MX2011008073A - Hidrocloruro de n-{(1-s)-2-amino -1-[(3-fluorofenil)metil]etil}-5- cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino. - Google Patents
Hidrocloruro de n-{(1-s)-2-amino -1-[(3-fluorofenil)metil]etil}-5- cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino.Info
- Publication number
- MX2011008073A MX2011008073A MX2011008073A MX2011008073A MX2011008073A MX 2011008073 A MX2011008073 A MX 2011008073A MX 2011008073 A MX2011008073 A MX 2011008073A MX 2011008073 A MX2011008073 A MX 2011008073A MX 2011008073 A MX2011008073 A MX 2011008073A
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- Mexico
- Prior art keywords
- cancer
- leukemia
- chloro
- methyl
- lymphoma
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Classifications
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
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| US14849009P | 2009-01-30 | 2009-01-30 | |
| PCT/US2010/022323 WO2010088331A1 (en) | 2009-01-30 | 2010-01-28 | Crystalline n-{(1-s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride |
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| MX2011008073A true MX2011008073A (es) | 2011-11-18 |
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| MX2011008073A MX2011008073A (es) | 2009-01-30 | 2010-01-28 | Hidrocloruro de n-{(1-s)-2-amino -1-[(3-fluorofenil)metil]etil}-5- cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino. |
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| MX2011008073A (es) | 2009-01-30 | 2011-11-18 | Glaxosmithkline Llc | Hidrocloruro de n-{(1-s)-2-amino -1-[(3-fluorofenil)metil]etil}-5- cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino. |
| US20130072507A1 (en) * | 2010-05-21 | 2013-03-21 | Glaxosmithkline Llc | Combination |
| WO2011150044A1 (en) * | 2010-05-26 | 2011-12-01 | Glaxosmithkline Llc | Combination |
| SG10201600077RA (en) * | 2011-01-11 | 2016-02-26 | Glaxosmithkline Llc | Combination |
| PE20142356A1 (es) | 2012-04-24 | 2015-01-30 | Glaxosmithkline Intellectual Property (N 2) Limited | Metodo de tratamiento de las dermatosis sensibles a los esteroides |
| CA2909434A1 (en) * | 2013-04-18 | 2014-10-23 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for inhibiting lymphocyte proliferation in a subject in need thereof |
| US20160235714A1 (en) * | 2013-10-01 | 2016-08-18 | Novartis Ag | Enzalutamide in combination with afuresertib for the treatment of cancer |
| WO2015049649A1 (en) | 2013-10-01 | 2015-04-09 | Gbglaxosmithkline Intellectual Property (No.2) Limited | Combination |
| KR20160127754A (ko) * | 2014-03-12 | 2016-11-04 | 노파르티스 아게 | Btk 억제제 및 akt 억제제를 포함하는 조합물 |
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