MX2007010478A - Glicopeptidos semisinteticos con actividad antibiotica. - Google Patents
Glicopeptidos semisinteticos con actividad antibiotica.Info
- Publication number
- MX2007010478A MX2007010478A MX2007010478A MX2007010478A MX2007010478A MX 2007010478 A MX2007010478 A MX 2007010478A MX 2007010478 A MX2007010478 A MX 2007010478A MX 2007010478 A MX2007010478 A MX 2007010478A MX 2007010478 A MX2007010478 A MX 2007010478A
- Authority
- MX
- Mexico
- Prior art keywords
- scaffolds
- certain
- amino
- compounds
- semi
- Prior art date
Links
- 108010015899 Glycopeptides Proteins 0.000 title abstract 2
- 102000002068 Glycopeptides Human genes 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000004048 modification Effects 0.000 abstract 3
- 238000012986 modification Methods 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 230000010933 acylation Effects 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- BEVDFPMXVNOQBI-AXNWEOKVSA-N (19R,22R,34S,37R,40R,52S)-64-[(2S,3R,4R,5S,6S)-3-amino-6-carboxy-4,5-dihydroxyoxan-2-yl]oxy-5,32-dichloro-2,26,31,49-tetrahydroxy-22-(methylamino)-21,35,38,54,56,59-hexaoxo-47-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14(63),15,17(62),23(61),24,26,29(60),30,32,41,43,45(57),46(51),47,49,65-henicosaene-52-carboxylic acid Chemical group CN[C@@H]1c2ccc(O)c(Oc3cc(O)c(Cl)c(c3)[C@@H]3NC(=O)[C@@H](Cc4ccc(Oc5cc6cc(Oc7ccc(cc7Cl)C(O)C7NC(=O)[C@H](NC(=O)[C@@H]6NC3=O)c3cccc(c3)-c3c(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)cc(O)cc3[C@H](NC7=O)C(O)=O)c5O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3N)C(O)=O)cc4)NC1=O)c2 BEVDFPMXVNOQBI-AXNWEOKVSA-N 0.000 abstract 1
- -1 A82846B Chemical compound 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 108010053950 Teicoplanin Proteins 0.000 abstract 1
- 108010059993 Vancomycin Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- DDTDNCYHLGRFBM-YZEKDTGTSA-N chembl2367892 Chemical compound CC(=O)N[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1O[C@@H]([C@H]1C(N[C@@H](C2=CC(O)=CC(O[C@@H]3[C@H]([C@H](O)[C@H](O)[C@@H](CO)O3)O)=C2C=2C(O)=CC=C(C=2)[C@@H](NC(=O)[C@@H]2NC(=O)[C@@H]3C=4C=C(O)C=C(C=4)OC=4C(O)=CC=C(C=4)[C@@H](N)C(=O)N[C@H](CC=4C=C(Cl)C(O5)=CC=4)C(=O)N3)C(=O)N1)C(O)=O)=O)C(C=C1Cl)=CC=C1OC1=C(O[C@H]3[C@H]([C@@H](O)[C@H](O)[C@H](CO)O3)NC(C)=O)C5=CC2=C1 DDTDNCYHLGRFBM-YZEKDTGTSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108010013356 eremomycin Proteins 0.000 abstract 1
- UECIPBUIMXSXEI-BNSVOVDNSA-N eremomycin Chemical compound O([C@@H]1C2=CC=C(C=C2)OC=2C=C3C=C(C=2O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2O[C@@H](C)[C@H](O)[C@@](C)(N)C2)OC2=CC=C(C=C2Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]2C(=O)N[C@@H]1C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@@H](O)[C@H](C)O1 UECIPBUIMXSXEI-BNSVOVDNSA-N 0.000 abstract 1
- UECIPBUIMXSXEI-UHFFFAOYSA-N eremomycin Natural products C=1C2=CC=C(O)C=1C1=C(O)C=C(O)C=C1C(C(O)=O)NC(=O)C1NC(=O)C2NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC(C=3OC4C(C(O)C(O)C(CO)O4)OC4OC(C)C(O)C(C)(N)C4)=CC2=CC=3OC(C=C2)=CC=C2C1OC1CC(C)(N)C(O)C(C)O1 UECIPBUIMXSXEI-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229960001608 teicoplanin Drugs 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1
- 229960003165 vancomycin Drugs 0.000 abstract 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65729705P | 2005-02-28 | 2005-02-28 | |
| PCT/US2006/007049 WO2006093947A2 (en) | 2005-02-28 | 2006-02-27 | Semi-synthetic glycopeptides with antibiotic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007010478A true MX2007010478A (es) | 2008-02-07 |
Family
ID=36941732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007010478A MX2007010478A (es) | 2005-02-28 | 2006-02-27 | Glicopeptidos semisinteticos con actividad antibiotica. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7632918B2 (https=) |
| EP (1) | EP1861115A4 (https=) |
| JP (2) | JP2008531702A (https=) |
| KR (1) | KR20080004455A (https=) |
| CN (1) | CN101222933A (https=) |
| AU (1) | AU2006218665A1 (https=) |
| BR (1) | BRPI0607702A2 (https=) |
| CA (1) | CA2600453A1 (https=) |
| MX (1) | MX2007010478A (https=) |
| WO (1) | WO2006093947A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7368422B2 (en) * | 2005-02-28 | 2008-05-06 | Novartis Vaccines And Diagnostics Inc. | Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity |
| US20070185015A1 (en) * | 2005-02-28 | 2007-08-09 | Chiron Corporation and North China Pharmaceutical Corporation | Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity |
| US7632918B2 (en) | 2005-02-28 | 2009-12-15 | Novartis Vaccines And Diagnostics, Inc. | Semi-synthetic glycopeptides with antibiotic activity |
| CN101959849A (zh) * | 2007-12-26 | 2011-01-26 | 利德治疗公司 | 作为抗菌剂的新型半合成糖肽 |
| CN101343313B (zh) * | 2008-09-03 | 2011-11-16 | 南京农业大学 | 一种葡萄糖二肽类化合物及其制备方法和用途 |
| US20100105607A1 (en) * | 2008-10-24 | 2010-04-29 | Lead Therapeutics, Inc. | Novel semi-synthetic glycopeptides as antibacterial agents |
| GB2465863A (en) * | 2008-12-05 | 2010-06-09 | Lead Therapeutics Inc | Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections |
| CN101928330B (zh) * | 2009-06-26 | 2013-10-16 | 上海来益生物药物研究开发中心有限责任公司 | 一种新的化合物及其应用 |
| US20170342110A1 (en) | 2014-12-25 | 2017-11-30 | Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) | Glycopeptides and uses thereof |
| EP3281942A4 (en) * | 2015-09-16 | 2018-08-15 | Xuanzhu Pharma Co., Ltd. | B-lactamase inhibitor and application thereof |
| CN107619433B (zh) * | 2016-07-15 | 2023-03-17 | 上海来益生物药物研究开发中心有限责任公司 | 糖肽类衍生物及其药学可接受的盐、制备方法和应用 |
| GB2577420B (en) * | 2017-05-22 | 2022-07-06 | Insmed Inc | Glycopeptide derivative compounds and uses thereof |
| CN109422800A (zh) * | 2017-08-22 | 2019-03-05 | 复旦大学 | 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途 |
| CN108774158A (zh) * | 2018-06-20 | 2018-11-09 | 南京肽业生物科技有限公司 | 一种Fmoc和疏水性氨基酸的反应 |
| CN110938114B (zh) * | 2018-09-21 | 2023-04-28 | 中国科学院上海药物研究所 | 一类万古霉素硫鎓衍生物、其制备方法、药物组合物和用途 |
| EP3883590A4 (en) * | 2018-11-21 | 2022-09-21 | Insmed Incorporated | GLYCOPEPTIDE DERIVATIVE COMPOUNDS AND USES THEREOF |
| JP7808465B2 (ja) * | 2021-12-20 | 2026-01-29 | 花王株式会社 | 有機化合物、試薬、及び分析方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3011278B1 (de) | 1980-03-24 | 1981-04-02 | Rohde & Schwarz GmbH & Co KG, 8000 München | Funkpeiler |
| US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| GB8522574D0 (en) * | 1985-09-12 | 1985-10-16 | Lepetit Spa | Amides of teicoplanin compounds |
| GB8701872D0 (en) | 1987-01-28 | 1987-03-04 | Lepetit Spa | N15-alkyl & n15,n15-dialkyl derivatives |
| CA1339808C (en) | 1988-10-19 | 1998-04-07 | Manuel Debono | Glycopeptide antibiotics |
| US5500410A (en) * | 1989-03-29 | 1996-03-19 | Gruppo Lepetit S.P.A. | Substituted alkylamide derivatives of teicoplanin |
| MY128335A (en) | 1994-01-28 | 2007-01-31 | Lilly Co Eli | Glycopeptide antibiotic derivatives |
| US5840684A (en) * | 1994-01-28 | 1998-11-24 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
| US5488131A (en) * | 1994-03-23 | 1996-01-30 | California Institute Of Technology | Synthesis of compounds with predetermined chirality |
| US5919756A (en) * | 1996-06-28 | 1999-07-06 | Eli Lilly And Company | Amides |
| DE69908819T2 (de) * | 1998-12-23 | 2004-05-06 | Theravance, Inc., South San Francisco | Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten |
| AU4054900A (en) | 1999-04-02 | 2000-10-23 | Advanced Medicine East, Inc. | Desleucyl glycopeptide antibiotics and methods of making same |
| US6699836B2 (en) | 1999-04-02 | 2004-03-02 | The Trustees Of Princeton University | Vancomycin analogs |
| AU5029700A (en) * | 1999-05-19 | 2000-12-05 | Merck & Co., Inc. | Glycopeptide antibacterial compounds, compositions containing same and methods of using same |
| MXPA02007739A (es) | 2000-02-11 | 2002-10-11 | Lilly Co Eli | N-acilacion selectiva de analogos del glicopeptido a82846. |
| US20030008812A1 (en) * | 2001-02-02 | 2003-01-09 | Christensen Burton G. | Glycopeptide derivatives |
| US7348309B2 (en) * | 2001-03-30 | 2008-03-25 | Wisconsin Alumni Research Foundation | Glycorandomization and production of novel vancomycin analogs |
| EP1534316A2 (en) | 2002-08-30 | 2005-06-01 | K.U. Leuven Research and Development | Glycopeptide antibiotics and semisynthetic derivatives thereof and their use as antiviral agents |
| AU2003287605A1 (en) * | 2002-11-12 | 2004-06-03 | Enzon Pharmaceuticals, Inc. | Polymeric prodrugs of vancomycin |
| US7521418B2 (en) * | 2003-05-27 | 2009-04-21 | Theravance, Inc. | Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent |
| US7368422B2 (en) * | 2005-02-28 | 2008-05-06 | Novartis Vaccines And Diagnostics Inc. | Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity |
| US7632918B2 (en) | 2005-02-28 | 2009-12-15 | Novartis Vaccines And Diagnostics, Inc. | Semi-synthetic glycopeptides with antibiotic activity |
| US20070185015A1 (en) | 2005-02-28 | 2007-08-09 | Chiron Corporation and North China Pharmaceutical Corporation | Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity |
-
2006
- 2006-02-24 US US11/361,852 patent/US7632918B2/en not_active Expired - Fee Related
- 2006-02-27 CA CA002600453A patent/CA2600453A1/en not_active Abandoned
- 2006-02-27 JP JP2007558127A patent/JP2008531702A/ja active Pending
- 2006-02-27 BR BRPI0607702-1A patent/BRPI0607702A2/pt not_active IP Right Cessation
- 2006-02-27 MX MX2007010478A patent/MX2007010478A/es not_active Application Discontinuation
- 2006-02-27 KR KR1020077019508A patent/KR20080004455A/ko not_active Withdrawn
- 2006-02-27 EP EP06721111A patent/EP1861115A4/en not_active Withdrawn
- 2006-02-27 CN CNA2006800146971A patent/CN101222933A/zh active Pending
- 2006-02-27 AU AU2006218665A patent/AU2006218665A1/en not_active Abandoned
- 2006-02-27 WO PCT/US2006/007049 patent/WO2006093947A2/en not_active Ceased
-
2009
- 2009-02-18 JP JP2009035666A patent/JP2009102446A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101222933A (zh) | 2008-07-16 |
| US7632918B2 (en) | 2009-12-15 |
| EP1861115A4 (en) | 2011-03-16 |
| BRPI0607702A2 (pt) | 2009-11-03 |
| AU2006218665A1 (en) | 2006-09-08 |
| KR20080004455A (ko) | 2008-01-09 |
| EP1861115A2 (en) | 2007-12-05 |
| WO2006093947A3 (en) | 2007-05-31 |
| JP2009102446A (ja) | 2009-05-14 |
| WO2006093947A2 (en) | 2006-09-08 |
| US20060276623A1 (en) | 2006-12-07 |
| CA2600453A1 (en) | 2006-09-08 |
| JP2008531702A (ja) | 2008-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |