BRPI0812856A2 - Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa. - Google Patents

Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa.

Info

Publication number
BRPI0812856A2
BRPI0812856A2 BRPI0812856-1A2A BRPI0812856A BRPI0812856A2 BR PI0812856 A2 BRPI0812856 A2 BR PI0812856A2 BR PI0812856 A BRPI0812856 A BR PI0812856A BR PI0812856 A2 BRPI0812856 A2 BR PI0812856A2
Authority
BR
Brazil
Prior art keywords
adjuvant
antigen
vaccine compositions
water stage
emulsion vaccine
Prior art date
Application number
BRPI0812856-1A2A
Other languages
English (en)
Inventor
David Leon Lutz
Jeffrey Harold Rodenberg
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BRPI0812856A2 publication Critical patent/BRPI0812856A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
BRPI0812856-1A2A 2007-06-20 2008-06-19 Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa. BRPI0812856A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93657107P 2007-06-20 2007-06-20
PCT/US2008/067433 WO2008157659A1 (en) 2007-06-20 2008-06-19 Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase

Publications (1)

Publication Number Publication Date
BRPI0812856A2 true BRPI0812856A2 (pt) 2014-12-09

Family

ID=39720537

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812856-1A2A BRPI0812856A2 (pt) 2007-06-20 2008-06-19 Composições de vacina de emulsão que compreendem antígeno e adjuvante na fase aquosa.

Country Status (26)

Country Link
US (2) US8980288B2 (pt)
EP (1) EP2164510B1 (pt)
JP (2) JP5457340B2 (pt)
KR (1) KR101569218B1 (pt)
CN (2) CN105148268A (pt)
AR (1) AR067087A1 (pt)
AU (1) AU2008265745B2 (pt)
BR (1) BRPI0812856A2 (pt)
CA (1) CA2692098C (pt)
CL (1) CL2008001806A1 (pt)
CO (1) CO6251273A2 (pt)
CY (1) CY1114451T1 (pt)
DK (1) DK2164510T3 (pt)
ES (1) ES2429296T3 (pt)
HK (1) HK1218717A1 (pt)
HR (1) HRP20130939T1 (pt)
ME (1) ME01527B (pt)
MX (1) MX2009014070A (pt)
NZ (1) NZ582132A (pt)
PL (1) PL2164510T3 (pt)
PT (1) PT2164510E (pt)
RS (1) RS52947B (pt)
SI (1) SI2164510T1 (pt)
TW (1) TWI507214B (pt)
WO (1) WO2008157659A1 (pt)
ZA (1) ZA200909173B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008001806A1 (es) * 2007-06-20 2008-09-05 Wyeth Corp Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.
JP5659332B2 (ja) 2008-06-27 2015-01-28 ゾエティス・エルエルシー 新規なアジュバント組成物
AU2010232180B2 (en) * 2009-03-31 2016-09-22 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Method for prophylaxis of influenza using vaccine for intranasal administration
BR112012018640B1 (pt) 2010-01-29 2020-12-15 Donaldson Company, Inc. Montagens de separador de água de fluxo de ar de entrada e método de separar água de um fluxo de ar de entrada
CN101829323A (zh) * 2010-04-28 2010-09-15 洛阳普莱柯生物工程有限公司 一种禽用油乳剂疫苗及其制备方法
WO2012139179A1 (pt) 2011-04-12 2012-10-18 Ouro Fino Participações E Empreendimentos S/A Peptídeos com atividade antimicrobiana, composições medicamentosas para o tratamento e profilaxia de animais, composições para o tratamento e profilaxia de plantas, usos dos ditos peptídeos, e, usos do extrato de paenibacillus elgii ourofinensis
CA2924526A1 (en) * 2013-09-19 2015-03-26 Paul Joseph Dominowski Water-in-oil emulsions comprising immunostimulatory oligonucleotides
WO2015084594A1 (en) * 2013-12-06 2015-06-11 Advanced Bionutrition Corporation Composition for oral delivery of bioactive agents
AR103427A1 (es) 2015-01-16 2017-05-10 Zoetis Services Llc Vacuna contra la fiebre aftosa
GB201506948D0 (en) * 2015-04-23 2015-06-10 Croda Int Plc Emulsions for injectable formulations
CN106177939B (zh) * 2015-06-01 2021-01-19 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN106344920B (zh) * 2015-07-16 2020-11-27 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN107281482B (zh) * 2016-04-05 2021-06-11 普莱柯生物工程股份有限公司 一种免疫佐剂组合物及其制备方法
EP3764991A4 (en) * 2018-03-13 2022-12-07 Capsular Technologies Pty Ltd. VACCINE COMPOSITION
CN110404065B (zh) * 2018-04-27 2023-06-16 洛阳赛威生物科技有限公司 一种猪用佐剂组合物及其制备方法
CA3106341A1 (en) * 2018-07-13 2020-01-16 Biomune Company New vaccines against avian reoviruses
EP3830105A4 (en) 2018-07-27 2022-07-27 Research Development Foundation CHIMERIC IMMUNOGENIC POLYPEPTIDES
CN114306585A (zh) * 2021-12-30 2022-04-12 广西壮族自治区水产科学研究院 一种鱼类高纯度抗原乳剂的制备方法

