MX2010003002A - Analogos de azacitidina y sus usos. - Google Patents
Analogos de azacitidina y sus usos.Info
- Publication number
- MX2010003002A MX2010003002A MX2010003002A MX2010003002A MX2010003002A MX 2010003002 A MX2010003002 A MX 2010003002A MX 2010003002 A MX2010003002 A MX 2010003002A MX 2010003002 A MX2010003002 A MX 2010003002A MX 2010003002 A MX2010003002 A MX 2010003002A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compounds
- azacytidine
- analogues
- azacytidine analogues
- Prior art date
Links
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical class O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97543707P | 2007-09-26 | 2007-09-26 | |
| PCT/US2008/077669 WO2009042766A1 (en) | 2007-09-26 | 2008-09-25 | Azacytidine analogues and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010003002A true MX2010003002A (es) | 2010-07-05 |
Family
ID=40511851
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010003002A MX2010003002A (es) | 2007-09-26 | 2008-09-25 | Analogos de azacitidina y sus usos. |
| MX2010003261A MX2010003261A (es) | 2007-09-26 | 2008-09-25 | Analogos de azacitidina y usos de los mismos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010003261A MX2010003261A (es) | 2007-09-26 | 2008-09-25 | Analogos de azacitidina y usos de los mismos. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8158605B2 (enExample) |
| EP (2) | EP2197274A4 (enExample) |
| JP (2) | JP2010540556A (enExample) |
| KR (2) | KR20100102092A (enExample) |
| CN (2) | CN101815437A (enExample) |
| AU (2) | AU2008304380A1 (enExample) |
| BR (2) | BRPI0817269A2 (enExample) |
| CA (2) | CA2700267A1 (enExample) |
| IL (1) | IL204690A0 (enExample) |
| MX (2) | MX2010003002A (enExample) |
| NZ (2) | NZ583923A (enExample) |
| RU (1) | RU2488591C2 (enExample) |
| UA (2) | UA99308C2 (enExample) |
| WO (2) | WO2009042766A1 (enExample) |
| ZA (1) | ZA201001660B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497292B2 (en) | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| JP2010540556A (ja) * | 2007-09-26 | 2010-12-24 | マウント サイナイ スクール オブ メディシン | アザシチジン類似体およびその使用 |
| ES2927556T3 (es) | 2008-05-15 | 2022-11-08 | Celgene Corp | Formulaciones orales de análogos de citidina y métodos de uso de los mismos |
| WO2010014883A2 (en) * | 2008-08-01 | 2010-02-04 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
| AR076418A1 (es) * | 2009-04-27 | 2011-06-08 | Reddys Lab Inc Dr | Preparacion de decitabina |
| JP2014503597A (ja) | 2011-01-31 | 2014-02-13 | セルジーン コーポレイション | シチジンアナログの医薬組成物及びその使用方法 |
| TW201303295A (zh) * | 2011-04-15 | 2013-01-16 | 克雷維斯製藥公司 | 偵測血液失調中之人平衡型核苷轉運蛋白１（ｈＥＮＴ１）表現用之系統和方法 |
| JP6162709B2 (ja) | 2011-11-01 | 2017-07-12 | セルジーン コーポレイション | シチジンアナログの経口製剤を使用して癌を治療する方法 |
| MY174308A (en) | 2012-02-24 | 2020-04-06 | Signal Pharm Llc | Methods for treating non-small cell lung using tor kinase inhibitor combination therapy |
| US9493500B2 (en) | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
| BR112015026247B1 (pt) * | 2013-04-17 | 2022-08-23 | Signal Pharmaceuticals, Llc | Uso de compostos em combinação com um análogo de citidina, composição farmacêutica que os compreende, e kit |
| WO2015195786A2 (en) | 2014-06-17 | 2015-12-23 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| LT3236972T (lt) * | 2014-12-26 | 2021-11-10 | Emory University | Antivirusiniai n4-hidroksicitidino dariniai |
| WO2017090264A1 (ja) | 2015-11-27 | 2017-06-01 | 大原薬品工業株式会社 | ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル |
| CA3007357C (en) | 2015-12-03 | 2023-12-05 | Epidestiny, Inc. | Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof |
| SG11201906404RA (en) | 2017-03-20 | 2019-08-27 | Vaccinex Inc | Treatment of cancer with a semaphorin-4d antibody in combination with an epigenetic modulating agent |
| CN110996955A (zh) | 2017-06-22 | 2020-04-10 | 细胞基因公司 | 以乙型肝炎病毒感染为特征的肝细胞癌的治疗 |
| KR102810546B1 (ko) * | 2018-04-19 | 2025-05-20 | 써던 리서취 인스티튜트 | 암의 치료를 위한 4'-티오-뉴클레오타이드 및 -뉴클레오사이드 전구약물 |
