MX2009008068A - Compuesto macrolido en forma solida, proceso para su preparacion y composicion farmaceutica que lo contiene. - Google Patents

Compuesto macrolido en forma solida, proceso para su preparacion y composicion farmaceutica que lo contiene.

Info

Publication number
MX2009008068A
MX2009008068A MX2009008068A MX2009008068A MX2009008068A MX 2009008068 A MX2009008068 A MX 2009008068A MX 2009008068 A MX2009008068 A MX 2009008068A MX 2009008068 A MX2009008068 A MX 2009008068A MX 2009008068 A MX2009008068 A MX 2009008068A
Authority
MX
Mexico
Prior art keywords
solid
pharmaceutical composition
production
same
macrolide compound
Prior art date
Application number
MX2009008068A
Other languages
English (en)
Inventor
Masashi Yoshida
Hiroshi Ishihara
Manabu Sasho
Keizo Sato
Kamahara Takashi
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2009008068A publication Critical patent/MX2009008068A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invención proporciona el compuesto de fórmula (I) en forma sólida que, como medicamento a granel para la fabricación farmacéutica, es uniforme, tiene una alta pureza y es fácil de trabajar. La invención proporciona además un proceso para la preparación de este compuesto y composiciones farmacéuticas que lo contienen. Se desarrolló Una forma sólida de (8E,12E,14E)-7-{(4-cicloheptilpiperazin-1-il)carbonil}oxi-3,6,16, 21-tetrahidroxi-6,10,12,16,20-pentamentil-18,19-epoxitricosa-8,12 ,14-trien-11-olido que tiene especificaciones uniformes y que resulta fácil de trabajar.
MX2009008068A 2007-01-29 2008-01-28 Compuesto macrolido en forma solida, proceso para su preparacion y composicion farmaceutica que lo contiene. MX2009008068A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007017491 2007-01-29
US88825707P 2007-02-05 2007-02-05
PCT/JP2008/051695 WO2008093853A1 (ja) 2007-01-29 2008-01-28 マクロライド系化合物の固体およびその製造法並びにその医薬組成物

Publications (1)

Publication Number Publication Date
MX2009008068A true MX2009008068A (es) 2009-11-18

Family

ID=39674155

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008068A MX2009008068A (es) 2007-01-29 2008-01-28 Compuesto macrolido en forma solida, proceso para su preparacion y composicion farmaceutica que lo contiene.

Country Status (17)

Country Link
US (1) US7790887B2 (es)
EP (1) EP2116542A4 (es)
JP (1) JPWO2008093853A1 (es)
KR (1) KR20090104002A (es)
CN (1) CN101616912A (es)
AR (1) AR065045A1 (es)
AU (1) AU2008211950A1 (es)
BR (1) BRPI0805837A2 (es)
CA (1) CA2673734A1 (es)
CL (1) CL2008000231A1 (es)
IL (1) IL200103A0 (es)
MX (1) MX2009008068A (es)
NZ (1) NZ575828A (es)
PE (1) PE20081705A1 (es)
RU (1) RU2009132476A (es)
WO (1) WO2008093853A1 (es)
ZA (1) ZA200904530B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI334866B (en) * 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
MX2009008068A (es) 2007-01-29 2009-11-18 Eisai R&D Man Co Ltd Compuesto macrolido en forma solida, proceso para su preparacion y composicion farmaceutica que lo contiene.
CA2692644A1 (en) * 2007-07-06 2009-01-15 Toshio Tsuchida Method for producing macrolide compound and production intermediate therof
AU2019251096B2 (en) 2018-04-09 2023-04-20 Eisai R&D Management Co., Ltd. Pladienolide compounds and their use
JOP20200244A1 (ar) 2018-04-12 2020-09-29 Eisai R&D Man Co Ltd مشتقات بلاديينوليد كعوامل تستهدف جسيمات الوصل لعلاج السرطان

