MX2010000162A - Conversion de tebaina a la morfina derivados. - Google Patents
Conversion de tebaina a la morfina derivados.Info
- Publication number
- MX2010000162A MX2010000162A MX2010000162A MX2010000162A MX2010000162A MX 2010000162 A MX2010000162 A MX 2010000162A MX 2010000162 A MX2010000162 A MX 2010000162A MX 2010000162 A MX2010000162 A MX 2010000162A MX 2010000162 A MX2010000162 A MX 2010000162A
- Authority
- MX
- Mexico
- Prior art keywords
- conversion
- thebaine
- morphine derivatives
- morphine
- hydrocodone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención proporciona métodos para la conversión de la tebaína a un derivado de morfina, tales como hidrocodona. Se proporcionan intermediarios de cetal nuevos. Un procedimiento de un solo paso para la conversión que se compone del tratamiento de la tebaína con un ácido en la presencia de un catalizador metal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/771,259 US7928234B2 (en) | 2007-06-29 | 2007-06-29 | Conversion of thebaine to morphine derivatives |
PCT/CA2008/001178 WO2009003271A1 (en) | 2007-06-29 | 2008-06-30 | Conversion of thebaine to morphine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010000162A true MX2010000162A (es) | 2010-03-22 |
Family
ID=40161386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010000162A MX2010000162A (es) | 2007-06-29 | 2008-06-30 | Conversion de tebaina a la morfina derivados. |
Country Status (9)
Country | Link |
---|---|
US (1) | US7928234B2 (es) |
EP (1) | EP2173754A1 (es) |
JP (1) | JP2010531813A (es) |
KR (1) | KR20100055393A (es) |
CN (1) | CN101801976A (es) |
AU (1) | AU2008271863A1 (es) |
CA (1) | CA2692429C (es) |
MX (1) | MX2010000162A (es) |
WO (1) | WO2009003271A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2849988C (en) | 2011-10-03 | 2019-09-10 | Johnson Matthey Public Limited Company | Process for preparing buprenorphine |
US9127008B2 (en) | 2013-03-15 | 2015-09-08 | Johnson Matthey Public Limited Company | Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain |
AU2014298257B2 (en) * | 2013-08-02 | 2016-11-10 | Macfarlan Smith Limited | Process for the preparation of oxymorphone |
PL3065743T3 (pl) * | 2013-11-07 | 2019-12-31 | SpecGx LLC | Sposób wytwarzania 6-hydroksymorfinanów bez izolowania związków pośrednich |
US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
CA2881229C (en) | 2014-02-07 | 2022-04-05 | Tomas Hudlicky | Methods for the preparation of hydromorphone |
US10081636B2 (en) | 2016-07-08 | 2018-09-25 | Cody Laboratories, Inc. | Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates |
CN113845526B (zh) * | 2021-01-18 | 2022-11-08 | 四川大学 | 一种蒂巴因衍生物及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4277604A (en) | 1980-01-25 | 1981-07-07 | The United States Of America As Represented By The Department Of Health And Human Services | Facile synthesis of codeine precursors from thebaine |
US5668285A (en) | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
EP1893616B1 (en) | 2005-06-16 | 2010-12-29 | Mallinckrodt, Inc. | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
-
2007
- 2007-06-29 US US11/771,259 patent/US7928234B2/en not_active Expired - Fee Related
-
2008
- 2008-06-30 CA CA2692429A patent/CA2692429C/en not_active Expired - Fee Related
- 2008-06-30 MX MX2010000162A patent/MX2010000162A/es not_active Application Discontinuation
- 2008-06-30 KR KR1020107002072A patent/KR20100055393A/ko not_active Application Discontinuation
- 2008-06-30 EP EP08772838A patent/EP2173754A1/en not_active Withdrawn
- 2008-06-30 JP JP2010513589A patent/JP2010531813A/ja active Pending
- 2008-06-30 WO PCT/CA2008/001178 patent/WO2009003271A1/en active Application Filing
- 2008-06-30 AU AU2008271863A patent/AU2008271863A1/en not_active Abandoned
- 2008-06-30 CN CN200880022624A patent/CN101801976A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2010531813A (ja) | 2010-09-30 |
AU2008271863A1 (en) | 2009-01-08 |
CA2692429C (en) | 2017-03-21 |
KR20100055393A (ko) | 2010-05-26 |
US20090005563A1 (en) | 2009-01-01 |
EP2173754A1 (en) | 2010-04-14 |
US7928234B2 (en) | 2011-04-19 |
CA2692429A1 (en) | 2009-01-08 |
CN101801976A (zh) | 2010-08-11 |
WO2009003271A1 (en) | 2009-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |