MX2009011412A - Compuestos moduladores de receptores de crth2 y/o pgd2 y su uso para el tratamiento de asma e inflamacion alergica. - Google Patents

Compuestos moduladores de receptores de crth2 y/o pgd2 y su uso para el tratamiento de asma e inflamacion alergica.

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Publication number
MX2009011412A
MX2009011412A MX2009011412A MX2009011412A MX2009011412A MX 2009011412 A MX2009011412 A MX 2009011412A MX 2009011412 A MX2009011412 A MX 2009011412A MX 2009011412 A MX2009011412 A MX 2009011412A MX 2009011412 A MX2009011412 A MX 2009011412A
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MX
Mexico
Prior art keywords
compounds
crth2
treating asthma
allergic inflammation
linkage selected
Prior art date
Application number
MX2009011412A
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English (en)
Inventor
Wang Shen
Julio C Medina
Jiwen Liu
Yingcai Wang
Sarah E Lively
Michael G Johnson
An-Rong Li
Xuemei Wang
Matthew Brown
Original Assignee
Amgen Inc
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Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2009011412A publication Critical patent/MX2009011412A/es

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Abstract

La presente invención se relaciona con compuestos, composiciones y métodos útiles para el tratamiento de enfermedades y afecciones inflamatorias e inmunes relacionadas. Los compuestos son moduladores de los receptores de prostaglandina D2 (PGD2) que incluyen los receptores de CRTH2 y DP. Los compuestos objetivo son derivados de ácidos carboxílicos de las fórmulas (II) y (III), en donde X representa un enlace divalente seleccionado de -O- -S(O)k-, _CRaRb_ -C(O)-, -NR8- y -C(NR9)-; Y es un enlace divalente seleccionado de un enlace simple, -S(O)kNR10-, -C(O)NR10-, alquileno (C1-C4), heteroalquileno (C2-C4), -N(R11)C(O)NR10-, -N(R11)S(O)kNR10-, -N(R11)CO2-, -NR11-, -O- y -S(O)k-; Z es -CO2R12, -C(O)NR12R13 o heteroarilo; L representa un enlace divalente seleccionado de un enlace simple, alquileno (C1-C6), alquenileno (C2-C6), alquinileno (C2-C6) y heteroalquileno (C2-C4).
MX2009011412A 2007-05-02 2008-05-01 Compuestos moduladores de receptores de crth2 y/o pgd2 y su uso para el tratamiento de asma e inflamacion alergica. MX2009011412A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92754507P 2007-05-02 2007-05-02
PCT/US2008/005611 WO2008137027A2 (en) 2007-05-02 2008-05-01 Compounds as crth2 and/or pgd2 receptors modulators and their use for treating asthma and allergic inflammation

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MX2009011412A true MX2009011412A (es) 2009-11-05

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US (1) US7960567B2 (es)
EP (1) EP2164828B1 (es)
JP (1) JP5537417B2 (es)
AU (1) AU2008248201B2 (es)
CA (1) CA2685215C (es)
ES (1) ES2402987T3 (es)
MX (1) MX2009011412A (es)
WO (1) WO2008137027A2 (es)

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JP5491199B2 (ja) * 2007-01-19 2014-05-14 アルデア バイオサイエンシズ，インコーポレイティド Ｍｅｋのインヒビター
CA2707789A1 (en) * 2007-12-19 2009-07-09 Amgen Inc. Phenyl acetic acid derivatives as inflammation modulators
BRPI0907364A2 (pt) 2008-02-01 2015-07-14 Amira Pharmaceuticals Inc Antagonistas aminoalquilbifenil n,n-disubstituídos de receptores d2 de prostaglandina
JP2011512359A (ja) 2008-02-14 2011-04-21 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体のアンタゴニストとしての環式ジアリールエーテル化合物
US8497381B2 (en) 2008-02-25 2013-07-30 Panmira Pharmaceuticals, Llc Antagonists of prostaglandin D2 receptors
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