MX2009007394A - Tapones puntuales y metodos de entrega de agentes terapeuticos. - Google Patents

Tapones puntuales y metodos de entrega de agentes terapeuticos.

Info

Publication number
MX2009007394A
MX2009007394A MX2009007394A MX2009007394A MX2009007394A MX 2009007394 A MX2009007394 A MX 2009007394A MX 2009007394 A MX2009007394 A MX 2009007394A MX 2009007394 A MX2009007394 A MX 2009007394A MX 2009007394 A MX2009007394 A MX 2009007394A
Authority
MX
Mexico
Prior art keywords
methods
therapeutic agents
delivering therapeutic
punctal plugs
present
Prior art date
Application number
MX2009007394A
Other languages
English (en)
Inventor
Alan L Weiner
David Allen Marsh
Theron R Rodstrom
Larry Ii Smith
Youqin Tian
Shivalik Bakshi
Original Assignee
Alcon Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Res Ltd filed Critical Alcon Res Ltd
Publication of MX2009007394A publication Critical patent/MX2009007394A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con dispositivos oculares implantables para la liberación sostenida de medicación al ojo, y métodos para fabricar y usar dichos dispositivos. En una modalidad,. La presente invención proporciona un dispositivo que comprende: (a) un cuerpo que comprende una matriz de una prostaglandina y una silicona; (b) un revestimiento de parileno en la superficie externa del cuerpo; y (c) uno o más poros que se extienden desde la superficie externa del revestimiento de parileno a la superficie externa del cuerpo.
MX2009007394A 2007-01-31 2008-01-30 Tapones puntuales y metodos de entrega de agentes terapeuticos. MX2009007394A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89859907P 2007-01-31 2007-01-31
PCT/US2008/052439 WO2008094989A2 (en) 2007-01-31 2008-01-30 Punctal plugs and methods of delivering therapeutic agents

Publications (1)

Publication Number Publication Date
MX2009007394A true MX2009007394A (es) 2009-08-12

Family

ID=39313204

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007394A MX2009007394A (es) 2007-01-31 2008-01-30 Tapones puntuales y metodos de entrega de agentes terapeuticos.

Country Status (24)

Country Link
US (1) US8753666B2 (es)
EP (1) EP2114531B1 (es)
JP (1) JP2010517630A (es)
KR (1) KR20090104099A (es)
CN (1) CN101600476B (es)
AR (1) AR065235A1 (es)
AU (1) AU2008210541B2 (es)
BR (1) BRPI0807340A2 (es)
CA (1) CA2674913A1 (es)
CL (1) CL2008000306A1 (es)
CY (1) CY1113075T1 (es)
DK (1) DK2114531T3 (es)
ES (1) ES2390991T3 (es)
HK (1) HK1133218A1 (es)
HR (1) HRP20120608T1 (es)
MX (1) MX2009007394A (es)
PL (1) PL2114531T3 (es)
PT (1) PT2114531E (es)
RU (1) RU2459646C2 (es)
SI (1) SI2114531T1 (es)
TW (1) TW200838485A (es)
UY (1) UY30883A1 (es)
WO (1) WO2008094989A2 (es)
ZA (1) ZA200904713B (es)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
EP3470108A1 (en) 2004-07-02 2019-04-17 Mati Therapeutics Inc. Treatment medium delivery device for delivery of treatment media to the eye
CA2833354C (en) 2006-03-14 2015-12-15 University Of Southern California Mems device and method for delivery of therapeutic agents
DK2010096T3 (en) 2006-03-31 2017-10-02 Mati Therapeutics Inc NASOLACRIMAL DRAINAGE SYSTEM IMPLANTS FOR PHARMACEUTICAL THERAPY
NZ598483A (en) * 2007-09-07 2013-08-30 Quadra Logic Tech Inc Drug cores for sustained release of therapeutic agents
WO2009032328A1 (en) 2007-09-07 2009-03-12 Qlt Plug Delivery, Inc Lacrimal implants and related methods
RU2010112417A (ru) 2007-09-07 2011-10-10 Клт Плаг Диливери, Инк. (Us) Обнаружение лакримальных имплантатов
JP5542691B2 (ja) 2007-12-20 2014-07-09 ユニバーシティ オブ サザン カリフォルニア 治療薬を送達するための装置および方法
MX2010007382A (es) 2008-01-03 2010-12-20 Univ Southern California Dispositivos implantables para suministro de farmacos, y aparato y metodos para recargar los dispositivos.
US9132088B2 (en) 2008-04-30 2015-09-15 Mati Therapeutics Inc. Composite lacrimal insert and related methods
CN102202706A (zh) * 2008-05-08 2011-09-28 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
EP2898911A1 (en) 2008-05-08 2015-07-29 MiniPumps, LLC Implantable pumps and cannulas therefor
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
EP2323716B1 (en) 2008-05-08 2015-03-04 MiniPumps, LLC Drug-delivery pumps
JP2011520805A (ja) * 2008-05-09 2011-07-21 キューエルティー プラグ デリバリー，インク． 緑内障および高眼圧症治療のための活性剤の持続送達
TW201012469A (en) * 2008-06-24 2010-04-01 Qlt Plug Delivery Inc Combination treatment of glaucoma
US20100104654A1 (en) * 2008-10-27 2010-04-29 Allergan, Inc. Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof
EP2376019A1 (en) * 2008-12-19 2011-10-19 QLT, Inc. Substance delivering punctum implants and methods
MX2011007804A (es) * 2009-01-23 2011-12-06 Quadra Logic Tech Inc Suministro de liberación sostenida de uno o más agentes.
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
AU2010208046B2 (en) 2009-01-29 2014-10-02 Forsight Vision4, Inc. Posterior segment drug delivery
SG174133A1 (en) * 2009-02-23 2011-10-28 Quadra Logic Tech Inc Lacrimal implants and related methods
US20100226962A1 (en) * 2009-03-03 2010-09-09 Rodstrom Theron R Peri-corneal drug delivery device
US9421127B2 (en) 2009-03-31 2016-08-23 Johnson & Johnson Vision Care, Inc. Punctal plugs
TWI495459B (zh) * 2009-03-31 2015-08-11 Johnson & Johnson Vision Care 淚管塞（二）
CN105726201B (zh) * 2009-05-18 2020-08-25 多斯医学公司 给药眼植入物
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CA2764063C (en) 2009-06-03 2019-05-14 Forsight Labs, Llc Anterior segment drug delivery
WO2010151269A1 (en) 2009-06-26 2010-12-29 Biotic Laboratories, Inc. Para-xylylene based multilayer drug elution devices
AU2010284216B2 (en) 2009-08-18 2015-10-15 Minipumps, Llc Electrolytic drug-delivery pump with adaptive control
US8469934B2 (en) * 2010-01-27 2013-06-25 Alcon Research, Ltd. Pulsatile peri-corneal drug delivery device
WO2013022801A1 (en) * 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US9259351B2 (en) * 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
US9259352B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
JP2013523821A (ja) * 2010-04-06 2013-06-17 アラーガン、インコーポレイテッド 前房内薬剤送達のための徐放性リザーバーインプラント
SI2600812T1 (sl) * 2010-08-05 2021-12-31 ForSight Vision4, Inc., Naprava za zdravljenje očesa
WO2012019139A1 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8591484B2 (en) 2010-09-15 2013-11-26 AlphaMed, Inc. Lacrimal punctum measurement and occlusion
CA2818612C (en) 2010-11-19 2020-12-29 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US8715713B2 (en) 2011-04-29 2014-05-06 Allergan, Inc. Solvent cast film sustained release latanoprost implant
EP2726016B1 (en) 2011-06-28 2023-07-19 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
US20130018360A1 (en) * 2011-07-13 2013-01-17 Marissa Dockendorf Method for delivering ophthalmic drugs
WO2013030679A2 (en) 2011-08-29 2013-03-07 Qlt Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
WO2013040426A2 (en) 2011-09-14 2013-03-21 Forsight Labs, Llc Ocular insert apparatus and methods
PL2755600T3 (pl) 2011-09-16 2021-09-20 Forsight Vision4, Inc. Urządzenie do wymiany płynów
US8911227B2 (en) * 2012-01-11 2014-12-16 Johnson & Johnson Vision Care, Inc. Device for injection molding silicone rubber
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
FR2986703B1 (fr) * 2012-02-09 2015-01-16 Horus Pharma Dispositif de conditionnement et de distribution d'un produit a usage ophtalmique
WO2013164671A1 (en) 2012-05-03 2013-11-07 Qlt Inc. Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
RU2520834C2 (ru) * 2012-09-11 2014-06-27 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Дагестанский Государственный Технический Университет" (Дгту) Способ профилактики и лечения синдрома сухих глаз
CN104884006B (zh) 2012-10-26 2017-12-15 弗赛特影像5股份有限公司 用于持续释放药物到眼睛的眼科系统
AU2014207687B2 (en) 2013-01-15 2018-01-25 The Regents Of The University Of Colorado, A Body Corporate Lacrimal system drug delivery device
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
WO2014160828A1 (en) * 2013-03-27 2014-10-02 Forsight Vision5, Inc. Bimatoprost ocular silicone inserts and methods of use thereof
JP6385423B2 (ja) 2013-03-28 2018-09-05 フォーサイト・ビジョン フォー・インコーポレーテッド 治療物質送達用の眼移植片
CN105813578A (zh) * 2013-10-15 2016-07-27 弗赛特影像5股份有限公司 用于增加或减少粘液的制剂和方法
JP6655610B2 (ja) 2014-05-29 2020-02-26 グローコス コーポレーション 制御された薬物送達機能を備えるインプラント及びそれを使用する方法
RU2557423C1 (ru) * 2014-06-25 2015-07-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт глазных болезней" (ФГБНУ "НИИ глазных болезней") Способ лечения частичного дакриостеноза
CN106687079B (zh) 2014-07-15 2019-10-11 弗赛特影像4股份有限公司 眼睛植入输送装置和方法
MY182793A (en) 2014-08-08 2021-02-05 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
CN110478119B (zh) 2014-11-10 2022-04-15 弗赛特影像4股份有限公司 可膨胀药物递送装置和使用方法
CA2968926C (en) * 2014-11-25 2023-01-17 Izhar Halahmi Compositions and methods for delivering a bio-active agent or bio-active agents
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
CN106264777A (zh) * 2015-06-08 2017-01-04 三鼎生物科技股份有限公司 辅助排泪管
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053751A1 (en) * 2015-09-24 2017-03-30 California Institute Of Technology Implantable device for retaining live cells and providing nutrients thereto
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
CN108430405B (zh) 2015-11-20 2021-04-13 弗赛特影像4股份有限公司 用于缓释药物递送装置的多孔结构
JP6885609B2 (ja) 2015-11-23 2021-06-16 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ 薬物送達のための涙器システム
BR112018070383A2 (pt) 2016-04-05 2019-02-05 Forsight Vision4 Inc dispositivos para aplicação de fármaco oculares implantáveis
JP7003110B2 (ja) 2016-04-20 2022-01-20 ドーズ メディカル コーポレーション 生体吸収性眼球薬物送達デバイス
US11207211B2 (en) 2016-05-20 2021-12-28 The Regents Of The University Of Colorado, A Body Corporate Lacrimal drug delivery device
CN106667656A (zh) * 2016-06-30 2017-05-17 广州聚明生物科技有限公司 生物可降解泪道栓及其制备方法和应用
CN111278401B (zh) * 2017-05-30 2023-08-15 艾克思摩尔有限公司 递送抗生素大环内酯治疗干眼综合征的组合物和方法
CN115607358A (zh) 2017-11-21 2023-01-17 弗赛特影像4股份有限公司 用于可扩展端口递送系统的流体交换装置及使用方法
US20220125637A1 (en) * 2019-01-18 2022-04-28 Avisi Technologies, Inc. Method and device for treating eye disease
KR102414314B1 (ko) * 2019-02-27 2022-06-30 사회복지법인 삼성생명공익재단 코팅층을 포함하는 안질환용 임플란트

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949750A (en) * 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US3992518A (en) * 1974-10-24 1976-11-16 G. D. Searle & Co. Method for making a microsealed delivery device
US4053580A (en) * 1975-01-01 1977-10-11 G. D. Searle & Co. Microsealed pharmaceutical delivery device
FR2534580A1 (fr) 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
US5049142A (en) 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US4660546A (en) 1984-11-07 1987-04-28 Robert S. Herrick Method for treating for deficiency of tears
US5053030A (en) 1984-11-07 1991-10-01 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US5151444B1 (en) * 1987-09-18 1999-07-06 R Tech Ueno Ltd Ocular hypotensive agents
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension
US4915684A (en) * 1988-06-21 1990-04-10 Mackeen Donald L Method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus
US5296504A (en) 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
ES2213504T1 (es) 1988-09-06 2004-09-01 Pfizer Health Ab Derivados de prostaglandina para el tratamiento del glaucoma o hipertension ocular.
SU1671295A1 (ru) * 1988-10-24 1991-08-23 Туркменский государственный медицинский институт Устройство дл регулировани внутриглазного давлени при глаукоме
US4959048A (en) * 1989-01-17 1990-09-25 Helix Medical, Inc. Lacrimal duct occluder
US5067491A (en) * 1989-12-08 1991-11-26 Becton, Dickinson And Company Barrier coating on blood contacting devices
US5171270A (en) 1990-03-29 1992-12-15 Herrick Robert S Canalicular implant having a collapsible flared section and method
US5163959A (en) 1990-03-29 1992-11-17 Herrick Robert S Method for treating an eye with a canalicular implant having a collapsible flared section
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5283063A (en) 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
EP0561073B1 (en) 1992-03-19 2001-10-24 R-Tech Ueno Ltd. Treatment of ocular hypertension with beta-blockers and derivatives of prostanoic acid
US5469867A (en) 1992-09-02 1995-11-28 Landec Corporation Cast-in place thermoplastic channel occluder
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5922773A (en) 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
US5417651A (en) 1993-07-01 1995-05-23 Guena; Nicolas Punctum plug and monocanalicular probe for lacrimal pathology
US5510383A (en) 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
EP0664699A1 (en) 1993-08-13 1995-08-02 Vitaphore Corporation Hydrogel-based microsphere drug delivery systems
US5423777A (en) 1993-10-27 1995-06-13 Tajiri; Akira Punctum plug
JP3486758B2 (ja) 1994-06-24 2004-01-13 株式会社高研 注入可能な涙小管閉鎖剤
US6149684A (en) 1995-06-07 2000-11-21 Herrick; Robert S. Punctum plug having a thin elongated lip and a distal starting tip and method of using
US5723005A (en) 1995-06-07 1998-03-03 Herrick Family Limited Partnership Punctum plug having a collapsible flared section and method
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5741292A (en) 1995-10-26 1998-04-21 Eagle Vision Punctum dilating and plug inserting instrument with push-button plug release
JP3792775B2 (ja) 1996-04-08 2006-07-05 有限会社エム・エル・シー 涙道挿管器具
JPH1033584A (ja) 1996-07-26 1998-02-10 M L C:Kk 涙道挿管器具
US6016806A (en) 1997-03-27 2000-01-25 Eaglevision, Inc Punctum plug
US6041785A (en) 1997-03-27 2000-03-28 Eaglevision, Inc. Punctum plug
US6027470A (en) 1998-06-10 2000-02-22 Eagle Vision, Inc. Punctum plug and method for inserting the same into the punctual opening
US5830171A (en) 1997-08-12 1998-11-03 Odyssey Medical, Inc. Punctal occluder
NL1008090C2 (nl) 1998-01-22 1999-07-26 Lubberman Bernardus H M Plug voor het afsluiten van een traanbuis.
US6290684B1 (en) 1998-03-02 2001-09-18 Herrick Family Limited Partnership Punctum plug having a collapsible expanded section and distal tip extending substantially perpendicular thereto and method of inserting same
US6196993B1 (en) * 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
US6306114B1 (en) 1998-06-16 2001-10-23 Eagle Vision, Inc. Valved canalicular plug for lacrimal duct occlusion
CN1344156A (zh) 1999-02-23 2002-04-10 血管技术药物公司 用于改善身体通道和腔完整性的组合物及方法
US6234175B1 (en) 1999-03-23 2001-05-22 Medennium, Inc. Smart ocular plug design and method of insertion for punctal and intracanalicular implants
US6383192B1 (en) 1999-04-28 2002-05-07 Mlc Limited Company Apparatus for intubation of lacrimal duct
US6344047B1 (en) 2000-02-02 2002-02-05 Eagle Vision Instrument for inserting a punctum plug and method for manufacturing the instrument
CA2415480C (en) 2000-08-04 2009-05-26 Medennium, Inc. Ocular plug for punctal and intracanalicular implants
AU2002241834B2 (en) 2001-01-09 2006-11-09 Microchips, Inc. Flexible microchip devices for opthalmic and other applications
US6827738B2 (en) * 2001-01-30 2004-12-07 Timothy R. Willis Refractive intraocular implant lens and method
US6685626B2 (en) 2001-02-02 2004-02-03 Regeneration Technologies, Inc. Compositions, devices, methods, and kits for induction of adhesions
JP2002263124A (ja) 2001-03-12 2002-09-17 Masashige Nakayama 動物の眼病治療方法及びそれに用いる人工涙管
US6605108B2 (en) * 2001-04-13 2003-08-12 Eagle Vision, Inc. Monocanalicular stent
US20040022853A1 (en) 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
US7404825B2 (en) 2001-06-11 2008-07-29 Herrick Ii Robert S Implant capable of forming a differential image in an eye
DE10133870A1 (de) 2001-07-12 2003-02-06 Chris P Lohmann Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge
US7204995B2 (en) 2002-01-31 2007-04-17 El-Sherif Dalia M Treatment and control of dry eye by use of biodegradable polymer capsules
US20040043067A1 (en) * 2002-06-19 2004-03-04 Salamone Joseph C. Fluorosiloxane matrix controlled diffusion drug delivery systems
BR0312635A (pt) 2002-07-15 2005-04-19 Alcon Inc Composições de implante farmacêutico lipofìlico não polimérico para uso intraocular
FR2844182B1 (fr) * 2002-09-11 2004-12-03 Humanoptics Ag Bouchon d'obturation d'un canalicule lacrymal
JP2006515186A (ja) 2002-09-26 2006-05-25 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 血管周囲ラップ
AU2004207507B2 (en) * 2003-01-24 2009-11-19 Eyepoint Pharmaceuticals Us, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
AU2004207523A1 (en) 2003-01-24 2004-08-12 Control Delivery Systems, Inc. Controlled release of highly soluble agents
JP4824549B2 (ja) * 2003-05-02 2011-11-30 サーモディクス，インコーポレイティド 制御放出型の生体活性物質デリバリー・デバイス
AU2004291062A1 (en) * 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US7799336B2 (en) * 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US7252006B2 (en) * 2004-06-07 2007-08-07 California Institute Of Technology Implantable mechanical pressure sensor and method of manufacturing the same
EP3470108A1 (en) * 2004-07-02 2019-04-17 Mati Therapeutics Inc. Treatment medium delivery device for delivery of treatment media to the eye
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US7575781B2 (en) * 2004-08-03 2009-08-18 Sur Modics, Inc. Method for depositing a polymeric coating on a substrate
WO2006031658A2 (en) 2004-09-10 2006-03-23 Allergan, Inc. Therapeutic lacrimal canalicular inserts and related methods
DK2010096T3 (en) 2006-03-31 2017-10-02 Mati Therapeutics Inc NASOLACRIMAL DRAINAGE SYSTEM IMPLANTS FOR PHARMACEUTICAL THERAPY
US9173773B2 (en) 2006-06-21 2015-11-03 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US9474645B2 (en) 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US20080045911A1 (en) 2006-06-21 2008-02-21 Borgia Maureen J Punctal plugs for the delivery of active agents
US20080086101A1 (en) 2006-08-25 2008-04-10 David Freilich Ophthalmic insert

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CN101600476A (zh) 2009-12-09
AU2008210541B2 (en) 2013-09-26
PT2114531E (pt) 2012-10-09
CA2674913A1 (en) 2008-08-07
EP2114531A2 (en) 2009-11-11
CY1113075T1 (el) 2016-04-13
BRPI0807340A2 (pt) 2017-05-02
US8753666B2 (en) 2014-06-17
JP2010517630A (ja) 2010-05-27
ES2390991T3 (es) 2012-11-20
UY30883A1 (es) 2008-05-31
EP2114531B1 (en) 2012-07-11
HK1133218A1 (en) 2010-03-19
PL2114531T3 (pl) 2012-10-31
ZA200904713B (en) 2010-09-29
TW200838485A (en) 2008-10-01
RU2459646C2 (ru) 2012-08-27
DK2114531T3 (da) 2012-07-30
KR20090104099A (ko) 2009-10-05
SI2114531T1 (sl) 2012-09-28
CN101600476B (zh) 2013-08-21
RU2009132493A (ru) 2011-03-10
WO2008094989A3 (en) 2009-04-30
AR065235A1 (es) 2009-05-27
AU2008210541A1 (en) 2008-08-07
WO2008094989A2 (en) 2008-08-07
CL2008000306A1 (es) 2008-09-05
US20080181930A1 (en) 2008-07-31
HRP20120608T1 (hr) 2012-08-31

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