MX2012005380A - Biomarcadores secretores de proteina para expresion de una proteina de alta eficiencia. - Google Patents
Biomarcadores secretores de proteina para expresion de una proteina de alta eficiencia.Info
- Publication number
- MX2012005380A MX2012005380A MX2012005380A MX2012005380A MX2012005380A MX 2012005380 A MX2012005380 A MX 2012005380A MX 2012005380 A MX2012005380 A MX 2012005380A MX 2012005380 A MX2012005380 A MX 2012005380A MX 2012005380 A MX2012005380 A MX 2012005380A
- Authority
- MX
- Mexico
- Prior art keywords
- high efficiency
- protein
- biomarkers
- secretory
- protein expression
- Prior art date
Links
- 102000040739 Secretory proteins Human genes 0.000 title 1
- 108091058545 Secretory proteins Proteins 0.000 title 1
- 239000000090 biomarker Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención se refiere al campo de la producción de proteínas y en particular se refiere a composiciones y procesos para mejorar los niveles de producción de proteínas recombinantes expresadas en las células huésped.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25952709P | 2009-11-09 | 2009-11-09 | |
US12/941,347 US8524458B2 (en) | 2009-11-09 | 2010-11-08 | Secretory protein biomarkers for high efficiency protein expression |
PCT/US2010/055953 WO2011057239A2 (en) | 2009-11-09 | 2010-11-09 | Secretory protein biomarkers for high efficiency protein expression |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012005380A true MX2012005380A (es) | 2012-05-29 |
Family
ID=43431809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012005380A MX2012005380A (es) | 2009-11-09 | 2010-11-09 | Biomarcadores secretores de proteina para expresion de una proteina de alta eficiencia. |
Country Status (14)
Country | Link |
---|---|
US (2) | US8524458B2 (es) |
EP (1) | EP2499254A2 (es) |
JP (1) | JP2013510324A (es) |
KR (1) | KR20120115494A (es) |
CN (1) | CN102666873A (es) |
AU (1) | AU2010314922A1 (es) |
BR (1) | BR112012010976A2 (es) |
CA (1) | CA2778254A1 (es) |
IL (1) | IL219518A0 (es) |
IN (1) | IN2012DN03358A (es) |
MX (1) | MX2012005380A (es) |
RU (1) | RU2012124114A (es) |
WO (1) | WO2011057239A2 (es) |
ZA (1) | ZA201202966B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6507542B2 (ja) * | 2014-09-22 | 2019-05-08 | 東洋紡株式会社 | バイオマーカーを用いた組換えタンパク質生産量の予測方法 |
EP3255054A1 (en) | 2016-06-06 | 2017-12-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the purification of biological macromolecular complexes |
CN108467890A (zh) * | 2018-05-02 | 2018-08-31 | 首都医科大学附属北京天坛医院 | Vat1基因及vat1基因的干扰物的应用和应用vat1基因的产品 |
CN109470756B (zh) * | 2018-10-11 | 2020-08-25 | 昆明理工大学 | 测定14-3-3蛋白与质膜H+-ATPase蛋白互作的电化学方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
US5302517A (en) * | 1987-06-16 | 1994-04-12 | The Board Of Regents Of The University Of Nebraska | Method of controlling the expression of a gene in a cell culture, cell culture vector used in the method and method of making the vector |
ATE135397T1 (de) | 1988-09-23 | 1996-03-15 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
US20050272055A1 (en) * | 2000-02-01 | 2005-12-08 | Rina Das | Method of treating lethal shock induced by toxic agents and diagnosing exposure to toxic agents by measuring distinct pattern in the levels of expression of specific genes |
AU2007314524A1 (en) * | 2006-04-21 | 2008-05-08 | Dublin City University | Differential expression profiling analysis of cell culture phenotypes and the uses thereof |
US8242057B2 (en) * | 2006-06-26 | 2012-08-14 | Cleveland Biolabs, Inc. | Methods for identifying modulators of apoptosis |
CA2726563A1 (en) * | 2008-06-04 | 2009-12-10 | Proteosys Ag | Protein biomarkers for in vitro testing of developmental toxicity and embryotoxicity of chemical substances |
-
2010
- 2010-11-08 US US12/941,347 patent/US8524458B2/en not_active Expired - Fee Related
- 2010-11-09 KR KR1020127014730A patent/KR20120115494A/ko not_active Application Discontinuation
- 2010-11-09 CN CN2010800503369A patent/CN102666873A/zh active Pending
- 2010-11-09 CA CA2778254A patent/CA2778254A1/en not_active Abandoned
- 2010-11-09 IN IN3358DEN2012 patent/IN2012DN03358A/en unknown
- 2010-11-09 EP EP10778803A patent/EP2499254A2/en not_active Withdrawn
- 2010-11-09 BR BR112012010976A patent/BR112012010976A2/pt not_active IP Right Cessation
- 2010-11-09 AU AU2010314922A patent/AU2010314922A1/en not_active Abandoned
- 2010-11-09 JP JP2012538076A patent/JP2013510324A/ja active Pending
- 2010-11-09 MX MX2012005380A patent/MX2012005380A/es not_active Application Discontinuation
- 2010-11-09 WO PCT/US2010/055953 patent/WO2011057239A2/en active Application Filing
- 2010-11-09 RU RU2012124114/10A patent/RU2012124114A/ru not_active Application Discontinuation
-
2012
- 2012-04-23 ZA ZA2012/02966A patent/ZA201202966B/en unknown
- 2012-05-01 IL IL219518A patent/IL219518A0/en unknown
-
2013
- 2013-08-30 US US14/016,035 patent/US20140004531A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8524458B2 (en) | 2013-09-03 |
WO2011057239A2 (en) | 2011-05-12 |
EP2499254A2 (en) | 2012-09-19 |
RU2012124114A (ru) | 2013-12-20 |
IL219518A0 (en) | 2012-06-28 |
WO2011057239A3 (en) | 2011-06-30 |
IN2012DN03358A (es) | 2015-10-23 |
AU2010314922A1 (en) | 2012-05-31 |
CN102666873A (zh) | 2012-09-12 |
KR20120115494A (ko) | 2012-10-18 |
ZA201202966B (en) | 2012-12-27 |
US20140004531A1 (en) | 2014-01-02 |
BR112012010976A2 (pt) | 2016-08-16 |
US20110236906A1 (en) | 2011-09-29 |
JP2013510324A (ja) | 2013-03-21 |
CA2778254A1 (en) | 2011-05-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights |
Owner name: ABBVIE INC. |
|
FA | Abandonment or withdrawal |