MX2011004174A - Metodos y composiciones para diagnosis y prognosis de lesion renal e insuficiencia renal. - Google Patents

Metodos y composiciones para diagnosis y prognosis de lesion renal e insuficiencia renal.

Info

Publication number
MX2011004174A
MX2011004174A MX2011004174A MX2011004174A MX2011004174A MX 2011004174 A MX2011004174 A MX 2011004174A MX 2011004174 A MX2011004174 A MX 2011004174A MX 2011004174 A MX2011004174 A MX 2011004174A MX 2011004174 A MX2011004174 A MX 2011004174A
Authority
MX
Mexico
Prior art keywords
soluble
methods
growth factor
receptor
ligand
Prior art date
Application number
MX2011004174A
Other languages
English (en)
Inventor
Joseph Anderberg
Jeff Gray
Kevin Nakamura
Paul Mcpherson
Original Assignee
Astute Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42119666&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2011004174(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astute Medical Inc filed Critical Astute Medical Inc
Publication of MX2011004174A publication Critical patent/MX2011004174A/es

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5088Supracellular entities, e.g. tissue, organisms of vertebrates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/34Genitourinary disorders
    • G01N2800/347Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/56Staging of a disease; Further complications associated with the disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis

Abstract

La presente invención es concerniente con métodos y composiciones para el monitoreo, diagnosis, prognosis y determinación de regímenes de tratamiento en sujetos que sufren de o sospechosos de tener lesión renal. En particular, la invención es concerniente con el uso de análisis que detectan uno o más marcadores seleccionados del grupo que consiste de aspartato aminotransferasa citoplásmica, miembro 5 de la superfamilia del receptor del factor de necrosis de tumor soluble, ligando de CD40 soluble, porción de quimiocina 16 C-X-C soluble, S100-A12, Eotaxina, E-selectina soluble, fibronectina, factor estimulador de colonia de granulocito, factor estimulador de colonia de granulocito-macrófago, factor 2 de crecimiento de enlace de heparina, receptor del factor de crecimiento de hepatocito soluble, antagonita de receptor de interleucina 1, interleucina-1 beta, interleucina-10, interleucina-15, interleucina-3, mieloperoxidasa, nidogen-1, receptor 1 de lipoproteína de baja densidad oxidado soluble, papalisina-1, ligando 1 de glicoproteina de P-selectina soluble, antileucoproteinasa, ligando de Kit soluble, inhibidor de tejido de, metaloproteinasa 1, inhibidor de tejido de metaloproteinasa 2, factor de necrosis de tumor soluble, molécula 1 de adhesión celular vascular soluble y factor A de crecimiento endotelial vascular como biomarcadores de diagnóstico y prognóstico en lesiones renales.
MX2011004174A 2008-10-21 2009-10-21 Metodos y composiciones para diagnosis y prognosis de lesion renal e insuficiencia renal. MX2011004174A (es)

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
US10730408P 2008-10-21 2008-10-21
US10729008P 2008-10-21 2008-10-21
US10730108P 2008-10-21 2008-10-21
US10728108P 2008-10-21 2008-10-21
US10729708P 2008-10-21 2008-10-21
US11302108P 2008-11-10 2008-11-10
US11309608P 2008-11-10 2008-11-10
US11310208P 2008-11-10 2008-11-10
US11304508P 2008-11-10 2008-11-10
US11305608P 2008-11-10 2008-11-10
US11305008P 2008-11-10 2008-11-10
US11308308P 2008-11-10 2008-11-10
US11501908P 2008-11-14 2008-11-14
US11501708P 2008-11-14 2008-11-14
US11502208P 2008-11-14 2008-11-14
US11505708P 2008-11-15 2008-11-15
US11504808P 2008-11-15 2008-11-15
US11504508P 2008-11-15 2008-11-15
US11505108P 2008-11-15 2008-11-15
US11504708P 2008-11-15 2008-11-15
US11504408P 2008-11-15 2008-11-15
US11714008P 2008-11-22 2008-11-22
US11715408P 2008-11-22 2008-11-22
US11716708P 2008-11-22 2008-11-22
US11715208P 2008-11-22 2008-11-22
US11714608P 2008-11-22 2008-11-22
US11715708P 2008-11-22 2008-11-22
US11714108P 2008-11-22 2008-11-22
US11717208P 2008-11-22 2008-11-22
PCT/US2009/061561 WO2010048346A1 (en) 2008-10-21 2009-10-21 Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Publications (1)

Publication Number Publication Date
MX2011004174A true MX2011004174A (es) 2011-09-27

Family

ID=42119666

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011004174A MX2011004174A (es) 2008-10-21 2009-10-21 Metodos y composiciones para diagnosis y prognosis de lesion renal e insuficiencia renal.

