MX2009005012A - Una forma pura de rapamicina y procedimiento para la recuperacion y purificacion de la misma. - Google Patents

Una forma pura de rapamicina y procedimiento para la recuperacion y purificacion de la misma.

Info

Publication number
MX2009005012A
MX2009005012A MX2009005012A MX2009005012A MX2009005012A MX 2009005012 A MX2009005012 A MX 2009005012A MX 2009005012 A MX2009005012 A MX 2009005012A MX 2009005012 A MX2009005012 A MX 2009005012A MX 2009005012 A MX2009005012 A MX 2009005012A
Authority
MX
Mexico
Prior art keywords
rapamycin
product
pure form
solvent
purification
Prior art date
Application number
MX2009005012A
Other languages
English (en)
Inventor
Nitin Sopanrao Patil
Syed Idris Hussaini
Ashish Kumar Singh
Rakesh Bhaiyyaram Mendhe
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of MX2009005012A publication Critical patent/MX2009005012A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a una forma pura de rapamicina con un contenido total de impurezas de menos de 1.2%; un procedimiento para recuperar y purificar la rapamicina que comprende los pasos de: (a) tratar el caldo de fermentación, extractos o soluciones que contienen rapamicina con un solvente no miscible en agua y la concentración, (b) la adición de un solvente miscible en agua para efectuar la separación de las impurezas que estén presentes; (c) opcionalmente, unir el solvente que contiene el producto del paso (b) con un sólido inerte, lavar el sólido con una base y ácido, seguido por la elusión; (d) someter el eluído del paso (c) o el solvente que contiene el producto del paso (b) a cromatografía en gel de sílice; (e) la cristalización del producto obtenido en el paso (d); (f) someter una solución del producto del paso (e) a integración hidrófoba o cromatografía de fase invertida; y (g) la recristalización para producir rapidamente en una forma sustancialmente pura.
MX2009005012A 2006-11-10 2006-12-26 Una forma pura de rapamicina y procedimiento para la recuperacion y purificacion de la misma. MX2009005012A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2079CH2006 2006-11-10
PCT/IN2006/000502 WO2008056372A1 (en) 2006-11-10 2006-12-26 A pure form of rapamycin and a process for recovery and purification thereof

Publications (1)

Publication Number Publication Date
MX2009005012A true MX2009005012A (es) 2009-09-07

Family

ID=39364224

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005012A MX2009005012A (es) 2006-11-10 2006-12-26 Una forma pura de rapamicina y procedimiento para la recuperacion y purificacion de la misma.

Country Status (10)

Country Link
US (1) US20100029933A1 (es)
EP (1) EP2079748A4 (es)
JP (1) JP2010509317A (es)
KR (1) KR20090080110A (es)
AU (1) AU2006350684B2 (es)
BR (1) BRPI0621967A2 (es)
CA (1) CA2669714A1 (es)
MX (1) MX2009005012A (es)
RU (1) RU2009122202A (es)
WO (1) WO2008056372A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7146409B1 (en) * 2001-07-24 2006-12-05 Brightplanet Corporation System and method for efficient control and capture of dynamic database content
EP2090580B1 (en) * 2006-11-27 2014-06-04 Terumo Kabushiki Kaisha Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative
EP2380006A4 (en) * 2009-01-21 2012-05-16 Biocon Ltd PROCESS FOR DETERMINING THE SIROLIMUS STABILITY AND METHOD FOR PRODUCING ITS STABLE FORM
CN102443012B (zh) * 2010-10-13 2016-03-02 鲁南制药集团股份有限公司 一种从发酵液中提纯雷帕霉素的方法
CN102464668B (zh) * 2010-11-17 2015-04-29 浙江海正药业股份有限公司 雷帕霉素或其衍生物的制备色谱纯化方法
CN102372726B (zh) * 2011-11-08 2014-02-19 福建省微生物研究所 西罗莫司粗晶的制备方法
WO2014072984A1 (en) * 2012-11-06 2014-05-15 Natco Pharma Limited Improved process for isolation and purification of rapamycin from fermentation broth
ES2897473T3 (es) 2013-03-15 2022-03-01 Biosensors Int Group Ltd Purificación de derivados de la rapamicina
CN106061482A (zh) 2013-10-08 2016-10-26 拉姆医疗公司 用于治疗淋巴管平滑肌瘤病的雷帕霉素
HUE062742T2 (hu) 2014-04-04 2023-12-28 Ai Therapeutics Inc Belélegezhetõ rapamicin készítmény életkorral kapcsolatos állapotok kezelésére
BR112017006842A2 (pt) 2014-10-07 2017-12-12 Lam Therapeutics Inc formulação de rapamicina inalável para o tratamento de hipertensão pulmonar
CN105585578B (zh) * 2014-10-23 2017-12-05 重庆乾泰生物医药有限公司 一种雷帕霉素的制备方法
CN104844620B (zh) * 2015-04-10 2018-06-19 鲁南新时代生物技术有限公司 一种雷帕霉素的分离纯化方法
CN105301159B (zh) * 2015-10-29 2017-01-18 无锡福祈制药有限公司 一种西罗莫司的高效液相色谱分析方法
CN108976245B (zh) * 2017-11-09 2020-08-07 北大方正集团有限公司 一种雷帕霉素的提取方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993749A (en) * 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
GB9125660D0 (en) * 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound
UA41884C2 (uk) * 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
KR20050114262A (ko) * 2003-03-31 2005-12-05 테바 기오기스제르갸르 레스즈베니타르사사그 마크로라이드의 결정화 및 정제
AU2003269473A1 (en) * 2003-08-26 2005-03-10 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
RU2007130406A (ru) * 2005-03-02 2009-04-10 Вайет (Us) Очистка рапамицина

Also Published As

Publication number Publication date
EP2079748A4 (en) 2011-05-04
KR20090080110A (ko) 2009-07-23
JP2010509317A (ja) 2010-03-25
US20100029933A1 (en) 2010-02-04
BRPI0621967A2 (pt) 2011-12-27
AU2006350684A1 (en) 2008-05-15
RU2009122202A (ru) 2010-12-20
CA2669714A1 (en) 2008-05-15
WO2008056372A1 (en) 2008-05-15
EP2079748A1 (en) 2009-07-22
AU2006350684B2 (en) 2012-07-05

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