MX2008012943A - Derivados azaheterociclico de androstanos y androstenos como medicamentos para trastornos cardiovasculares. - Google Patents

Derivados azaheterociclico de androstanos y androstenos como medicamentos para trastornos cardiovasculares.

Info

Publication number
MX2008012943A
MX2008012943A MX2008012943A MX2008012943A MX2008012943A MX 2008012943 A MX2008012943 A MX 2008012943A MX 2008012943 A MX2008012943 A MX 2008012943A MX 2008012943 A MX2008012943 A MX 2008012943A MX 2008012943 A MX2008012943 A MX 2008012943A
Authority
MX
Mexico
Prior art keywords
medicaments
cardiovascular disorders
androstenes
androstanes
compounds
Prior art date
Application number
MX2008012943A
Other languages
English (en)
Inventor
Alberto Cerri
Giuseppe Bianchi
Patrizia Ferrari
Rosamaria Micheletti
Giorgio Fedrizzi
Alessandra Benicchio
Mauro Gobbini
Marco Pozzi
Pieroenrico Scotti
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of MX2008012943A publication Critical patent/MX2008012943A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Se describen compuestos de la fórmula (I) (ver fórmula (I)) en donde: los grupos son como se definió en la descripción, que son útiles en al preparación de medicamentos para el tratamiento de trastornos cardiovasculares, en particular insuficiencia cardiaca e hipertensión. Los compuestos son inhibidores de la actividad enzimática de la Na+, K+-ATPasa. Los compuestos se usan en la preparación de un medicamento para el tratamiento de una enfermedad causada por los efectos hipertensores de ouabaína endógena, tales como progresión de insuficiencia renal en enfermedad renal poliquística autosómica dominante (ADPKD), hipertensión preeclámpsica y proteinuria y progresión de insuficiencia renal en pacientes con polimorfismos de aducina.
MX2008012943A 2006-04-13 2007-04-11 Derivados azaheterociclico de androstanos y androstenos como medicamentos para trastornos cardiovasculares. MX2008012943A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112605 2006-04-13
PCT/EP2007/053521 WO2007118830A1 (en) 2006-04-13 2007-04-11 Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Publications (1)

Publication Number Publication Date
MX2008012943A true MX2008012943A (es) 2008-10-15

Family

ID=37309533

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008012943A MX2008012943A (es) 2006-04-13 2007-04-11 Derivados azaheterociclico de androstanos y androstenos como medicamentos para trastornos cardiovasculares.

Country Status (16)

Country Link
US (1) US8536160B2 (es)
EP (1) EP2004669B1 (es)
JP (1) JP5438502B2 (es)
KR (1) KR101411280B1 (es)
CN (1) CN101466726B (es)
AU (1) AU2007239516B2 (es)
BR (1) BRPI0710613A2 (es)
CA (1) CA2649173C (es)
EA (1) EA015622B1 (es)
ES (1) ES2403366T3 (es)
HK (1) HK1134820A1 (es)
MX (1) MX2008012943A (es)
PL (1) PL2004669T3 (es)
PT (1) PT2004669E (es)
TW (1) TWI389917B (es)
WO (1) WO2007118830A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010108855A1 (en) * 2009-03-23 2010-09-30 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. 5-β, 14-β-ANDROSTANE DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEINURIA, GLOMERULOSCLEROSIS AND RENAL FAILURE
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
US20130303500A1 (en) * 2010-07-30 2013-11-14 Medexis S.A. Compounds and methods for treating neoplasia
CN103304623B (zh) * 2012-03-08 2015-05-20 华东师范大学 一种6β,19-环氧雄甾-3,17-二酮的合成方法
AU2016288230A1 (en) 2015-07-02 2018-01-25 Horizon Orphan Llc ADO-resistant cysteamine analogs and uses thereof
CN105237455A (zh) * 2015-10-14 2016-01-13 湖南华腾制药有限公司 一种3-取代氮杂环丁烷的制备方法
CN108707180A (zh) * 2018-08-08 2018-10-26 齐齐哈尔医学院 3β-羟基-5α,8α-过氧雄甾-6-烯-17-(靛红取代)腙衍生物及制备和应用
DK3805243T3 (da) * 2019-10-09 2024-01-02 Windtree Therapeutics Inc Androstanderivater med aktivitet som rene eller hovedsageligt rene stimulatorer af serca2a til behandling af hjertesvigt
CN113461771B (zh) * 2020-03-31 2022-09-30 南方科技大学 钠钾atp酶抑制剂的制备方法
CN115850359A (zh) * 2022-12-14 2023-03-28 梯尔希（南京）药物研发有限公司 一种孕二烯酮杂质i的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB868303A (en) 1956-09-08 1961-05-17 Syntex Sa New cyclopentanophenanthrene derivatives and process for the production thereof
BE589491A (es) * 1959-04-10
US3210386A (en) 1961-01-09 1965-10-05 Upjohn Co 3-aminoethers of 3beta-hydroxy androstanes
BE621470A (es) 1961-08-17
FR7725M (es) 1967-06-22 1970-03-02
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
DE19633349A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
US6100279A (en) 1998-11-05 2000-08-08 Schering Corporation Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
DE19906159A1 (de) * 1999-02-09 2000-08-10 Schering Ag 16-Hydroxyestratriene als selektiv wirksame Estrogene
FR2826011B1 (fr) 2001-06-14 2004-12-10 Oreal Nouveaux derives de la 7-oxo-dhea et utilisation cosmetique
FR2831440B1 (fr) 2001-10-25 2003-12-26 Oreal Composition cosmetique, renfermant un derive de la dhea et un agent apaisant
PT1689410E (pt) * 2003-11-26 2008-08-18 Bayer Schering Pharma Ag Prevenção e tratamento de doenças cardíacas hipertensivas pelos estrogénios selectivos 8beta-vinil-estra-1,3,5(10)-trieno-3,17beta-diol e 17beta-fluoro-9alfa-vinil-estra-1,3,5(10)-trieno-3,16alfa-diol

Also Published As

Publication number Publication date
AU2007239516A1 (en) 2007-10-25
KR20080109916A (ko) 2008-12-17
EA200870433A1 (ru) 2009-04-28
JP5438502B2 (ja) 2014-03-12
BRPI0710613A2 (pt) 2011-08-16
ES2403366T3 (es) 2013-05-17
PT2004669E (pt) 2013-04-18
CA2649173C (en) 2013-11-19
EP2004669B1 (en) 2013-01-23
TW200801032A (en) 2008-01-01
WO2007118830A1 (en) 2007-10-25
TWI389917B (zh) 2013-03-21
AU2007239516B2 (en) 2011-11-17
PL2004669T3 (pl) 2013-06-28
KR101411280B1 (ko) 2014-06-24
CA2649173A1 (en) 2007-10-25
HK1134820A1 (en) 2010-05-14
CN101466726B (zh) 2014-09-24
EA015622B1 (ru) 2011-10-31
AU2007239516A2 (en) 2009-01-08
EP2004669A1 (en) 2008-12-24
JP2009533391A (ja) 2009-09-17
US8536160B2 (en) 2013-09-17
US20090275542A1 (en) 2009-11-05
CN101466726A (zh) 2009-06-24

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