MX2010006438A - Derivados de tetrahidro-imidazo [1,5-a] pirazina proceso de preparacion y su uso medicinal. - Google Patents

Derivados de tetrahidro-imidazo [1,5-a] pirazina proceso de preparacion y su uso medicinal.

Info

Publication number
MX2010006438A
MX2010006438A MX2010006438A MX2010006438A MX2010006438A MX 2010006438 A MX2010006438 A MX 2010006438A MX 2010006438 A MX2010006438 A MX 2010006438A MX 2010006438 A MX2010006438 A MX 2010006438A MX 2010006438 A MX2010006438 A MX 2010006438A
Authority
MX
Mexico
Prior art keywords
imidazo
tetrahydro
preparation methods
pyrazine derivatives
medical uses
Prior art date
Application number
MX2010006438A
Other languages
English (en)
Inventor
Peng Cho Tang
Yang Wang
Tao Yang
Fanglong Yang
Jiang Fan
Hu Feng
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2010006438A publication Critical patent/MX2010006438A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Derivados de tetrahidro-imidazol, [l,5-a]pirazina de la fórmula (I), sus métodos de preparación, composiciones farmacéuticas que contienen estos derivados, y sus usos como medicamentos, especialmente como inhibidores de la dipeptidil-peptidasa IV, donde los sustituyentes de la fórmula (I) se definen como en la descripción. (Ver fórmula I).
MX2010006438A 2007-12-26 2008-11-27 Derivados de tetrahidro-imidazo [1,5-a] pirazina proceso de preparacion y su uso medicinal. MX2010006438A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA2007103023359A CN101468988A (zh) 2007-12-26 2007-12-26 哌嗪类衍生物,其制备方法及其在医药上的应用
PCT/CN2008/001936 WO2009082881A1 (fr) 2007-12-26 2008-11-27 Dérivés de tétrahydroimidazo[1,5-a]pyrazine, leurs procédés de préparation et leurs utilisations médicales

Publications (1)

Publication Number Publication Date
MX2010006438A true MX2010006438A (es) 2010-10-13

Family

ID=40823770

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010006438A MX2010006438A (es) 2007-12-26 2008-11-27 Derivados de tetrahidro-imidazo [1,5-a] pirazina proceso de preparacion y su uso medicinal.

Country Status (16)

Country Link
US (2) US8207161B2 (es)
EP (1) EP2230241B1 (es)
JP (1) JP5481008B2 (es)
KR (1) KR101685103B1 (es)
CN (2) CN101468988A (es)
AU (1) AU2008342461B2 (es)
BR (1) BRPI0821440A2 (es)
CA (1) CA2706735C (es)
ES (1) ES2529435T3 (es)
HK (1) HK1134817A1 (es)
MX (1) MX2010006438A (es)
PT (1) PT2230241E (es)
RU (1) RU2483070C2 (es)
UA (1) UA101002C2 (es)
WO (1) WO2009082881A1 (es)
ZA (1) ZA201004154B (es)

