MX2009013327A - Ingenieria basada en secuencias y optimizacion de anticuerpos de cadena simple. - Google Patents

Ingenieria basada en secuencias y optimizacion de anticuerpos de cadena simple.

Info

Publication number
MX2009013327A
MX2009013327A MX2009013327A MX2009013327A MX2009013327A MX 2009013327 A MX2009013327 A MX 2009013327A MX 2009013327 A MX2009013327 A MX 2009013327A MX 2009013327 A MX2009013327 A MX 2009013327A MX 2009013327 A MX2009013327 A MX 2009013327A
Authority
MX
Mexico
Prior art keywords
antibodies
single chain
sequence based
solubility
methods
Prior art date
Application number
MX2009013327A
Other languages
English (en)
Inventor
David Urech
Leonardo Borras
Original Assignee
Esbatech An Alcon Biomedical R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech An Alcon Biomedical R filed Critical Esbatech An Alcon Biomedical R
Publication of MX2009013327A publication Critical patent/MX2009013327A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment

Abstract

La invención proporciona los métodos para utilizar el análisis basado en secuencia y las estrategias racionales para modificar y mejorar las propiedades estructurales y biofísicas de los anticuerpos de cadena simple (scFvs), incluyendo la estabilidad, la solubilidad, y la afinidad de enlace al antígeno. Estos métodos y las estrategias pueden ser utilizados individualmente o en combinación. Los métodos de la presente invención también incluyen el uso de una base de datos que comprende las secuencias de scFvs provenientes de una biblioteca de scFv experimentalmente seleccionada, de anticuerpos que han sido seleccionados por tener solubilidad y estabilidad superiores. La invención también proporciona los métodos para utilizar las propiedades encontradas para estos anticuerpos seleccionados, en un procedimiento general para reconformar los anticuerpos de scFv para mejorar las propiedades de estabilidad y de solubilidad de un fragmento de anticuerpo de cadena simple.
MX2009013327A 2007-06-25 2008-06-25 Ingenieria basada en secuencias y optimizacion de anticuerpos de cadena simple. MX2009013327A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93711207P 2007-06-25 2007-06-25
US6905708P 2008-03-12 2008-03-12
PCT/CH2008/000284 WO2009000098A2 (en) 2007-06-25 2008-06-25 Sequence based engineering and optimization of single chain antibodies

Publications (1)

Publication Number Publication Date
MX2009013327A true MX2009013327A (es) 2010-06-02

Family

ID=39855147

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013327A MX2009013327A (es) 2007-06-25 2008-06-25 Ingenieria basada en secuencias y optimizacion de anticuerpos de cadena simple.

Country Status (20)