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NZ221306A (en) 1986-08-15 1990-02-26 Commw Scient Ind Res Org 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof
ES2037072T3 (es) * 1986-12-19 1993-06-16 Duphar International Research B.V Suspension coadyuvante estabilizada que comprende bromuro de dimetil-dioctadecil-amonio.
US5951988A (en) * 1993-03-30 1999-09-14 University Of Saskatchewan Adjuvant formulation with enhanced immunogenic activity, and related compositions and methods
BE1008977A5 (fr) 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
US5744137A (en) 1995-02-06 1998-04-28 The United States Of America As Represented By The Secretary Of The Agriculture Oil emulsion vaccines prepared with animal, vegetable, and synthetic oils using a mixture of nonionic surfactants
US6086901A (en) * 1997-12-16 2000-07-11 Chiron Corporation Use of microparticles combined with submicron oil-in-water emulsions
FR2775601B1 (fr) * 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
FR2776928B1 (fr) 1998-04-03 2000-06-23 Merial Sas Vaccins adn adjuves
BR0111366A (pt) * 2000-05-24 2003-05-20 Merial Sas Vacina de poxvìrus recombinante do vìrus da sìndrome respiratória e reprodutiva de porcino (prrsv)
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US20030129161A1 (en) 2001-09-17 2003-07-10 Hsien-Jue Chu Interleukin-12 as a veterinary vaccine adjuvant
JP3812814B2 (ja) * 2001-10-19 2006-08-23 株式会社微生物化学研究所 動物用多価オイルアジュバントワクチン
US7862821B2 (en) 2006-06-01 2011-01-04 Merial Limited Recombinant vaccine against bluetongue virus
CL2008001806A1 (es) * 2007-06-20 2008-09-05 Wyeth Corp Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.

Also Published As

Publication number Publication date
CN105148268A (zh) 2015-12-16
RS52947B (en) 2014-02-28
US8980288B2 (en) 2015-03-17
EP2164510A1 (en) 2010-03-24
PL2164510T3 (pl) 2014-03-31
CA2692098A1 (en) 2008-12-24
MX2009014070A (es) 2010-05-19
TW200906448A (en) 2009-02-16
ES2429296T3 (es) 2013-11-14
CA2692098C (en) 2016-06-14
JP2014088423A (ja) 2014-05-15
AU2008265745B2 (en) 2013-05-30
HK1218717A1 (zh) 2017-03-10
US20150297710A1 (en) 2015-10-22
ME01527B (me) 2014-04-20
CN101790378A (zh) 2010-07-28
TWI507214B (zh) 2015-11-11
CO6251273A2 (es) 2011-02-21
JP5802285B2 (ja) 2015-10-28
AR067087A1 (es) 2009-09-30
PT2164510E (pt) 2013-10-07
CL2008001806A1 (es) 2008-09-05
US9545439B2 (en) 2017-01-17
AU2008265745A1 (en) 2008-12-24
WO2008157659A1 (en) 2008-12-24
JP2010530877A (ja) 2010-09-16
US20090017067A1 (en) 2009-01-15
ZA200909173B (en) 2010-08-25
KR101569218B1 (ko) 2015-11-13
HRP20130939T1 (hr) 2013-11-22
CY1114451T1 (el) 2016-10-05
DK2164510T3 (da) 2013-09-23
EP2164510B1 (en) 2013-07-17
JP5457340B2 (ja) 2014-04-02
NZ582132A (en) 2012-04-27
KR20100022115A (ko) 2010-02-26
SI2164510T1 (sl) 2013-11-29

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: PAH W LLC (US)

B25D Requested change of name of applicant approved

Owner name: ZOETIS W LLC (US)

B15K Others concerning applications: alteration of classification

Ipc: A61K 39/39 (2006.01), A61K 39/145 (2006.01)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]