CN104418825B - 利普司他汀的提纯方法 - Google Patents
利普司他汀的提纯方法 Download PDFInfo
- Publication number
- CN104418825B CN104418825B CN201310367722.6A CN201310367722A CN104418825B CN 104418825 B CN104418825 B CN 104418825B CN 201310367722 A CN201310367722 A CN 201310367722A CN 104418825 B CN104418825 B CN 104418825B
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- CN
- China
- Prior art keywords
- lipstatin
- organic solvent
- liquid
- alkane
- obtains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (25)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310367722.6A CN104418825B (zh) | 2013-08-21 | 2013-08-21 | 利普司他汀的提纯方法 |
Applications Claiming Priority (1)
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CN201310367722.6A CN104418825B (zh) | 2013-08-21 | 2013-08-21 | 利普司他汀的提纯方法 |
Publications (2)
Publication Number | Publication Date |
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CN104418825A CN104418825A (zh) | 2015-03-18 |
CN104418825B true CN104418825B (zh) | 2016-12-28 |
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Family Applications (1)
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CN201310367722.6A Expired - Fee Related CN104418825B (zh) | 2013-08-21 | 2013-08-21 | 利普司他汀的提纯方法 |
Country Status (1)
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CN (1) | CN104418825B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105061365A (zh) * | 2015-07-20 | 2015-11-18 | 聊城大学 | 一锅法从发酵液中提取利普司他汀的方法 |
CN110066260B (zh) * | 2019-04-19 | 2022-05-24 | 大邦(湖南)生物制药有限公司 | 一种纯化利普斯他汀的方法 |
CN112062680B (zh) * | 2020-08-25 | 2021-06-22 | 南京工业大学 | 一种有机质子型离子液体、二维钙钛矿纯相量子阱结构薄膜、制备方法及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2141236A1 (en) * | 2008-07-03 | 2010-01-06 | KRKA, D.D., Novo Mesto | Process for production of lipstatin and microorganisms therefore |
CN101885713A (zh) * | 2010-07-19 | 2010-11-17 | 大邦(湖南)生物制药有限公司 | 一种毒三素链霉菌发酵液中分离提取利普司他汀的新工艺 |
CN102965407A (zh) * | 2012-11-28 | 2013-03-13 | 广州明新医药科技有限公司 | 一种利普司他汀生产工艺 |
CN102993134A (zh) * | 2012-12-31 | 2013-03-27 | 鲁南新时代生物技术有限公司 | 一种利普司他汀的提纯方法 |
CN103131739A (zh) * | 2013-03-19 | 2013-06-05 | 广州迈达康医药科技有限公司 | 制备尼泊司他汀的生产工艺 |
-
2013
- 2013-08-21 CN CN201310367722.6A patent/CN104418825B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2141236A1 (en) * | 2008-07-03 | 2010-01-06 | KRKA, D.D., Novo Mesto | Process for production of lipstatin and microorganisms therefore |
CN101885713A (zh) * | 2010-07-19 | 2010-11-17 | 大邦(湖南)生物制药有限公司 | 一种毒三素链霉菌发酵液中分离提取利普司他汀的新工艺 |
CN102965407A (zh) * | 2012-11-28 | 2013-03-13 | 广州明新医药科技有限公司 | 一种利普司他汀生产工艺 |
CN102993134A (zh) * | 2012-12-31 | 2013-03-27 | 鲁南新时代生物技术有限公司 | 一种利普司他汀的提纯方法 |
CN103131739A (zh) * | 2013-03-19 | 2013-06-05 | 广州迈达康医药科技有限公司 | 制备尼泊司他汀的生产工艺 |
Non-Patent Citations (1)
Title |
---|
毒三素链霉菌生产利普司他汀的发酵与提取工艺;胡为民等;《中国医药工业杂志》;20071031;第38卷(第10期);第705-708页 * |
Also Published As
Publication number | Publication date |
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CN104418825A (zh) | 2015-03-18 |
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CP01 | Change in the name or title of a patent holder |
Address after: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee after: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee after: CHONGQING DAXIN PHARMACEUTICAL Co.,Ltd. Patentee after: PKU HEALTHCARE INDUSTRY Group Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: Peking University International Hospital Group Chongqing Daxin Pharmaceutical Co.,Ltd. Patentee before: Pku Healthcare Industry Group Co.,Ltd. |
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CP01 | Change in the name or title of a patent holder | ||
TR01 | Transfer of patent right |
Effective date of registration: 20221012 Address after: 3007, Hengqin international financial center building, No. 58, Huajin street, Hengqin new area, Zhuhai, Guangdong 519031 Patentee after: New founder holdings development Co.,Ltd. Patentee after: CHONGQING DAXIN PHARMACEUTICAL Co.,Ltd. Patentee after: Peking University Medical Management Co.,Ltd. Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: CHONGQING DAXIN PHARMACEUTICAL Co.,Ltd. Patentee before: PKU HEALTHCARE INDUSTRY Group |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161228 |
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CF01 | Termination of patent right due to non-payment of annual fee |