CN104418825A - 利普司他汀的提纯方法 - Google Patents
利普司他汀的提纯方法 Download PDFInfo
- Publication number
- CN104418825A CN104418825A CN201310367722.6A CN201310367722A CN104418825A CN 104418825 A CN104418825 A CN 104418825A CN 201310367722 A CN201310367722 A CN 201310367722A CN 104418825 A CN104418825 A CN 104418825A
- Authority
- CN
- China
- Prior art keywords
- lipstatin
- organic solvent
- obtains
- alkane
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (13)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310367722.6A CN104418825B (zh) | 2013-08-21 | 2013-08-21 | 利普司他汀的提纯方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310367722.6A CN104418825B (zh) | 2013-08-21 | 2013-08-21 | 利普司他汀的提纯方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104418825A true CN104418825A (zh) | 2015-03-18 |
CN104418825B CN104418825B (zh) | 2016-12-28 |
Family
ID=52969028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310367722.6A Expired - Fee Related CN104418825B (zh) | 2013-08-21 | 2013-08-21 | 利普司他汀的提纯方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104418825B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105061365A (zh) * | 2015-07-20 | 2015-11-18 | 聊城大学 | 一锅法从发酵液中提取利普司他汀的方法 |
CN110066260A (zh) * | 2019-04-19 | 2019-07-30 | 大邦(湖南)生物制药有限公司 | 一种纯化利普斯他汀的方法 |
CN112062680A (zh) * | 2020-08-25 | 2020-12-11 | 南京工业大学 | 一种有机质子型离子液体、二维钙钛矿纯相量子阱结构薄膜、制备方法及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2141236A1 (en) * | 2008-07-03 | 2010-01-06 | KRKA, D.D., Novo Mesto | Process for production of lipstatin and microorganisms therefore |
CN101885713A (zh) * | 2010-07-19 | 2010-11-17 | 大邦(湖南)生物制药有限公司 | 一种毒三素链霉菌发酵液中分离提取利普司他汀的新工艺 |
CN102965407A (zh) * | 2012-11-28 | 2013-03-13 | 广州明新医药科技有限公司 | 一种利普司他汀生产工艺 |
CN102993134A (zh) * | 2012-12-31 | 2013-03-27 | 鲁南新时代生物技术有限公司 | 一种利普司他汀的提纯方法 |
CN103131739A (zh) * | 2013-03-19 | 2013-06-05 | 广州迈达康医药科技有限公司 | 制备尼泊司他汀的生产工艺 |
-
2013
- 2013-08-21 CN CN201310367722.6A patent/CN104418825B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2141236A1 (en) * | 2008-07-03 | 2010-01-06 | KRKA, D.D., Novo Mesto | Process for production of lipstatin and microorganisms therefore |
CN101885713A (zh) * | 2010-07-19 | 2010-11-17 | 大邦(湖南)生物制药有限公司 | 一种毒三素链霉菌发酵液中分离提取利普司他汀的新工艺 |
CN102965407A (zh) * | 2012-11-28 | 2013-03-13 | 广州明新医药科技有限公司 | 一种利普司他汀生产工艺 |
CN102993134A (zh) * | 2012-12-31 | 2013-03-27 | 鲁南新时代生物技术有限公司 | 一种利普司他汀的提纯方法 |
CN103131739A (zh) * | 2013-03-19 | 2013-06-05 | 广州迈达康医药科技有限公司 | 制备尼泊司他汀的生产工艺 |
Non-Patent Citations (1)
Title |
---|
胡为民等: "毒三素链霉菌生产利普司他汀的发酵与提取工艺", 《中国医药工业杂志》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105061365A (zh) * | 2015-07-20 | 2015-11-18 | 聊城大学 | 一锅法从发酵液中提取利普司他汀的方法 |
CN110066260A (zh) * | 2019-04-19 | 2019-07-30 | 大邦(湖南)生物制药有限公司 | 一种纯化利普斯他汀的方法 |
CN112062680A (zh) * | 2020-08-25 | 2020-12-11 | 南京工业大学 | 一种有机质子型离子液体、二维钙钛矿纯相量子阱结构薄膜、制备方法及其应用 |
CN112062680B (zh) * | 2020-08-25 | 2021-06-22 | 南京工业大学 | 一种有机质子型离子液体、二维钙钛矿纯相量子阱结构薄膜、制备方法及其应用 |
Also Published As
Publication number | Publication date |
---|---|
CN104418825B (zh) | 2016-12-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102391112B (zh) | 一种工业化生产二十碳五烯酸乙酯的方法 | |
CN111487356B (zh) | 一种利用超临界流体色谱系统分离辅酶q10的方法 | |
WO2021036386A1 (zh) | 一种模拟移动床连续层析色谱系统及其应用以及纯化辅酶q10的方法 | |
WO2020015316A1 (zh) | 辅酶q10的提取纯化方法及由其制备的辅酶q10 | |
CN114436924B (zh) | 一种羟基频哪酮视黄酸酯的合成方法 | |
CN104418825A (zh) | 利普司他汀的提纯方法 | |
CN102993134B (zh) | 一种利普司他汀的提纯方法 | |
CN102010387A (zh) | 一种提纯奥利司他的方法 | |
CN102993135B (zh) | 一种奥利司他的纯化方法 | |
JP2004504853A5 (zh) | ||
CN113004134A (zh) | 一种利用棕榈油提取物分离纯化发酵液中维生素k2的方法 | |
CN107033114B (zh) | 一种二氢杨梅素的分离纯化方法 | |
KR20080071841A (ko) | 조효소 q10의 분리 및 정제 방법 | |
CN108164415B (zh) | 一种从鱼油中完全分离epa和dha的方法 | |
CN105732663A (zh) | 6-氨基青霉烷酸的制备方法 | |
JP2002121174A (ja) | プラバスタチンを精製する方法 | |
CN110396058A (zh) | 一种新型骨化二醇(25-羟基维生素d3)分离纯化方法 | |
CN107162910B (zh) | 从鱼油中制备高纯度epa-ee的方法 | |
CN102399210B (zh) | 一种从发酵液中分离提取高纯度布雷菲德菌素a的方法 | |
CN102827244A (zh) | 一种精制谷胱甘肽发酵液的方法 | |
CN104447950A (zh) | 一种罗米地辛的分离纯化方法 | |
CN105418409B (zh) | 分离纯化高纯度青蒿酸的方法 | |
CN101792476A (zh) | 一种提取分离夫西地酸的方法 | |
CN114702487B (zh) | 一种麦角酸的纯化方法 | |
WO2018218903A1 (zh) | 一种全细胞催化制备曲克芦丁酯的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee after: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee after: CHONGQING DAXIN PHARMACEUTICAL Co.,Ltd. Patentee after: PKU HEALTHCARE INDUSTRY Group Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: Peking University International Hospital Group Chongqing Daxin Pharmaceutical Co.,Ltd. Patentee before: Pku Healthcare Industry Group Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20221012 Address after: 3007, Hengqin international financial center building, No. 58, Huajin street, Hengqin new area, Zhuhai, Guangdong 519031 Patentee after: New founder holdings development Co.,Ltd. Patentee after: CHONGQING DAXIN PHARMACEUTICAL Co.,Ltd. Patentee after: Peking University Medical Management Co.,Ltd. Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: CHONGQING DAXIN PHARMACEUTICAL Co.,Ltd. Patentee before: PKU HEALTHCARE INDUSTRY Group |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161228 |