Country Status (13)

Country Link
US (3) US8778615B2 (es)
EP (4) EP3974836A1 (es)
JP (4) JP2012506537A (es)
KR (1) KR101760314B1 (es)
CN (6) CN104391116B (es)
AU (1) AU2009308497B2 (es)
BR (1) BRPI0919640A2 (es)
CA (1) CA2740788C (es)
ES (1) ES2836218T3 (es)
HK (1) HK1159755A1 (es)
MX (1) MX2011004174A (es)
NZ (3) NZ607703A (es)
WO (1) WO2010048346A1 (es)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG187453A1 (en) 2008-01-18 2013-02-28 Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
GB0807214D0 (en) 2008-04-21 2008-05-28 Belfast Health And Social Care Biomarkers
BRPI0917711A2 (pt) 2008-08-28 2017-06-20 Astute Medical Inc método para avaliar o estado renal em um paciente, e, uso de um ou mais marcadores de lesão renal
WO2010025434A1 (en) * 2008-08-29 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3974836A1 (en) 2008-10-21 2022-03-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2740923A1 (en) * 2008-10-21 2010-04-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
BRPI0922021A2 (pt) 2008-11-10 2019-09-24 Astute Medical Inc método para avaliar a condição renal em um indivíduo, e, uso de um ou mais marcadores de lesão renal
NZ604873A (en) * 2008-11-22 2014-05-30 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2462440B1 (en) 2009-08-07 2017-05-17 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ599105A (en) * 2009-09-21 2014-08-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EA201290192A1 (ru) 2009-11-07 2013-02-28 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности
MX2012005210A (es) * 2009-11-07 2012-08-03 Astute Medical Inc Metodos y composiciones para diagnostico y pronostico de lesion renal y falla renal.
US20120156701A1 (en) * 2009-12-20 2012-06-21 Joseph Anderberg Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2784889C (en) 2009-12-20 2018-06-19 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ700695A (en) 2010-02-05 2016-05-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9029093B2 (en) 2010-02-26 2015-05-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2585825B1 (en) 2010-06-23 2018-01-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2011269775B2 (en) 2010-06-23 2015-01-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2011279712B2 (en) * 2010-07-14 2015-06-18 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104569395A (zh) * 2010-07-19 2015-04-29 霍夫曼-拉罗奇有限公司 鉴定响应抗癌疗法的可能性升高的患者的方法
US20120053073A1 (en) 2010-07-23 2012-03-01 President And Fellows Of Harvard College Methods for Detecting Signatures of Disease or Conditions in Bodily Fluids
WO2012012704A2 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting kidney-associated diseases or conditions
CA2806293A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
MX2013000917A (es) 2010-07-23 2013-07-05 Harvard College Metodos para detectar las enfermedades o condiciones usando celulas fagociticas.
CA2806304A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
WO2012094658A2 (en) * 2011-01-08 2012-07-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2012094657A1 (en) * 2011-01-08 2012-07-12 Astute Medical, Inc. Method and compositions for diagnosis and prognosis of renal injury and renal failure
EP2668497B1 (en) * 2011-01-26 2020-03-25 University of Pittsburgh - Of the Commonwealth System of Higher Education Urine biomarkers for prediction of recovery after acute kidney injury : proteomics
EP2518512A1 (en) 2011-04-29 2012-10-31 Medizinische Universität Wien Method for indicating a renal disease in a patient by determining at least one protein in isolated HDL
EP2707524A4 (en) * 2011-05-12 2015-05-06 Astute Medical Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency
EP3489690A1 (en) * 2011-08-26 2019-05-29 Astute Medical, Inc. Methods and compositions for evaluation of the renal status