Country Link
US (1) US9908945B2 (es)
EP (1) EP2164961B1 (es)
JP (2) JP5506670B2 (es)
KR (1) KR101530723B1 (es)
CN (1) CN101688200B (es)
AU (1) AU2008267733B2 (es)
BR (1) BRPI0813287A2 (es)
CA (1) CA2689064C (es)
DK (1) DK2164961T3 (es)
ES (1) ES2532725T3 (es)
HK (1) HK1137035A1 (es)
IL (1) IL202352A (es)
MX (1) MX2009013327A (es)
NZ (1) NZ581470A (es)
PL (1) PL2164961T3 (es)
PT (1) PT2164961E (es)
RU (1) RU2010102064A (es)
SI (1) SI2164961T1 (es)
WO (1) WO2009000098A2 (es)
ZA (1) ZA200908314B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ563580A (en) * 2005-06-07 2010-09-30 Esbatech An Alcon Biomedical R Stable and soluble antibodies inhibiting TNFaplha
ES2568436T3 (es) 2006-03-31 2016-04-29 Chugai Seiyaku Kabushiki Kaisha Procedimiento para controlar la farmacocinética en sangre de anticuerpos
CA2680564C (en) * 2007-03-12 2018-05-01 Esbatech Ag Sequence based engineering and optimization of single chain antibodies
DK2164961T3 (en) 2007-06-25 2015-03-02 Esbatech Alcon Biomed Res Unit Sequence based forward position and optimization of single chain ​​antibodies
WO2009000099A2 (en) 2007-06-25 2008-12-31 Esbatech Ag Methods of modifying antibodies, and modified antibodies with improved functional properties
EP3689912A1 (en) 2007-09-26 2020-08-05 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in cdr
EP4238993A3 (en) 2008-04-11 2023-11-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
DK3241843T3 (da) 2008-06-25 2021-09-06 Novartis Ag Opløselighedsoptimering af immunbindere
KR20190133077A (ko) 2008-06-25 2019-11-29 에스바테크 - 어 노바티스 컴파니 엘엘씨 ＴＮＦα를 저해하는 안정한 가용성 항체
KR101882352B1 (ko) 2008-06-25 2018-07-26 에스바테크 - 어 노바티스 컴파니 엘엘씨 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화
CA3020290A1 (en) 2008-06-25 2009-12-30 Esbatech, An Alcon Biomedical Research Unit Llc Stable and soluble antibodies inhibiting vegf
EP2304033B1 (en) 2008-06-30 2016-09-07 ESBATech, an Alcon Biomedical Research Unit LLC Functionalized polypeptides
CN102088958A (zh) 2008-07-10 2011-06-08 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 用于大分子的增强的递送的方法和组合物
US8399625B1 (en) 2009-06-25 2013-03-19 ESBATech, an Alcon Biomedical Research Unit, LLC Acceptor framework for CDR grafting
MX2012006626A (es) 2009-12-22 2012-06-25 Hoffmann La Roche Agregacion dependiente de secuencia.
KR101721187B1 (ko) * 2009-12-23 2017-03-29 에스바테크 - 어 노바티스 컴파니 엘엘씨 면역원성의 감소 방법
MX360336B (es) * 2010-07-16 2018-10-30 Adimab Llc Star Colecciones de anticuerpos.
JP5704386B2 (ja) * 2010-10-12 2015-04-22 日本電気株式会社 タンパク質分子のアミノ酸置換部位選択装置、置換アミノ酸選択装置、アミノ酸置換部位選択方法、置換アミノ酸選択方法、プログラムおよび記録媒体
UY33679A (es) * 2010-10-22 2012-03-30 Esbatech Anticuerpos estables y solubles
SG190727A1 (en) 2010-11-30 2013-07-31 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
EP2476754A1 (en) * 2011-01-14 2012-07-18 Bundesrepublik Deutschland, Letztvertreten Durch Den Präsidenten Des Paul-Ehrlich-Instituts Methods for the identification and repair of amino acid residues destabilizing single-chain variable fragments (scFv)
KR101287625B1 (ko) * 2011-10-10 2013-07-23 대유라디에터공업 주식회사 열교환기용 튜브 제조방법
JP6774164B2 (ja) 2012-08-24 2020-10-21 中外製薬株式会社 マウスＦｃγＲＩＩ特異的Ｆｃ抗体
TWI697501B (zh) 2012-08-24 2020-07-01 日商中外製藥股份有限公司 ＦｃγＲＩＩｂ特異性Ｆｃ區域變異體
WO2014163101A1 (ja) 2013-04-02 2014-10-09 中外製薬株式会社 Ｆｃ領域改変体
TWI808330B (zh) 2014-12-19 2023-07-11 日商中外製藥股份有限公司 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法
TW202248212A (zh) 2015-02-05 2022-12-16 日商中外製藥股份有限公司 包含離子濃度依賴之抗原結合域的抗體、Fc區變體、IL-8結合抗體與其用途
GB201502590D0 (en) * 2015-02-16 2015-04-01 Lonza Ag Method and apparatus for designing proteins
WO2016199898A1 (ja) * 2015-06-10 2016-12-15 公立大学法人 富山県立大学 活性型変異酵素の製造方法および新規活性型変異酵素、並びに可溶性化変異タンパク質の製造方法
EP3394098A4 (en) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE
EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATING TO IL-8
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
TWI827585B (zh) 2018-03-15 2024-01-01 日商中外製藥股份有限公司 對茲卡病毒具有交叉反應性的抗登革病毒抗體及其使用方法
WO2022171771A1 (en) 2021-02-12 2022-08-18 Boehringer Ingelheim International Gmbh Complement c3 antigen binding proteins
US20220340894A1 (en) 2021-03-09 2022-10-27 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same
CA3210289A1 (en) 2021-03-09 2022-09-15 Anna Maria SOBIERAJ Mage-a4 peptide-mhc antigen binding proteins
WO2023110918A1 (en) 2021-12-14 2023-06-22 Cdr-Life Ag Dual mhc-targeting t cell engager
WO2023220038A1 (en) * 2022-05-10 2023-11-16 Amgen Inc. Machine learning techniques for predicting thermostability
US20240091262A1 (en) 2022-09-14 2024-03-21 Cdr-Life Ag Mage-a4 peptide dual t cell engagers

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
US5824307A (en) 1991-12-23 1998-10-20 Medimmune, Inc. Human-murine chimeric antibodies against respiratory syncytial virus
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
EP0752248B1 (en) 1992-11-13 2000-09-27 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
DK0698097T3 (da) 1993-04-29 2001-10-08 Unilever Nv Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
US6740734B1 (en) 1994-01-14 2004-05-25 Biovitrum Ab Bacterial receptor structures
SI9720020B (en) 1996-02-09 2001-12-31 Basf Ag Human antibodies that bind human TNF alpha
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
EP0985039B1 (en) 1997-06-12 2008-02-20 Novartis International Pharmaceutical Ltd. Artificial antibody polypeptides
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
MY136203A (en) 1998-08-11 2008-08-29 Idec Pharma Corp Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
WO2000035510A1 (en) 1998-12-14 2000-06-22 Osteotech, Inc. Bone graft and guided bone regeneration method
US6602977B1 (en) 1999-04-19 2003-08-05 Biovitrum Ab Receptor structures
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1479694B1 (en) 1999-12-28 2016-10-26 ESBATech, an Alcon Biomedical Research Unit LLC Intrabodies ScFv with defined framework that is stable in a reducing environment
BR0015875A (pt) 2000-05-10 2003-06-24 Mayo Foundation Anticorpos igm humano com a capacidade de induzir remielinização, e usos diagnósticos e terapêutico dos mesmos, particularmente no sistema nervoso central
ATE448301T1 (de) 2000-09-08 2009-11-15 Univ Zuerich Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US20030157561A1 (en) 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
WO2002088171A2 (en) 2001-04-26 2002-11-07 Avidia Research Institute Combinatorial libraries of monomer domains
CA2453662A1 (en) * 2001-07-19 2003-01-30 Stefan Ewert Modification of human variable domains
HUE048922T2 (hu) 2002-05-22 2020-09-28 Novartis Ag Immunglobulin vázrégiók, amelyek intracelluláris környezetben fokozott stabilitást mutatnak, továbbá eljárások azonosításukra
CA2531482A1 (en) 2003-06-30 2005-01-20 Centocor, Inc. Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
AU2003264100A1 (en) 2003-08-25 2005-03-10 Pieris Proteolab Ag Muteins of a bilin-binding protein with affinity for a given target
RU2006122946A (ru) 2003-11-28 2008-01-10 Астразенека Аб (Se) Антитела
WO2006083275A2 (en) 2004-05-21 2006-08-10 The Uab Research Foundation Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof
GB0416651D0 (en) 2004-07-26 2004-08-25 Proteo Target Aps Polypeptide
US7462697B2 (en) 2004-11-08 2008-12-09 Epitomics, Inc. Methods for antibody engineering
NZ563580A (en) 2005-06-07 2010-09-30 Esbatech An Alcon Biomedical R Stable and soluble antibodies inhibiting TNFaplha
PL2481753T3 (pl) 2005-12-13 2018-09-28 Eli Lilly And Company Przeciwciała anty-IL-17
AU2007272224B2 (en) 2006-07-10 2013-05-02 Novartis Ag scFv antibodies which pass epithelial and/or endothelial layers
CA2680564C (en) 2007-03-12 2018-05-01 Esbatech Ag Sequence based engineering and optimization of single chain antibodies
DK2164961T3 (en) 2007-06-25 2015-03-02 Esbatech Alcon Biomed Res Unit Sequence based forward position and optimization of single chain ​​antibodies
WO2009000099A2 (en) 2007-06-25 2008-12-31 Esbatech Ag Methods of modifying antibodies, and modified antibodies with improved functional properties

Also Published As

Publication number Publication date
AU2008267733A1 (en) 2008-12-31
BRPI0813287A2 (pt) 2014-12-30
NZ581470A (en) 2013-04-26
DK2164961T3 (en) 2015-03-02
WO2009000098A2 (en) 2008-12-31
JP2014051508A (ja) 2014-03-20
ES2532725T3 (es) 2015-03-31
CN101688200A (zh) 2010-03-31
PL2164961T3 (pl) 2015-08-31
EP2164961B1 (en) 2015-01-07
JP5506670B2 (ja) 2014-05-28
KR101530723B1 (ko) 2015-06-22
US9908945B2 (en) 2018-03-06
KR20100028053A (ko) 2010-03-11
EP2164961A2 (en) 2010-03-24
CA2689064C (en) 2018-04-24
SI2164961T1 (sl) 2015-05-29
CA2689064A1 (en) 2008-12-31
RU2010102064A (ru) 2011-07-27
JP2010532324A (ja) 2010-10-07
HK1137035A1 (en) 2010-07-16
AU2008267733B2 (en) 2013-11-14
IL202352A0 (en) 2011-08-01
US20090028848A1 (en) 2009-01-29
ZA200908314B (en) 2011-02-23
IL202352A (en) 2015-06-30
PT2164961E (pt) 2015-04-08
CN101688200B (zh) 2012-08-08
WO2009000098A3 (en) 2009-04-23

Similar Documents

Publication Publication Date Title
MX2009013327A (es) Ingenieria basada en secuencias y optimizacion de anticuerpos de cadena simple.
IN2009DN05758A (es)
MX2009013328A (es) Metodos para modificar anticuerpos, y anticuerpos modificados con propiedades funcionales mejoradas.
AR095980A1 (es) Anticuerpos biespecíficos específicos para fap (proteína de activación fibroblástica) y dr5 (receptor de muerte 5), anticuerpos específicos para dr5 y métodos de utilización
AR083747A1 (es) Anticuerpos anti-il-23
ATE431423T1 (de) Verfahren zum screening der leichten kette eines antikörpers
MX346024B (es) Optimización de solubilidad de inmuno-aglutinantes.
NZ706377A (en) Il-6 antagonists and uses thereof
UA99701C2 (ru) Человеческое моноклональное антитело, которое специфически связывается с лигандом-1 запрограммированной гибели клеток (pd-l1)
PH12015501505A1 (en) Antibodies that bind to tl1a and their uses
GEP20125517B (en) Humanized monoclonical antibodies to hepatocyte growth factor
CR20110577A (es) Proteínas de unión a il-1
MXPA06010715A (es) Anticuerpo del receptor del factor de crecimiento humano anti-epidermico.
GEP20094829B (en) Fully human antibodies against human 4-1bb (cd137)
NZ594466A (en) Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
TN2014000120A1 (en) Cd27l antigen binding proteins
UA106070C2 (uk) Антитіло, що специфічно зв'язується з egfr і her3
NO20092285L (no) Humane, monoklonale antistoffer til BTLA og fremgangsmater for anvendelse
DE602006013029D1 (de) Anti-egfr-antikörper
IN2014MN00873A (es)
MX342413B (es) Anticuerpos para metaloproteinasa-9 de matriz.
MX2018007630A (es) Anticuerpos contra la metaloproteinasa de matriz 9.
NZ720765A (en) Antibodies and methods of use
DE602005027399D1 (de) Für humane matriptase spezifische bindungsproteine
MX2010006767A (es) Anticuerpos de virus de hepatitis c.

Legal Events

Date Code Title Description
FG Grant or registration