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL27183A (en) 1966-02-01 1970-07-19 Upjohn Co Parenteral composition comprising freeze dried mannitol
JPS6054933B2 (ja) 1978-01-27 1985-12-03 小野薬品工業株式会社 プロスタグランジン及びプロスタグランジン類似化合物製剤の安定化法
JPH04352783A (ja) 1991-05-27 1992-12-07 Taisho Pharmaceut Co Ltd １２員環マクロライド系化合物
JPH10502616A (ja) 1994-04-25 1998-03-10 協和醗酵工業株式会社 Ｄｘ−５２−１化合物の安定化法及びその凍結乾燥組成物
EP1192147A1 (en) 1999-06-03 2002-04-03 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Mycolactone and related compounds, compositions and methods of use
US6391903B1 (en) 1999-09-09 2002-05-21 Sankyo Company, Limited Triazole derivatives having antifungal activity
JP3240129B1 (ja) * 1999-09-09 2001-12-17 三共株式会社 トリアゾール抗真菌剤
JP4953501B2 (ja) * 1999-09-30 2012-06-13 大塚化学株式会社 ３−セフェム誘導体結晶の製造方法
US6562602B2 (en) 2000-08-03 2003-05-13 Kosan Biosciences, Inc. Fermentation and purification of mycolactones
TWI311558B (en) * 2001-02-01 2009-07-01 Mercian Corporatio Novel physiologically active substance
TWI233361B (en) 2001-04-13 2005-06-01 Gen Hospital Corp Methods of preventing UVB-induced skin damage
TWI334866B (en) 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
JP2004269488A (ja) * 2002-06-06 2004-09-30 Hayashibara Biochem Lab Inc 結晶α−Ｄ−グルコシルα−Ｄ−ガラクトシドとこれを含有する糖質及びこれらの製造方法並びに用途
RU2338741C2 (ru) 2002-07-31 2008-11-20 Мершан Корпорейшн Новые физиологически активные вещества
AU2003252299A1 (en) 2002-07-31 2004-02-16 Eisai Co., Ltd. Novel physiologically active substance
WO2004050890A1 (ja) 2002-11-29 2004-06-17 Mercian Corporation マクロライド系化合物の製造方法
CN100376251C (zh) 2003-05-07 2008-03-26 卫材R&D管理有限公司 含有甲基维生素b12的冻干制剂及其制备方法
CN100540550C (zh) 2004-01-29 2009-09-16 卫材R&D管理有限公司 大环内酯类化合物的稳定化方法
US20080280288A1 (en) * 2004-02-06 2008-11-13 Toshimitsu Uenaka Assay Method to Predict Sensitivity of Cancer Cell to Anticancer Drug
JP2007269628A (ja) * 2004-05-28 2007-10-18 Takeda Chem Ind Ltd 医薬化合物の結晶
CA2584358A1 (en) * 2004-12-01 2006-06-08 Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag Non-hygroscopic and powdery amorphous pimecrolimus
KR100598119B1 (ko) 2005-01-17 2006-07-10 삼성전자주식회사 디스플레이장치 및 그 제어방법
WO2006121104A1 (ja) * 2005-05-11 2006-11-16 Eisai R & D Management Co., Ltd. ピペリジン環を有するインドール誘導体の結晶およびその製法
JPWO2007043621A1 (ja) 2005-10-13 2009-04-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 プラジエノライドｂ及びプラジエノライドｄの全合成方法
JPWO2008020584A1 (ja) 2006-08-14 2010-01-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定な凍結乾燥製剤
MX2009008068A (es) 2007-01-29 2009-11-18 Eisai R&D Man Co Ltd Compuesto macrolido en forma solida, proceso para su preparacion y composicion farmaceutica que lo contiene.

Also Published As

Publication number Publication date
CA2673734A1 (en) 2008-08-07
AR065045A1 (es) 2009-05-13
BRPI0805837A2 (pt) 2011-08-30
EP2116542A4 (en) 2011-05-04
ZA200904530B (en) 2010-09-29
KR20090104002A (ko) 2009-10-05
EP2116542A1 (en) 2009-11-11
NZ575828A (en) 2011-04-29
RU2009132476A (ru) 2011-03-10
PE20081705A1 (es) 2008-12-22
US7790887B2 (en) 2010-09-07
WO2008093853A1 (ja) 2008-08-07
AU2008211950A1 (en) 2008-08-07
CN101616912A (zh) 2009-12-30
US20080214564A1 (en) 2008-09-04
CL2008000231A1 (es) 2008-05-30
IL200103A0 (en) 2010-04-15
JPWO2008093853A1 (ja) 2010-05-20

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