ES2734494T3 (es) * 2011-12-08 2019-12-10 Astute Medical Inc Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal
WO2013113018A1 (en) * 2012-01-28 2013-08-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2865563A1 (en) * 2012-02-27 2013-09-06 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20150010929A1 (en) * 2012-02-27 2015-01-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
GB201210571D0 (en) 2012-06-14 2012-08-01 Belfast Health And Social Care Trust Predictive biomarker
GB201210587D0 (en) * 2012-06-14 2012-08-01 Belfast Health And Social Care Trust Predictive biomarker
GB201214440D0 (en) * 2012-08-13 2012-09-26 Randox Lab Ltd Kidney disease biomarker
EP2719771A1 (en) * 2012-10-11 2014-04-16 Ciber de Enfermedades Respiratorias (CIBERES) Marker for assessing the risk of developing acute kidney injury
CA3158996A1 (en) 2013-01-17 2014-07-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US11585814B2 (en) 2013-03-09 2023-02-21 Immunis.Ai, Inc. Methods of detecting prostate cancer
EP2965077B1 (en) 2013-03-09 2022-07-13 Harry Stylli Methods of detecting cancer
MX2016001573A (es) 2013-08-07 2016-09-07 Astute Medical Inc Ensayos para timp2 con mejor rendimiento en muestras biológicas.
EP2843414B1 (en) * 2013-08-26 2018-09-19 Roche Diagniostics GmbH Marker for statin treatment stratification in heart failure
WO2015084939A1 (en) 2013-12-03 2015-06-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
SG11201607487UA (en) * 2014-03-21 2016-10-28 Sanofi Aventis Deutschland New markers for the assessment of the risk for development of a cardiovascular disorder
AU2015314813B2 (en) 2014-09-11 2022-02-24 Immunis.Ai, Inc. Methods of detecting prostate cancer
ES2943579T3 (es) 2014-12-18 2023-06-14 Astute Medical Inc Procedimientos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
US10611123B2 (en) 2015-02-20 2020-04-07 3M Innovative Properties Company Silicone carbonate polymers as release layers for pressure sensitive adhesive containing articles
US11243202B2 (en) 2015-04-09 2022-02-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2016176483A1 (en) * 2015-04-28 2016-11-03 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US11506672B2 (en) * 2015-06-11 2022-11-22 Astute Medical, Inc. Follistatin-related protein 3 for diagnosis and prognosis of renal injury and renal failure
CN109844526A (zh) 2016-06-06 2019-06-04 机敏医药股份有限公司 使用胰岛素样生长因子结合蛋白7和金属蛋白酶2的组织抑制剂管理急性肾损伤
CN106370856B (zh) * 2016-08-16 2019-04-02 北京师范大学 肺纤维化的尿液蛋白标志物及其在诊断和预后中的用途
JP7100030B2 (ja) 2016-10-28 2022-07-12 アスチュート メディカル,インコーポレイテッド 腎機能の改善のためのtimp-2に対する抗体の使用
JP2018096710A (ja) * 2016-12-08 2018-06-21 国立大学法人金沢大学 血中タンパク質を測定することにより、ネフローゼ症候群の疾患活動性を判定する方法
WO2018117011A1 (ja) 2016-12-19 2018-06-28 国立大学法人大阪大学 インビトロでのIgM型メモリーB細胞分化培養系を用いた臓器移植後抗体関連型拒絶反応の早期診断法
WO2018145117A1 (en) 2017-02-06 2018-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP7315466B2 (ja) 2017-04-05 2023-07-26 アスチュート メディカル,インコーポレイテッド 生体試料中において改善した性能を有する、timp2に関するアッセイ
CN109975553B (zh) * 2017-12-28 2020-10-09 北京师范大学 慢性阻塞性肺病的尿液蛋白标志物及其在早期诊断中的用途
US11435364B2 (en) 2018-05-24 2022-09-06 Renibus Therapeutics, Inc. Methods of treating patients at risk for renal injury and renal failure
KR102319190B1 (ko) * 2018-12-19 2021-10-29 서울대학교병원 신장 질환 진단용 바이오 마커
KR102077987B1 (ko) * 2018-12-19 2020-02-17 주식회사 헬릭스미스 신장 질환 진단용 바이오 마커
RU2726314C1 (ru) * 2019-11-15 2020-07-14 Федеральное государственное бюджетное образовательное учреждение высшего образования "Тихоокеанский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ раннего прогнозирования риска острого повреждения почек у пациентов с ишемической болезнью сердца после реваскуляризации миокарда методом аортокоронарного шунтирования
CN115469026B (zh) * 2022-07-14 2023-10-20 中日友好医院(中日友好临床医学研究所) 用于检测环孢素a肾毒性相关标志物的检测试剂、试剂盒及其用途

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1429031A1 (ru) 1986-06-20 1988-10-07 Калининский Государственный Медицинский Институт Способ дифференциальной диагностики гломерулонефрита и пиелонефрита
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
AU658374B2 (en) 1990-09-14 1995-04-13 Biosite Diagnostics Incorporated Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
US5955377A (en) 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
EP0585310B1 (en) 1991-04-10 1999-03-17 Biosite Diagnostics Inc. Crosstalk inhibitors and their uses
ES2150915T3 (es) 1991-04-12 2000-12-16 Biosite Diagnostics Inc Nuevos conjugados y dosificados destinados para la deteccion simultanea de ligandos multiples.
US6019944A (en) 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5494829A (en) 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
JP3569577B2 (ja) * 1995-09-04 2004-09-22 株式会社いかがく 腎・尿路系疾患の鑑別診断用キット
JP3599895B2 (ja) * 1996-04-05 2004-12-08 株式会社いかがく 糖尿病性腎症および糸球体腎炎の早期診断用キット
US6498142B1 (en) * 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
ES2258793T5 (es) * 1996-05-24 2010-01-25 Biogen Idec Ma Inc. Moduladores de la regeneracion tisular.
US5753455A (en) 1996-09-03 1998-05-19 Bayer Corporation Method for the detection of lysozyme using a protein error indicator dye in conjunction with an alkane sulfonic acid
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
JP2002512524A (ja) 1997-06-03 2002-04-23 財団法人相模中央化学研究所 膜貫通ドメインを有するヒト蛋白質及びそれをコードするdna
US20060223077A1 (en) * 1997-06-06 2006-10-05 Human Genome Sciences, Inc. 207 human secreted proteins
US6218122B1 (en) * 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
US6958147B1 (en) * 1998-10-26 2005-10-25 Licentia Ltd Use of VEGF-C to prevent restenosis
MXPA01006404A (es) * 1998-12-21 2003-06-06 Univ Monash Deteccion y tratamiento de enfermedad renal.
WO2001028500A2 (en) * 1999-10-18 2001-04-26 The Board Of Trustees Of The University Of Arkansas Uses of antileukoprotease in carcinoma
EP1282823B1 (en) 2000-05-17 2014-05-07 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Proteolytic enzymes for the diagnosis of kidney disorders
US20020115626A1 (en) 2000-05-25 2002-08-22 Luca Rastelli Method of detecting inflammatory lung disorders
RU2180965C1 (ru) 2000-07-03 2002-03-27 Габбасова Наталья Вадимовна Способ дифференциальной диагностики заболеваний почек
AU2002216273A1 (en) * 2000-12-29 2002-07-16 Oxford Glycosciences (Uk) Limited Proteins, genes and their use for diagnosis and treatment of kidney response
CA2442820A1 (en) * 2001-03-29 2002-10-10 Van Andel Institute Microarray gene expression profiling in clear cell renal cell carcinoma: prognosis and drug target identification
US20070015146A1 (en) * 2001-05-22 2007-01-18 Gene Logic, Inc. Molecular nephrotoxicology modeling
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20030003588A1 (en) * 2001-06-28 2003-01-02 Comper Wayne D. Method for kidney disease detection by protein profiling
DE60237455D1 (de) * 2001-07-12 2010-10-07 Kyowa Medex Co Ltd Verfahren zur quantifizierung von denaturiertem lipoprotein
HUP0400659A3 (en) * 2001-07-24 2005-06-28 Zhu Zhou Woodbridge Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease
US6784154B2 (en) * 2001-11-01 2004-08-31 University Of Utah Research Foundation Method of use of erythropoietin to treat ischemic acute renal failure
US8404229B2 (en) * 2001-12-07 2013-03-26 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to treat acute tubular necrosis
GB0130557D0 (en) 2001-12-20 2002-02-06 Serono Internat S A Proteins
AU2003219275B2 (en) 2002-03-07 2008-01-24 Cambridge Enterprise Ltd SCD fingerprints
EP1532268A4 (en) * 2002-03-21 2006-07-05 Yissum Res Dev Co PERIPHERAL BLOOD CELL MARKERS USEFUL IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS AND METHODS AND KITS COMPRISING SUCH MARKERS
US7138230B2 (en) * 2002-12-06 2006-11-21 Renovar, Inc. Systems and methods for characterizing kidney diseases
US7138229B2 (en) * 2002-12-06 2006-11-21 Renovar, Inc. Systems and methods for characterizing kidney diseases
US20040029200A1 (en) * 2002-05-22 2004-02-12 Thomas Weimbs Method and kits for the detection of renal cell carcinoma in a biological fluid of a patient
AU2003281287A1 (en) 2002-07-04 2004-01-23 Oxford Glycosciences (Uk) Ltd Toxicity markers
US6941172B2 (en) * 2002-11-18 2005-09-06 Zvi Nachum Method and device for restoring kidney function using electromagnetic stimulation
US20060063156A1 (en) * 2002-12-06 2006-03-23 Willman Cheryl L Outcome prediction and risk classification in childhood leukemia
JP2005120070A (ja) 2003-03-10 2005-05-12 Taisho Pharmaceut Co Ltd エラスターゼ遊離抑制剤及び脳梗塞治療薬
CN1791797A (zh) * 2003-03-27 2006-06-21 儿童医院医疗中心 用于检测肾小管细胞损伤的早发的方法和试剂盒
US7354584B2 (en) * 2003-04-11 2008-04-08 Medimmune, Inc. Recombinant IL-9 antibodies
WO2005002416A2 (en) * 2003-06-04 2005-01-13 Joslin Diabetes Center, Inc. Predictors of renal disease
US20050148029A1 (en) * 2003-09-29 2005-07-07 Biosite, Inc. Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
GB0329288D0 (en) * 2003-12-18 2004-01-21 Inverness Medical Switzerland Monitoring method and apparatus
US20070280930A1 (en) 2004-03-17 2007-12-06 Kasper Mathias Antoon Rouschop Cd44-Targeting for Reducing/Preventing Ischemia-Reperfusion-Injury
BRPI0510266A (pt) * 2004-04-26 2007-10-30 Childrens Medical Center métodos para a detecção de uma doença ou distúrbio angiogênico em um indivìduo, para a detecção de cáncer em um indivìduo, para o tratamento de um indivìduo afetado com uma doença ou distúrbio angiogênico, para a determinação da probabilidade de eficácia de uma terapia anti-angiogênica, para a determinação da eficácia de uma terapia de teste na modulação dos nìveis de reguladores angiogênicos de plaqueta, para a criação de um registro ou perfil de plaqueta para uma doença ou distúrbio angiogênico e para a monitoração da eficácia de uma terapia em um indivìduo com uma doença ou distúrbio angiogênico
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
CN101010001A (zh) * 2004-05-06 2007-08-01 哥伦比亚大学受托人 Ngal用于减少和改善局部缺血和肾中毒损伤
FR2872579B1 (fr) 2004-06-30 2006-11-24 Pasteur Institut Detection de la tuberculose et de l'infection par mycobacterium tuberculosis a l'aide de hbha
US20080038192A1 (en) * 2004-07-19 2008-02-14 Neurochem Inc. Diagnostic Methods Of Multiple Organ Amyloidosis
US7588892B2 (en) * 2004-07-19 2009-09-15 Entelos, Inc. Reagent sets and gene signatures for renal tubule injury
US7141382B1 (en) * 2004-10-12 2006-11-28 Parikh Chirag R Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality
WO2006083986A2 (en) 2005-02-01 2006-08-10 Government Of The U.S.A, As Represented By The Secretary Department Of Health & Human Services Biomarkers for tissue status
DE102005005872A1 (de) 2005-02-09 2006-08-10 Deutsche Thomson-Brandt Gmbh Getaktete Stromversorgung
EP2604703B1 (en) * 2005-03-14 2017-02-01 The Board of Trustees of the Leland Stanford Junior University Methods for evaluating graft survival in a solid organ transplant recipient
US7608413B1 (en) * 2005-03-25 2009-10-27 Celera Corporation Kidney disease targets and uses thereof
US20070037232A1 (en) * 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
EP1877559B1 (en) * 2005-04-18 2010-10-13 Mitomics Inc. Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
US20070087387A1 (en) * 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
US20090178145A1 (en) 2005-05-11 2009-07-09 The Procter & Gamble Company Methods and targets for identifying compounds for regulating angiogenesis
JP4067557B2 (ja) * 2005-06-03 2008-03-26 持田製薬株式会社 抗cd14抗体融合蛋白質
CA2614935A1 (en) * 2005-07-21 2007-02-01 The Johns Hopkins University Methods of detecting and treating acute kidney injury
US7759077B2 (en) * 2005-08-02 2010-07-20 Shariat Shahrokh F Soluble fas urinary marker for the detection of bladder transitional cell carcinoma
EP1757940A1 (en) * 2005-08-26 2007-02-28 Cézanne S.A.S. In vitro method for diagnosing and monitoring renal cell carcinoma (RCC) using MMP-7 as humoral biomarker for RCC
ES2331252T3 (es) * 2005-09-20 2009-12-28 Peter Jon Nelson Inhibidor tisular de metaloproteinasas (timp) unido a anclajes de glucosilfosfatidilinositol (gpi) para el tratamiento del cancer.
EP1931990A4 (en) 2005-10-03 2010-03-10 Biosite Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND / OR FORECASTING IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROMES
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
US8329408B2 (en) * 2005-10-31 2012-12-11 Bayer Healthcare Llc Methods for prognosis and monitoring cancer therapy
US10716749B2 (en) * 2005-11-03 2020-07-21 Palo Alto Investors Methods and compositions for treating a renal disease condition in a subject
US20080133141A1 (en) * 2005-12-22 2008-06-05 Frost Stephen J Weighted Scoring Methods and Use Thereof in Screening
TW200726845A (en) * 2006-01-02 2007-07-16 Nat Defense Medical Ct Biomarker molecular of renal illness and detecting method for the same
KR20080085093A (ko) * 2006-01-12 2008-09-22 얀센 파마슈티카 엔.브이. 키마아제에 의한 slpi의 프로세싱
US20070203216A1 (en) * 2006-02-14 2007-08-30 Bjarke Ebert Method of treating inflammatory diseases
US7623910B2 (en) 2006-03-10 2009-11-24 University Of Rochester ECG-based differentiation of LQT1 and LQT2 mutation
GB0605217D0 (en) * 2006-03-15 2006-04-26 Novartis Ag Method and compositions for assessing acute rejection
GB0606776D0 (en) * 2006-04-03 2006-05-10 Novartis Pharma Ag Predictive biomarkers for chronic allograft nephropathy
GB0607943D0 (en) 2006-04-21 2006-05-31 Novartis Ag Biomarkers for chronic transplant dysfunction
US7662578B2 (en) * 2006-04-21 2010-02-16 Children's Hospital Medical Center Method and kit for the early detection of impaired renal status
US20080038269A1 (en) * 2006-05-25 2008-02-14 Mount Sinai Hospital Methods for detecting and treating kidney disease
WO2008084331A2 (en) 2006-06-21 2008-07-17 Hopitaux Universitaires De Geneve Biomarkers for renal disorders
WO2008005375A2 (en) * 2006-06-30 2008-01-10 Merck & Co., Inc. Kidney toxicity biomarkers
EP2049713A4 (en) * 2006-07-21 2010-06-16 Univ Alberta TISSUE REJECTION
GB0617429D0 (en) 2006-09-05 2006-10-18 Electrophoretics Ltd Markers of renal transplant rejection and renal damage
US20080206794A1 (en) * 2006-09-15 2008-08-28 Renovar Incorporated Systems And Methods For Characterizing Contrast Induced-Nephropathy
WO2008061149A2 (en) 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for diagnosis and prognosis of renal artery stenosis
WO2008060607A2 (en) 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
CA2665489C (en) * 2006-12-08 2017-08-29 The Children's Hospital Of Philadelphia Prrg4-associated compositions and methods of use thereof in methods of tumor diagnosis
GB0701626D0 (en) * 2007-01-22 2007-03-07 Cambridge Entpr Ltd Methods and biomarkers for diagnosing and monitoring psychotic disorders
WO2008104803A2 (en) 2007-02-26 2008-09-04 Oxford Genome Sciences (Uk) Limited Proteins
ES2430290T3 (es) 2007-03-06 2013-11-19 F. Hoffmann-La Roche Ag Utilización de péptidos de tipo PNC para predecir la necesidad de diálisis
JP5105583B2 (ja) * 2007-03-14 2012-12-26 国立大学法人信州大学 心血管系疾患既往区別方法
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
ES2397484T3 (es) 2007-03-26 2013-03-07 Novartis Ag Biomarcadores predictivos de seguridad renal y firmas de biomarcadores para monitorizar la función renal
WO2008122670A2 (en) 2007-04-10 2008-10-16 Integragen Human diabetes susceptibility tnfrsf10b gene
US8080394B2 (en) * 2007-04-27 2011-12-20 Brigham And Women's Hospital Method for determining predisposition to pulmonary infection
WO2008150488A1 (en) * 2007-06-01 2008-12-11 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
EP2160478B1 (en) 2007-06-06 2014-08-27 Siemens Healthcare Diagnostics Inc. Predictive diagnostics for kidney disease
US20090047689A1 (en) * 2007-06-20 2009-02-19 John Kolman Autoantigen biomarkers for early diagnosis of lung adenocarcinoma
US20100267041A1 (en) * 2007-09-14 2010-10-21 Predictive Biosciences, Inc. Serial analysis of biomarkers for disease diagnosis
WO2009038742A2 (en) 2007-09-20 2009-03-26 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Method for estimating risk of acute kidney injury
US8039227B2 (en) * 2007-09-20 2011-10-18 University Of Louisville Research Foundation, Inc. Peptide biomarkers predictive of renal function decline and kidney disease
US8003333B2 (en) * 2007-09-28 2011-08-23 Mayo Foundation For Medical Education And Research Serum biomarkers for early detection of acute cellular rejection
