MX2013000288A - Metodo para fabricar quinolina-3-carboxamidas. - Google Patents

Metodo para fabricar quinolina-3-carboxamidas.

Info

Publication number
MX2013000288A
MX2013000288A MX2013000288A MX2013000288A MX2013000288A MX 2013000288 A MX2013000288 A MX 2013000288A MX 2013000288 A MX2013000288 A MX 2013000288A MX 2013000288 A MX2013000288 A MX 2013000288A MX 2013000288 A MX2013000288 A MX 2013000288A
Authority
MX
Mexico
Prior art keywords
mixture
carboxamides
quinoline
manufacturing
vapors
Prior art date
Application number
MX2013000288A
Other languages
English (en)
Inventor
Lillemor Maria Bock
Paer Henning Holmberg
Karl-Erik Jansson
Original Assignee
Active Biotech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Biotech Ab filed Critical Active Biotech Ab
Publication of MX2013000288A publication Critical patent/MX2013000288A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un método de preparación de un compuesto de la fórmula (I) haciendo reaccionar el éster de alquilo apropiado y un derivado de anilina, en una mezcla a reflujo que contiene un solvente alifático o una mezcla de solventes alifáticos que tienen un punto de ebullición en el intervalo de 68-191 °C; condensar los vapores de la mezcla a reflujo; tratar los vapores condensados con un agente depurador del alcohol ouna mezcla de agentes depuradores del alcohol; y regresar los vapores condensados de regreso a la mezcla de la reacción.
MX2013000288A 2010-07-09 2011-07-07 Metodo para fabricar quinolina-3-carboxamidas. MX2013000288A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36284910P 2010-07-09 2010-07-09
EP10169162 2010-07-09
PCT/EP2011/061490 WO2012004338A1 (en) 2010-07-09 2011-07-07 Method for manufacturing of quinoline-3-carboxamides

Publications (1)

Publication Number Publication Date
MX2013000288A true MX2013000288A (es) 2013-05-22

Family

ID=43348982

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000288A MX2013000288A (es) 2010-07-09 2011-07-07 Metodo para fabricar quinolina-3-carboxamidas.

Country Status (21)

