MX2007002099A - Compuestos de aren retenio (ii) y su uso en la terapia del cancer. - Google Patents
Compuestos de aren retenio (ii) y su uso en la terapia del cancer.Info
- Publication number
- MX2007002099A MX2007002099A MX2007002099A MX2007002099A MX2007002099A MX 2007002099 A MX2007002099 A MX 2007002099A MX 2007002099 A MX2007002099 A MX 2007002099A MX 2007002099 A MX2007002099 A MX 2007002099A MX 2007002099 A MX2007002099 A MX 2007002099A
- Authority
- MX
- Mexico
- Prior art keywords
- compound according
- carbocyclic
- alkyl
- compound
- ring
- Prior art date
Links
- -1 Arene ruthenium (ii) compounds Chemical class 0.000 title claims abstract description 50
- 238000011275 oncology therapy Methods 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 115
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 60
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 53
- 239000003446 ligand Substances 0.000 claims abstract description 46
- 125000003118 aryl group Chemical group 0.000 claims abstract description 34
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- 229940002612 prodrug Drugs 0.000 claims abstract description 13
- 239000000651 prodrug Substances 0.000 claims abstract description 13
- 239000012453 solvate Substances 0.000 claims abstract description 13
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 12
- 150000003568 thioethers Chemical class 0.000 claims abstract description 12
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 11
- 125000000751 azo group Chemical group [*]N=N[*] 0.000 claims abstract description 11
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 10
- 125000002252 acyl group Chemical group 0.000 claims abstract description 9
- 125000003368 amide group Chemical group 0.000 claims abstract description 7
- MSOONVMMTIVQIJ-UHFFFAOYSA-N S(=O)(=O)(O)S(=O)(=O)NONS(=O)(=O)S(=O)(=O)O Chemical compound S(=O)(=O)(O)S(=O)(=O)NONS(=O)(=O)S(=O)(=O)O MSOONVMMTIVQIJ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 3
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- 238000000034 method Methods 0.000 claims description 21
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- 206010028980 Neoplasm Diseases 0.000 claims description 11
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 11
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- 239000003937 drug carrier Substances 0.000 claims description 2
- 150000007944 thiolates Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000003627 8 membered carbocyclic group Chemical group 0.000 abstract 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 6
- GHCAUEMXBSLMGU-UHFFFAOYSA-N oxadiazole;1,2,5-oxadiazole Chemical compound C=1C=NON=1.C1=CON=N1 GHCAUEMXBSLMGU-UHFFFAOYSA-N 0.000 description 6
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- 125000003342 alkenyl group Chemical group 0.000 description 4
- 125000000304 alkynyl group Chemical group 0.000 description 4
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- 229940125782 compound 2 Drugs 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- HGGNZMUHOHGHBJ-UHFFFAOYSA-N dioxepane Chemical compound C1CCOOCC1 HGGNZMUHOHGHBJ-UHFFFAOYSA-N 0.000 description 4
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- 125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 description 1
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- 239000008251 pharmaceutical emulsion Substances 0.000 description 1
- 229950000688 phenothiazine Drugs 0.000 description 1
- GJSGGHOYGKMUPT-UHFFFAOYSA-N phenoxathiine Chemical compound C1=CC=C2OC3=CC=CC=C3SC2=C1 GJSGGHOYGKMUPT-UHFFFAOYSA-N 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 238000002428 photodynamic therapy Methods 0.000 description 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical compound C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 description 1
- LYKMMUBOEFYJQG-UHFFFAOYSA-N piperoxan Chemical compound C1OC2=CC=CC=C2OC1CN1CCCCC1 LYKMMUBOEFYJQG-UHFFFAOYSA-N 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical compound N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- CRTBNOWPBHJICM-UHFFFAOYSA-N pyrazine Chemical compound C1=CN=CC=N1.C1=CN=CC=N1 CRTBNOWPBHJICM-UHFFFAOYSA-N 0.000 description 1
- 150000003216 pyrazines Chemical class 0.000 description 1
- UBRJWPDONDYLLX-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1.C1CNNC1 UBRJWPDONDYLLX-UHFFFAOYSA-N 0.000 description 1
- GPHQHTOMRSGBNZ-UHFFFAOYSA-N pyridine-4-carbonitrile Chemical compound N#CC1=CC=NC=C1 GPHQHTOMRSGBNZ-UHFFFAOYSA-N 0.000 description 1
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
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- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- YYMWVZQRBNARFZ-UHFFFAOYSA-M sodium;2-[2,3-bis(sulfanyl)propoxy]ethanesulfonate Chemical compound [Na+].[O-]S(=O)(=O)CCOCC(S)CS YYMWVZQRBNARFZ-UHFFFAOYSA-M 0.000 description 1
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- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- 239000012086 standard solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 208000001608 teratocarcinoma Diseases 0.000 description 1
- FGTJJHCZWOVVNH-UHFFFAOYSA-N tert-butyl-[tert-butyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)O[Si](C)(C)C(C)(C)C FGTJJHCZWOVVNH-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- IFLREYGFSNHWGE-UHFFFAOYSA-N tetracene Chemical compound C1=CC=CC2=CC3=CC4=CC=CC=C4C=C3C=C21 IFLREYGFSNHWGE-UHFFFAOYSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- GVIJJXMXTUZIOD-UHFFFAOYSA-N thianthrene Chemical compound C1=CC=C2SC3=CC=CC=C3SC2=C1 GVIJJXMXTUZIOD-UHFFFAOYSA-N 0.000 description 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- XSROQCDVUIHRSI-UHFFFAOYSA-N thietane Chemical compound C1CSC1 XSROQCDVUIHRSI-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- BQAJJINKFRRSFO-UHFFFAOYSA-N thiolane Chemical compound C1CCSC1.C1CCSC1 BQAJJINKFRRSFO-UHFFFAOYSA-N 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
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- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0418643.3A GB0418643D0 (en) | 2004-08-20 | 2004-08-20 | Ruthenium (II) compounds |
| PCT/GB2005/003242 WO2006018649A1 (en) | 2004-08-20 | 2005-08-19 | Arene ruthenium (ii) compounds and their use in cancer therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007002099A true MX2007002099A (es) | 2007-04-24 |
Family
ID=33042406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007002099A MX2007002099A (es) | 2004-08-20 | 2005-08-19 | Compuestos de aren retenio (ii) y su uso en la terapia del cancer. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1786412A1 (https=) |
| JP (1) | JP2008510693A (https=) |
| KR (1) | KR20070060091A (https=) |
| CN (1) | CN101043885A (https=) |
| AU (1) | AU2005273726A1 (https=) |
| BR (1) | BRPI0514430A (https=) |
| CA (1) | CA2578280A1 (https=) |
| GB (1) | GB0418643D0 (https=) |
| MX (1) | MX2007002099A (https=) |
| NO (1) | NO20071481L (https=) |
| WO (1) | WO2006018649A1 (https=) |
| ZA (1) | ZA200702093B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006017594A1 (de) * | 2006-04-13 | 2007-10-18 | Wacker Chemie Ag | Neuartige Ru-Komplexe, deren Herstellung und Verwendung |
| US9018199B2 (en) | 2006-05-09 | 2015-04-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis |
| GB0711849D0 (en) * | 2007-06-19 | 2007-07-25 | Oxford Biosensors Ltd | Redox Mediators |
| EP2067771A1 (en) | 2007-12-03 | 2009-06-10 | EPFL Ecole Polytechnique Fédérale de Lausanne | Derivatives of Dihydroxypyrrolidine as Anti-Cancer Compounds |
| EP2409697A1 (en) | 2010-07-20 | 2012-01-25 | Université de Neuchâtel | Medicaments Based on Dinuclear Ruthenium, Osmium and Iron Complexes Comprising Triply Bridging Thiolato, Selenolato, Alkoxo and/or Amido Ligands |
| WO2013038395A1 (en) | 2011-09-16 | 2013-03-21 | Universidade De Lisboa | Transition metal complexes for pharmaceutical applications |
| WO2013136296A2 (en) | 2012-03-14 | 2013-09-19 | Universidade De Lisboa | Water-soluble organometallic ruthenium and iron compunds presenting heteroaromatic ligands |
| BR112015023568B8 (pt) | 2013-03-15 | 2024-01-02 | Ann Mcfarland Sherri | Composto à base de metal como composto fotodinâmico |
| US9751081B2 (en) | 2014-12-01 | 2017-09-05 | Clemson University | Self-regenerating antioxidant catalysts and methods of using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19736152A1 (de) * | 1997-08-14 | 1999-02-18 | Martin Wehlan | Azido-Aziridinkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JP2003512471A (ja) * | 1999-10-27 | 2003-04-02 | ユニバーシティ コート， エディンバラ大学 | 窒素および配位子を含む癌治療用の半サンドイッチ状ルテニウム（ｉｉ）化合物 |
| GB0016052D0 (en) * | 2000-06-30 | 2000-08-23 | Univ Edinburgh | Ruthenium (II) compounds |
| GB0215526D0 (en) * | 2002-07-05 | 2002-08-14 | Univ Edinburgh | Anticancer compounds |
-
2004
- 2004-08-20 GB GBGB0418643.3A patent/GB0418643D0/en not_active Ceased
-
2005
- 2005-08-19 JP JP2007526570A patent/JP2008510693A/ja active Pending
- 2005-08-19 WO PCT/GB2005/003242 patent/WO2006018649A1/en not_active Ceased
- 2005-08-19 MX MX2007002099A patent/MX2007002099A/es not_active Application Discontinuation
- 2005-08-19 BR BRPI0514430-2A patent/BRPI0514430A/pt not_active IP Right Cessation
- 2005-08-19 CN CNA2005800355417A patent/CN101043885A/zh active Pending
- 2005-08-19 CA CA002578280A patent/CA2578280A1/en not_active Abandoned
- 2005-08-19 AU AU2005273726A patent/AU2005273726A1/en not_active Abandoned
- 2005-08-19 EP EP05771813A patent/EP1786412A1/en not_active Withdrawn
- 2005-08-19 KR KR1020077006364A patent/KR20070060091A/ko not_active Withdrawn
-
2007
- 2007-03-12 ZA ZA200702093A patent/ZA200702093B/xx unknown
- 2007-03-20 NO NO20071481A patent/NO20071481L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070060091A (ko) | 2007-06-12 |
| GB0418643D0 (en) | 2004-09-22 |
| CA2578280A1 (en) | 2006-02-23 |
| WO2006018649A1 (en) | 2006-02-23 |
| EP1786412A1 (en) | 2007-05-23 |
| NO20071481L (no) | 2007-05-16 |
| CN101043885A (zh) | 2007-09-26 |
| JP2008510693A (ja) | 2008-04-10 |
| BRPI0514430A (pt) | 2008-05-06 |
| ZA200702093B (en) | 2008-08-27 |
| AU2005273726A1 (en) | 2006-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |