CO6251273A2 - Composiciones para vacuna en emulsion que comprenden antigeno y un adyuvante en la fase acuosa y su metodo de elaboracion - Google Patents
Composiciones para vacuna en emulsion que comprenden antigeno y un adyuvante en la fase acuosa y su metodo de elaboracionInfo
- Publication number
- CO6251273A2 CO6251273A2 CO09144676A CO09144676A CO6251273A2 CO 6251273 A2 CO6251273 A2 CO 6251273A2 CO 09144676 A CO09144676 A CO 09144676A CO 09144676 A CO09144676 A CO 09144676A CO 6251273 A2 CO6251273 A2 CO 6251273A2
- Authority
- CO
- Colombia
- Prior art keywords
- adjuvant
- paa
- vaccine composition
- acrylic polymer
- alkyl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 10
- 229960005486 vaccine Drugs 0.000 title abstract 9
- 239000000427 antigen Substances 0.000 title abstract 4
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 239000000839 emulsion Substances 0.000 title abstract 3
- 229920002125 Sokalan® Polymers 0.000 abstract 10
- 239000002671 adjuvant Substances 0.000 abstract 9
- 229920000058 polyacrylate Polymers 0.000 abstract 5
- PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 abstract 3
- ZLDPNFYTUDQDMJ-UHFFFAOYSA-N n-octadecyloctadecan-1-amine;hydrobromide Chemical compound Br.CCCCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCCCC ZLDPNFYTUDQDMJ-UHFFFAOYSA-N 0.000 abstract 3
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 239000004584 polyacrylic acid Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 239000007762 w/o emulsion Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16171—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Se utilizan formulaciones de vacuna en emulsión que contienen un antígeno y un adyuvante en la fase acuosa para la vacunación de animales en donde el adyuvante es un polímero acrílico y/o bromuro de dimetil dioctadecil amonio (DDA). Estas formulaciones se pueden preparar al mezclar una fase acuosa que contiene el antígeno y adyuvante con una fase aceitosa en la presencia de un emulsificador. 1.- Una composición de vacuna que comprende una emulsión agua en aceite, en donde dicha emulsión comprende un componente de aceite y un componente acuoso; y en donde dicho componente acuoso comprende por lo menos un antígeno y por lo menos un adyuvante seleccionado del grupo que consiste de un polímero acrílico y bromuro de dimetil dioctadecil amonio (DDA). 2.- La composición de vacuna de la reivindicación 1, en donde dicho por lo menos un adyuvante es un polímero acrílico. 3.- La composición de vacuna de la reivindicación 2, en donde dicho polímero acrílico es un polímero de ácido acrílico reticulado con sacarosa polialilo. 4.- La composición de vacuna de la reivindicación 2 en donde dicho polímero acrílico es un adyuvante de ácido alquil-poliacrílico ("alquil-PAA"). 5.- La composición de vacuna de la reivindicación 4, en donde dicho adyuvante de alquil-PAA se selecciona del grupo que consiste de decil-PAA, octil-PAA, butil-PAA, y metil-PAA. 6.- La composición de vacuna de la reivindicación 5, en donde dicho adyuvante alquil-PAA es octil-PAA. 7.- La composición de vacuna de la reivindicación 1, en donde dicho por lo menos un adyuvante es bromuro de dimetil dioctadecil amonio (DDA).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93657107P | 2007-06-20 | 2007-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6251273A2 true CO6251273A2 (es) | 2011-02-21 |
Family
ID=39720537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09144676A CO6251273A2 (es) | 2007-06-20 | 2009-12-17 | Composiciones para vacuna en emulsion que comprenden antigeno y un adyuvante en la fase acuosa y su metodo de elaboracion |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8980288B2 (es) |
| EP (1) | EP2164510B1 (es) |
| JP (2) | JP5457340B2 (es) |
| KR (1) | KR101569218B1 (es) |
| CN (2) | CN105148268A (es) |
| AR (1) | AR067087A1 (es) |
| AU (1) | AU2008265745B2 (es) |
| BR (1) | BRPI0812856A2 (es) |
| CA (1) | CA2692098C (es) |
| CL (1) | CL2008001806A1 (es) |
| CO (1) | CO6251273A2 (es) |
| CY (1) | CY1114451T1 (es) |
| DK (1) | DK2164510T3 (es) |
| ES (1) | ES2429296T3 (es) |
| HK (1) | HK1218717A1 (es) |
| HR (1) | HRP20130939T1 (es) |
| ME (1) | ME01527B (es) |
| MX (1) | MX2009014070A (es) |
| NZ (1) | NZ582132A (es) |
| PL (1) | PL2164510T3 (es) |
| PT (1) | PT2164510E (es) |
| RS (1) | RS52947B (es) |
| SI (1) | SI2164510T1 (es) |
| TW (1) | TWI507214B (es) |
| WO (1) | WO2008157659A1 (es) |
| ZA (1) | ZA200909173B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2008001806A1 (es) * | 2007-06-20 | 2008-09-05 | Wyeth Corp | Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion. |
| ES2728949T3 (es) | 2008-06-27 | 2019-10-29 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
| ES2588183T3 (es) * | 2009-03-31 | 2016-10-31 | Japan As Represented By Director-General Of National Institute Of Infectious Diseases | Procedimiento para la prevención de la gripe utilizando una vacuna para administración intranasal |
| CN102741537B (zh) | 2010-01-29 | 2016-01-06 | 唐纳森公司 | 用于空气滤清器的水分离器组件及发动机空气流入口结构 |
| CN101829323A (zh) * | 2010-04-28 | 2010-09-15 | 洛阳普莱柯生物工程有限公司 | 一种禽用油乳剂疫苗及其制备方法 |
| MX2013012045A (es) | 2011-04-12 | 2014-05-27 | Uniao Brasiliense De Educacao E Cultura Ubec | Péptidos con actividad antimicrobiana, composiciones farmacéuticas para la profilaxis y el tratamiento de animales, composiciones para la profilaxis y el tratamiento de vegetales, usos de esos péptidos y usos del extracto de paenibacillus elgii ourofinensis. |
| WO2015042369A2 (en) * | 2013-09-19 | 2015-03-26 | Zoetis Llc | Oil-based adjuvants |
| CA2932681C (en) * | 2013-12-06 | 2022-08-30 | Moti Harel | Composition for oral delivery of bioactive agents |
| PL3244920T3 (pl) | 2015-01-16 | 2023-09-25 | Zoetis Services Llc | Szczepionka przeciw pryszczycy |
| GB201506948D0 (en) * | 2015-04-23 | 2015-06-10 | Croda Int Plc | Emulsions for injectable formulations |
| CN106177939B (zh) * | 2015-06-01 | 2021-01-19 | 普莱柯生物工程股份有限公司 | 一种疫苗用佐剂及其应用 |
| CN106344920B (zh) * | 2015-07-16 | 2020-11-27 | 普莱柯生物工程股份有限公司 | 一种疫苗用佐剂及其应用 |
| CN107281482B (zh) * | 2016-04-05 | 2021-06-11 | 普莱柯生物工程股份有限公司 | 一种免疫佐剂组合物及其制备方法 |
| AU2019235613A1 (en) * | 2018-03-13 | 2020-10-01 | Swinburne University Of Technology | Vaccine composition |
| CN110404065B (zh) * | 2018-04-27 | 2023-06-16 | 洛阳赛威生物科技有限公司 | 一种猪用佐剂组合物及其制备方法 |
| US11813321B2 (en) | 2018-07-13 | 2023-11-14 | Biomune Company | Vaccines against avian reoviruses |
| EP3830105A4 (en) | 2018-07-27 | 2022-07-27 | Research Development Foundation | CHIMERIC IMMUNOGENIC POLYPEPTIDES |
| CN114306585A (zh) * | 2021-12-30 | 2022-04-12 | 广西壮族自治区水产科学研究院 | 一种鱼类高纯度抗原乳剂的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639577A (en) * | 1968-02-23 | 1972-02-01 | Haver Lockhart Lab Inc | Injectable adjuvant,method of preparing same and compositions including such adjuvant |
| NZ221306A (en) * | 1986-08-15 | 1990-02-26 | Commw Scient Ind Res Org | 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof |
| DE3768232D1 (de) * | 1986-12-19 | 1991-04-04 | Duphar Int Res | Dimethyldioctadecylammoniumbromid enthaltende stabilisierte adjuvanssuspension. |
| US5951988A (en) * | 1993-03-30 | 1999-09-14 | University Of Saskatchewan | Adjuvant formulation with enhanced immunogenic activity, and related compositions and methods |
| BE1008977A5 (fr) * | 1994-12-27 | 1996-10-01 | Solvay | Adjuvants pour vaccins. |
| US5744137A (en) * | 1995-02-06 | 1998-04-28 | The United States Of America As Represented By The Secretary Of The Agriculture | Oil emulsion vaccines prepared with animal, vegetable, and synthetic oils using a mixture of nonionic surfactants |
| CA2314934C (en) * | 1997-12-16 | 2006-08-29 | Chiron Corporation | Use of microparticles combined with submicron oil-in-water emulsions |
| FR2775601B1 (fr) * | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
| FR2776928B1 (fr) * | 1998-04-03 | 2000-06-23 | Merial Sas | Vaccins adn adjuves |
| JP2003533989A (ja) * | 2000-05-24 | 2003-11-18 | メリアル | ブタ生殖・呼吸症候群ウィルス（ｐｒｒｓｖ）の組換えポックスウィルスワクチン |
| FR2810888B1 (fr) * | 2000-06-29 | 2004-07-30 | Merial Sas | Vaccin contre la fievre aphteuse |
| US6585978B1 (en) * | 2000-09-09 | 2003-07-01 | Akzo Nobel | EIA vaccine and diagnostic |
| US7018638B2 (en) * | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
| US6676958B2 (en) * | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
| US20030129161A1 (en) * | 2001-09-17 | 2003-07-10 | Hsien-Jue Chu | Interleukin-12 as a veterinary vaccine adjuvant |
| JP3812814B2 (ja) * | 2001-10-19 | 2006-08-23 | 株式会社微生物化学研究所 | 動物用多価オイルアジュバントワクチン |
| US7862821B2 (en) * | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
| CL2008001806A1 (es) * | 2007-06-20 | 2008-09-05 | Wyeth Corp | Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion. |
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2008
- 2008-06-18 CL CL200801806A patent/CL2008001806A1/es unknown
- 2008-06-19 DK DK08771428.3T patent/DK2164510T3/da active
- 2008-06-19 JP JP2010513396A patent/JP5457340B2/ja not_active Expired - Fee Related
- 2008-06-19 ES ES08771428T patent/ES2429296T3/es active Active
- 2008-06-19 CN CN201510450651.5A patent/CN105148268A/zh active Pending
- 2008-06-19 BR BRPI0812856-1A2A patent/BRPI0812856A2/pt not_active IP Right Cessation
- 2008-06-19 KR KR1020107001106A patent/KR101569218B1/ko not_active IP Right Cessation
- 2008-06-19 NZ NZ582132A patent/NZ582132A/en not_active IP Right Cessation
- 2008-06-19 PT PT87714283T patent/PT2164510E/pt unknown
- 2008-06-19 CA CA2692098A patent/CA2692098C/en not_active Expired - Fee Related
- 2008-06-19 WO PCT/US2008/067433 patent/WO2008157659A1/en active Application Filing
- 2008-06-19 SI SI200831038T patent/SI2164510T1/sl unknown
- 2008-06-19 RS RS20130408A patent/RS52947B/en unknown
- 2008-06-19 AU AU2008265745A patent/AU2008265745B2/en active Active
- 2008-06-19 ME MEP-2013-101A patent/ME01527B/me unknown
- 2008-06-19 MX MX2009014070A patent/MX2009014070A/es active IP Right Grant
- 2008-06-19 PL PL08771428T patent/PL2164510T3/pl unknown
- 2008-06-19 EP EP08771428.3A patent/EP2164510B1/en active Active
- 2008-06-19 CN CN200880024112A patent/CN101790378A/zh active Pending
- 2008-06-19 US US12/142,160 patent/US8980288B2/en active Active
- 2008-06-20 AR ARP080102641A patent/AR067087A1/es not_active Application Discontinuation
- 2008-06-20 TW TW097123236A patent/TWI507214B/zh not_active IP Right Cessation
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2009
- 2009-12-17 CO CO09144676A patent/CO6251273A2/es not_active Application Discontinuation
- 2009-12-22 ZA ZA200909173A patent/ZA200909173B/xx unknown
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2010
- 2010-11-09 HK HK16106725.1A patent/HK1218717A1/zh unknown
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2013
- 2013-10-03 CY CY20131100855T patent/CY1114451T1/el unknown
- 2013-10-07 HR HRP20130939AT patent/HRP20130939T1/hr unknown
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2014
- 2014-01-09 JP JP2014002096A patent/JP5802285B2/ja not_active Expired - Fee Related
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2015
- 2015-02-10 US US14/618,628 patent/US9545439B2/en active Active
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