (1) WO2013109819A1 (OSRAM)
ZA (1) ZA201404675B (OSRAM)

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MX2011002418A (es) * 2008-09-10 2011-04-05 Genentech Inc Metodos para inhibir la angiogenesis ocular.
JP5861469B2 (ja) * 2012-01-23 2016-02-16 日本電気硝子株式会社 ガラス管の清浄切断装置と清浄切断方法
RU2017103289A (ru) 2014-07-11 2018-08-14 Дженентек, Инк. Ингибирование пути notch
EP3191526B1 (en) 2014-09-12 2023-02-22 The Board of Trustees of the Leland Stanford Junior University Wnt signaling agonist molecules
ES2907486T3 (es) * 2015-09-24 2022-04-25 Univ North Carolina Chapel Hill Métodos y composiciones para reducir metástasis
CN106367517A (zh) * 2016-09-28 2017-02-01 湖北工业大学 一种低密度脂蛋白受体相关蛋白5基因突变检测的试剂及应用
WO2018204909A2 (en) * 2017-05-05 2018-11-08 Wendelin Dailey Norrin induced expression of genes and use thereof to treat disease
BR112019022729A2 (pt) 2017-05-31 2020-05-19 Boehringer Ingelheim Int polipeptídeos que antagonizam sinalização da wnt em células de tumor
WO2019126398A1 (en) 2017-12-19 2019-06-27 Surrozen, Inc. Wnt surrogate molecules and uses thereof
AU2018393076B2 (en) * 2017-12-19 2025-11-20 Surrozen Operating, Inc. Anti-LRP5/6 antibodies and methods of use
CN111655729B (zh) 2017-12-19 2023-10-20 瑟罗泽恩奥普瑞汀公司 抗卷曲蛋白抗体和使用方法
EP3731865A1 (en) * 2017-12-29 2020-11-04 F. Hoffmann-La Roche AG Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody
EP4013791A4 (en) * 2019-08-14 2024-01-24 Modmab Therapeutics Inc. Antibodies that bind to lrp5 proteins and methods of use
JP2023529557A (ja) * 2020-05-04 2023-07-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗enpp1抗体の阻害
CN111909935B (zh) * 2020-07-17 2022-11-15 武汉纽福斯生物科技有限公司 重组人卷曲蛋白受体4(fzd4)的表达载体及其应用
KR102536092B1 (ko) * 2020-09-29 2023-05-24 조선대학교산학협력단 Lrp5 발현 또는 활성 억제제를 포함하는 허혈성 심장질환의 예방 또는 치료용 약학적 조성물
IL303342A (en) 2020-12-18 2023-08-01 Antlera Therapeutics Inc Tetravalent FZD and WNT receptor binding antibody compounds
WO2023250402A2 (en) * 2022-06-22 2023-12-28 Antlera Therapeutics Inc. Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
CN118599000A (zh) * 2024-05-11 2024-09-06 中山大学附属第三医院 Lrp5作为靶向分子在治疗糖尿病肾病中的应用

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US20170166636A1 (en) 2017-06-15
SG11201404198TA (en) 2014-08-28
US20130183320A1 (en) 2013-07-18
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IL233317A0 (en) 2014-08-31
AU2013209707A1 (en) 2014-07-24
JP6242813B2 (ja) 2017-12-06
US9200072B2 (en) 2015-12-01
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US20160185855A1 (en) 2016-06-30
CN104066449B (zh) 2018-04-27
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PH12014501605A1 (en) 2014-10-08
PE20141561A1 (es) 2014-11-12
BR112014017518A8 (pt) 2017-07-04
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BR112014017518A2 (pt) 2018-09-04
TW201335187A (zh) 2013-09-01
IN2014DN05885A (OSRAM) 2015-06-05
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