| WO2022035852A1 (en) * | 2020-08-10 | 2022-02-17 | The Johns Hopkins University | Decitabine analogs for immunological and oncological therapy |
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| BE612384A (fr) | 1961-01-10 | 1962-05-02 | Spofa Vereinigte Pharma Werke | Procédé de préparation des 1-glycosyle-6-aza-uraciles |
| GB1050899A (enExample) | 1963-12-22 | |||
| DE2012888C3 (de) | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
| DE2122991C2 (de) | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
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| JP2010540556A (ja) * | 2007-09-26 | 2010-12-24 | マウント サイナイ スクール オブ メディシン | アザシチジン類似体およびその使用 |
-
2008
- 2008-09-25 JP JP2010527140A patent/JP2010540556A/ja active Pending
- 2008-09-25 BR BRPI0817269-2A2A patent/BRPI0817269A2/pt not_active IP Right Cessation
- 2008-09-25 WO PCT/US2008/077669 patent/WO2009042766A1/en not_active Ceased
- 2008-09-25 BR BRPI0817234-0A2A patent/BRPI0817234A2/pt not_active IP Right Cessation
- 2008-09-25 EP EP08834291A patent/EP2197274A4/en not_active Withdrawn
- 2008-09-25 RU RU2010116274/04A patent/RU2488591C2/ru not_active IP Right Cessation
- 2008-09-25 US US12/238,125 patent/US8158605B2/en not_active Expired - Fee Related
- 2008-09-25 JP JP2010527139A patent/JP2010540555A/ja active Pending
- 2008-09-25 MX MX2010003002A patent/MX2010003002A/es active IP Right Grant
- 2008-09-25 NZ NZ583923A patent/NZ583923A/en not_active IP Right Cessation
- 2008-09-25 AU AU2008304380A patent/AU2008304380A1/en not_active Abandoned
- 2008-09-25 KR KR1020107008902A patent/KR20100102092A/ko not_active Withdrawn
- 2008-09-25 EP EP08832961A patent/EP2205073A4/en not_active Withdrawn
- 2008-09-25 CN CN200880108584A patent/CN101815437A/zh active Pending
- 2008-09-25 CN CN2008801085550A patent/CN101877964A/zh active Pending
- 2008-09-25 CA CA2700267A patent/CA2700267A1/en not_active Abandoned
- 2008-09-25 AU AU2008304381A patent/AU2008304381A1/en not_active Abandoned
- 2008-09-25 NZ NZ583824A patent/NZ583824A/en not_active IP Right Cessation
- 2008-09-25 WO PCT/US2008/077673 patent/WO2009042767A1/en not_active Ceased
- 2008-09-25 KR KR1020107007252A patent/KR20100072230A/ko not_active Withdrawn
- 2008-09-25 US US12/238,054 patent/US8399420B2/en not_active Expired - Fee Related
- 2008-09-25 UA UAA201004927A patent/UA99308C2/ru unknown
- 2008-09-25 UA UAA201004928A patent/UA99836C2/ru unknown
- 2008-09-25 CA CA2700207A patent/CA2700207A1/en not_active Abandoned
- 2008-09-25 MX MX2010003261A patent/MX2010003261A/es not_active Application Discontinuation
-
2010
- 2010-03-08 ZA ZA2010/01660A patent/ZA201001660B/en unknown
- 2010-03-23 IL IL204690A patent/IL204690A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ583923A (en) | 2012-05-25 |
| CA2700207A1 (en) | 2009-04-02 |
| AU2008304380A1 (en) | 2009-04-02 |
| KR20100102092A (ko) | 2010-09-20 |
| AU2008304381A1 (en) | 2009-04-02 |
| JP2010540556A (ja) | 2010-12-24 |
| WO2009042766A9 (en) | 2009-05-28 |
| CA2700267A1 (en) | 2009-04-02 |
| US8399420B2 (en) | 2013-03-19 |
| EP2205073A4 (en) | 2013-03-06 |
| BRPI0817269A2 (pt) | 2014-10-07 |
| JP2010540555A (ja) | 2010-12-24 |
| RU2488591C2 (ru) | 2013-07-27 |
| UA99836C2 (en) | 2012-10-10 |
| CN101815437A (zh) | 2010-08-25 |
| NZ583824A (en) | 2012-06-29 |
| BRPI0817234A2 (pt) | 2014-09-30 |
| US20090209482A1 (en) | 2009-08-20 |
| WO2009042767A1 (en) | 2009-04-02 |
| MX2010003261A (es) | 2010-08-18 |
| WO2009042766A1 (en) | 2009-04-02 |
| CN101877964A (zh) | 2010-11-03 |
| UA99308C2 (ru) | 2012-08-10 |
| RU2010116154A (ru) | 2011-11-10 |
| RU2010116274A (ru) | 2011-11-10 |
| US8158605B2 (en) | 2012-04-17 |
| EP2205073A1 (en) | 2010-07-14 |
| EP2197274A4 (en) | 2013-03-06 |
| US20090209477A1 (en) | 2009-08-20 |
| EP2197274A1 (en) | 2010-06-23 |
| IL204690A0 (en) | 2010-11-30 |
| ZA201001660B (en) | 2011-05-25 |
| KR20100072230A (ko) | 2010-06-30 |
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