BRPI0907802A2 (pt) 2008-02-29 2016-08-23 Univ Nagoya Nat Univ Corp biomarcador para lesão renal aguda e estimativa de seu prognóstico, e sua aplicação
WO2009146450A2 (en) * 2008-05-30 2009-12-03 Therapeutic Monitoring Services, L.L.C. Methods for monitoring immunosuppressant drug levels, renal function, and hepatic function using small volume samples
US8241861B1 (en) * 2008-07-08 2012-08-14 Insilicos, Llc Methods and compositions for diagnosis or prognosis of cardiovascular disease
US20110190156A1 (en) 2008-07-15 2011-08-04 Trustees Of Dartmouth College Molecular signatures for diagnosing scleroderma
EP2149613A1 (en) * 2008-07-28 2010-02-03 Greenwood Genetic Center, Inc. Methods for determining dysregulation of methylation of brain expressed genes on the X chromosome to diagnose autism spectrum disorders
WO2010022210A2 (en) * 2008-08-21 2010-02-25 Pxbiosciences Llc Diagnosis and monitoring of renal failure using peptide biomarkers
BRPI0917711A2 (pt) * 2008-08-28 2017-06-20 Astute Medical Inc método para avaliar o estado renal em um paciente, e, uso de um ou mais marcadores de lesão renal
WO2010025434A1 (en) 2008-08-29 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US8501489B2 (en) * 2008-09-26 2013-08-06 University of Pittsburgh—of the Commonwealth System of Higher Education Urinary biomarkers to predict long-term dialysis
EP3974836A1 (en) 2008-10-21 2022-03-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2740923A1 (en) 2008-10-21 2010-04-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
BRPI0922021A2 (pt) 2008-11-10 2019-09-24 Astute Medical Inc método para avaliar a condição renal em um indivíduo, e, uso de um ou mais marcadores de lesão renal
US9229010B2 (en) * 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ594771A (en) 2009-02-06 2013-06-28 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and failure
WO2010111746A1 (en) 2009-04-03 2010-10-07 Vegenics Limited Anti-vegf-d antibodies
US20120183543A1 (en) 2009-05-08 2012-07-19 Novartis Ag Diagnostic biomarkers for fibrotic disorders
EP2462447A4 (en) * 2009-08-07 2013-01-30 Rules Based Medicine Inc METHODS AND DEVICES FOR DETECTING RENAL INJURY
NZ599105A (en) * 2009-09-21 2014-08-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2784889C (en) 2009-12-20 2018-06-19 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ700695A (en) 2010-02-05 2016-05-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9029093B2 (en) 2010-02-26 2015-05-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2011269775B2 (en) 2010-06-23 2015-01-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20130210043A1 (en) 2010-06-23 2013-08-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20130035290A1 (en) * 2011-05-17 2013-02-07 Yale University Chitinase-3-Like Protein 1 as a Biomarker of Recovery from Kidney Injury
EP3489690A1 (en) 2011-08-26 2019-05-29 Astute Medical, Inc. Methods and compositions for evaluation of the renal status
ES2734494T3 (es) 2011-12-08 2019-12-10 Astute Medical Inc Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal
CA3158996A1 (en) 2013-01-17 2014-07-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2014197729A1 (en) 2013-06-05 2014-12-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
MX2016001573A (es) 2013-08-07 2016-09-07 Astute Medical Inc Ensayos para timp2 con mejor rendimiento en muestras biológicas.
CA2929547C (en) 2013-11-06 2023-02-28 Astute Medical, Inc. Assays for igfbp7 having improved performance in biological samples
WO2015084939A1 (en) 2013-12-03 2015-06-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US11243202B2 (en) 2015-04-09 2022-02-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN109844526A (zh) 2016-06-06 2019-06-04 机敏医药股份有限公司 使用胰岛素样生长因子结合蛋白7和金属蛋白酶2的组织抑制剂管理急性肾损伤
JP7100030B2 (ja) 2016-10-28 2022-07-12 アスチュート メディカル,インコーポレイテッド 腎機能の改善のためのtimp-2に対する抗体の使用
WO2018145117A1 (en) 2017-02-06 2018-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP7315466B2 (ja) 2017-04-05 2023-07-26 アスチュート メディカル,インコーポレイテッド 生体試料中において改善した性能を有する、timp2に関するアッセイ
WO2018208684A1 (en) 2017-05-07 2018-11-15 Astute Medical, Inc. Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy

Also Published As

Publication number Publication date
JP2014139569A (ja) 2014-07-31
CN104399089A (zh) 2015-03-11
JP2019023641A (ja) 2019-02-14
JP2012506537A (ja) 2012-03-15
EP2364444A4 (en) 2012-08-08
CN104391116A (zh) 2015-03-04
JP2017032581A (ja) 2017-02-09
CN102246035B (zh) 2014-10-22
EP3246707A1 (en) 2017-11-22
NZ592358A (en) 2013-05-31
AU2009308497B2 (en) 2014-10-23
CN103760359B (zh) 2017-01-11
JP6580227B2 (ja) 2019-09-25
US11754566B2 (en) 2023-09-12
CA2740788C (en) 2023-03-14
ES2836218T3 (es) 2021-06-24
KR101760314B1 (ko) 2017-07-21
WO2010048346A1 (en) 2010-04-29
US8778615B2 (en) 2014-07-15
HK1159755A1 (en) 2012-08-03
US20210055298A1 (en) 2021-02-25
JP6400651B2 (ja) 2018-10-03
CA2740788A1 (en) 2010-04-29
NZ607703A (en) 2014-09-26
US10823733B2 (en) 2020-11-03
JP6247948B2 (ja) 2017-12-13
CN104391115A (zh) 2015-03-04
CN103760359A (zh) 2014-04-30
EP2364444A1 (en) 2011-09-14
EP3974836A1 (en) 2022-03-30
CN106370857A (zh) 2017-02-01
CN104391116B (zh) 2016-09-07
BRPI0919640A2 (pt) 2016-05-03
EP3246707B1 (en) 2020-09-30
CN102246035A (zh) 2011-11-16
CN104399089B (zh) 2017-04-19
NZ628843A (en) 2016-02-26
EP3783363A1 (en) 2021-02-24
KR20110084263A (ko) 2011-07-21
US20140323594A1 (en) 2014-10-30
US20110201038A1 (en) 2011-08-18
AU2009308497A1 (en) 2010-04-29
CN104391115B (zh) 2017-04-19

Similar Documents

Publication Publication Date Title
MX2011004174A (es) Metodos y composiciones para diagnosis y prognosis de lesion renal e insuficiencia renal.
MX341191B (es) Metodos y composiciones para diagnostico y prognosis de lesion renal y falla renal.
SG10201407718WA (en) Compounds and methods for kinase modulation, and indications therefor
MX342967B (es) Metodos y composiciones para la diagnosis y prognosis de lesion renal y falla renal.
EP2743702A3 (en) Methods and compositions for diagnosis and prognosis of renal injury and renal failure
BRPI0413028A (pt) composto, uso de um composto, composição farmacêutica, e, kit farmacêutico
SG162807A1 (en) Azaindazole compounds and methods of use
MX2007003470A (es) Compuestos de carbonilo los cuales pueden utilizarse como inhibidores del factor de coagulacion xa.
EP1773294A4 (en) COMPOSITIONS FOR THE DELIVERY OF HIGHLY WATER-SOLUBLE DRUGS
IL201284A (en) K3pi alpha pyridopyrimidinone inhibitor for use in combination with one or more therapeutic agents selected from Taxol, Rapamycin, Carboplatin and Arlutinib for cancer treatment
WO2007143211A3 (en) Methods for identifying agents and their use for the prevention of restenosis
WO2007136790A3 (en) Intracellular kinase inhibitors
GEP20115239B (en) Pyrazoline compounds as mineralocorticoid receptor antagonists
EA200801046A1 (ru) Неинвазивный способ выявления переходно-клеточной карциномы мочевого пузыря in vitro
Yang et al. Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated
EE200100459A (et) Ravimaine kombinatsioonis prootonpumba inhibiitori või H2 retseptori antagonistiga ning neid sisaldav farmatseutiline kompositsioon kasutamiseks mao-soolkonna häirete ravis
BRPI0707040B8 (pt) Método in vitro de seleção de um composto, método in vitro de previsão da presença de câncer, método de determinação in vitro da eficiência de um tratamento anticancerígeno e uso de um composto
EP2527466A3 (en) Genetic variants on CHR2 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
EP2585826A4 (en) METHODS AND COMPOSITIONS FOR DIAGNOSING AND PROGNOSING RENAL INJURY AND RENAL FAILURE
ATE531721T1 (de) Cyanoaminochinolone als gsk-3-inhibitoren
WO2007076294A3 (en) Method of screening the activity of the smoothened receptor to identify theraputic modulation agents or diagnose disease
GB2451987A (en) Assessment of the effects of topical administration of chemodenervating pharmaceuticals
BRPI0512379A (pt) composições farmacêuticas compreendendo inibidores de nep, inibidores do sistema de produção de endotelina endógena e antagonista do receptor at1
Bracarda et al. Protein kinase inhibitors in the treatment of renal cell carcinoma: sorafenib
MX2009004436A (es) Derivados de quinazolina macrociclicos como inhibidores del factor de crecimiento endotelial vascular r3.

Legal Events

Date Code Title Description
FG Grant or registration