MX2013004427A - Preparacion de los compuestos de biciclo [2.2.2] octan-2-ona. - Google Patents
Preparacion de los compuestos de biciclo [2.2.2] octan-2-ona.Info
- Publication number
- MX2013004427A MX2013004427A MX2013004427A MX2013004427A MX2013004427A MX 2013004427 A MX2013004427 A MX 2013004427A MX 2013004427 A MX2013004427 A MX 2013004427A MX 2013004427 A MX2013004427 A MX 2013004427A MX 2013004427 A MX2013004427 A MX 2013004427A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- formula
- present
- octan
- preparation
- Prior art date
Links
- VEPYQCZRVLNDBC-UHFFFAOYSA-N bicyclo[2.2.2]octan-3-one Chemical class C1CC2C(=O)CC1CC2 VEPYQCZRVLNDBC-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 4
- ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 2-octanone Chemical class CCCCCCC(C)=O ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 1
- 238000004611 spectroscopical analysis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2010054747 | 2010-10-20 | ||
| PCT/IB2011/054660 WO2012052939A2 (en) | 2010-10-20 | 2011-10-19 | Preparation of bicyclo[2.2.2]octan-2-one compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013004427A true MX2013004427A (es) | 2013-07-17 |
Family
ID=45757740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013004427A MX2013004427A (es) | 2010-10-20 | 2011-10-19 | Preparacion de los compuestos de biciclo [2.2.2] octan-2-ona. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9296673B2 (enExample) |
| EP (1) | EP2630111B1 (enExample) |
| JP (1) | JP5909237B2 (enExample) |
| KR (1) | KR101876594B1 (enExample) |
| CN (1) | CN103168019B (enExample) |
| CA (1) | CA2813131C (enExample) |
| DK (1) | DK2630111T3 (enExample) |
| ES (1) | ES2536897T3 (enExample) |
| HU (1) | HUE025195T2 (enExample) |
| IL (1) | IL225763A (enExample) |
| MX (1) | MX2013004427A (enExample) |
| TW (2) | TWI551583B (enExample) |
| WO (1) | WO2012052939A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2630111B1 (en) * | 2010-10-20 | 2015-02-25 | Actelion Pharmaceuticals Ltd. | Preparation of bicyclo[2.2.2]octan-2-one compounds |
| ES2692656T3 (es) | 2010-10-20 | 2018-12-04 | Idorsia Pharmaceuticals Ltd | Preparación diastereoselectiva de los compuestos de biciclo[2.2.2]octan-2-ona |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3046106A1 (de) | 1980-12-06 | 1982-07-15 | Studiengesellschaft Kohle mbH, 4330 Mülheim | Optisch reine bicyclo(2.2.2)oct-5-en-2.one, verfahren zu ihrer herstellung und ihre verwendung |
| JP3439255B2 (ja) * | 1994-03-31 | 2003-08-25 | 長瀬産業株式会社 | 不斉マイケル反応を触媒する金属錯体 |
| SI2152670T1 (sl) | 2007-04-27 | 2014-04-30 | Actelion Pharmaceuticals Ltd. | Premoščene šestčlenske obročne spojine |
| US20110039905A1 (en) | 2008-04-25 | 2011-02-17 | Francis Hubler | Benzimidazole derivatives as calcium channel blockers |
| EP2630111B1 (en) * | 2010-10-20 | 2015-02-25 | Actelion Pharmaceuticals Ltd. | Preparation of bicyclo[2.2.2]octan-2-one compounds |
| ES2692656T3 (es) | 2010-10-20 | 2018-12-04 | Idorsia Pharmaceuticals Ltd | Preparación diastereoselectiva de los compuestos de biciclo[2.2.2]octan-2-ona |
-
2011
- 2011-10-19 EP EP11820867.7A patent/EP2630111B1/en active Active
- 2011-10-19 KR KR1020137012606A patent/KR101876594B1/ko not_active Expired - Fee Related
- 2011-10-19 CN CN201180050144.2A patent/CN103168019B/zh not_active Expired - Fee Related
- 2011-10-19 CA CA2813131A patent/CA2813131C/en active Active
- 2011-10-19 TW TW100137955A patent/TWI551583B/zh not_active IP Right Cessation
- 2011-10-19 JP JP2013534440A patent/JP5909237B2/ja not_active Expired - Fee Related
- 2011-10-19 WO PCT/IB2011/054660 patent/WO2012052939A2/en not_active Ceased
- 2011-10-19 US US13/880,520 patent/US9296673B2/en not_active Expired - Fee Related
- 2011-10-19 ES ES11820867.7T patent/ES2536897T3/es active Active
- 2011-10-19 DK DK11820867.7T patent/DK2630111T3/en active
- 2011-10-19 TW TW100137956A patent/TWI511949B/zh not_active IP Right Cessation
- 2011-10-19 HU HUE11820867A patent/HUE025195T2/en unknown
- 2011-10-19 MX MX2013004427A patent/MX2013004427A/es active IP Right Grant
-
2013
- 2013-04-15 IL IL225763A patent/IL225763A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2630111A2 (en) | 2013-08-28 |
| TWI511949B (zh) | 2015-12-11 |
| TW201217325A (en) | 2012-05-01 |
| TW201217324A (en) | 2012-05-01 |
| ES2536897T3 (es) | 2015-05-29 |
| WO2012052939A3 (en) | 2012-06-21 |
| KR20130138268A (ko) | 2013-12-18 |
| HUE025195T2 (en) | 2016-02-29 |
| KR101876594B1 (ko) | 2018-08-02 |
| IL225763A (en) | 2016-04-21 |
| CA2813131A1 (en) | 2012-04-26 |
| CN103168019B (zh) | 2015-05-27 |
| CA2813131C (en) | 2019-02-12 |
| WO2012052939A2 (en) | 2012-04-26 |
| EP2630111B1 (en) | 2015-02-25 |
| TWI551583B (zh) | 2016-10-01 |
| US20130211104A1 (en) | 2013-08-15 |
| JP5909237B2 (ja) | 2016-04-26 |
| DK2630111T3 (en) | 2015-04-20 |
| JP2013544796A (ja) | 2013-12-19 |
| IL225763A0 (en) | 2013-06-27 |
| US9296673B2 (en) | 2016-03-29 |
| CN103168019A (zh) | 2013-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |