MX2009008228A - N-adamantil benzamidas como inhibidores de la dehidrogenasa 11-beta-hidroxiesteroide. - Google Patents

N-adamantil benzamidas como inhibidores de la dehidrogenasa 11-beta-hidroxiesteroide.

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Publication number
MX2009008228A
MX2009008228A MX2009008228A MX2009008228A MX2009008228A MX 2009008228 A MX2009008228 A MX 2009008228A MX 2009008228 A MX2009008228 A MX 2009008228A MX 2009008228 A MX2009008228 A MX 2009008228A MX 2009008228 A MX2009008228 A MX 2009008228A
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MX
Mexico
Prior art keywords
compounds
hydroxysteroid dehydrogenase
inhibitors
beta
benzamides
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MX2009008228A
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English (en)
Inventor
Soeren Ebdrup
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High Point Pharmaceuticals Llc
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Application filed by High Point Pharmaceuticals Llc filed Critical High Point Pharmaceuticals Llc
Publication of MX2009008228A publication Critical patent/MX2009008228A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C2603/74—Adamantanes

Abstract

Se describen los inhibidores basados en benzamida sustituida novedosos, su uso en terapia, las composiciones farmacéuticas que comprenden los compuestos, el uso de dichos compuestos en la fabricación de medicamentos y los métodos terapéuticos que comprende la administración de dichos compuestos. Los presentes compuestos modulan la actividad de la dehidrogenasa 11ß-hidroxiesteroide tipo 1 (11ßHSD1) y por consiguiente son útiles en el tratamiento de las enfermedades en la cuales dicha modulación es benéfica, tal como el síndrome metabólico.
MX2009008228A 2007-02-23 2008-02-19 N-adamantil benzamidas como inhibidores de la dehidrogenasa 11-beta-hidroxiesteroide. MX2009008228A (es)

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PCT/EP2008/051971 WO2008101914A2 (en) 2007-02-23 2008-02-19 N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase

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ZA200904916B (en) 2010-09-29
WO2008101914A2 (en) 2008-08-28
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US8383820B2 (en) 2013-02-26
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US20140315905A1 (en) 2014-10-23
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IL199853A0 (en) 2010-04-15
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