Country Link
US (1) US8871936B2 (es)
EP (1) EP2590949B1 (es)
JP (1) JP5881691B2 (es)
KR (1) KR101855195B1 (es)
CN (1) CN103119023B (es)
AU (1) AU2011275720B2 (es)
BR (1) BR112012033465A2 (es)
CA (1) CA2802006C (es)
DK (1) DK2590949T5 (es)
EA (1) EA021171B1 (es)
ES (1) ES2563208T3 (es)
HK (1) HK1183864A1 (es)
IL (1) IL223583A (es)
MX (1) MX2013000288A (es)
NZ (1) NZ604176A (es)
PL (1) PL2590949T3 (es)
PT (1) PT2590949E (es)
SG (1) SG186430A1 (es)
UA (1) UA108381C2 (es)
WO (1) WO2012004338A1 (es)
ZA (1) ZA201209370B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103626701A (zh) * 2012-08-28 2014-03-12 天津药物研究院 一种制备喹啉衍生物的方法
CN103626702A (zh) * 2012-08-30 2014-03-12 天津药物研究院 一种制备喹啉酮衍生物的方法
CN108358842A (zh) * 2014-08-28 2018-08-03 杭州普晒医药科技有限公司 他喹莫德的晶型及其制备方法、其药物组合物和用途
CN107108510B (zh) 2014-09-23 2020-10-23 活跃生物技术有限公司 用于治疗多发性骨髓瘤的喹啉甲酰胺
EP3180005B1 (en) 2014-11-19 2017-12-27 Active Biotech AB Quinoline carboxamides for use in the treatment of leukemia
KR101807124B1 (ko) * 2015-12-02 2017-12-07 현대자동차 주식회사 연료전지차량의 비상 운전 제어 방법
CN115209881A (zh) 2020-03-03 2022-10-18 活跃生物技术有限公司 用于组合疗法的他喹莫德或其药学上可接受的盐
CN111732540B (zh) * 2020-07-20 2020-11-13 湖南速博生物技术有限公司 一种罗喹美克的制备方法
IL300068A (en) 2020-07-23 2023-03-01 Univ Erasmus Med Ct Rotterdam S100 proteins as new therapeutic targets in myeloproliferative catalysis
JP2024503372A (ja) 2021-01-18 2024-01-25 アクティブ バイオテック エイビー 骨髄異形成症候群の処置における使用のためのタスキニモドまたはその薬学的に許容される塩
IL308542A (en) 2021-05-25 2024-01-01 Active Biotech Ab Multiparticles of tesquinimod and their use
WO2023275248A1 (en) 2021-07-02 2023-01-05 Active Biotech Ab A pharmaceutical product containing tasquinimod and a method for assessing the purity of said product
KR20230149402A (ko) 2022-04-20 2023-10-27 목포대학교산학협력단 판막 석회화 예방 또는 치료용 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868379A (en) 1972-04-28 1975-02-25 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2H-1-benzothiopyran-3-carboxylic acid 1,1-dioxide
US3769292A (en) * 1972-04-28 1973-10-30 Warner Lambert Co N-(pyridyl)2h 1-benzothiopyran-3-carboxamide-4-hydroxy 1,1-dioxides
AT345847B (de) * 1974-11-08 1978-10-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer 4-hydroxy-2h- naphtho- (2,1-e)-1,2-thiazin-3-carboxamid-1,1-dioxid und deren salze
US4786644A (en) * 1987-11-27 1988-11-22 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinolinecarboxamide
US5912349A (en) 1997-01-31 1999-06-15 Pharmacia & Upjohn Company Process for the preparation of roquinimex
US6077851A (en) 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
SE9801474D0 (sv) 1998-04-27 1998-04-27 Active Biotech Ab Quinoline Derivatives
US6133285A (en) 1998-07-15 2000-10-17 Active Biotech Ab Quinoline derivatives
US7560557B2 (en) * 2002-06-12 2009-07-14 Active Biotech Ag Process for the manufacture of quinoline derivatives
US6875869B2 (en) 2002-06-12 2005-04-05 Active Biotech Ab Process for the manufacture of quinoline derivatives
SE0201778D0 (sv) * 2002-06-12 2002-06-12 Active Biotech Ab Process for the manufacture of quinoline derivatives
JP2011512357A (ja) * 2008-02-15 2011-04-21 メルク・シャープ・エンド・ドーム・コーポレイション 縮合ピリドンｍ１受容体ポジティブアロステリックモジュレーター
EP2276740B8 (en) * 2008-04-28 2015-02-18 Actavis Group PCT ehf Improved process for preparing quinoline-3-carboxamide derivatives

Also Published As

Publication number Publication date
ZA201209370B (en) 2014-03-26
NZ604176A (en) 2014-10-31
PT2590949E (pt) 2016-03-07
EA201300103A1 (ru) 2013-06-28
AU2011275720A1 (en) 2013-01-10
EP2590949A1 (en) 2013-05-15
DK2590949T3 (en) 2016-02-29
EP2590949B1 (en) 2015-11-25
US20130109860A1 (en) 2013-05-02
CN103119023B (zh) 2014-12-24
ES2563208T3 (es) 2016-03-11
CA2802006A1 (en) 2012-01-12
WO2012004338A1 (en) 2012-01-12
IL223583A (en) 2016-03-31
SG186430A1 (en) 2013-01-30
US8871936B2 (en) 2014-10-28
CA2802006C (en) 2018-09-25
AU2011275720B2 (en) 2015-05-14
KR20130091730A (ko) 2013-08-19
JP2013529672A (ja) 2013-07-22
KR101855195B1 (ko) 2018-05-08
DK2590949T5 (en) 2016-05-23
CN103119023A (zh) 2013-05-22
UA108381C2 (uk) 2015-04-27
EA021171B1 (ru) 2015-04-30
HK1183864A1 (zh) 2014-01-10
BR112012033465A2 (pt) 2017-06-20
JP5881691B2 (ja) 2016-03-09
PL2590949T3 (pl) 2016-06-30

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