MX2009014070A - Composiciones para vacuna en emulsion que comprenden antigeno y un adyuvante en la fase acuosa. - Google Patents

Composiciones para vacuna en emulsion que comprenden antigeno y un adyuvante en la fase acuosa.

Info

Publication number
MX2009014070A
MX2009014070A MX2009014070A MX2009014070A MX2009014070A MX 2009014070 A MX2009014070 A MX 2009014070A MX 2009014070 A MX2009014070 A MX 2009014070A MX 2009014070 A MX2009014070 A MX 2009014070A MX 2009014070 A MX2009014070 A MX 2009014070A
Authority
MX
Mexico
Prior art keywords
adjuvant
antigen
aqueous phase
vaccine compositions
emulsion vaccine
Prior art date
Application number
MX2009014070A
Other languages
English (en)
Inventor
Mahesh Kumar
Jeffrey Harold Rodenberg
David Leon Lutz
Evans James Diehl
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of MX2009014070A publication Critical patent/MX2009014070A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se utilizan formulaciones de vacuna en emulsión que contienen un antígeno y un adyuvante en la fase acuosa para la vacunación de animales en donde el adyuvante es un polímero acrílico y/o bromuro de dimetil dioctadecil amonio (DDA). Estas formulaciones se pueden preparar al mezclar una fase acuosa que contiene el antígeno y adyuvante con una fase aceitosa en la presencia de un emulsificador.
MX2009014070A 2007-06-20 2008-06-19 Composiciones para vacuna en emulsion que comprenden antigeno y un adyuvante en la fase acuosa. MX2009014070A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93657107P 2007-06-20 2007-06-20
PCT/US2008/067433 WO2008157659A1 (en) 2007-06-20 2008-06-19 Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase

Publications (1)

Publication Number Publication Date
MX2009014070A true MX2009014070A (es) 2010-05-19

Family

ID=39720537

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009014070A MX2009014070A (es) 2007-06-20 2008-06-19 Composiciones para vacuna en emulsion que comprenden antigeno y un adyuvante en la fase acuosa.

Country Status (26)

Country Link
US (2) US8980288B2 (es)
EP (1) EP2164510B1 (es)
JP (2) JP5457340B2 (es)
KR (1) KR101569218B1 (es)
CN (2) CN101790378A (es)
AR (1) AR067087A1 (es)
AU (1) AU2008265745B2 (es)
BR (1) BRPI0812856A2 (es)
CA (1) CA2692098C (es)
CL (1) CL2008001806A1 (es)
CO (1) CO6251273A2 (es)
CY (1) CY1114451T1 (es)
DK (1) DK2164510T3 (es)
ES (1) ES2429296T3 (es)
HK (1) HK1218717A1 (es)
HR (1) HRP20130939T1 (es)
ME (1) ME01527B (es)
MX (1) MX2009014070A (es)
NZ (1) NZ582132A (es)
PL (1) PL2164510T3 (es)
PT (1) PT2164510E (es)
RS (1) RS52947B (es)
SI (1) SI2164510T1 (es)
TW (1) TWI507214B (es)
WO (1) WO2008157659A1 (es)
ZA (1) ZA200909173B (es)

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* Cited by examiner, † Cited by third party
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CL2008001806A1 (es) * 2007-06-20 2008-09-05 Wyeth Corp Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.
ES2728949T3 (es) 2008-06-27 2019-10-29 Zoetis Services Llc Composiciones adyuvantes novedosas
US9603919B2 (en) 2009-03-31 2017-03-28 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Method for prophylaxis of influenza using vaccine for intranasal administration
CN102741537B (zh) 2010-01-29 2016-01-06 唐纳森公司 用于空气滤清器的水分离器组件及发动机空气流入口结构
CN101829323A (zh) * 2010-04-28 2010-09-15 洛阳普莱柯生物工程有限公司 一种禽用油乳剂疫苗及其制备方法
MX2013012045A (es) 2011-04-12 2014-05-27 Uniao Brasiliense De Educacao E Cultura Ubec Péptidos con actividad antimicrobiana, composiciones farmacéuticas para la profilaxis y el tratamiento de animales, composiciones para la profilaxis y el tratamiento de vegetales, usos de esos péptidos y usos del extracto de paenibacillus elgii ourofinensis.
AU2014321369B2 (en) 2013-09-19 2020-04-16 Zoetis Services Llc Oil-based adjuvants
WO2015084594A1 (en) * 2013-12-06 2015-06-11 Advanced Bionutrition Corporation Composition for oral delivery of bioactive agents
WO2016115456A1 (en) 2015-01-16 2016-07-21 Zoetis Services Llc Foot-and-mouth disease vaccine
GB201506948D0 (en) * 2015-04-23 2015-06-10 Croda Int Plc Emulsions for injectable formulations
CN106177939B (zh) * 2015-06-01 2021-01-19 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN106344920B (zh) * 2015-07-16 2020-11-27 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN107281482B (zh) * 2016-04-05 2021-06-11 普莱柯生物工程股份有限公司 一种免疫佐剂组合物及其制备方法
EP3764991A4 (en) * 2018-03-13 2022-12-07 Capsular Technologies Pty Ltd. VACCINE COMPOSITION
CN110404065B (zh) * 2018-04-27 2023-06-16 洛阳赛威生物科技有限公司 一种猪用佐剂组合物及其制备方法
CA3106341A1 (en) 2018-07-13 2020-01-16 Biomune Company New vaccines against avian reoviruses
EP3830105A4 (en) 2018-07-27 2022-07-27 Research Development Foundation CHIMERIC IMMUNOGENIC POLYPEPTIDES
CN114306585A (zh) * 2021-12-30 2022-04-12 广西壮族自治区水产科学研究院 一种鱼类高纯度抗原乳剂的制备方法

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Also Published As

Publication number Publication date
ES2429296T3 (es) 2013-11-14
SI2164510T1 (sl) 2013-11-29
EP2164510A1 (en) 2010-03-24
JP5457340B2 (ja) 2014-04-02
PL2164510T3 (pl) 2014-03-31
US8980288B2 (en) 2015-03-17
CO6251273A2 (es) 2011-02-21
EP2164510B1 (en) 2013-07-17
TWI507214B (zh) 2015-11-11
PT2164510E (pt) 2013-10-07
CN105148268A (zh) 2015-12-16
CY1114451T1 (el) 2016-10-05
CA2692098A1 (en) 2008-12-24
KR101569218B1 (ko) 2015-11-13
TW200906448A (en) 2009-02-16
CA2692098C (en) 2016-06-14
HRP20130939T1 (hr) 2013-11-22
JP5802285B2 (ja) 2015-10-28
KR20100022115A (ko) 2010-02-26
HK1218717A1 (zh) 2017-03-10
US9545439B2 (en) 2017-01-17
JP2014088423A (ja) 2014-05-15
CL2008001806A1 (es) 2008-09-05
AR067087A1 (es) 2009-09-30
AU2008265745A1 (en) 2008-12-24
US20150297710A1 (en) 2015-10-22
WO2008157659A1 (en) 2008-12-24
ME01527B (me) 2014-04-20
CN101790378A (zh) 2010-07-28
RS52947B (en) 2014-02-28
AU2008265745B2 (en) 2013-05-30
DK2164510T3 (da) 2013-09-23
NZ582132A (en) 2012-04-27
BRPI0812856A2 (pt) 2014-12-09
JP2010530877A (ja) 2010-09-16
US20090017067A1 (en) 2009-01-15
ZA200909173B (en) 2010-08-25

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