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CN101899048B (zh) * 2009-05-27 2013-04-17 上海恒瑞医药有限公司 (R)-7-[3-氨基-4-(2,4,5-三氟-苯基)-丁酰]-3-三氟甲基-5,6,7,8-四氢-咪唑并[1,5-a]吡嗪-1-羧酸甲酯的盐
CN101961336B (zh) * 2009-07-21 2012-05-30 江苏恒瑞医药股份有限公司 治疗哺乳动物包括人2型糖尿病的药物组合物
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
RU2533560C2 (ru) * 2010-03-08 2014-11-20 Цзянсу Хэнжуй Медицин Ко., Лтд. Фармацевтическая композиция для лечения диабета 2 типа
CN102199102B (zh) * 2010-03-25 2014-04-02 浙江九洲药业股份有限公司 西他列汀中间体及制备方法和用途
WO2011127794A1 (zh) * 2010-04-12 2011-10-20 上海源力生物技术有限公司 手性环状β-氨基芳基丁酸衍生物、其制备方法及通过其制备手性β-氨基芳基丁酸衍生物的方法
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
CN102372716A (zh) 2010-08-09 2012-03-14 江苏恒瑞医药股份有限公司 酞嗪酮类衍生物、其制备方法及其在医药上的应用
TWI462925B (zh) * 2010-09-27 2014-12-01 Jiangsu Hengrui Medicine Co 治療２型糖尿病的藥物組合物
TWI494313B (zh) * 2010-12-29 2015-08-01 Jiangsu Hengrui Medicine Co 治療包括人類之哺乳動物中第２型糖尿病的醫藥組成物
WO2012088682A1 (en) * 2010-12-29 2012-07-05 Shanghai Fochon Pharmaceutical Co Ltd. 2-(3-aminopiperidin-1-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7(3h,6h)-dione derivates as dipeptidyl peptidase iv(dpp-iv) inhibitors
SI2736909T1 (sl) 2011-07-27 2017-08-31 Farma Grs, D.O.O. Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN103087067A (zh) * 2012-08-02 2013-05-08 盛世泰科生物医药技术(苏州)有限公司 作为二肽基酶抑制剂的化合物及其组合物，以及它们的用途
CN106892926B (zh) * 2012-10-16 2019-09-06 江苏盛迪医药有限公司 一种dpp-iv抑制剂的中间体、其制备方法和通过其制备dpp-iv抑制剂的方法
TWI500613B (zh) 2012-10-17 2015-09-21 Cadila Healthcare Ltd 新穎之雜環化合物
WO2014064215A1 (en) 2012-10-24 2014-05-01 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL
MX2016005142A (es) * 2013-10-30 2016-10-28 Shanghai hengrui pharmaceutical co ltd Derivados de pirazolopirimidona o pirrolotriazona, metodo y preparacion de los mismos y aplicaciones farmaceuticas de los mismos.
CN103664962A (zh) * 2013-12-20 2014-03-26 南京华威医药科技开发有限公司 哌嗪类衍生物
SI3087076T1 (en) * 2013-12-23 2018-01-31 Merck Patent Gmbh IMIDAZOPIRAZINONE DERIVATIVES
CN103910734B (zh) * 2014-03-28 2016-01-13 南京华威医药科技开发有限公司 一种具有哌嗪结构的dpp-4抑制剂
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
KR101709127B1 (ko) * 2015-06-16 2017-02-22 경동제약 주식회사 Dpp-iv 억제제의 제조를 위한 신규 중간체, 이의 제조방법 및 이를 이용한 dpp-iv 억제제의 제조방법
CN108658990B (zh) * 2017-03-31 2021-03-23 南京科技职业学院 一类新型咪唑并[1,5-a]吡嗪类布鲁顿激酶抑制剂
AU2018307761A1 (en) * 2017-07-24 2020-02-20 Isocure Biosciences Inc. Inhibitors of mutant isocitrate dehydrogenases and compositions and methods thereof
RU2020131507A (ru) * 2018-03-29 2022-05-04 Боард Оф Реджентс, Де Юниверсити Оф Техас Систем Имидазопиперазиновые ингибиторы белков-активаторов транскрипции
US10899769B2 (en) 2018-04-06 2021-01-26 Board Of Regents, The University Of Texas System Imidazopiperazinone inhibitors of transcription activating proteins
CN108383845B (zh) * 2018-04-26 2020-11-06 盛世泰科生物医药技术(苏州)有限公司 盛格列汀盐的晶型和无定形及其制备方法和用途
CN113620957B (zh) * 2020-05-08 2022-04-19 盛世泰科生物医药技术(苏州)有限公司 一种胺甲基吡嗪类化合物的制备方法
CN113773323B (zh) * 2020-06-10 2023-05-12 江苏恒瑞医药股份有限公司 3r-氨基取代丁酰胺衍生物的制备方法
CN114478536A (zh) * 2020-10-28 2022-05-13 上海森辉医药有限公司 四氢吡嗪稠环衍生物的制备方法
WO2024015889A2 (en) * 2022-07-14 2024-01-18 The Scripps Research Institute Small molecule regulators of alveolar type 2 cell proliferation for the treatment of pulmonary diseases
CN115583935A (zh) * 2022-11-03 2023-01-10 浙江工业大学 一种4-(2,4,5-三氟苯基)-3-氧丁酸酯的制备方法

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Also Published As

Publication number Publication date
EP2230241B1 (en) 2014-11-26
JP2011508735A (ja) 2011-03-17
RU2483070C2 (ru) 2013-05-27
AU2008342461A1 (en) 2009-07-09
PT2230241E (pt) 2015-02-10
AU2008342461A2 (en) 2010-09-09
ZA201004154B (en) 2011-08-31
EP2230241A1 (en) 2010-09-22
EP2230241A4 (en) 2011-06-22
BRPI0821440A2 (pt) 2015-06-16
US20100273786A1 (en) 2010-10-28
US20120220766A1 (en) 2012-08-30
CA2706735A1 (en) 2009-07-09
US8207161B2 (en) 2012-06-26
US8513411B2 (en) 2013-08-20
CN101641361A (zh) 2010-02-03
KR101685103B1 (ko) 2016-12-09
JP5481008B2 (ja) 2014-04-23
CN101641361B (zh) 2012-02-08
UA101002C2 (ru) 2013-02-25
ES2529435T3 (es) 2015-02-20
RU2010125703A (ru) 2012-02-10
CA2706735C (en) 2016-04-12
HK1134817A1 (en) 2010-05-14
AU2008342461B2 (en) 2013-09-05
CN101468988A (zh) 2009-07-01
KR20110002003A (ko) 2011-01-06
WO2009082881A1 (fr) 2009-07-09

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